PCF publications
Publications 2024
PCSK1N as a tumor size marker and an ER stress response protein in corticotroph pituitary adenomas
J Clin Endocrinol Metab (in press)
DOI 10.1210/clinem/dgae643, PubMed 39288010
Evaluation of cerebrospinal fluid (CSF) and interstitial fluid (ISF) mouse proteomes for the validation and description of Alzheimer's disease biomarkers
J Neurosci Methods, 411, 110239
DOI 10.1016/j.jneumeth.2024.110239, PubMed 39102902
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
iScience, 27 (7), 110185
DOI 10.1016/j.isci.2024.110185, PubMed 39015150
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
Nature, 628 (8009), 844-853
DOI 10.1038/s41586-024-07260-z, PubMed 38570685
Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
NPJ Syst Biol Appl, 10 (1), 73
DOI 10.1038/s41540-024-00402-z, PubMed 38997321
Aerobic adaptation and metabolic dynamics of Propionibacterium freudenreichii DSM 20271: insights from comparative transcriptomics and surfaceome analysis
mSystems, 9 (10), e0061524
DOI 10.1128/msystems.00615-24, PubMed 39345151
Time-dependent reduction in oxidative capacity among cultured myotubes from spinal cord injured individuals
Acta Physiol (Oxf), 240 (7), e14156
DOI 10.1111/apha.14156, PubMed 38711362
Publications 2023
Lipopolysaccharide Primes Human Macrophages for Noncanonical Inflammasome-Induced Extracellular Vesicle Secretion
J Immunol, 210 (3), 322-334
DOI 10.4049/jimmunol.2200444, PubMed 36525001
Bacterial Brain Abscesses Expand Despite Effective Antibiotic Treatment: A Process Powered by Osmosis Due to Neutrophil Cell Death
Neurosurgery, 94 (5), 1079-87 (in press)
DOI 10.1227/neu.0000000000002792, PubMed 38084989
Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants
Front Bioeng Biotechnol, 11, 1116513
DOI 10.3389/fbioe.2023.1116513, PubMed 36896010
Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice
Front Mol Neurosci, 16, 1175851
DOI 10.3389/fnmol.2023.1175851, PubMed 37251643
In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies
mSystems, 8 (3), e0107322
DOI 10.1128/msystems.01073-22, PubMed 37184670
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039
Towards optimised extracellular vesicle proteomics from cerebrospinal fluid
Sci Rep, 13 (1), 9564
DOI 10.1038/s41598-023-36706-z, PubMed 37308520
SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation
Metabol Open, 18, 100234
DOI 10.1016/j.metop.2023.100234, PubMed 37013149
Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism
Biomedicines, 11 (11)
DOI 10.3390/biomedicines11112908, PubMed 38001909
A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis
Brain, 146 (8), 3513-3527
DOI 10.1093/brain/awad086, PubMed 36917474
Identifying a core protein signature of small extracellular vesicles derived from B-cell precursor acute lymphoblastic leukaemia
Scand J Immunol, 99 (3), e13341
DOI 10.1111/sji.13341, PubMed 38441169
Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization
J Infect, 86 (5), 489-492
DOI 10.1016/j.jinf.2023.02.024, PubMed 36822413
Distinct microRNA and protein profiles of extracellular vesicles secreted from myotubes from morbidly obese donors with type 2 diabetes in response to electrical pulse stimulation
Front Physiol, 14, 1143966
DOI 10.3389/fphys.2023.1143966, PubMed 37064893
Publications 2022
Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation
ACS Chem Biol, 17 (9), 2631-2642
DOI 10.1021/acschembio.2c00538, PubMed 36070465
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors
Fluids Barriers CNS, 19 (1), 45
DOI 10.1186/s12987-022-00333-z, PubMed 35659255
Label-free quantitative proteomics and immunoblotting identifies immunoreactive and other excretory-secretory (E/S) proteins of Anoplocephala perfoliata
Front Immunol, 13, 1045468
DOI 10.3389/fimmu.2022.1045468, PubMed 36466892
Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation
BMC Neurol, 22 (1), 299
DOI 10.1186/s12883-022-02828-6, PubMed 35971119
Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome
Front Physiol, 13, 928195
DOI 10.3389/fphys.2022.928195, PubMed 35874526
Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer
Breast Cancer Res, 24 (1), 52
DOI 10.1186/s13058-022-01547-7, PubMed 35850772
Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins
Front Immunol, 13, 977353
DOI 10.3389/fimmu.2022.977353, PubMed 36189227
Publications 2021
Tyr192 Regulates Lymphocyte-Specific Tyrosine Kinase Activity in T Cells
J Immunol, 207 (4), 1128-1137
DOI 10.4049/jimmunol.2001105, PubMed 34321230
Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia
Eur Heart J, 42 (39), 4064-4072
DOI 10.1093/eurheartj/ehab506, PubMed 34405870
Inflammasomes and SARS-CoV-2 Infection
Viruses, 13 (12)
DOI 10.3390/v13122513, PubMed 34960782
Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients
Proteomics Clin Appl, 15 (6), e2100022
DOI 10.1002/prca.202100022, PubMed 34510746
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552
Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer
Carcinogenesis, 42 (5), 685-693
DOI 10.1093/carcin/bgab015, PubMed 33609362
Surfaceome and Exoproteome Dynamics in Dual-Species Pseudomonas aeruginosa and Staphylococcus aureus Biofilms
Front Microbiol, 12, 672975
DOI 10.3389/fmicb.2021.672975, PubMed 34248881
Liquid chromatography, a key tool for the advancement of single-cell omics analysis
Anal Chim Acta, 1178, 338551
DOI 10.1016/j.aca.2021.338551, PubMed 34482862
Modulation of virulence factors of Staphylococcus aureus by nanostructured surfaces
Mater. Des., 208, 109879
DOI 10.1016/j.matdes.2021.109879
Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence
mSystems, 6 (3), e0050021
DOI 10.1128/mSystems.00500-21, PubMed 34156290
Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes
Curr Res Pharmacol Drug Discov, 2, 100039
DOI 10.1016/j.crphar.2021.100039, PubMed 34909668
Progress and challenges in mass spectrometry-based analysis of antibody repertoires
Trends Biotechnol, 40 (4), 463-481
DOI 10.1016/j.tibtech.2021.08.006, PubMed 34535228
In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge
Adv Sci (Weinh), 8 (4), 2003526
DOI 10.1002/advs.202003526, PubMed 33643806
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk
Sci Rep, 11 (1), 21936
DOI 10.1038/s41598-021-01334-y, PubMed 34754007
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
Front Pharmacol, 12, 638646
DOI 10.3389/fphar.2021.638646, PubMed 34163352
Publications 2020
Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas
Cancers (Basel), 12 (10)
DOI 10.3390/cancers12102980, PubMed 33066652
Identification of Antiestrogen-Bound Estrogen Receptor α Interactomes in Hormone-Responsive Human Breast Cancer Cell Nuclei
Proteomics, 20 (19-20), e2000135
DOI 10.1002/pmic.202000135, PubMed 32865868
Quantitative Changes in the Mitochondrial Proteome of Cerebellar Synaptosomes From Preclinical Cystatin B-Deficient Mice
Front Mol Neurosci, 13, 570640
DOI 10.3389/fnmol.2020.570640, PubMed 33281550
Pancreatic cancer cells show lower oleic acid oxidation and their conditioned medium inhibits oleic acid oxidation in human myotubes
Pancreatology, 20 (4), 676-682
DOI 10.1016/j.pan.2020.04.014, PubMed 32360002
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377
The Cardiac Syndecan-2 Interactome
Front Cell Dev Biol, 8, 792
DOI 10.3389/fcell.2020.00792, PubMed 32984315
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
J Immunol, 204 (12), 3063-3069
DOI 10.4049/jimmunol.2000373, PubMed 32513874
Inflammasomes: Exosomal miRNAs loaded for action
J Cell Biol, 219 (10)
DOI 10.1083/jcb.202008130, PubMed 32970793
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072
Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of Staphylococcus aureus
Microorganisms, 8 (1)
DOI 10.3390/microorganisms8010106, PubMed 31940921
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia
J Cell Mol Med, 24 (6), 3534-3548
DOI 10.1111/jcmm.15043, PubMed 32040259
Publications 2019
Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer
Mol Cell Proteomics, 19 (2), 245-260
DOI 10.1074/mcp.RA119.001817, PubMed 31792072
Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials
Microorganisms, 7 (12)
DOI 10.3390/microorganisms7120584, PubMed 31756969
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis, 296, 74-82
DOI 10.1016/j.atherosclerosis.2019.12.008, PubMed 31870625
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423, PubMed 30967474
The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei
Sci Data, 6 (1), 173
DOI 10.1038/s41597-019-0179-2, PubMed 31527615
Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells
Sci Adv, 5 (2), eaav5590
DOI 10.1126/sciadv.aav5590, PubMed 30775443
Mitochondrial stress response triggered by defects in protein synthesis quality control
Life Sci Alliance, 2 (1)
DOI 10.26508/lsa.201800219, PubMed 30683687
Growth Mode and Carbon Source Impact the Surfaceome Dynamics of Lactobacillus rhamnosus GG
Front Microbiol, 10, 1272
DOI 10.3389/fmicb.2019.01272, PubMed 31231350
Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis
J Neuroimmunol, 333, 576966
DOI 10.1016/j.jneuroim.2019.576966, PubMed 31153015
Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J Immunol, 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382, PubMed 31427442
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, 104 (5), e229
DOI 10.3324/haematol.2019.220533, PubMed 31040234
Publications 2018
From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?
Front Immunol, 9, 2188
DOI 10.3389/fimmu.2018.02188, PubMed 30319640
Secretome profiling of Propionibacterium freudenreichii reveals highly variable responses even among the closely related strains
Microb Biotechnol, 11 (3), 510-526
DOI 10.1111/1751-7915.13254, PubMed 29488359
Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells
Sci Data, 5, 180031
DOI 10.1038/sdata.2018.31, PubMed 29509190
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271
Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications
Sci Rep, 8 (1), 498
DOI 10.1038/s41598-017-18985-5, PubMed 29323256
A high-throughput pipeline for validation of antibodies
Nat Methods, 15 (11), 909-912
DOI 10.1038/s41592-018-0179-8, PubMed 30377371
High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines
Int J Mol Sci, 19 (12)
DOI 10.3390/ijms19124123, PubMed 30572598
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445
Publications 2017
Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense
FASEB J, 31 (11), 4770-4782
DOI 10.1096/fj.201700296R, PubMed 28705811
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
Viruses, 9 (10)
DOI 10.3390/v9100271, PubMed 28946654
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404
Food-Like Growth Conditions Support Production of Active Vitamin B12 by Propionibacterium freudenreichii 2067 without DMBI, the Lower Ligand Base, or Cobalt Supplementation
Front Microbiol, 8, 368
DOI 10.3389/fmicb.2017.00368, PubMed 28337185
PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease
FASEB J, 31 (9), 3978-3990
DOI 10.1096/fj.201601265R, PubMed 28550045
The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus
J Neurosurg, 129 (3), 829-837
DOI 10.3171/2017.4.JNS17284, PubMed 29053067
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Rep, 20 (10), 2357-2367
DOI 10.1016/j.celrep.2017.08.036, PubMed 28877470
Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation
Mol Cell Proteomics, 16 (4 suppl 1), S187-S199
DOI 10.1074/mcp.M116.064840, PubMed 28196878
Mass spectrometry-based proteomic exploration of the human immune system: focus on the inflammasome, global protein secretion, and T cells
Expert Rev Proteomics, 14 (5), 395-407
DOI 10.1080/14789450.2017.1319768, PubMed 28406322
Proteomics to study macrophage response to viral infection
J Proteomics, 180, 99-107
DOI 10.1016/j.jprot.2017.06.018, PubMed 28647517
Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics
Methods Mol Biol, 1636, 235-251
DOI 10.1007/978-1-4939-7154-1_15, PubMed 28730483
The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading
Genome Biol, 18 (1), 189
DOI 10.1186/s13059-017-1321-0, PubMed 29017520
Publications 2016
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Biochim Biophys Acta, 1859 (11), 1440-1448
DOI 10.1016/j.bbagrm.2016.09.005, PubMed 27664935
The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone
mBio, 7 (4)
DOI 10.1128/mBio.01228-16, PubMed 27507828
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression
EMBO J, 35 (13), 1385-99
DOI 10.15252/embj.201593458, PubMed 27234299
Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection
J Proteome Res, 16 (1), 217-227
DOI 10.1021/acs.jproteome.6b00596, PubMed 27723984
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Nucleic Acids Res, 44 (22), 10588-10602
DOI 10.1093/nar/gkw785, PubMed 27638884
JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses
Antiviral Res, 133, 23-31
DOI 10.1016/j.antiviral.2016.07.008, PubMed 27451344
Regulation of kynurenine biosynthesis during influenza virus infection
FEBS J, 284 (2), 222-236
DOI 10.1111/febs.13966, PubMed 27860276
Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein
Kidney Int Rep, 2 (3), 461-469
DOI 10.1016/j.ekir.2016.11.005, PubMed 29142973
Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction
Viruses, 8 (10)
DOI 10.3390/v8100269, PubMed 27690086
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages
Mol Cell Proteomics, 15 (10), 3203-3219
DOI 10.1074/mcp.M116.057984, PubMed 27486199
The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling
J Virol, 90 (21), 9743-9757
DOI 10.1128/JVI.01382-16, PubMed 27535052
Comparative protein profiling of B16 mouse melanoma cells susceptible and non-susceptible to alphavirus infection: Effect of the tumor microenvironment
Cancer Biol Ther, 17 (10), 1035-1050
DOI 10.1080/15384047.2016.1219813, PubMed 27636533
Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages
J Immunol, 197 (8), 3315-3325
DOI 10.4049/jimmunol.1501840, PubMed 27638862
Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion
Exp Cell Res, 350 (2), 336-348
DOI 10.1016/j.yexcr.2016.12.010, PubMed 28011197
Publications 2015
The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice
J Gen Virol, 96 (8), 2086-2091
DOI 10.1099/vir.0.000171, PubMed 25934792
Mechanisms underlying AQP4 accumulation in astrocyte endfeet
Glia, 63 (11), 2073-2091
DOI 10.1002/glia.22878, PubMed 26119521
Activating stimuli induce platelet microRNA modulation and proteome reorganisation
Thromb Haemost, 114 (1), 96-108
DOI 10.1160/TH14-09-0726, PubMed 25903651
Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice
Genetics, 200 (1), 221-35
DOI 10.1534/genetics.115.175596, PubMed 25808953
Penicillin G increases the synthesis of a suicidal marker (CidC) and virulence (HlgBC) proteins in Staphylococcus aureus biofilm cells
Int J Med Microbiol, 306 (1), 69-74
DOI 10.1016/j.ijmm.2015.11.006, PubMed 26725755
Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells
Proteomics, 15 (11), 1801-7
DOI 10.1002/pmic.201400404, PubMed 25604459
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine
Antiviral Res, 126, 69-80
DOI 10.1016/j.antiviral.2015.12.011, PubMed 26738783
Biological properties of extracellular vesicles and their physiological functions
J Extracell Vesicles, 4, 27066
DOI 10.3402/jev.v4.27066, PubMed 25979354
Phosphoproteome characterization reveals that Sendai virus infection activates mTOR signaling in human epithelial cells
Proteomics, 15 (12), 2087-97
DOI 10.1002/pmic.201400586, PubMed 25764225
Publications 2014
Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation
J Proteome Res, 13 (5), 2468-77
DOI 10.1021/pr4012552, PubMed 24670152
Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro
Antimicrob Agents Chemother, 58 (7), 3689-96
DOI 10.1128/AAC.02798-13, PubMed 24752266
Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia
Proteomics, 14 (21-22), 2443-53
DOI 10.1002/pmic.201300460, PubMed 25211154
Uncovering surface-exposed antigens of Lactobacillus rhamnosus by cell shaving proteomics and two-dimensional immunoblotting
J Proteome Res, 14 (2), 1010-24
DOI 10.1021/pr501041a, PubMed 25531588
Mutation update and genotype-phenotype correlations of novel and previously described mutations in TPM2 and TPM3 causing congenital myopathies
Hum Mutat, 35 (7), 779-90
DOI 10.1002/humu.22554, PubMed 24692096
Post-transcriptional regulation of human breast cancer cell proteome by unliganded estrogen receptor β via microRNAs
Mol Cell Proteomics, 13 (4), 1076-90
DOI 10.1074/mcp.M113.030403, PubMed 24525454
A Streptococcus uberis transposon mutant screen reveals a negative role for LiaR homologue in biofilm formation
J Appl Microbiol, 118 (1), 1-10
DOI 10.1111/jam.12664, PubMed 25308550
Genomics and Proteomics Provide New Insight into the Commensal and Pathogenic Lifestyles of Bovine- and Human-Associated Staphylococcus epidermidis Strains
J Proteome Res, 13 (8), 3748-3762
DOI 10.1021/pr500322d, PubMed 25014494
Comparative proteome profiling of bovine and human Staphylococcus epidermidis strains for screening specifically expressed virulence and adaptation proteins
Proteomics, 14 (16), 1890-4
DOI 10.1002/pmic.201300275, PubMed 24909406
Comparative exoprotein profiling of different Staphylococcus epidermidis strains reveals potential link between nonclassical protein export and virulence
J Proteome Res, 13 (7), 3249-61
DOI 10.1021/pr500075j, PubMed 24840314
PhosFox: a bioinformatics tool for peptide-level processing of LC-MS/MS-based phosphoproteomic data
Proteome Sci, 12, 36
DOI 10.1186/1477-5956-12-36, PubMed 25028575
Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes
Am J Pathol, 184 (6), 1727-39
DOI 10.1016/j.ajpath.2014.03.002, PubMed 24726496
OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity
Exp Cell Res, 331 (2), 278-91
DOI 10.1016/j.yexcr.2014.10.019, PubMed 25447204
Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway
Mol Cell Proteomics, 13 (10), 2604-17
DOI 10.1074/mcp.M114.038968, PubMed 24997996
Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages
J Immunol, 192 (12), 5952-62
DOI 10.4049/jimmunol.1303213, PubMed 24808366
Isolation and characterization of platelet-derived extracellular vesicles
J Extracell Vesicles, 3
DOI 10.3402/jev.v3.24692, PubMed 25147646
Publications 2013
Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway
Hum Immunol, 75 (2), 134-40
DOI 10.1016/j.humimm.2013.11.010, PubMed 24269698
Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells
Cell Biol Int, 37 (10), 1080-8
DOI 10.1002/cbin.10134, PubMed 23686814
A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation
Curr Biol, 23 (6), 535-41
DOI 10.1016/j.cub.2013.02.019, PubMed 23453957
HnRNPH1/H2, U1 snRNP, and U11 snRNP cooperate to regulate the stability of the U11-48K pre-mRNA
RNA, 19 (3), 380-9
DOI 10.1261/rna.036715.112, PubMed 23335637
Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages
Mol Cell Proteomics, 12 (3), 749-63
DOI 10.1074/mcp.M112.024661, PubMed 23292187
Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion
J Cell Sci, 126 (Pt 11), 2459-69
DOI 10.1242/jcs.120022, PubMed 23549787
Publications 2012
Comparative analysis of excretory-secretory antigens of Trichinella spiralis and Trichinella britovi muscle larvae by two-dimensional difference gel electrophoresis and immunoblotting
Proteome Sci, 10 (1), 10
DOI 10.1186/1477-5956-10-10, PubMed 22325190
Molecular mechanisms of selective estrogen receptor modulator activity in human breast cancer cells: identification of novel nuclear cofactors of antiestrogen-ERα complexes by interaction proteomics
J Proteome Res, 12 (1), 421-31
DOI 10.1021/pr300753u, PubMed 23170835
APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration
Mol Biol Cell, 23 (11), 2109-21
DOI 10.1091/mbc.E10-12-1000, PubMed 22496417
Netrin-4 promotes glioblastoma cell proliferation through integrin β4 signaling
Neoplasia, 14 (3), 219-27
DOI 10.1593/neo.111396, PubMed 22496621
Global secretome characterization of herpes simplex virus 1-infected human primary macrophages
J Virol, 86 (23), 12770-8
DOI 10.1128/JVI.01545-12, PubMed 22973042
Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure
Lung Cancer, 77 (2), 450-9
DOI 10.1016/j.lungcan.2012.03.024, PubMed 22537621
Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins
Biol Psychiatry, 73 (6), 583-90
DOI 10.1016/j.biopsych.2012.08.012, PubMed 23036959
Publications 2011
New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564
J Proteome Res, 11 (1), 95-108
DOI 10.1021/pr200956s, PubMed 22112206
Effect of acid stress on protein expression and phosphorylation in Lactobacillus rhamnosus GG
J Proteomics, 75 (4), 1357-74
DOI 10.1016/j.jprot.2011.11.009, PubMed 22119544
Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin
Neoplasia, 13 (7), 643-52
DOI 10.1593/neo.11356, PubMed 21750658
Quantitative subcellular proteome and secretome profiling of influenza A virus-infected human primary macrophages
PLoS Pathog, 7 (5), e1001340
DOI 10.1371/journal.ppat.1001340, PubMed 21589892
Growth phase-associated changes in the proteome and transcriptome of Lactobacillus rhamnosus GG in industrial-type whey medium
Microb Biotechnol, 4 (6), 746-66
DOI 10.1111/j.1751-7915.2011.00275.x, PubMed 21883975
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer
Nat Commun, 2, 330
DOI 10.1038/ncomms1332, PubMed 21629263
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate
Rheumatol Int, 32 (5), 1271-6
DOI 10.1007/s00296-010-1765-y, PubMed 21267570
Recognition of cytoplasmic RNA results in cathepsin-dependent inflammasome activation and apoptosis in human macrophages
J Immunol, 186 (5), 3085-92
DOI 10.4049/jimmunol.1002051, PubMed 21257972
Comparative proteome cataloging of Lactobacillus rhamnosus strains GG and Lc705
J Proteome Res, 10 (8), 3460-73
DOI 10.1021/pr2000896, PubMed 21615180
Publications 2010
Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei
Mol Cell Proteomics, 9 (6), 1352-67
DOI 10.1074/mcp.M900519-MCP200, PubMed 20308691
Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG
Mol Cell Proteomics, 10 (2), M110.002741
DOI 10.1074/mcp.M110.002741, PubMed 21078892
Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model
J Invest Dermatol, 130 (12), 2743-51
DOI 10.1038/jid.2010.208, PubMed 20631725
Thaumatin-like protein and baker's respiratory allergy
Ann Allergy Asthma Immunol, 104 (2), 139-46
DOI 10.1016/j.anai.2009.11.062, PubMed 20306817
Compid: a new software tool to integrate and compare MS/MS based protein identification results from Mascot and Paragon
J Proteome Res, 9 (12), 6795-800
DOI 10.1021/pr100824w, PubMed 20973569
Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation
Mol Cell Proteomics, 9 (9), 1937-53
DOI 10.1074/mcp.M900483-MCP200, PubMed 20467038
A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei
Proteomics, 11 (1), 159-65
DOI 10.1002/pmic.201000344, PubMed 21182203
Comparative analysis of nuclear estrogen receptor alpha and beta interactomes in breast cancer cells
Mol Biosyst, 7 (3), 667-76
DOI 10.1039/c0mb00145g, PubMed 21173974
Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes
J Proteome Res, 9 (3), 1549-64
DOI 10.1021/pr901040u, PubMed 20070120
Pripper: prediction of caspase cleavage sites from whole proteomes
BMC Bioinformatics, 11, 320
DOI 10.1186/1471-2105-11-320, PubMed 20546630
Temperature-induced structural transition in-situ in porcine lens--changes observed in void size distribution
Biochim Biophys Acta, 1798 (5), 958-65
DOI 10.1016/j.bbamem.2010.01.011, PubMed 20122897
Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS
Proteomics, 11 (1), 172-9
DOI 10.1002/pmic.201000217, PubMed 21182205
Sec1p and Mso1p C-terminal tails cooperate with the SNAREs and Sec4p in polarized exocytosis
Mol Biol Cell, 22 (2), 230-44
DOI 10.1091/mbc.E10-07-0592, PubMed 21119007
Publications 2009
An update on clinical proteomics in Alzheimer's research
J Neurochem, 112 (6), 1386-414
DOI 10.1111/j.1471-4159.2009.06558.x, PubMed 20050976
Actin and RIG-I/MAVS signaling components translocate to mitochondria upon influenza A virus infection of human primary macrophages
J Immunol, 182 (9), 5682-92
DOI 10.4049/jimmunol.0803093, PubMed 19380815
Filtering strategies for improving protein identification in high-throughput MS/MS studies
Proteomics, 9 (4), 848-60
DOI 10.1002/pmic.200800517, PubMed 19160393
Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry
Rapid Commun Mass Spectrom, 23 (17), 2754-62
DOI 10.1002/rcm.4185, PubMed 19639564
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
Biol Chem, 390 (2), 99-107
DOI 10.1515/BC.2009.019, PubMed 19040354
Identification of novel Stat6 regulated proteins in IL-4-treated mouse lymphocytes
Proteomics, 9 (4), 1087-98
DOI 10.1002/pmic.200800161, PubMed 19180534
Publications 2008
Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation
Mol Cell Proteomics, 8 (1), 32-44
DOI 10.1074/mcp.M800139-MCP200, PubMed 18701445
3rd Annual FinnProt Meeting: from cells to systems
Expert Rev Proteomics, 5 (3), 389-91
DOI 10.1586/14789450.5.3.389, PubMed 18532906
Publications 2007
Proteome changes in bovine longissimus thoracis muscle during the early postmortem storage period
J Proteome Res, 6 (7), 2720-31
DOI 10.1021/pr070173o, PubMed 17567165
Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease
Clin Chem, 53 (4), 657-65
DOI 10.1373/clinchem.2006.078014, PubMed 17289803
Proteome analysis of human macrophages reveals the upregulation of manganese-containing superoxide dismutase after toll-like receptor activation
Proteomics, 7 (3), 378-84
DOI 10.1002/pmic.200600582, PubMed 17211829
Publications 2006
Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation
Mol Cell Proteomics, 6 (2), 238-51
DOI 10.1074/mcp.M600290-MCP200, PubMed 17114647
Identification of new Golgi complex specific proteins by direct organelle proteomic analysis
Proteomics, 6 (12), 3502-8
DOI 10.1002/pmic.200500516, PubMed 16691549
TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner
Cell Cycle, 5 (23), 2787-95
DOI 10.4161/cc.5.23.3523, PubMed 17172861
Publications 2005
Geometrical distortions in two-dimensional gels: applicable correction methods
J Chromatogr B Analyt Technol Biomed Life Sci, 815 (1-2), 25-37
DOI 10.1016/j.jchromb.2004.07.037, PubMed 15652796
Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector
J Neurosci, 25 (27), 6350-61
DOI 10.1523/JNEUROSCI.1517-05.2005, PubMed 16000625
Characterization of microsomal fraction proteome in human lymphoblasts reveals the down-regulation of galectin-1 by interleukin-12
Proteomics, 5 (18), 4719-32
DOI 10.1002/pmic.200402016, PubMed 16247730
Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain
Neurobiol Dis, 20 (3), 858-70
DOI 10.1016/j.nbd.2005.05.021, PubMed 15979880
Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain
Neurobiol Aging, 27 (1), 42-53
DOI 10.1016/j.neurobiolaging.2004.11.010, PubMed 16298240
A comparative evaluation of software for the analysis of liquid chromatography-tandem mass spectrometry data from isotope coded affinity tag experiments
Proteomics, 5 (11), 2748-60
DOI 10.1002/pmic.200401187, PubMed 15952233
Proteome characterization of human NK-92 cells identifies novel IFN-alpha and IL-15 target genes
J Proteome Res, 4 (1), 75-82
DOI 10.1021/pr049857b, PubMed 15707360
Proteome profiling of interleukin-12 treated human T helper cells
Proteomics, 5 (12), 3137-41
DOI 10.1002/pmic.200401151, PubMed 16038020
Proteomic and transcriptomic characterization of interferon-alpha-induced human primary T helper cells
Proteomics, 5 (2), 371-9
DOI 10.1002/pmic.200400967, PubMed 15700245
Quality classification of tandem mass spectrometry data
Bioinformatics, 22 (4), 400-6
DOI 10.1093/bioinformatics/bti829, PubMed 16352652
Publications 2004
Proteome characterization of human T helper 1 and 2 cells
Proteomics, 4 (1), 84-92
DOI 10.1002/pmic.200300510, PubMed 14730674
The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity
Biochem J, 382 (Pt 1), 261-8
DOI 10.1042/BJ20040285, PubMed 15186217
Publications 2003
Comparison of PDQuest and Progenesis software packages in the analysis of two-dimensional electrophoresis gels
Proteomics, 3 (10), 1936-46
DOI 10.1002/pmic.200300544, PubMed 14625856
Publications 2002
18S rDNA phylogeny of the Tubificidae (Clitellata) and its constituent taxa: dismissal of the Naididae
Mol Phylogenet Evol, 22 (3), 414-22
DOI 10.1006/mpev.2001.1063, PubMed 11884166
Hierarchical grid transformation for image warping in the analysis of two-dimensional electrophoresis gels
Proteomics, 2 (11), 1504-15
DOI 10.1002/1615-9861(200211)2:11<1504::AID-PROT1504>3.0.CO;2-B, PubMed 12442250
Publications 2001
The role of mass spectrometry in proteome studies
Biomol Eng, 18 (5), 221-7
DOI 10.1016/s1389-0344(01)00097-1, PubMed 11911089
A proteome database of human primary T helper cells
Electrophoresis, 22 (20), 4375-82
DOI 10.1002/1522-2683(200112)22:20<4375::AID-ELPS4375>3.0.CO;2-P, PubMed 11824605
Scots pine expresses short-root-specific peroxidases during development
Eur J Biochem, 268 (1), 86-92
DOI 10.1046/j.1432-1327.2001.01853.x, PubMed 11121106
Publications 2000
Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes
Eur J Biochem, 267 (13), 4011-9
DOI 10.1046/j.1432-1327.2000.01433.x, PubMed 10866800
Publications 1998
Structural characterisation of N-linked and O-linked oligosaccharides derived from interferon-alpha2b and interferon-alpha14c produced by Sendai-virus-induced human peripheral blood leukocytes
Eur J Biochem, 253 (2), 485-93
DOI 10.1046/j.1432-1327.1998.2530485.x, PubMed 9654101
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes
Biochem J, 329 ( Pt 2) (Pt 2), 295-302
DOI 10.1042/bj3290295, PubMed 9425112