Gareth J. Sullivan

  • Senior scientist; MSc, PhD
  • +47 23 07 27 97

Publications 2022

Bogdanova M, Zabirnyk A, Malashicheva A, Semenova D, Kvitting JP, Kaljusto ML, Perez MDM, Kostareva A, Stensløkken KO, Sullivan GJ, Rutkovskiy A, Vaage J (2022)
Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview
Front Pharmacol, 13, 835825
DOI 10.3389/fphar.2022.835825, PubMed 35721220

Chen A, Kristiansen CK, Høyland LE, Ziegler M, Wang J, Sullivan GJ, Li X, Bindoff LA, Liang KX (2022)
POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
Cell Cycle, 21 (11), 1178-1193
DOI 10.1080/15384101.2022.2044136, PubMed 35298342

Kogler S, Aizenshtadt A, Harrison S, Skottvoll FS, Berg HE, Abadpour S, Scholz H, Sullivan G, Thiede B, Lundanes E, Bogen IL, Krauss S, Røberg-Larsen H, Wilson SR (2022)
"Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry
Anal Chem, 94 (50), 17677-17684
DOI 10.1021/acs.analchem.2c04530, PubMed 36484723

Kristiansen CK, Chen A, Høyland LE, Ziegler M, Sullivan GJ, Bindoff LA, Liang KX (2022)
Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations
Cell Cycle, 21 (20), 2206-2221
DOI 10.1080/15384101.2022.2092185, PubMed 35815665

Publications 2021

Aprigliano R, Aksu ME, Bradamante S, Mihaljevic B, Wang W, Rian K, Montaldo NP, Grooms KM, Fordyce Martin SL, Bordin DL, Bosshard M, Peng Y, Alexov E, Skinner C, Liabakk NB, Sullivan GJ, Bjørås M, Schwartz CE, van Loon B (2021)
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
Cell Rep Med, 2 (4), 100240
DOI 10.1016/j.xcrm.2021.100240, PubMed 33948573

Chen A, Kristiansen CK, Hong Y, Kianian A, Fang EF, Sullivan GJ, Wang J, Li X, Bindoff LA, Liang KX (2021)
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
Front Cell Dev Biol, 9, 737304
DOI 10.3389/fcell.2021.737304, PubMed 34631714

Convery N, Samardzhieva I, Stormonth-Darling JM, Harrison S, Sullivan GJ, Gadegaard N (2021)
3D Printed Tooling for Injection Molded Microfluidics
Macromol. Mater. Eng., 306 (11), 2100464
DOI 10.1002/mame.202100464

Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ (2021)
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
J Hepatol, 75 (4), 935-959
DOI 10.1016/j.jhep.2021.06.021, PubMed 34171436

Harrison SP, Baumgarten SF, Verma R, Lunov O, Dejneka A, Sullivan GJ (2021)
Liver Organoids: Recent Developments, Limitations and Potential
Front Med (Lausanne), 8, 574047
DOI 10.3389/fmed.2021.574047, PubMed 34026769

Kim J, Sullivan GJ, Park IH (2021)
How well do brain organoids capture your brain?
iScience, 24 (2), 102063
DOI 10.1016/j.isci.2021.102063, PubMed 33554067

Mostafavi S, Balafkan N, Pettersen IKN, Nido GS, Siller R, Tzoulis C, Sullivan GJ, Bindoff LA (2021)
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
Front Cell Dev Biol, 9, 744777
DOI 10.3389/fcell.2021.744777, PubMed 34722525

Sharma K, Asp NT, Harrison S, Siller R, Baumgarten SF, Gupta S, Chollet ME, Andersen E, Sullivan GJ, Simonsen A (2021)
Autophagy modulates cell fate decisions during lineage commitment
Autophagy, 18 (8), 1915-1931
DOI 10.1080/15548627.2021.2008691, PubMed 34923909

Skottvoll FS, Hansen FA, Harrison S, Boger IS, Mrsa A, Restan MS, Stein M, Lundanes E, Pedersen-Bjergaard S, Aizenshtadt A, Krauss S, Sullivan G, Bogen IL, Wilson SR (2021)
Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies
Anal Chem, 93 (7), 3576-3585
DOI 10.1021/acs.analchem.0c05082, PubMed 33534551

Publications 2020

Balafkan N, Mostafavi S, Schubert M, Siller R, Liang KX, Sullivan G, Bindoff LA (2020)
A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates
Sci Rep, 10 (1), 18498
DOI 10.1038/s41598-020-73656-2, PubMed 33116175

Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA (2020)
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations
EMBO Mol Med, 12 (10), e12146
DOI 10.15252/emmm.202012146, PubMed 32840960

Liang KX, Vatne GH, Kristiansen CK, Ievglevskyi O, Kondratskaya E, Glover JC, Chen A, Sullivan GJ, Bindoff LA (2020)
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation
Exp Neurol, 337, 113536
DOI 10.1016/j.expneurol.2020.113536, PubMed 33264635

Tanaka Y, Cakir B, Xiang Y, Sullivan GJ, Park IH (2020)
Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Cell Rep, 30 (6), 1682-1689.e3
DOI 10.1016/j.celrep.2020.01.038, PubMed 32049002

Xiang Y, Tanaka Y, Patterson B, Hwang SM, Hysolli E, Cakir B, Kim KY, Wang W, Kang YJ, Clement EM, Zhong M, Lee SH, Cho YS, Patra P, Sullivan GJ, Weissman SM, Park IH (2020)
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons
Mol Cell, 79 (1), 84-98.e9
DOI 10.1016/j.molcel.2020.05.016, PubMed 32526163

Publications 2019

Bogdanova M, Zabirnyk A, Malashicheva A, Enayati KZ, Karlsen TA, Kaljusto ML, Kvitting JP, Dissen E, Sullivan GJ, Kostareva A, Stensløkken KO, Rutkovskiy A, Vaage J (2019)
Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties
Sci Rep, 9 (1), 12934
DOI 10.1038/s41598-019-49016-0, PubMed 31506459

Lin A, Sved Skottvoll F, Rayner S, Pedersen-Bjergaard S, Sullivan G, Krauss S, Ray Wilson S, Harrison S (2019)
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry
Electrophoresis, 41 (1-2), 56-64
DOI 10.1002/elps.201900170, PubMed 31544246

Publications 2018

Bogdanova M, Kostina A, Zihlavnikova Enayati K, Zabirnyk A, Malashicheva A, Stensløkken KO, Sullivan GJ, Kaljusto ML, Kvitting JP, Kostareva A, Vaage J, Rutkovskiy A (2018)
Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells
Front Physiol, 9, 1635
DOI 10.3389/fphys.2018.01635, PubMed 30524301

Kim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH (2018)
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
Nat Commun, 9 (1), 2583
DOI 10.1038/s41467-018-04818-0, PubMed 29968706

Pisal RV, Suchanek J, Siller R, Soukup T, Hrebikova H, Bezrouk A, Kunke D, Micuda S, Filip S, Sullivan G, Mokry J (2018)
Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth
Sci Rep, 8 (1), 6168
DOI 10.1038/s41598-018-24421-z, PubMed 29670257

Publications 2017

Gamal W, Treskes P, Samuel K, Sullivan GJ, Siller R, Srsen V, Morgan K, Bryans A, Kozlowska A, Koulovasilopoulos A, Underwood I, Smith S, Del-Pozo J, Moss S, Thompson AI, Henderson NC, Hayes PC, Plevris JN, Bagnaninchi PO, Nelson LJ (2017)
Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver
Sci Rep, 7, 37541
DOI 10.1038/srep37541, PubMed 28134251

Rutkovskiy A, Malashicheva A, Sullivan G, Bogdanova M, Kostareva A, Stensløkken KO, Fiane A, Vaage J (2017)
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification
J Am Heart Assoc, 6 (9)
DOI 10.1161/JAHA.117.006339, PubMed 28912209

Scarfe L, Brillant N, Kumar JD, Ali N, Alrumayh A, Amali M, Barbellion S, Jones V, Niemeijer M, Potdevin S, Roussignol G, Vaganov A, Barbaric I, Barrow M, Burton NC, Connell J, Dazzi F, Edsbagge J, French NS, Holder J, Hutchinson C, Jones DR, Kalber T, Lovatt C, Lythgoe MF et al. (2017)
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
NPJ Regen Med, 2, 28
DOI 10.1038/s41536-017-0029-9, PubMed 29302362

Siller R, Dufour E, Lycke M, Wilmut I, Jung YW, Park IH, Sullivan GJ (2017)
Development of an inducible platform for intercellular protein delivery
Int J Pharm, 522 (1-2), 1-10
DOI 10.1016/j.ijpharm.2017.02.067, PubMed 28254654

Siller R, Greenhough S, Mathapati S, Si-Tayeb K, Sullivan GJ (2017)
Future Challenges in the Generation of Hepatocyte-Like Cells From Human Pluripotent Stem Cells
Curr. Pathobiol. Rep., 5 (3), 301-314
DOI 10.1007/s40139-017-0150-x

Siller R, Sullivan GJ (2017)
Rapid Screening of the Endodermal Differentiation Potential of Human Pluripotent Stem Cells
Curr Protoc Stem Cell Biol, 43, 1G.7.1-1G.7.23
DOI 10.1002/cpsc.36, PubMed 29140570

Publications 2016

Mathapati S, Siller R, Impellizzeri AA, Lycke M, Vegheim K, Almaas R, Sullivan GJ (2016)
Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells
Curr Protoc Stem Cell Biol, 38, 1G.6.1-1G.6.18
DOI 10.1002/cpsc.13, PubMed 27532814

Siller R, Naumovska E, Mathapati S, Lycke M, Greenhough S, Sullivan GJ (2016)
Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines
Sci Rep, 6, 37178
DOI 10.1038/srep37178, PubMed 27872482

Xu M, Stattin EL, Shaw G, Heinegård D, Sullivan G, Wilmut I, Colman A, Önnerfjord P, Khabut A, Aspberg A, Dockery P, Hardingham T, Murphy M, Barry F (2016)
Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly
Stem Cells Transl Med, 5 (9), 1171-81
DOI 10.5966/sctm.2015-0384, PubMed 27388238

Publications 2015

Siller R, Greenhough S, Naumovska E, Sullivan GJ (2015)
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells
Stem Cell Reports, 4 (5), 939-52
DOI 10.1016/j.stemcr.2015.04.001, PubMed 25937370

Publications 2013

Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S (2013)
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells"
Sci Transl Med, 5 (188), 188le2
DOI 10.1126/scitranslmed.3005065, PubMed 23740897

Dajani R, Koo SE, Sullivan GJ, Park IH (2013)
Investigation of Rett syndrome using pluripotent stem cells
J Cell Biochem, 114 (11), 2446-53
DOI 10.1002/jcb.24597, PubMed 23744605

Siller R, Greenhough S, Park IH, Sullivan GJ (2013)
Modelling human disease with pluripotent stem cells
Curr Gene Ther, 13 (2), 99-110
DOI 10.2174/1566523211313020004, PubMed 23444871

Publications 2012

Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S (2012)
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Proc Natl Acad Sci U S A, 109 (15), 5803-8
DOI 10.1073/pnas.1202922109, PubMed 22451909

Kim KY, Jung YW, Sullivan GJ, Chung L, Park IH (2012)
Cellular reprogramming: a novel tool for investigating autism spectrum disorders
Trends Mol Med, 18 (8), 463-71
DOI 10.1016/j.molmed.2012.06.002, PubMed 22771169

Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, Gygi SP, Shneider NA, Maniatis T, Reed R (2012)
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA
Cell Rep, 2 (4), 799-806
DOI 10.1016/j.celrep.2012.08.025, PubMed 23022481

Zhou XL, Sullivan GJ, Sun P, Park IH (2012)
Humanized murine model for HBV and HCV using human induced pluripotent stem cells
Arch Pharm Res, 35 (2), 261-9
DOI 10.1007/s12272-012-0206-8, PubMed 22370780

Publications 2011

Ruzov A, Tsenkina Y, Serio A, Dudnakova T, Fletcher J, Bai Y, Chebotareva T, Pells S, Hannoun Z, Sullivan G, Chandran S, Hay DC, Bradley M, Wilmut I, De Sousa P (2011)
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development
Cell Res, 21 (9), 1332-42
DOI 10.1038/cr.2011.113, PubMed 21747414

Wilmut I, Sullivan G, Chambers I (2011)
The evolving biology of cell reprogramming
Philos Trans R Soc Lond B Biol Sci, 366 (1575), 2183-97
DOI 10.1098/rstb.2011.0051, PubMed 21727124

Wilmut I, Wongtawan T, Quigley M, Sullivan G (2011)
Biomedical and social contributions to sustainability
Philos Trans A Math Phys Eng Sci, 369 (1942), 1730-47
DOI 10.1098/rsta.2010.0370, PubMed 21464068

Publications 2010

Aledealat K, Mihajlović G, Chen K, Field M, Sullivan GJ, Xiong P, Chase PB, von Molnár S (2010)
Dynamic micro-Hall detection of superparamagnetic beads in a microfluidic channel
J Magn Magn Mater, 322 (24), L69-L72
DOI 10.1016/j.jmmm.2010.08.006, PubMed 21655331

Hannoun Z, Filippi C, Sullivan G, Hay DC, Iredale JP (2010)
Hepatic endoderm differentiation from human embryonic stem cells
Curr Stem Cell Res Ther, 5 (3), 233-44
DOI 10.2174/157488810791824403, PubMed 20214561

Sullivan GJ, Bai Y, Fletcher J, Wilmut I (2010)
Induced pluripotent stem cells: epigenetic memories and practical implications
Mol Hum Reprod, 16 (12), 880-5
DOI 10.1093/molehr/gaq091, PubMed 21059705

Sullivan GJ, Hay DC, Park IH, Fletcher J, Hannoun Z, Payne CM, Dalgetty D, Black JR, Ross JA, Samuel K, Wang G, Daley GQ, Lee JH, Church GM, Forbes SJ, Iredale JP, Wilmut I (2010)
Generation of functional human hepatic endoderm from human induced pluripotent stem cells
Hepatology, 51 (1), 329-35
DOI 10.1002/hep.23335, PubMed 19877180

Taylor J, Wilmut I, Sullivan G (2010)
What are the limits to cell plasticity?
Cell Res, 20 (5), 502-3
DOI 10.1038/cr.2010.59, PubMed 20436508

Publications 2009

Folks L, Troup AS, Boone TD, Katine JA, Nishioka M, Grobis M, Sullivan GJ, Ikhlassi A, Field M, Gurney BA (2009)
Near-surface nanoscale InAs Hall cross sensitivity to localized magnetic and electric fields
J Phys Condens Matter, 21 (25), 255802
DOI 10.1088/0953-8984/21/25/255802, PubMed 21828442

Wilmut I, Sullivan G, Taylor J (2009)
A decade of progress since the birth of Dolly
Reprod Fertil Dev, 21 (1), 95-100
DOI 10.1071/rd08216, PubMed 19152750

Publications 2002

O'Sullivan AC, Sullivan GJ, McStay B (2002)
UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat
Mol Cell Biol, 22 (2), 657-68
DOI 10.1128/MCB.22.2.657-668.2002, PubMed 11756560

Publications 2001

Sullivan GJ, Bridger JM, Cuthbert AP, Newbold RF, Bickmore WA, McStay B (2001)
Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli
EMBO J, 20 (11), 2867-74
DOI 10.1093/emboj/20.11.2867, PubMed 11387219

Publications 1999

Sullivan GJ (1999)
Medical malpractice tort reform in California
Cost Qual, 5 (3), 27-8, 33
PubMed 10622985

Publications 1998

Sullivan GJ, McStay B (1998)
Dimerization and HMG box domains 1-3 present in Xenopus UBF are sufficient for its role in transcriptional enhancement
Nucleic Acids Res, 26 (15), 3555-61
DOI 10.1093/nar/26.15.3555, PubMed 9671818

Publications 1997

McStay B, Sullivan GJ, Cairns C (1997)
The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter
EMBO J, 16 (2), 396-405
DOI 10.1093/emboj/16.2.396, PubMed 9029158

Publications 1994

Orchard MT, Sullivan GJ (1994)
Overlapped block motion compensation: an estimation-theoretic approach
IEEE Trans Image Process, 3 (5), 693-9
DOI 10.1109/83.334974, PubMed 18291963

Sullivan GJ, Baker RL (1994)
Efficient quadtree coding of images and video
IEEE Trans Image Process, 3 (3), 327-31
DOI 10.1109/83.287030, PubMed 18291934

Publications 1992

Kiang SZ, Baker RL, Sullivan GJ, Chiu CY (1992)
Recursive optimal pruning with applications to tree structured vector quantizers
IEEE Trans Image Process, 1 (2), 162-9
DOI 10.1109/83.136593, PubMed 18296151

Publications 1991

Woodward MJ, Sullivan GJ (1991)
Nucleotide sequence of a repetitive element isolated from Leptospira interrogans serovar hardjo type hardjo-bovis
J Gen Microbiol, 137 (5), 1101-9
DOI 10.1099/00221287-137-5-1101, PubMed 1650813

Woodward MJ, Sullivan GJ, Palmer NM, Woolley JC, Redstone JS (1991)
Development of a PCR test specific for Leptospira hardjo genotype bovis
Vet Rec, 128 (12), 282-3
DOI 10.1136/vr.128.12.282, PubMed 2038811

Page visits: 4173