Runar Almaas

  • Scientist and group leader, Head of Department; MD, PhD
  • +47 23 07 24 94
 

Publications 2024

Harrison SP, Baumgarten SF, Chollet ME, Stavik B, Bhattacharya A, Almaas R, Sullivan GJ (2024)
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
J Pediatr Gastroenterol Nutr, 78 (5), 1047-1058
DOI 10.1002/jpn3.12195, PubMed 38529852

Westerberg NS, Atneosen-Åsegg M, Melheim M, Chollet ME, Harrison SP, Siller R, Sullivan GJ, Almaas R (2024)
Effect of hypoxia on aquaporins and hepatobiliary transport systems in human hepatic cells
Pediatr Res (in press)
DOI 10.1038/s41390-024-03368-0, PubMed 38951656

Ziegler A, Sæves I, Almaas R (2024)
Differences in bile acid profiles between cholestatic diseases - Development of a high throughput assay for dried bloodspots
Clin Chim Acta, 562, 119864
DOI 10.1016/j.cca.2024.119864, PubMed 38992821

Ziegler A, Sæves I, Almaas R (2024)
Corrigendum to "Differences in bile acid profiles between cholestatic diseases - Development of a high throughput assay for dried bloodspots" [Clin. Chim. Acta 562 (2024) 119864]
Clin Chim Acta, 562, 119882
DOI 10.1016/j.cca.2024.119882, PubMed 39054215

Publications 2023

Almaas R, Atneosen-Åsegg M, Ytre-Arne ME, Melheim M, Sorte HS, Cízková D, Reims HM, Bezrouk A, Harrison SP, Strand J, Hermansen JU, Andersen SS, Eiklid KL, Mokrý J, Sullivan GJ, Stray-Pedersen A (2023)
Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5'-untranslated region of UNC45A
J Hepatol, 79 (4), 945-954
DOI 10.1016/j.jhep.2023.05.037, PubMed 37328071

Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS et al. (2023)
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039

Lin X, Wang W, Yang M, Damseh N, de Sousa MML, Jacob F, Lång A, Kristiansen E, Pannone M, Kissova M, Almaas R, Kuśnierczyk A, Siller R, Shahrour M, Al-Ashhab M, Abu-Libdeh B, Tang W, Slupphaug G, Elpeleg O, Bøe SO, Eide L, Sullivan GJ, Rinholm JE, Song H, Ming GL et al. (2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment
Genome Biol, 24 (1), 216
DOI 10.1186/s13059-023-03037-1, PubMed 37773136

Rieneck K, Rasmussen KK, Schoof EM, Clausen FB, Holze H, Bergholt T, Jørgensen MH, Christensen VB, Almaas R, Jordal PL, Locard-Paulet M, Runager K, Nielsen LK, Schlotmann BC, Weischenfeldt JL, Jensen LJ, Dziegiel MH (2023)
Hunting for the elusive target antigen in gestational alloimmune liver disease (GALD)
PLoS One, 18 (10), e0286432
DOI 10.1371/journal.pone.0286432, PubMed 37862305

Publications 2022

Erichsen Landsverk HC, Almaas R, Saugstad OD (2022)
50 Years Ago in TheJournalofPediatrics: Hemiallogeneic Stem Cell Transplantation-from Last Resort to a Viable Treatment Option
J Pediatr, 243, 213
DOI 10.1016/j.jpeds.2021.12.064, PubMed 35341548

Haflidadottir S, Østensen AB, Matthews IL, Line PD, Almaas R (2022)
Mycophenolate mofetil use is associated with reduced incidence of food allergy in liver transplanted children
J Pediatr Gastroenterol Nutr, 75 (1), 138-144
DOI 10.1097/MPG.0000000000003509, PubMed 35666879

Publications 2021

Almaas R, Saugstad OD (2021)
50 Years Ago in TheJournalofPediatrics: Hepatopulmonary Syndrome: Transplantation Is the Big Difference
J Pediatr, 229, 69
DOI 10.1016/j.jpeds.2020.08.074, PubMed 33487230

Almaas R, Saugstad OD (2021)
50 Years Ago in TheJournalofPediatrics: Pregnancy in Women with Galactosemia
J Pediatr, 233, 118
DOI 10.1016/j.jpeds.2021.02.032, PubMed 34030831

Almaas R, Saugstad OD (2021)
50 Years Ago in TheJournalofPediatrics: Diagnosis of Self-Mutilation and Hyperuricemia
J Pediatr, 237, 86
DOI 10.1016/j.jpeds.2021.07.034, PubMed 34563325

Almaas R, Saugstad OD (2021)
Hepatopulmonary Syndrome: Transplantation Is the Big Difference
J. Pediatr., 229, 69

Almaas R, Saugstad OD (2021)
Pregnancy in Women with Galactosemia
J. Pediatr., 233, 118

Almaas R, Saugstad OD (2021)
Diagnosis of Self-Mutilation and Hyperuricemia
J. Pediatr., 237, 86

Thrane KJ, Müller LSO, Suther KR, Thomassen KS, Holmström H, Thaulow E, Almaas R, Möller T, de Lange C (2021)
Spectrum of Fontan-associated liver disease assessed by MRI and US in young adolescents
Abdom Radiol (NY), 46 (7), 3205-3216
DOI 10.1007/s00261-021-02994-0, PubMed 33688987

Østensen AB, Skarbø AB, Sanengen T, Line PD, Almaas R (2021)
Impaired Neurocognitive Performance in Children after Liver Transplantation
J Pediatr, 243, 135-141.e2
DOI 10.1016/j.jpeds.2021.12.033, PubMed 34953814

Publications 2020

Atneosen-Åsegg M, Melheim M, Almaas R (2020)
MicroRNA in dried blood spots from patients with Aagenaes syndrome and evaluation of pre-analytical and analytical factors
Pediatr Res, 89 (7), 1780-1787
DOI 10.1038/s41390-020-01153-3, PubMed 32932426

Bjørnland K, Hukkinen M, Gatzinsky V, Arnell H, Pakarinen MP, Almaas R, Svensson JF (2020)
Partial Biliary Diversion May Promote Long-Term Relief of Pruritus and Native Liver Survival in Children with Cholestatic Liver Diseases
Eur J Pediatr Surg, 31 (4), 341-346
DOI 10.1055/s-0040-1714657, PubMed 32707578

de Lange C, Thrane KJ, Thomassen KS, Geier O, Nguyen B, Tomterstad A, Ording Müller LS, Thaulow E, Almaas R, Døhlen G, Suther KR, Möller T (2020)
Hepatic magnetic resonance T1-mapping and extracellular volume fraction compared to shear-wave elastography in pediatric Fontan-associated liver disease
Pediatr Radiol, 51 (1), 66-76
DOI 10.1007/s00247-020-04805-y, PubMed 33033916

Haflidadottir S, Matthews IL, Almaas R (2020)
Cytokine profile in children with food allergy following liver transplantation
Pediatr Transplant, 24 (2), e13657
DOI 10.1111/petr.13657, PubMed 32067305

Thorsteinsdottir H, Möller T, Bjerre A, Almaas R (2020)
GDF-15 - A matter of the heart or the kidney?
Int J Cardiol, 313, 47
DOI 10.1016/j.ijcard.2020.03.017, PubMed 32517965

Thorsteinsdottir H, Salvador CL, Mjøen G, Lie A, Sugulle M, Tøndel C, Brun A, Almaas R, Bjerre A (2020)
Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation
Dis Markers, 2020, 6162892
DOI 10.1155/2020/6162892, PubMed 32089755

Publications 2019

Almaas R (2019)
Diagnosing autoimmune hepatitis in paediatric patients - we still haven't found what we are looking for
Acta Paediatr, 108 (9), 1562-1563
DOI 10.1111/apa.14890, PubMed 31264728

Diab SG, Godang K, Müller LO, Almaas R, de Lange C, Brunvand L, Hansen KM, Myhre AG, Døhlen G, Thaulow E, Bollerslev J, Möller T (2019)
Progressive loss of bone mass in children with Fontan circulation
Congenit Heart Dis, 14 (6), 996-1004
DOI 10.1111/chd.12848, PubMed 31600039

Åsberg A, Bjerre A, Almaas R, Luis-Lima S, Robertsen I, Salvador CL, Porrini E, Schwartz GJ, Hartmann A, Bergan S (2019)
Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance
Kidney Int Rep, 5 (2), 189-198
DOI 10.1016/j.ekir.2019.11.012, PubMed 32043033

Publications 2018

Almaas R, Haflidadottir S, Kaldestad RH, Matthews IL (2018)
Asthma, Eczema, and Food Allergy in Children Following Liver Transplantation
J Pediatr, 204, 263-269
DOI 10.1016/j.jpeds.2018.08.050, PubMed 30270158

Bjørnland K, Hinna M, Aksnes G, Stensrud KJ, Ertresvåg K, Bjørnstad-Østensen A, Sanengen T, Line PD, Aagenæs I, Aabakken L, Emblem R, Almaas R (2018)
Outcome for biliary atresia patients treated at a low-volume centre
Scand J Gastroenterol, 53 (4), 471-474
DOI 10.1080/00365521.2018.1439097, PubMed 29546790

Publications 2017

Pakarinen MP, Johansen LS, Svensson JF, Bjørnland K, Gatzinsky V, Stenström P, Koivusalo A, Kvist N, Almström M, Emblem R, Björnsson S, Backman T, Almaas R, Jalanko H, Fischler B, Thorup J, Nordic Pediatric Surgery Study Consortium (2017)
Outcomes of biliary atresia in the Nordic countries - a multicenter study of 158 patients during 2005-2016
J Pediatr Surg, 53 (8), 1509-1515
DOI 10.1016/j.jpedsurg.2017.08.048, PubMed 28947328

Østensen AB, Sanengen T, Holter E, Line PD, Almaas R (2017)
No effect of treatment with intravenous ganciclovir on Epstein-Barr virus viremia demonstrated after pediatric liver transplantation
Pediatr Transplant, 21 (6)
DOI 10.1111/petr.13010, PubMed 28653462

Publications 2016

Mathapati S, Siller R, Impellizzeri AA, Lycke M, Vegheim K, Almaas R, Sullivan GJ (2016)
Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells
Curr Protoc Stem Cell Biol, 38, 1G.6.1-1G.6.18
DOI 10.1002/cpsc.13, PubMed 27532814

Publications 2015

Almaas R, Jensen U, Loennecken MC, Tveter AT, Sanengen T, Scholz T, Holm I (2015)
Impaired motor competence in children with transplanted liver
J Pediatr Gastroenterol Nutr, 60 (6), 723-8
DOI 10.1097/MPG.0000000000000757, PubMed 25658058

Publications 2013

Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2013)
Clinical experience with microdialysis catheters in pediatric liver transplants
Liver Transpl, 19 (3), 305-14
DOI 10.1002/lt.23578, PubMed 23193034

Stølen LH, Lilje R, Jørgensen JV, Bliksrud YT, Almaas R (2013)
High dietary folic Acid and high plasma folate in children and adults with phenylketonuria
JIMD Rep, 13, 83-90
DOI 10.1007/8904_2013_260, PubMed 24136656

Westheim BH, Aagenæs I, Østensen AB, Sanengen T, Almaas R (2013)
Effect of operator experience and frequency of procedure performance on complication rate after ultrasound-guided percutaneous liver biopsies
J Pediatr Gastroenterol Nutr, 57 (5), 638-43
DOI 10.1097/MPG.0b013e3182a0c7a5, PubMed 24177785

Publications 2012

Almaas R, Hankø E, Mollnes TE, Rootwelt T (2012)
Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons
Brain Res, 1458, 12-7
DOI 10.1016/j.brainres.2012.04.007, PubMed 22546346

Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Waelgaard L, Pischke SE, Mollnes TE, Inge Tønnessen T (2012)
Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts
Liver Transpl, 18 (12), 1421-9
DOI 10.1002/lt.23503, PubMed 22767413

Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2012)
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transpl, 18 (7), 839-49
DOI 10.1002/lt.23425, PubMed 22407878

Westheim BH, Østensen AB, Aagenæs I, Sanengen T, Almaas R (2012)
Evaluation of risk factors for bleeding after liver biopsy in children
J Pediatr Gastroenterol Nutr, 55 (1), 82-7
DOI 10.1097/MPG.0b013e318249c12a, PubMed 22249806

Publications 2006

Frøyland E, Pedersen ED, Kvissel AK, Almaas R, Pharo A, Skålhegg BS, Mollnes TE, Rootwelt T (2006)
Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons
Brain Res, 1113 (1), 64-73
DOI 10.1016/j.brainres.2006.07.051, PubMed 16919250

Hankø E, Hansen TW, Almaas R, Rootwelt T (2006)
Recovery after short-term bilirubin exposure in human NT2-N neurons
Brain Res, 1103 (1), 56-64
DOI 10.1016/j.brainres.2006.05.083, PubMed 16814266

Publications 2005

Frøyland E, Wibrand F, Almaas R, Dalen I, Lindstad JK, Rootwelt T (2005)
Acidosis during reoxygenation has an early detrimental effect on neuronal metabolic activity
Pediatr Res, 57 (4), 488-93
DOI 10.1203/01.PDR.0000155946.82230.2E, PubMed 15695602

Ghanima W, Almaas V, Aballi S, Dörje C, Nielssen BE, Holmen LO, Almaas R, Abdelnoor M, Sandset PM (2005)
Management of suspected pulmonary embolism (PE) by D-dimer and multi-slice computed tomography in outpatients: an outcome study
J Thromb Haemost, 3 (9), 1926-32
DOI 10.1111/j.1538-7836.2005.01544.x, PubMed 16102097

Hankø E, Hansen TW, Almaas R, Paulsen R, Rootwelt T (2005)
Synergistic protection of a general caspase inhibitor and MK-801 in bilirubin-induced cell death in human NT2-N neurons
Pediatr Res, 59 (1), 72-7
DOI 10.1203/01.pdr.0000191135.63586.08, PubMed 16326984

Publications 2004

Hankø E, Hansen TW, Almaas R, Lindstad J, Rootwelt T (2004)
Bilirubin induces apoptosis and necrosis in human NT2-N neurons
Pediatr Res, 57 (2), 179-84
DOI 10.1203/01.PDR.0000148711.11519.A5, PubMed 15611354

Publications 2003

Almaas R (2003)
Hypoxia in human NT2-N neurons: the role of free radicals and glutamate
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 124, 1 b. (flere pag.)
BIBSYS 031759297, ISBN 82-8072-092-8

Almaas R, Pytte M, Lindstad JK, Wright M, Saugstad OD, Pleasure D, Rootwelt T (2003)
Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation
J Neurochem, 84 (5), 1018-27
DOI 10.1046/j.1471-4159.2003.01593.x, PubMed 12603826

Publications 2002

Almaas R, Saugstad OD, Pleasure D, Rootwelt T (2002)
Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons
Pediatr Res, 51 (2), 136-43
DOI 10.1203/00006450-200202000-00004, PubMed 11809906

Publications 2000

Almaas R, Robertson B, Linderholm B, Lundberg E, Saugstad OD, Moen A (2000)
Reversal of meconium inhibition of pulmonary surfactant by ferric chloride, copper chloride, and acetic acid
Am J Respir Crit Care Med, 162 (5), 1789-94
DOI 10.1164/ajrccm.162.5.2002068, PubMed 11069814

Almaas R, Saugstad OD, Pleasure D, Rootwelt T (2000)
Effect of barbiturates on hydroxyl radicals, lipid peroxidation, and hypoxic cell death in human NT2-N neurons
Anesthesiology, 92 (3), 764-74
DOI 10.1097/00000542-200003000-00020, PubMed 10719955

Publications 1998

Elsner R, Oyasaeter S, Almaas R, Saugstad OD (1998)
Diving seals, ischemia-reperfusion and oxygen radicals
Comp Biochem Physiol A Mol Integr Physiol, 119 (4), 975-80
DOI 10.1016/s1095-6433(98)00012-9, PubMed 9773490

Moen A, Yu XQ, Almaas R, Curstedt T, Saugstad OD (1998)
Acute effects on systemic circulation after intratracheal instillation of Curosurf or Survanta in surfactant-depleted newborn piglets
Acta Paediatr, 87 (3), 297-303
DOI 10.1080/08035259850157354, PubMed 9560037

Rootwelt T, Dunn M, Yudkoff M, Itoh T, Almaas R, Pleasure D (1998)
Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors
J Neurochem, 71 (4), 1544-53
DOI 10.1046/j.1471-4159.1998.71041544.x, PubMed 9751188

Publications 1997

Almaas R, Rootwelt T, Oyasaeter S, Saugstad OD (1997)
Ascorbic acid enhances hydroxyl radical formation in iron-fortified infant cereals and infant formulas
Eur J Pediatr, 156 (6), 488-92
DOI 10.1007/s004310050645, PubMed 9208249

Almaas R, Sundar TB, Rootwelt T, Oyasaeter S, Saugstad OD (1997)
Plasma hypoxanthine reacts more abruptly to changes in oxygenation than base deficit and uric acid in newborn piglets
J Perinat Med, 25 (4), 353-60
DOI 10.1515/jpme.1997.25.4.353, PubMed 9350606

Ward N, Almas R (1997)
Explaining change in the international agro-food system
Rev. Int. Polit. Econ., 4 (4), 611-629
DOI 10.1080/09672299708565785

Publications 1995

Hukkanen M, Konttinen YT, Santavirta S, Nordsletten L, Madsen JE, Almaas R, Oestreicher AB, Rootwelt T, Polak JM (1995)
Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus
Clin Orthop Relat Res (311), 247-57
PubMed 7634582

Rootwelt T, Almaas R, Oyasaeter S, Moen A, Saugstad OD (1995)
Release of xanthine oxidase to the systemic circulation during resuscitation from severe hypoxemia in newborn pigs
Acta Paediatr, 84 (5), 507-11
DOI 10.1111/j.1651-2227.1995.tb13683.x, PubMed 7633144

Publications 1994

ALMAS R (1994)
THE RISE AND FALL OF AGRICULTURAL POLICY CYCLES - FROM PLANNED-ECONOMY TO GREEN LIBERALISM
J. Rural Stud., 10 (1), 15-25
DOI 10.1016/0743-0167(94)90003-5

Nordsletten L, Madsen JE, Almaas R, Rootwelt T, Halse J, Konttinen YT, Hukkanen M, Santavirta S (1994)
The neuronal regulation of fracture healing. Effects of sciatic nerve resection in rat tibia
Acta Orthop Scand, 65 (3), 299-304
DOI 10.3109/17453679408995457, PubMed 8042482

Stoltenberg L, Sundar T, Almaas R, Storm H, Rognum TO, Saugstad OD (1994)
Changes in apnea and autoresuscitation in piglets after intravenous and intrathecal interleukin-1 beta injection
J Perinat Med, 22 (5), 421-32
DOI 10.1515/jpme.1994.22.5.421, PubMed 7791018

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