Øyvind Haugen Lie

  • Group leader and Consultant interventional cardiologist; MD, PhD

Øyvind Haugen Lie, MD, PhD, Department of Cardiology, Rikshospitalet, Oslo University Hospital

Øyvind Haugen Lie successfully defended his PhD thesis "Risk stratification and management of patients with right ventricular arrhythmias" in December 2018. His supervisors were Associate Professor Kristina Hermann Haugaa, MD, PhD and Professor Thor Edvardsen, MD, PhD.

During his fellowship Lie was awarded with Prof. J. Roelandt’s Young Investigator Award for best original work in clinical science at the 2017 EuroEcho-Imaging Congress.  The award was given in recognition of the work “Harmful effects of exercise intensity and exercise duration in patients with arrhythmogenic cardiomyopathy”.

Lie also won the best poster prize in the session for “Diagnostic and therapeutical strategies for cardiac disease” at the annual Center for Heart Failure Research Symposium two years in a row. He was give the prize in recognition of the work “How many are too many – Frequent premature ventricular contractions and left ventricular function” and "V-3 QRS-duration of premature ventricular contractions relates to ventricular tachycardia in patients with outflow tract arrhythmia", respectively.

Lie, together with his colleagues, discovered that the threshold ectopy burden associated with impaired left ventricular function was lower than previously assumed when accurate and sensitive echocardiographic tools were used. Patients with frequent premature ventricular contractions of right ventricular outflow tract origin may contract an ectopy-induced cardiomyopathy, those with more than 8000 premature ventricular contractions per 24 hours may benefit from antiarrhythmic therapy.

Higher exercise intensity is a strong and independent marker of adverse outcome in patients with arrhythmogenic cardiomyopathy, irrespective of longer exercise duration. Together with ECG-abnormalities and subtle left ventricular contraction abnormalities, information on exercise intensity at study entry yielded precise risk stratification that may be useful in the challenging selection of patients with arrhythmogenic cardiomyopathy who may benefit from a primary preventive implantable cardioverter-defibrillator.

 

Publications 2021

Cadrin-Tourigny J, Bosman LP, Wang WJ, Tadros R, Bhonsale A, Bourfiss M, Lie OH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE, Judge DP, Yap SC et al. (2021)
Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy A Multinational Collaboration
Circ.-Arrhythmia Electrophysiol., 14 (1)
DOI 10.1161/CIRCEP.120.008509

Chivulescu M, Krohg-Sorensen K, Scheirlynck E, Lindberg BR, Dejgaard LA, Lie OH, Helle-Valle T, Skjolsvik ET, Estensen ME, Edvardsen T, Lingaas PS, Haugaa KH (2021)
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes
Eur. Heart J.-Cardiovasc. Imaging, 22 (9), 1035-1044
DOI 10.1093/ehjci/jeaa324

Christensen AH, Platonov PG, Jensen HK, Chivulescu M, Svensson A, Dahlberg P, Madsen T, Frederiksen TC, Helio T, Lie OH, Haugaa KH, Svendsen JH, Bundgaard H (2021)
Genotype-phenotype correlation in arrhythmogenic right ventricular cardiomyopathy-risk of arrhythmias and heart failure
J. Med. Genet.
DOI 10.1136/jmedgenet-2021-107911

Lie OH, Chivulescu M, Rootwelt-Norberg C, Ribe M, Bogsrud MP, Lyseggen E, Beitnes JO, Almaas V, Haugaa KH (2021)
Left Ventricular Dysfunction in Arrhythmogenic Cardiomyopathy: Association With Exercise Exposure, Genetic Basis, and Prognosis
J. Am. Heart Assoc., 10 (8), e018680
DOI 10.1161/JAHA.120.018680

Lie OH, Klaboe LG, Dejgaard LA, Skjolsvik ET, Grimsmo J, Bosse G, Hopp E, Edvardsen T, Haugaa KH (2021)
Cardiac Phenotypes and Markers of Adverse Outcome in Elite Athletes With Ventricular Arrhythmias
JACC-Cardiovasc. Imag., 14 (1), 148-158
DOI 10.1016/j.jcmg.2020.07.039

Lie OH, Lunde K (2021)
Left Ventricular Rupture
N. Engl. J. Med., 384 (2), e4
DOI 10.1056/NEJMicm2020871

Quattrone A, Lie OH, Nestaas E, de Lange C, Try K, Lindberg HL, Skulstad H, Erikssen G, Edvardsen T, Haugaa K, Estensen ME (2021)
Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot
Open Heart, 8 (1), e001400
DOI 10.1136/openhrt-2020-001400

Rootwelt-Norberg C, Lie OH, Chivulescu M, Castrini AI, Sarvari SI, Lyseggen E, Almaas VM, Bogsrud MP, Edvardsen T, Haugaa KH (2021)
Sex differences in disease progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy
Europace, 23 (7), 1084-1091
DOI 10.1093/europace/euab077

Aabel EW, Chivulescu M, Dejgaard LA, Ribe M, Gjertsen E, Hopp E, Hunt TE, Lie OH, Haugaa KH (2021)
Tricuspid Annulus Disjunction Novel Findings by Cardiac Magnetic Resonance in Patients With Mitral Annulus Disjunction
JACC-Cardiovasc. Imag., 14 (8), 1535-1543
DOI 10.1016/j.jcmg.2021.01.028

Publications 2020

Chivulescu M, Lie OH, Popescu BA, Skulstad H, Edvardsen T, Jurcut RO, Haugaa KH (2020)
High penetrance and similar disease progression in probands and in family members with arrhythmogenic cardiomyopathy
Eur. Heart J., 41 (14), 1401-1410
DOI 10.1093/eurheartj/ehz570

Kirkels FP, Lie OH, Cramer MJ, Chivulescu M, Rootwelt-Norberg C, Asselbergs FW, Teske AJ, Haugaa KH (2020)
Right Ventricular Functional Abnormalities in Arrhythmogenic Cardiomyopathy
JACC-Cardiovasc. Imag., 14 (5), 900-910
DOI 10.1016/j.jcmg.2020.12.028

Lie OH, Haugaa KH (2020)
The super healthy atrial fibrillation conundrum
Eur. Heart J.-Cardiovasc. Imaging, 21 (12), 1384-1385
DOI 10.1093/ehjci/jeaa217

Scheirlynck E, Chivulescu M, Lie OH, Motoc A, Koulalis J, de Asmundis C, Sieira J, Chierchia GB, Brugada P, Cosyns B, Edvardsen T, Droogmans S, Haugaa KH (2020)
Worse Prognosis in Brugada Syndrome Patients With Arrhythmogenic Cardiomyopathy Features
JACC-Clin. Electrophysiol., 6 (11), 1353-1363
DOI 10.1016/j.jacep.2020.05.026

Scheirlynck E, Van Malderen S, Motoc A, Lie OH, de Asmundis C, Sieira J, Chierchia GB, Brugada P, Cosyns B, Droogmans S (2020)
Contraction alterations in Brugada syndrome; association with life-threatening ventricular arrhythmias
Int. J. Cardiol., 299, 147-152
DOI 10.1016/j.ijcard.2019.06.074

Skjolsvik ET, Hasselberg NE, Dejgaard LA, Lie OH, Andersen K, Holm T, Edvardsen T, Haugaa KH (2020)
Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A/C Genotype
J. Am. Heart Assoc., 9 (2), e012937
DOI 10.1161/JAHA.119.012937

Publications 2019

Cadrin-Tourigny J, Bosman LP, Nozza A, Wang WJ, Tadros R, Bhonsale A, Bourfiss M, Fortier A, Lie OH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE et al. (2019)
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Eur. Heart J., 40 (23), 1850-1858
DOI 10.1093/eurheartj/ehz103

Castrini AI, Lie OH, Leren IS, Estensen ME, Stokke MK, Klaeboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur. Heart J.-Cardiovasc. Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061

Dejgaard LA, Lie OH, Helle-Valle TM, Edvardsen T, Haugaa KH (2019)
REPLY: Arrhythmic Mitral Annulus Disjunction and Mitral Valve Prolapse Components of the Same Clinical Spectrum?
J. Am. Coll. Cardiol., 73 (6), 739-740
DOI 10.1016/j.jacc.2018.12.008

Haugaa KH, Lie OH (2019)
Reveal the Concealed The Quest for Early Disease Detection in Family Members at Risk of Developing Arrhythmogenic Cardiomyopathy
JACC-Cardiovasc. Imag., 12 (3), 456-457
DOI 10.1016/j.jcmg.2018.02.007

Haugaa KH, Lie OH (2019)
Cardiac amyloidosis: can imaging shed light on mechanisms and prognosis?
Eur. Heart J.-Cardiovasc. Imaging, 20 (5), 500-501
DOI 10.1093/ehjci/jez009

Ktaeboe LG, Brekke PH, Lie OH, Aaberge L, Haugaa KH, Edvardsen T (2019)
Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block
Eur. Heart J.-Cardiovasc. Imaging, 20 (3), 271-278
DOI 10.1093/ehjci/jey127

Platonov PG, Haugaa KH, Bundgaard H, Svensson A, Gilljam T, Hansen J, Madsen T, Host AG, Carlson J, Lie OH, Jensen MK, Edvardsen T, Jensen HK, Svendsen JH (2019)
Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Am. J. Cardiol., 123 (7), 1156-1162
DOI 10.1016/j.amjcard.2018.12.049

Rootwelt-Norberg C, Lie OH, Dejgaard LA, Chivulescu M, Leren IS, Edvardsen T, Haugaa KH (2019)
Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center
Int. J. Cardiol., 279, 79-83
DOI 10.1016/j.ijcard.2018.12.066

Scheirlynck E, Dejgaard LA, Skjolsvik E, Lie OH, Motoc A, Hopp E, Tanaka K, Ueland T, Ribe M, Collet C, Edvardsen T, Droogmans S, Cosyns B, Haugaa KH (2019)
Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmias
Open Heart, 6 (1), UNSP e001016
DOI 10.1136/openhrt-2019-001016

Scheirlynck E, Van Malderen S, Motoc A, Lie OH, de Asmundis C, Sieira J, Chierchia GB, Brugada P, Cosyns B, Droogmans S (2019)
Speckle tracking echocardiography data in Brugada syndrome patients
Data Brief, 25, 104330
DOI 10.1016/j.dib.2019.104330

Publications 2018

Chivulescu M, Haugaa K, Lie OH, Edvardsen T, Ginghina C, Popescu BA, Jurcut R (2018)
Right ventricular remodeling in athletes and in arrhythmogenic cardiomyopathy
Scand. Cardiovasc. J., 52 (1), 13-19
DOI 10.1080/14017431.2017.1416158

Dejgaard LA, Haland TF, Lie OH, Ribe M, Bjune T, Leren IS, Berge KE, Edvardsen T, Haugaa KH (2018)
Vigorous exercise in patients with hypertrophic cardiomyopathy
Int. J. Cardiol., 250, 157-163
DOI 10.1016/j.ijcard.2017.07.015

Dejgaard LA, Skjolsvik ET, Lie OH, Ribe M, Stokke MK, Hegbom F, Scheirlynck ES, Gjertsen E, Andresen K, Helle-Valle TM, Hopp E, Edvardsen T, Haugaa KH (2018)
The Mitral Annulus Disjunction Arrhythmic Syndrome
J. Am. Coll. Cardiol., 72 (14), 1600-1609
DOI 10.1016/j.jacc.2018.07.070

Lie OH, Dejgaard LA, Saberniak J, Rootwelt C, Stokke MK, Edvardsen T, Haugaa KH (2018)
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC-Clin. Electrophysiol., 4 (6), 744-753
DOI 10.1016/j.jacep.2018.01.010

Lie OH, Rootwelt-Norberg C, Dejgaard LA, Leren IS, Stokke MK, Edvardsen T, Haugaa KH (2018)
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy A Primary Prevention Cohort Study
JACC-Cardiovasc. Imag., 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017

Publications 2017

Dejgaard LA, Haland TF, Lie OH, Ribe M, Bjune T, Leren IS, Berge KE, Edvardsen T, Haugaa KH (2017)
Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy
Data Brief, 15, 30-39
DOI 10.1016/j.dib.2017.08.018

Lie OH, Saberniak J, Dejgaard LA, Stokke MK, Hegbom F, Anfinsen OG, Edvardsen T, Haugaa KH (2017)
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail., 4 (4), 585-594
DOI 10.1002/ehf2.12180

Publications 2013

Hovde O, Lie OH, Johansson PA, Stubhaug O, Johnson E, Hofstad B, Hauge T (2013)
Iatrogenic esophago-tracheal fistula: Challenges in diagnosis and management
World J. Gastroenterol., 19 (4), 594-596
DOI 10.3748/wjg.v19.i4.594

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