Trond Stokke
- Retired senior scientist
Education:
1979: B.S. (Mathematics, Physics), University of Oslo, Oslo, Norway.
1982: M.S. (Biophysics, "Fluorescence lifetimes of some dyes commonly employed in cell biology"), University of Oslo, Oslo, Norway.
1988: Ph.D. (Biophysics, DNA specific dyes as probes of chromatin structure.), University of Oslo, Oslo, Norway.
1998: Evaluated, and found to be professor-competent.
Research interests/projects:
I studied chromatin structure during the PhD period. Later, I have studied cell cycle regulation and apoptosis. Most of the attention has been paid to the study of normal and malignant B-lymphocytes, and, more recently, the effects of ionizing radiation on such cells.
Previous employments:
Research scholar (83-89), post-doc (89-92), and scientist (94-03) at Institute for Cancer Research, DNR, Oslo, Norway. Post-doc at Division of Molecular Cytometry, UCSF, San Francisco, US (1993).
Assignments/duties:
- Member of the board for the Institute for Cancer Research at The Norwegian Radium Hospital (Instituttrådet ved Institutt for Kreftforskning, DNR).
- Member of the board for "Center for Education and Research within RadiationBiology" (SUFS, Senter for Utdanning og Forskning innen Strålebiologi) and the board for the microarray facilities.
- Member of the scientific evaluation committee in The Norwegian Cancer Society (Den Norske Kreftforening).
Memberships:
International Society for Analytical Cytology.
Publications 2023
Analysis of RNA Polymerase II Chromatin Binding by Flow Cytometry
Bio Protoc, 13 (8), e4659
DOI 10.21769/BioProtoc.4659, PubMed 37113330
N-acetyl cysteine turns EPAC activators into potent killers of acute lymphoblastic leukemia cells
J Biol Chem, 300 (1), 105509
DOI 10.1016/j.jbc.2023.105509, PubMed 38042493
Publications 2022
Anti-CD37 radioimmunotherapy with 177Lu-NNV003 synergizes with the PARP inhibitor olaparib in treatment of non-Hodgkin's lymphoma in vitro
PLoS One, 17 (4), e0267543
DOI 10.1371/journal.pone.0267543, PubMed 35486574
miR-200a/b/-429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer
Mol Oncol, 16 (6), 1402-1419
DOI 10.1002/1878-0261.13184, PubMed 35064630
Publications 2021
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Sci Rep, 11 (1), 6317
DOI 10.1038/s41598-021-85613-8, PubMed 33737576
Publications 2020
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Cancer Res, 80 (18), 3993-4003
DOI 10.1158/0008-5472.CAN-20-0950, PubMed 32606004
177Lu-Lilotomab Satetraxetan Has the Potential to Counteract Resistance to Rituximab in Non-Hodgkin Lymphoma
J Nucl Med, 61 (10), 1468-1475
DOI 10.2967/jnumed.119.237230, PubMed 32245896
Cell Cycle Analysis and Relevance for Single-Cell Gating in Mass Cytometry
Cytometry A, 97 (8), 832-844
DOI 10.1002/cyto.a.23960, PubMed 31943748
Publications 2019
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
Cell Rep, 28 (7), 1907-1922.e6
DOI 10.1016/j.celrep.2019.07.025, PubMed 31412255
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer
Neoplasia, 21 (4), 353-362
DOI 10.1016/j.neo.2019.01.002, PubMed 30856376
Publications 2018
Combination of 177 Lu-lilotomab with rituximab significantly improves the therapeutic outcome in preclinical models of non-Hodgkin's lymphoma
Eur J Haematol, 101 (4), 522-531
DOI 10.1111/ejh.13139, PubMed 29993152
The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia
Mol Biol Cell, 29 (13), 1542-1554
DOI 10.1091/mbc.E17-04-0248, PubMed 29742019
Publications 2017
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
DOI 10.18632/oncotarget.14089, PubMed 28030798
Publications 2016
Analyzing Schizosaccharomyces pombe DNA Content by Flow Cytometry
Cold Spring Harb Protoc, 2016 (6)
DOI 10.1101/pdb.prot091280, PubMed 27250946
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
DOI 10.1038/bjc.2016.278, PubMed 27599042
Publications 2015
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation
Cell Cycle, 14 (20), 3248-60
DOI 10.1080/15384101.2015.1085137, PubMed 26312527
New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX
Cell Cycle, 14 (20), 3261-9
DOI 10.1080/15384101.2015.1087617, PubMed 26317799
Mitochondrial DNA Deficiency in Ovarian Cancer Cells and Cancer Stem Cell-like Properties
Anticancer Res, 35 (7), 3743-53
PubMed 26124317
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
DOI 10.1093/nar/gkv744, PubMed 26250117
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
PLoS One, 10 (8), e0134789
DOI 10.1371/journal.pone.0134789, PubMed 26241740
Publications 2014
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer
Br J Cancer, 111 (2), 326-38
DOI 10.1038/bjc.2014.297, PubMed 24901235
Publications 2013
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome
Eur J Haematol, 91 (4), 332-8
DOI 10.1111/ejh.12171, PubMed 23859481
Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling
J Pathol, 230 (1), 59-69
DOI 10.1002/path.4168, PubMed 23335387
Publications 2011
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7
Eur J Immunol, 41 (11), 3135-45
DOI 10.1002/eji.201141558, PubMed 21898381
Side population cells in highly enriched CD34-positive cells from peripheral blood progenitor cells identify an immature subtype of hematopoietic progenitor cells but do not predict time to engraftment in patients treated with high-dose therapy
Eur J Haematol, 87 (6), 494-502
DOI 10.1111/j.1600-0609.2011.01681.x, PubMed 21752097
Cell-cycle analysis of fission yeast cells by flow cytometry
PLoS One, 6 (2), e17175
DOI 10.1371/journal.pone.0017175, PubMed 21386895
Three independent mechanisms for arrest in G2 after ionizing radiation
Cell Cycle, 10 (5), 819-29
DOI 10.4161/cc.10.5.14968, PubMed 21325885
Prostate cancer cell lines under hypoxia exhibit greater stem-like properties
PLoS One, 6 (12), e29170 (Retracted)
DOI 10.1371/journal.pone.0029170, PubMed 22216200
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Radiother Oncol, 101 (1), 24-7
DOI 10.1016/j.radonc.2011.05.060, PubMed 21722983
Publications 2010
CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation
Mol Biol Cell, 21 (15), 2555-67
DOI 10.1091/mbc.e09-06-0503, PubMed 20519441
Publications 2009
Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming
Int J Radiat Biol, 85 (12), 1157-65
DOI 10.3109/09553000903242107, PubMed 19995241
Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer
PLoS Genet, 5 (11), e1000719
DOI 10.1371/journal.pgen.1000719, PubMed 19911042
Publications 2008
Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis
Cancer Lett, 267 (1), 18-25
DOI 10.1016/j.canlet.2008.03.002, PubMed 18406515
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
DOI 10.1186/gb-2008-9-5-r86, PubMed 18500990
Publications 2007
A one-step method for determining the maximum number of bound antibodies, and the affinity and association rate constants for antibody binding
Nucl Med Commun, 28 (9), 742-7
DOI 10.1097/MNM.0b013e3282e2a86b, PubMed 17667754
Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas
Int J Cancer, 120 (12), 2734-8
DOI 10.1002/ijc.22537, PubMed 17354231
Log normal distribution of cellular uptake of radioactivity
J Nucl Med, 48 (2), 327; author reply 327-8
PubMed 17268032
Evaluation of the binding of radiolabeled rituximab to CD20-positive lymphoma cells: an in vitro feasibility study concerning low-dose-rate radioimmunotherapy with the alpha-emitter 227Th
Cancer Biother Radiopharm, 22 (4), 469-79
DOI 10.1089/cbr.2007.371, PubMed 17803441
Publications 2006
Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
Mol Cancer, 5, 20
DOI 10.1186/1476-4598-5-20, PubMed 16709241
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer
BMC Genomics, 7, 268
DOI 10.1186/1471-2164-7-268, PubMed 17054779
CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization
J Cell Physiol, 209 (1), 199-210
DOI 10.1002/jcp.20725, PubMed 16826565
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM
J Environ Pathol Toxicol Oncol, 25 (1-2), 159-71
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.90, PubMed 16566715
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
DOI 10.1038/sj.leu.2404094, PubMed 16437153
Publications 2005
Bystander effects in UV-induced genomic instability: antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation
J Carcinog, 4, 11
DOI 10.1186/1477-3163-4-11, PubMed 16091149
Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis
Radiat Res, 163 (3), 289-95
DOI 10.1667/rr3305, PubMed 15733036
Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells
Photochem Photobiol, 81 (1), 114-9
DOI 10.1562/2004-05-19-RA-174, PubMed 15453821
Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas
Leukemia, 19 (12), 2313-23
DOI 10.1038/sj.leu.2403954, PubMed 16193090
The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1
Anticancer Res, 25 (3B), 2259-67
PubMed 16158973
Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis
Br J Cancer, 92 (9), 1773-81
DOI 10.1038/sj.bjc.6602537, PubMed 15827557
Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype
Int J Cancer, 115 (6), 935-42
DOI 10.1002/ijc.20962, PubMed 15723354
Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization
Oncogene, 24 (7), 1159-73
DOI 10.1038/sj.onc.1208267, PubMed 15580290
Publications 2004
Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
Int J Oncol, 24 (5), 1279-88
PubMed 15067352
Counteraction of pRb-dependent protection after extreme hypoxia by elevated ribonucleotide reductase
Cell Prolif, 37 (5), 367-83
DOI 10.1111/j.1365-2184.2004.00319.x, PubMed 15377335
The response of malignant B lymphocytes to ionizing radiation: cell cycle arrest, apoptosis and protection against the cytotoxic effects of the mitotic inhibitor nocodazole
Radiat Res, 162 (4), 405-15
DOI 10.1667/rr3235, PubMed 15447042
Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
BMC Genomics, 5 (1), 10
DOI 10.1186/1471-2164-5-10, PubMed 15018648
Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix
Int J Cancer, 111 (3), 358-66
DOI 10.1002/ijc.20258, PubMed 15221962
Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?
Radiother Oncol, 72 (3), 305-10
DOI 10.1016/j.radonc.2004.07.002, PubMed 15450729
Publications 2003
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem. Photobiol. Sci., 2 (4), 407-411
DOI 10.1039/b211880g
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem Photobiol Sci, 2 (4), 407-11
DOI 10.1039/b211880g, PubMed 12760539
Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1
Oncogene, 22 (55), 8952-5
DOI 10.1038/sj.onc.1207000, PubMed 14654792
Hypoxia-induced irreversible S-phase arrest involves down-regulation of cyclin A
Cell Prolif, 36 (6), 321-32
DOI 10.1046/j.1365-2184.2003.00288.x, PubMed 14710850
Publications 2002
Proliferation-dependent expression and phosphorylation of pRB in B cell non-Hodgkin's lymphomas: dependence on RB1 copy number
Leukemia, 16 (8), 1549-55
DOI 10.1038/sj.leu.2402644, PubMed 12145697
Associations between gene expressions in breast cancer and patient survival
Hum Genet, 111 (4-5), 411-20
DOI 10.1007/s00439-002-0804-5, PubMed 12384785
Transfer of protoporphyrin IX between cells
Photochem Photobiol, 76 (5), 526-9
DOI 10.1562/0031-8655(2002)076<0526:topibc>2.0.co;2, PubMed 12462648
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
Exp Hematol, 30 (9), 990-1000
DOI 10.1016/s0301-472x(02)00868-8, PubMed 12225790
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
N Engl J Med, 346 (25), 1937-47
DOI 10.1056/NEJMoa012914, PubMed 12075054
Dye exclusion artifact in flow cytometers
Cytometry, 47 (3), 200-5
DOI 10.1002/cyto.10063, PubMed 11891725
Publications 2001
Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer
Int J Colorectal Dis, 16 (1), 38-45
DOI 10.1007/s003840000275, PubMed 11317696
Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nuclei
Radiat Res, 155 (2), 288-96
DOI 10.1667/0033-7587(2001)155[0288:rwapem]2.0.co;2, PubMed 11175663
Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma
Br J Cancer, 85 (12), 1900-13
DOI 10.1054/bjoc.2001.2164, PubMed 11747333
Publications 2000
Quantitative determination of gap junction intercellular communication using flow cytometric measurement of fluorescent dye transfer
Cell Adhes Commun, 7 (6), 501-12
DOI 10.3109/15419060009040307, PubMed 11051460
Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein
Biochem J, 352 Pt 3 (Pt 3), 629-35
DOI 10.1042/0264-6021:3520629, PubMed 11104667
Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma
Int J Cancer, 89 (4), 313-24
DOI 10.1002/1097-0215(20000720)89:4<313::aid-ijc1>3.0.co;2-d, PubMed 10956404
The Escherichia coli SeqA protein destabilizes mutant DnaA204 protein
Mol Microbiol, 37 (3), 629-38
DOI 10.1046/j.1365-2958.2000.02031.x, PubMed 10931356
Publications 1999
Regulation of the start of DNA replication in Schizosaccharomyces pombe
J Cell Sci, 112 ( Pt 6), 939-46
DOI 10.1242/jcs.112.6.939, PubMed 10036243
Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
Br J Cancer, 80 (3-4), 526-35
DOI 10.1038/sj.bjc.6690388, PubMed 10408863
c-MYC, RB-1, TP53, and centromere 8 and 17 copy number in B-cell non-Hodgkin's lymphomas assessed by dual-color fluorescence in situ hybridization
Cytometry, 38 (2), 53-60
DOI 10.1002/(sici)1097-0320(19990415)38:2<53::aid-cyto2>3.3.co;2-s, PubMed 10323217
Prognostic value of lymphoma-specific S-phase fraction compared with that of other cell proliferation markers
Acta Oncol, 38 (4), 495-503
DOI 10.1080/028418699432040, PubMed 10418718
Fas ligand promotes cell survival of immature human bone marrow CD34+CD38- hematopoietic progenitor cells by suppressing apoptosis
Exp Hematol, 27 (9), 1451-9
DOI 10.1016/s0301-472x(99)00073-9, PubMed 10480436
Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light
Br J Cancer, 79 (1), 72-81
DOI 10.1038/sj.bjc.6690014, PubMed 10408696
Publications 1998
The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein
Br J Cancer, 77 (6), 862-72
DOI 10.1038/bjc.1998.143, PubMed 9528826
Flow cytometry of bacterial cells: comparison between different flow cytometers and different DNA stains
Cytometry, 31 (1), 29-36
DOI 10.1002/(sici)1097-0320(19980101)31:1<29::aid-cyto4>3.0.co;2-e, PubMed 9450522
Hypoxia induces p53 accumulation in the S-phase and accumulation of hypophosphorylated retinoblastoma protein in all cell cycle phases of human melanoma cells
Br J Cancer, 78 (12), 1547-58
DOI 10.1038/bjc.1998.722, PubMed 9862563
Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
Mol Pathol, 51 (5), 254-61
DOI 10.1136/mp.51.5.254, PubMed 10193519
Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle
Int J Cancer, 75 (1), 134-9
DOI 10.1002/(sici)1097-0215(19980105)75:1<134::aid-ijc20>3.0.co;2-f, PubMed 9426701
Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1832-8
DOI 10.1038/bjc.1998.304, PubMed 9667654
Tumour cell proliferation, but not apoptosis, predicts survival in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1839-41
DOI 10.1038/bjc.1998.305, PubMed 9667655
Propidium iodide quenches the fluorescence of TdT-incorporated FITC-labeled dUTP in apoptotic cells
Cytometry, 33 (4), 428-34
DOI 10.1002/(SICI)1097-0320(19981201)33:4<428::AID-CYTO6>3.0.CO;2-4, PubMed 9845437
Publications 1997
Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level
Exp Cell Res, 232 (2), 361-70
DOI 10.1006/excr.1997.3497, PubMed 9168813
Measurement of nuclear DNA content in fission yeast by flow cytometry
Yeast, 13 (14), 1329-35
DOI 10.1002/(SICI)1097-0061(199711)13:14<1329::AID-YEA185>3.0.CO;2-M, PubMed 9392077
NO38 expression and nucleolar counts are correlated with cellular DNA content but not with proliferation parameters in colorectal carcinomas
Mol Pathol, 50 (4), 201-8
DOI 10.1136/mp.50.4.201, PubMed 9350304
A comparison of different modes for the detection of p53 protein accumulation. A study of bladder cancer
Pathol Res Pract, 193 (7), 471-8
DOI 10.1016/s0344-0338(97)80099-4, PubMed 9342752
Different pathways to apoptosis induced by tetraphenylporphine derivatives and light in V79 cells
P SOC PHOTO-OPT INS, 3191, 107-113
DOI 10.1117/12.297791
Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases
Cell Prolif, 30 (5), 197-218
DOI 10.1046/j.1365-2184.1997.00087.x, PubMed 9420612
Publications 1996
The retinoblastoma gene product is reversibly dephosphorylated and bound in the nucleus in S and G2 phases during hypoxic stress
Exp Cell Res, 227 (1), 106-15
DOI 10.1006/excr.1996.0255, PubMed 8806457
Coordinating DNA replication initiation with cell growth: differential roles for DnaA and SeqA proteins
Proc Natl Acad Sci U S A, 93 (22), 12206-11
DOI 10.1073/pnas.93.22.12206, PubMed 8901558
TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro
J Immunol, 157 (3), 1193-9
PubMed 8757625
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX
Br J Cancer, 74 (1), 22-9
DOI 10.1038/bjc.1996.310, PubMed 8679453
Solid-phase method for differential display of genes expressed in hematopoietic stem cells
Biotechniques, 21 (1), 114-21
DOI 10.2144/96211rr02, PubMed 8816245
Publications 1995
S phase arrest and induction of multinucleated cells after exposure to ultraviolet radiation
Carcinogenesis, 16 (5), 1087-94
DOI 10.1093/carcin/16.5.1087, PubMed 7767969
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo
Br J Cancer, 72 (2), 307-11
DOI 10.1038/bjc.1995.329, PubMed 7640210
Transforming growth factor-beta potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells
Blood, 86 (8), 2957-66
PubMed 7579388
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes
J Immunol, 154 (4), 1634-43
PubMed 7836748
A physical map of chromosome 20 established using fluorescence in situ hybridization and digital image analysis
Genomics, 26 (1), 134-7
DOI 10.1016/0888-7543(95)80092-z, PubMed 7782072
Publications 1994
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
Cancer Res, 54 (8), 2245-50
PubMed 8174134
Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver
Carcinogenesis, 15 (1), 53-9
DOI 10.1093/carcin/15.1.53, PubMed 8293549
Molecular cytogenetics of human breast cancer
Cold Spring Harb Symp Quant Biol, 59, 645-52
DOI 10.1101/sqb.1994.059.01.074, PubMed 7587125
The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle
Cell Prolif, 27 (2), 95-104
DOI 10.1111/j.1365-2184.1994.tb01408.x, PubMed 10465029
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization
Proc Natl Acad Sci U S A, 91 (6), 2156-60
DOI 10.1073/pnas.91.6.2156, PubMed 8134364
Sites of photodynamically induced DNA repair in human cells
Photochem Photobiol, 59 (4), 437-40
DOI 10.1111/j.1751-1097.1994.tb05061.x, PubMed 7912836
Cross-linking of CD53 promotes activation of resting human B lymphocytes
J Immunol, 153 (11), 4997-5007
PubMed 7963560
Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes
Cancer Res, 54 (16), 4257-60
PubMed 8044767
The initiation mass for DNA replication in Escherichia coli K-12 is dependent on growth rate
EMBO J, 13 (9), 2097-102
DOI 10.1002/j.1460-2075.1994.tb06485.x, PubMed 8187762
Publications 1993
P53 expression is associated with a high-degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas
Int J Oncol, 3 (2), 305-12
DOI 10.3892/ijo.3.2.305, PubMed 21573365
Binucleation and polyploidization patterns in developmental and regenerative rat liver growth
Cell Prolif, 26 (6), 557-65
DOI 10.1111/j.1365-2184.1993.tb00033.x, PubMed 9116122
The retinoblastoma gene product is bound in the nucleus in early G1 phase
Exp Cell Res, 204 (1), 147-55
DOI 10.1006/excr.1993.1019, PubMed 8416792
Publications 1992
Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma
Carcinogenesis, 13 (10), 1795-801
DOI 10.1093/carcin/13.10.1795, PubMed 1330342
Analytical methods for the study of liver cell proliferation
Cytometry, 13 (4), 404-15
DOI 10.1002/cyto.990130411, PubMed 1382009
Plateau distributions of DNA fragment lengths produced by extended light exposure of extranuclear photosensitizers in human cells
Nucleic Acids Res, 20 (24), 6687-93
DOI 10.1093/nar/20.24.6687, PubMed 1480490
Differential chromatin structure-dependent binding of 7-aminoactinomycin D in normal and malignant bone marrow hematopoietic cells
Cancer Res, 52 (18), 5007-12
PubMed 1516056
Publications 1991
Use of size fractionation of in vitro-activated human B lymphocytes for studies of cell cycle-dependent growth regulation
Scand J Immunol, 33 (1), 51-60
DOI 10.1111/j.1365-3083.1991.tb02491.x, PubMed 1899949
Differential effects of interferon-gamma and low molecular weight BCGF on growth of human B lymphocytes; interferon-gamma prolongs the increased c-MYC mRNA levels after activation
Scand J Immunol, 33 (4), 365-73
DOI 10.1111/j.1365-3083.1991.tb01783.x, PubMed 1902001
Establishment in monolayer culture and characterization of four human melanoma cell lines
Virchows Arch B Cell Pathol Incl Mol Pathol, 60 (3), 189-97
DOI 10.1007/BF02899546, PubMed 1679270
Cell cycle-specific expression and nuclear binding of DNA polymerase alpha
Mol Cell Biol, 11 (6), 3384-9
DOI 10.1128/mcb.11.6.3384-3389.1991, PubMed 2038340
Simultaneous assessment of chromatin structure, DNA content, and antigen expression by dual wavelength excitation flow cytometry
Cytometry, 12 (2), 172-8
DOI 10.1002/cyto.990120212, PubMed 1710961
Publications 1990
Functional properties of CD19+ B lymphocytes positively selected from buffy coats by immunomagnetic separation
Eur J Immunol, 20 (1), 201-6
DOI 10.1002/eji.1830200129, PubMed 1689662
The lengths of DNA fragments light-induced in the presence of a photosensitizer localized at the nuclear membrane of human cells
Biochim Biophys Acta, 1049 (1), 33-7
DOI 10.1016/0167-4781(90)90081-c, PubMed 2141534
Establishment and characterization of six human melanoma xenograft lines
APMIS, 98 (10), 945-53
DOI 10.1111/j.1699-0463.1990.tb05019.x, PubMed 2245014
Inhibition of polyphosphoinositide breakdown and c-myc induction accompanying inhibition of human B-cell activation by two monoclonal antibodies against the leucocyte common antigen (CD45)
Scand J Immunol, 31 (5), 583-91
DOI 10.1111/j.1365-3083.1990.tb02809.x, PubMed 1693226
Quenching of Hoechst 33258 fluorescence in erythroid precursors
Cytometry, 11 (6), 686-90
DOI 10.1002/cyto.990110605, PubMed 1696537
Publications 1989
Intracellular events associated with inhibition of B cell activation by monoclonal antibodies to HLA class II antigens
Eur J Immunol, 19 (7), 1221-5
DOI 10.1002/eji.1830190711, PubMed 2547623
Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma
Int J Cancer, 44 (6), 975-80
DOI 10.1002/ijc.2910440605, PubMed 2606582
Levels of myc protein, as analyzed by flow cytometry, correlate with cell growth potential in malignant B-cell lymphomas
Int J Cancer, 43 (1), 164-70
DOI 10.1002/ijc.2910430130, PubMed 2642893
DNA specific dyes as probes of chromatin structure
Department of Physics, The Norwegian Radium Hospital and The Norwegian Cancer Society, Oslo, 1 b. (flere pag.)
BIBSYS 890016461, ISBN 82-90187-46-7
Publications 1988
cAMP-mediated growth inhibition of a B-lymphoid precursor cell line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1
J Cell Physiol, 137 (3), 583-7
DOI 10.1002/jcp.1041370327, PubMed 2848044
Temperature-induced chromatin changes in ethanol-fixed cells
J Histochem Cytochem, 36 (12), 1495-501
DOI 10.1177/36.12.2461412, PubMed 2461412
Re: L. F. Pearlman et al., interaction of three second-generation anthracyclines with polynucleotides, RNA, DNA, and nucleosomes. Cancer Res., 46:341-346, 1986
Cancer Res, 48 (23), 6962-5
PubMed 2460232
INTERACTION OF 3 2ND-GENERATION ANTHRACYCLINES WITH POLYNUCLEOTIDES, RNA, DNA, AND NUCLEOSOMES
Cancer Res., 48 (23), 6962-6963
In vitro and in vivo activation of B-lymphocytes: a flow cytometric study of chromatin structure employing 7-aminoactinomycin D
Cancer Res, 48 (23), 6708-14
PubMed 3263191
Publications 1987
THE EFFECT OF BENZALDEHYDE ON TERBIUM FLUORESCENCE ENHANCEMENT IN HUMAN NHIK 3025 CELLS TREATED WITH CIS-DICHLORODIAMMINEPLATINUM(II)
INORG CHIM A-BIOINOR, 137 (1-2), 105-107
DOI 10.1016/S0020-1693(00)87126-1
Complement activation following multiple injuries
Acta Chir Scand, 153 (5-6), 325-30
PubMed 3499041
Distinction of leucocyte classes based on chromatin-structure-dependent DNA-binding of 7-aminoactinomycin D
Cytometry, 8 (6), 576-83
DOI 10.1002/cyto.990080608, PubMed 2448092
Publications 1986
Fluorescence spectra of cells stained with a DNA-specific dye, measured by flow cytometry
Cytometry, 7 (1), 104-6
DOI 10.1002/cyto.990070117, PubMed 2419053
Binding of Hoechst 33258 to chromatin in situ
Cytometry, 7 (3), 227-34
DOI 10.1002/cyto.990070302, PubMed 2423306
Fluorescence spectra of Hoechst 33258 bound to chromatin
Biochim Biophys Acta, 868 (1), 17-23
DOI 10.1016/0167-4781(86)90081-3, PubMed 2428400
Publications 1985
Multiple binding modes for Hoechst 33258 to DNA
J Histochem Cytochem, 33 (4), 333-8
DOI 10.1177/33.4.2579998, PubMed 2579998
Neither adriamycin nor actinomycin D displaces Tb3+ from DNA
Biochim Biophys Acta, 825 (4), 416-8
DOI 10.1016/0167-4781(85)90070-3, PubMed 4016123