Gudrun Høiseth
- Head of Research; MD; PhD
- +47 23 01 30 26
Publications 2024
Enantiomer-specific analysis of amphetamine in urine, oral fluid and blood
J Anal Toxicol, 48 (5), 254-262
DOI 10.1093/jat/bkae038, PubMed 38706158
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications
Basic Clin Pharmacol Toxicol, 134 (3), 333-344
DOI 10.1111/bcpt.13975, PubMed 38124280
Driving under the influence of cocaine and MDMA: Relationship between blood concentrations and results from clinical test of impairment
J Anal Toxicol, 48 (5), 380-387
DOI 10.1093/jat/bkae024, PubMed 38613441
The relationship between clinical impairment and blood drug concentration: Comparison between the most prevalent traffic relevant drug groups
Forensic Sci Int, 363, 112180
DOI 10.1016/j.forsciint.2024.112180, PubMed 39141931
Publications 2023
Kapittel 49 LAR-behandling med metadon og buprenorfin
In Lærebok i rettsmedisin , Gyldendahl, Oslo, 4
PublikaID 458, ISBN 9788205584167
A two-sample approach to retrograde extrapolation of blood THC concentrations - Is it feasible?
Forensic Sci Int, 352, 111833
DOI 10.1016/j.forsciint.2023.111833, PubMed 37793282
Impact of age, sex and cytochrome P450 genotype on quetiapine and N-desalkylquetiapine serum concentrations: A study based on real-world data from 8118 patients
Br J Clin Pharmacol, 89 (12), 3503-3511
DOI 10.1111/bcp.15849, PubMed 37438870
Driving under the influence of zopiclone: Elimination between two consecutive blood samples
Forensic Sci Int, 349, 111764
DOI 10.1016/j.forsciint.2023.111764, PubMed 37352736
Nystagmus among suspected amphetamine impaired drivers
J Forensic Leg Med, 95, 102502
DOI 10.1016/j.jflm.2023.102502, PubMed 36924680
Oxycodone, Morphine, and Fentanyl in Patients With Chronic Pain: Proposal of Dose-Specific Concentration Ranges
Ther Drug Monit, 45 (6), 777-785
DOI 10.1097/FTD.0000000000001112, PubMed 37296504
Publications 2022
Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations
J Addict Dis, 41 (1), 53-63
DOI 10.1080/10550887.2022.2057140, PubMed 35356868
[Ethanol is detected in the corpse, but had the deceased drunk alcohol?]
Tidsskr Nor Laegeforen, 142 (6)
DOI 10.4045/tidsskr.21.0896, PubMed 35383445
[High level of ferritin and HDL cholesterol is associated with high alcohol consumption]
Tidsskr Nor Laegeforen, 142 (17)
DOI 10.4045/tidsskr.22.0431, PubMed 36416649
Comment on the upper cutoff level for the alcohol biomarker phosphatidylethanol (PEth) for the assessment of alcohol consumption in forensic practice
Drug Test Anal, 15 (7), 791-792
DOI 10.1002/dta.3432, PubMed 36585567
Falsely low phosphatidylethanol may be associated with biomarkers of haemolytic disease
Basic Clin Pharmacol Toxicol, 132 (2), 223-230
DOI 10.1111/bcpt.13814, PubMed 36370095
Publications 2021
Subjective symptoms and serum methadone concentrations: what should guide dose adjustments in methadone maintenance treatment? A naturalistic cohort study from Norway
Subst Abuse Treat Prev Policy, 16 (1), 39
DOI 10.1186/s13011-021-00367-w, PubMed 33941217
Associations of Binge Drinking With the Risks of Ischemic Heart Disease and Stroke: A Study of Pooled Norwegian Health Surveys
Am J Epidemiol, 190 (8), 1592-1603
DOI 10.1093/aje/kwab063, PubMed 33720294
The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL-C
Basic Clin Pharmacol Toxicol, 130 (1), 182-190
DOI 10.1111/bcpt.13662, PubMed 34591374
Relationship between betahydroxybutyrate (BHB) and acetone concentrations in postmortem blood and cause of death
Forensic Sci Int, 321, 110726
DOI 10.1016/j.forsciint.2021.110726, PubMed 33631622
Frequency of postmortem ethanol formation in blood, urine and vitreous humor - Improving diagnostic accuracy with the use of ethylsulphate and putrefactive alcohols
Forensic Sci Int, 331, 111152
DOI 10.1016/j.forsciint.2021.111152, PubMed 34952291
Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations-an observational study using blood samples from 1223 patients
Eur J Clin Pharmacol, 77 (8), 1201-1208
DOI 10.1007/s00228-021-03114-z, PubMed 33616704
Alcohol Consumption, HDL-Cholesterol and Incidence of Colon and Rectal Cancer: A Prospective Cohort Study Including 250,010 Participants
Alcohol Alcohol, 56 (6), 718-725
DOI 10.1093/alcalc/agab007, PubMed 33604595
Publications 2020
Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis
Early Hum Dev, 143, 104997
DOI 10.1016/j.earlhumdev.2020.104997, PubMed 32146140
Oral Fluid to Blood Concentration Ratios of Different Psychoactive Drugs in Samples from Suspected Drugged Drivers
Ther Drug Monit, 42 (5), 795-800
DOI 10.1097/FTD.0000000000000760, PubMed 32251151
Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis
PLoS Med, 17 (2), e1003030
DOI 10.1371/journal.pmed.1003030, PubMed 32012170
The Relationship Between Ingested Dose of Ethanol and Amount of Ethyl Glucuronide Formed in Blood
J Anal Toxicol, 44 (8), 861-863
DOI 10.1093/jat/bkaa090, PubMed 32743665
Blood Concentrations of Designer Benzodiazepines: Relation to Impairment and Findings in Forensic Cases
J Anal Toxicol, 44 (8), 905-914
DOI 10.1093/jat/bkaa043, PubMed 32369173
Drug use may cause unexpected findings during urinary drug analysis
Tidsskr. Nor. Laegeforen., 140 (13), 1375
A comparison of driving related skills impaired by ethanol and zopiclone
Traffic Inj Prev, 22 (1), 26-31
DOI 10.1080/15389588.2020.1849643, PubMed 33320019
Evaluating the hip-flask defence using analytical data from ethanol and ethyl glucuronide. A comparison of two models
Forensic Sci Int, 316, 110409
DOI 10.1016/j.forsciint.2020.110409, PubMed 32871451
[Use of medicinal drugs may yield unexpected findings for analysis of drugs of abuse in urine]
Tidsskr Nor Laegeforen, 140 (13)
DOI 10.4045/tidsskr.20.0237, PubMed 32998501
Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients
Eur J Clin Pharmacol, 77 (2), 215-221
DOI 10.1007/s00228-020-03002-y, PubMed 33000414
Impact of CYP2D6 on serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol
Br J Clin Pharmacol, 87 (5), 2228-2235
DOI 10.1111/bcp.14626, PubMed 33118660
Rate of elimination of γ-hydroxybutyrate from blood determined by analysis of two consecutive samples from apprehended drivers in Norway
Forensic Sci Int, 314, 110374
DOI 10.1016/j.forsciint.2020.110374, PubMed 32604006
Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate-Deficient Transferrin as Biomarkers of Alcohol Consumption
Alcohol Clin Exp Res, 45 (1), 153-162
DOI 10.1111/acer.14503, PubMed 33164220
Publications 2019
Detection of Drugs in Simultaneously Collected Samples of Oral Fluid and Blood
J Anal Toxicol, 43 (3), 228-232
DOI 10.1093/jat/bky079, PubMed 30295809
Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing
J Anal Toxicol, 43 (5), 369-377
DOI 10.1093/jat/bky083, PubMed 30615130
Dynamic assessment of the pupillary reflex in patients on high-dose opioids
Scand J Pain, 19 (3), 465-471
DOI 10.1515/sjpain-2019-0032, PubMed 31031265
An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses
J Anal Toxicol, 43 (2), 104-111
DOI 10.1093/jat/bky062, PubMed 30517712
Prescribing antipsychotics to the elderly living at home 2006-2018
Tidsskr. Nor. Laegeforen., 139 (16), 1554-1558
[Prescribing of antipsychotic drugs to older patients living at home 2006–18]
Tidsskr Nor Laegeforen, 139 (16)
DOI 10.4045/tidsskr.19.0233, PubMed 31686488
Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status
Eur J Clin Pharmacol, 76 (1), 41-49
DOI 10.1007/s00228-019-02768-0, PubMed 31637453
The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections
J Clin Psychopharmacol, 39 (6), 561-566
DOI 10.1097/JCP.0000000000001126, PubMed 31688390
Publications 2018
Life course socioeconomic position, alcohol drinking patterns in midlife, and cardiovascular mortality: Analysis of Norwegian population-based health surveys
PLoS Med, 15 (1), e1002476
DOI 10.1371/journal.pmed.1002476, PubMed 29293492
Hair EtG: Alterations in segment levels accompanying hair growth
Drug Test Anal, 11 (1), 112-118
DOI 10.1002/dta.2474, PubMed 30084156
Fatal Adverse Event with Dabigatran in Elderly Patient with Reduced Kidney Function
Basic Clin Pharmacol Toxicol, 123 (2), 221-226
DOI 10.1111/bcpt.12985, PubMed 29438599
Is Hair Analysis Useful in Postmortem Cases?
J Anal Toxicol, 42 (1), 49-54
DOI 10.1093/jat/bkx077, PubMed 28977558
A fatal blood concentration of 5-APB
Forensic Sci Int, 291, e1-e3
DOI 10.1016/j.forsciint.2018.08.044, PubMed 30228015
Can measurements of heroin metabolites in post-mortem matrices other than peripheral blood indicate if death was rapid or delayed?
Forensic Sci Int, 290, 121-128
DOI 10.1016/j.forsciint.2018.06.041, PubMed 30015276
Metabolites of Heroin in Several Different Post-mortem Matrices
J Anal Toxicol, 42 (5), 311-320
DOI 10.1093/jat/bky002, PubMed 29409037
Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients
J Clin Psychopharmacol, 38 (6), 570-576
DOI 10.1097/JCP.0000000000000961, PubMed 30300295
Publications 2017
Ethyl Glucuronide Elimination Kinetics in Fingernails and Comparison to Levels in Hair
Alcohol Alcohol, 52 (5), 580-586
DOI 10.1093/alcalc/agx035, PubMed 28591773
THC and CBD in blood samples and seizures in Norway: Does CBD affect THC-induced impairment in apprehended subjects?
Forensic Sci Int, 276, 12-17
DOI 10.1016/j.forsciint.2017.04.006, PubMed 28463706
The Appearance, Taste, and Concentrations of Zolpidem Dissolved in Still Water and Carbonated Beverages
J Forensic Sci, 63 (3), 911-914
DOI 10.1111/1556-4029.13604, PubMed 28810070
Zopiclone concentrations in oral fluid and blood after, administration of therapeutic doses of zopiclone
Forensic Sci Int, 278, 177-183
DOI 10.1016/j.forsciint.2017.07.004, PubMed 28735217
Urinary Kinetics of Heroin Metabolites in Pigs Shortly After Intake
J Anal Toxicol, 41 (5), 451-454
DOI 10.1093/jat/bkx017, PubMed 28335030
A literature review of blood concentrations of new psychoactive substances classified as phenethylamines, aminoindanes, arylalkylamines, arylcyclohexylamines, and indolalkylamines
Forensic Sci Int, 276, 120-125
DOI 10.1016/j.forsciint.2017.02.024, PubMed 28527345
Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment
Ther Drug Monit, 39 (5), 550-555
DOI 10.1097/FTD.0000000000000437, PubMed 28723731
Publications 2016
Levels of Hair Ethyl Glucuronide in Patients with Decreased Kidney Function: Possibility of Misclassification of Social Drinkers
Alcohol Clin Exp Res, 40 (3), 451-6
DOI 10.1111/acer.12970, PubMed 26853225
Pharmacokinetics of heroin and its metabolites in vitreous humor and blood in a living pig model
Forensic Toxicol, 34 (2), 277-285
DOI 10.1007/s11419-016-0315-z, PubMed 27660664
Prevalence and concentrations of drugs in older suspected drugged drivers
Traffic Inj Prev, 18 (3), 231-236
DOI 10.1080/15389588.2016.1247209, PubMed 27740861
Impairment due to alcohol, tetrahydrocannabinol, and benzodiazepines in impaired drivers compared to experimental studies
Traffic Inj Prev, 18 (3), 244-250
DOI 10.1080/15389588.2016.1201205, PubMed 27327554
Blood concentrations of new designer benzodiazepines in forensic cases
Forensic Sci Int, 268, 35-38
DOI 10.1016/j.forsciint.2016.09.006, PubMed 27685473
Ethanol elimination rates at low concentrations based on two consecutive blood samples
Forensic Sci Int, 266, 191-196
DOI 10.1016/j.forsciint.2016.05.039, PubMed 27295074
Cohort Profile Update: The Norwegian Mother and Child Cohort Study (MoBa)
Int J Epidemiol, 45 (2), 382-8
DOI 10.1093/ije/dyw029, PubMed 27063603
Publications 2015
Rapport om konsekvenser for fosteret/barnet ved bruk av rusmidler/avhengighetsskapende legemidler i svangerskapet
Helsedirektoratet
PublikaID 460
Evaluation of the hip-flask defence by determination of ethyl glucuronide and ethyl sulphate concentrations in blood
Forensic Sci Int, 257, 398-402
DOI 10.1016/j.forsciint.2015.10.017, PubMed 26555501
Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data
Ther Drug Monit, 37 (5), 589-93
DOI 10.1097/FTD.0000000000000183, PubMed 25565674
Has Previous Abuse of Flunitrazepam Been Replaced by Clonazepam?
Eur Addict Res, 21 (4), 217-21
DOI 10.1159/000377628, PubMed 25895512
A fatal intoxication with phenazone (antipyrine)
Forensic Sci Int, 248, e13-5
DOI 10.1016/j.forsciint.2015.01.001, PubMed 25631541
Correlates of major medication side effects interfering with daily performance: results from a cross-sectional cohort study of older psychiatric patients
Int Psychogeriatr, 28 (2), 331-40
DOI 10.1017/S1041610215001544, PubMed 26412479
Publications 2014
Prevalence of ethyl glucuronide and ethyl sulphate among patients injured when driving or at work
Alcohol Alcohol, 50 (1), 68-73
DOI 10.1093/alcalc/agu070, PubMed 25318475
Impairment due to amphetamines and benzodiazepines, alone and in combination
Drug Alcohol Depend, 145, 174-9
DOI 10.1016/j.drugalcdep.2014.10.013, PubMed 25456327
Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20°C
Forensic Sci Int, 239, 6-10
DOI 10.1016/j.forsciint.2014.03.008, PubMed 24709028
Alcohol hangover as a cause of impairment in apprehended drivers
Traffic Inj Prev, 16 (4), 323-8
DOI 10.1080/15389588.2014.938324, PubMed 25023858
Genetic variants in loci 1p13 and 9p21 and fatal coronary heart disease in a Norwegian case-cohort study
Mol Biol Rep, 41 (5), 2733-43
DOI 10.1007/s11033-014-3096-7, PubMed 24728607
Assistance of ethyl glucuronide and ethyl sulfate in the interpretation of postmortem ethanol findings
Int J Legal Med, 128 (5), 765-70
DOI 10.1007/s00414-014-1031-z, PubMed 24935750
Pharmacokinetic interactions between ethanol and heroin: a study on post-mortem cases
Forensic Sci Int, 242, 127-134
DOI 10.1016/j.forsciint.2014.06.032, PubMed 25050840
Psychotropic medication in geriatric psychiatric patients: use and unreported use in relation to serum concentrations
Eur J Clin Pharmacol, 70 (9), 1139-45
DOI 10.1007/s00228-014-1720-z, PubMed 25031073
Changes in cognitive function during psychogeriatric treatment in relation to benzodiazepine cessation
Pharmacopsychiatry, 47 (4-5), 145-50
DOI 10.1055/s-0034-1381982, PubMed 24936805
Publications 2013
Less glucuronidation of morphine in the presence of ethanol in vivo
Eur J Clin Pharmacol, 69 (9), 1683-7
DOI 10.1007/s00228-013-1533-5, PubMed 23739999
Benzodiazepines in geriatric psychiatry: what doctors report and what patients actually use
Drugs Aging, 30 (2), 113-8
DOI 10.1007/s40266-012-0045-9, PubMed 23288602
Is ADH1C genotype relevant for the cardioprotective effect of alcohol?
Alcohol, 47 (2), 81-4
DOI 10.1016/j.alcohol.2012.12.005, PubMed 23321361
A clinical study of the cognitive effects of benzodiazepines in psychogeriatric patients
Pharmacopsychiatry, 46 (6), 209-13
DOI 10.1055/s-0033-1349131, PubMed 23832585
Publications 2012
Divergent associations of drinking frequency and binge consumption of alcohol with mortality within the same cohort
J Epidemiol Community Health, 67 (4), 350-7
DOI 10.1136/jech-2012-201564, PubMed 23235547
[Use of slow-release injections to administer antipsychotic drugs]
Tidsskr Nor Laegeforen, 132 (3), 301-3
DOI 10.4045/tidsskr.11.0721, PubMed 22314741
CYP2C19 genetics in fatal carisoprodol intoxications
Eur J Clin Pharmacol, 68 (11), 1561-5
DOI 10.1007/s00228-012-1278-6, PubMed 22527345
Higher levels of hair ethyl glucuronide in patients with decreased kidney function
Alcohol Clin Exp Res, 37 Suppl 1, E14-6
DOI 10.1111/j.1530-0277.2012.01882.x, PubMed 22698262
Prolonged urinary detection times of EtG and EtS in patients with decreased renal function
Alcohol Clin Exp Res, 36 (7), 1148-51
DOI 10.1111/j.1530-0277.2011.01713.x, PubMed 22316172
[Combination treatment of depression]
Tidsskr Nor Laegeforen, 132 (10), 1239-41
DOI 10.4045/tidsskr.11.1250, PubMed 22669385
Publications 2011
Controlling for high-density lipoprotein cholesterol does not affect the magnitude of the relationship between alcohol and coronary heart disease
Circulation, 124 (21), 2296-302
DOI 10.1161/CIRCULATIONAHA.111.036491, PubMed 22042888
Publications 2010
Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine
J Anal Toxicol, 34 (2), 84-8
DOI 10.1093/jat/34.2.84, PubMed 20223100
Ethyl glucuronide concentrations in oral fluid, blood, and urine after volunteers drank 0.5 and 1.0 g/kg doses of ethanol
J Anal Toxicol, 34 (6), 319-24
DOI 10.1093/jat/34.6.319, PubMed 20663284
Publications 2009
Use of ethyl glucuronide and ethyl sulphate in forensic toxicology
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 839, 1 b. (flere pag.)
BIBSYS 093812582, ISBN 978-82-8072-347-5
Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion
Int J Legal Med, 124 (2), 143-8
DOI 10.1007/s00414-009-0393-0, PubMed 19937334
The effect of scheduling and withdrawal of carisoprodol on prevalence of intoxications with the drug
Basic Clin Pharmacol Toxicol, 105 (5), 345-9
DOI 10.1111/j.1742-7843.2009.00459.x, PubMed 19663822
Ethyl glucuronide in hair compared with traditional alcohol biomarkers--a pilot study of heavy drinkers referred to an alcohol detoxification unit
Alcohol Clin Exp Res, 33 (5), 812-6
DOI 10.1111/j.1530-0277.2009.00900.x, PubMed 19298326
Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification
Forensic Sci Int, 188 (1-3), 52-6
DOI 10.1016/j.forsciint.2009.03.017, PubMed 19395207
Serum/whole blood concentration ratio for ethylglucuronide and ethyl sulfate
J Anal Toxicol, 33 (4), 208-11
DOI 10.1093/jat/33.4.208, PubMed 19470223
Publications 2008
Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment
Alcohol Alcohol, 43 (2), 187-91
DOI 10.1093/alcalc/agm175, PubMed 18230699
Acute intoxications with carisoprodol
Clin Toxicol (Phila), 46 (4), 307-9
DOI 10.1080/15563650701476953, PubMed 18363125
Publications 2007
A pharmacokinetic study of ethyl glucuronide in blood and urine: applications to forensic toxicology
Forensic Sci Int, 172 (2-3), 119-24
DOI 10.1016/j.forsciint.2007.01.005, PubMed 17306943
Disappearance of ethyl glucuronide during heavy putrefaction
Forensic Sci Int, 176 (2-3), 147-51
DOI 10.1016/j.forsciint.2007.08.002, PubMed 17884319
In vitro formation of ethanol in autopsy samples containing fluoride ions
Int J Legal Med, 122 (1), 63-6
DOI 10.1007/s00414-007-0166-6, PubMed 17387502
Publications 2006
Heroin-using drivers: importance of morphine and morphine-6-glucuronide on late clinical impairment
Eur J Clin Pharmacol, 62 (11), 905-12
DOI 10.1007/s00228-006-0195-y, PubMed 17021891
Carisoprodol intoxications: a retrospective study of forensic autopsy material from 1992-2003
Int J Legal Med, 121 (5), 403-9
DOI 10.1007/s00414-006-0139-1, PubMed 17115170
A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol
Forensic Sci Int, 165 (1), 41-5
DOI 10.1016/j.forsciint.2006.02.045, PubMed 16564658
[Psychiatric and cognitive long-term effects of ecstasy]
Tidsskr Nor Laegeforen, 126 (5), 596-8
PubMed 16505868
Publications 2005
[Phencyclidine--angel dust]
Tidsskr Nor Laegeforen, 125 (20), 2775-6
PubMed 16244678
[Ricin--a therapeutic agent and a biological weapon]
Tidsskr Nor Laegeforen, 125 (18), 2477-9
PubMed 16186864