Lars O. Baumbusch
- Senior scientist and group leader; MSc, PhD (Dr.)
- +47 23 07 33 72
Professional experience
10.2022 - present Dep. of Nursing, Health and Laboratory Science,
Østfold University College (HiØ), Fredrikstad, Norway
Adjunt professor (professor II)
04.2021 - present Dep. of Pediatric Research (PFI), Division of Pediatric and Adolescent Medicine,
Oslo University Hospital (OUS) Rikshospitalet, Oslo, Norway
Senior scientist and project group leader
01.-05. 2018 - 2021 Dep. of Mechanical, Electronics and Chemical Engineering,
Oslo Metropolitan University (OsloMet), Oslo, Norway
Professor / associate professor (førsteamanuensis)
11.2012 - 03.2021 Dep. of Pediatric Research, Division of Pediatric and Adolescent Medicine,
Oslo University Hospital Rikshospitalet, Oslo, Norway
Scientist and project manager
05.2007 - 10.2012 Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
Oslo University Hospital Radiumhospitalet, Oslo, Norway
Scientist and project group leader
09.2006 - 06.2010 Biomedical Research group, Dep. of Informatics, University of Oslo, Norway
Adjunct associate professor (førsteamanuensis-II)
12.2001 - 04.2007 Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
Oslo University Hospital Radiumhospitalet, Oslo, Norway
Post-doc
Education
01.2020 - 06.2020 Oslo Metropolitan University, Oslo, Norway
Evaluated for full professor competence
01.1997 - 11.2001 Div. of Molecular Biology, Dep. of Biology, University of Oslo, Norway
Dr. scient. (Ph.D.)
10.1993 - 06.1996 Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
Diploma in Biology (M.Sc. or cand. scient.)
10.1992 - 09.1993 Dep. of Botany, Trinity College Dublin, Ireland
Studies abroad and student project
10.1989 - 09.1992 Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
Intermediate diploma in biology
04.1989 - 09.1989 Philosophical faculty, Albert-Ludwig University of Freiburg, Germany
Philosophical studies
08.1987 - 03.1989 St. Fidelius Parish, Offenburg, Germany
Civilian service
08.1978 - 05.1987 Max-Planck Gymnasium Lahr, Germany
Abitur (university-entrance diploma or examen artium)
Research projects:
visit to the Baumbusch project group home page - Molecular biology of oxidative stress and cancer
Publications 2024
Correction: Whole exome sequencing of high-risk neuroblastoma identifies novel non-synonymous variants
PLoS One, 19 (7), e0306687
DOI 10.1371/journal.pone.0306687, PubMed 38950054
Publications 2023
Long Non-Coding RNAs in Hypoxia and Oxidative Stress: Novel Insights Investigating a Piglet Model of Perinatal Asphyxia
Biology (Basel), 12 (4)
DOI 10.3390/biology12040549, PubMed 37106749
From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients
Biomedicines, 11 (11)
DOI 10.3390/biomedicines11112907, PubMed 38001908
Publications 2022
Assessing nuclear versus mitochondrial cell-free DNA (cfDNA) by qRT-PCR and droplet digital PCR using a piglet model of perinatal asphyxia
Mol Biol Rep, 50 (2), 1533-1544
DOI 10.1007/s11033-022-08135-0, PubMed 36512170
Whole exome sequencing of high-risk neuroblastoma identifies novel non-synonymous variants
PLoS One, 17 (8), e0273280
DOI 10.1371/journal.pone.0273280, PubMed 36037157
Publications 2021
The Norwegian childhood cancer biobank
Cancer Rep (Hoboken), 5 (8), e1555
DOI 10.1002/cnr2.1555, PubMed 34541832
Publications 2020
Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity
Pediatr Res, 88 (3), 391-397
DOI 10.1038/s41390-020-0793-x, PubMed 32053824
Publications 2019
Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia
PLoS One, 14 (12), e0227066
DOI 10.1371/journal.pone.0227066, PubMed 31891615
Immune System Regulation Affected by a Murine Experimental Model of Bronchopulmonary Dysplasia: Genomic and Epigenetic Findings
Neonatology, 116 (3), 269-277
DOI 10.1159/000501461, PubMed 31454811
Pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia
J Matern Fetal Neonatal Med, 33 (12), 2122-2130
DOI 10.1080/14767058.2018.1541081, PubMed 30428746
Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy
Pediatr Res, 87 (3), 485-493
DOI 10.1038/s41390-019-0598-y, PubMed 31578039
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
Ital J Pediatr, 45 (1), 112
DOI 10.1186/s13052-019-0676-0, PubMed 31445514
Publications 2018
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide
Dis Markers, 2018, 5046372
DOI 10.1155/2018/5046372, PubMed 29651324
Correction to: A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 18 (1), 80
DOI 10.1186/s12885-017-3766-7, PubMed 29338700
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia
PLoS One, 13 (11), e0206601
DOI 10.1371/journal.pone.0206601, PubMed 30475817
Plasma proteome changes in cord blood samples from preterm infants
J Perinatol, 38 (9), 1182-1189
DOI 10.1038/s41372-018-0150-7, PubMed 29910464
Prospective plasma proteome changes in preterm infants with different gestational ages
Pediatr Res, 84 (1), 104-111
DOI 10.1038/s41390-018-0003-2, PubMed 29795197
An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity
Invest Ophthalmol Vis Sci, 59 (13), 5312-5319
DOI 10.1167/iovs.18-24914, PubMed 30398622
Publications 2017
Comparison of whole genome expression profile between preterm and full-term newborns
Ginekol Pol, 88 (8), 434-441
DOI 10.5603/GP.a2017.0080, PubMed 28930370
Publications 2016
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255, PubMed 27497671
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Genome Biol, 17 (1), 250
DOI 10.1186/s13059-016-1109-7, PubMed 27931250
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets
Neonatology, 111 (2), 133-139
DOI 10.1159/000449032, PubMed 27750254
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16 (1), 913
DOI 10.1186/s12885-016-2899-4, PubMed 27876019
Publications 2015
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs
PLoS One, 10 (10), e0140966
DOI 10.1371/journal.pone.0140966, PubMed 26501201
Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features
J Clin Immunol, 35 (4), 408-15
DOI 10.1007/s10875-015-0153-5, PubMed 25814142
Publications 2014
Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes
PLoS One, 9 (9), e106076
DOI 10.1371/journal.pone.0106076, PubMed 25264628
Publications 2013
Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data
PLoS One, 8 (1), e53014
DOI 10.1371/journal.pone.0053014, PubMed 23382830
High levels of genomic aberrations in serous ovarian cancers are associated with better survival
PLoS One, 8 (1), e54356
DOI 10.1371/journal.pone.0054356, PubMed 23372714
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
Breast Cancer Res Treat, 143 (1), 189-201
DOI 10.1007/s10549-013-2796-3, PubMed 24305980
Next-generation sequencing of disseminated tumor cells
Front Oncol, 3, 320
DOI 10.3389/fonc.2013.00320, PubMed 24427740
Publications 2012
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591, PubMed 23442169
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
Int J Cancer, 132 (6), 1300-10
DOI 10.1002/ijc.27783, PubMed 22907219
Publications 2011
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Int J Cancer, 131 (4), E405-15
DOI 10.1002/ijc.26444, PubMed 21935921
The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Breast Cancer Res, 13 (3), R61
DOI 10.1186/bcr2898, PubMed 21672237
Publications 2010
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Sci Transl Med, 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611, PubMed 20592421
Publications 2009
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays
Nucleic Acids Res, 37 (15), e105
DOI 10.1093/nar/gkp526, PubMed 19541849
Publications 2008
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
BMC Genomics, 9, 379
DOI 10.1186/1471-2164-9-379, PubMed 18691401
Publications 2006
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters
Mol Cancer, 5, 47
DOI 10.1186/1476-4598-5-47, PubMed 17054774
Publications 2004
LEC1, FUS3, ABI3 and Em expression reveals no correlation with dormancy in Arabidopsis
J Exp Bot, 55 (394), 77-87
DOI 10.1093/jxb/erh014, PubMed 14676287
CGH-Explorer: a program for analysis of array-CGH data
Bioinformatics, 21 (6), 821-2
DOI 10.1093/bioinformatics/bti113, PubMed 15531610
Publications 2001
Identification and analysis of genes controlling embryogenesis and embryo dormancy in plants
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 181, 1 b. (flere pag.)
BIBSYS 012230200
Efficient protocols for CAPS-based mapping in Arabidopsis
Plant Mol. Biol. Rep., 19 (2), 137-149
DOI 10.1007/BF02772156
The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes
Nucleic Acids Res, 29 (21), 4319-33
DOI 10.1093/nar/29.21.4319, PubMed 11691919
Publications 1999
Growth and protection against oxidative stress in young clones and mature spruce trees (Picea abies L.) at high altitudes
Oecologia, 121 (2), 149-156
DOI 10.1007/s004420050916, PubMed 28308554
Publications 1998
Interactive effects of ozone and low UV-B radiation on antioxidants in spruce (Picea abies) and pine (Pinus sylvestris) needles
Physiol Plant, 104 (2), 248-254
DOI 10.1034/j.1399-3054.1998.1040213.x, PubMed 28244603