John M. Aalen

  • Postdoc and cardiology fellow; MD, PhD

John Aalen graduated as MD from University of Oslo in 2012. Since then he has been working at Vestfold Hospital Trust (Sentralsykehuset i Vestfold), first as a part of his internship and the last year as resident in internal medicine. He joined our research group in April 2014.

His PhD work "Contractile Reserve in Dyssynchrony (CRID): A novel principle to identify candidates for cardiac resynchronization therapy" focuses on identifying candidates for cardiac resynchronization therapy and the effect of increased afterload on the left ventricle during left bundle branch block. He successfully defended his PhD thesis in May 2021.
Aalen has published several research papers and presented numerous abstracts at international and national conferences and has also won prizes for his work, including the Young Investigator Award for Basic Science at EuroEcho-Imaging Congress in Lisboa in 2017.”

PhD thesis:
Insights into left ventricular dyssynchrony: Consequences for myocardial function and response to cardiac resynchronization therapys (duo.uio.no)

 

Publications 2021

Degtiarova G, Claus P, Duchenne J, Bogaert J, Nuyts J, Voros G, Willems R, Larsen CK, Aalen JM, Fjeld JG, Stokke C, Hopp E, Smiseth OA, Voigt JU, Gheysens O (2021)
Left ventricular regional glucose metabolism in combination with septal scar extent identifies CRT responders
Eur. J. Nucl. Med. Mol. Imaging, 48 (8), 2437-2446
DOI 10.1007/s00259-020-05161-7

Galli E, Smiseth OA, Aalen JM, Larsen CK, Sade E, Hubert A, Anilkumar S, Penicka M, Linde C, Le Rolle V, Hernandez A, Leclercq C, Duchenne J, Voigt JU, Donal E (2021)
Prognostic utility of the assessment of diastolic function in patients undergoing cardiac resynchronization therapy
Int. J. Cardiol., 331, 144-151
DOI 10.1016/j.ijcard.2021.01.046

Sletten OJ, Aalen JM, Izci H, Duchenne J, Remme EW, Larsen CK, Hopp E, Galli E, Sirnes PA, Kongsgard E, Donal E, Voigt JU, Smiseth OA, Skulstad H (2021)
Lateral Wall Dysfunction Signals Onset of Progressive Heart Failure in Left Bundle Branch Block
JACC-Cardiovasc. Imag., 14 (11), 2059-2069
DOI 10.1016/j.jcmg.2021.04.017

Smiseth OA, Aalen JM (2021)
Right ventricular work: a step forward for non-invasive assessment of right ventricular function
Eur. Heart J.-Cardiovasc. Imaging, 22 (2), 153-154
DOI 10.1093/ehjci/jeaa296

Smiseth OA, Aalen JM, Skulstad H (2021)
Heart failure and systolic function: time to leave diagnostics based on ejection fraction?
Eur. Heart J., 42 (7), 786-788
DOI 10.1093/eurheartj/ehaa979

Aalen JM, Smiseth OA (2021)
Strain identifies pseudo-normalized right ventricular function in tricuspid regurgitation
Eur. Heart J.-Cardiovasc. Imaging, 22 (8), 876-877
DOI 10.1093/ehjci/jeab089

Publications 2020

Andersen OS, Krogh MR, Boe E, Storsten P, Aalen JM, Larsen CK, Skulstad H, Odland HH, Smiseth OA, Remme EW (2020)
Left bundle branch block increases left ventricular diastolic pressure during tachycardia due to incomplete relaxation
J. Appl. Physiol., 128 (4), 729-738
DOI 10.1152/japplphysiol.01002.2018

Duchenne J, Aalen JM, Cvijic M, Larsen CK, Galli E, Bezy S, Beela AS, Unlu S, Pagourelias ED, Winter S, Hopp E, Kongsgard E, Donal E, Fehske W, Smiseth OA, Voigt JU (2020)
Acute redistribution of regional left ventricular work by cardiac resynchronization therapy determines long-term remodelling
Eur. Heart J.-Cardiovasc. Imaging, 21 (6), 619-628
DOI 10.1093/ehjci/jeaa003

Larsen CK, Aalen JM, Stokke C, Fjeld JG, Kongsgaard E, Duchenne J, Degtiarova G, Gheysens O, Voigt JU, Smiseth OA, Hopp E (2020)
Regional myocardial work by cardiac magnetic resonance and non-invasive left ventricular pressure: a feasibility study in left bundle branch block
Eur. Heart J.-Cardiovasc. Imaging, 21 (2), 143-153
DOI 10.1093/ehjci/jez231

Sorensen J, Harms HJ, Aalen JM, Baron T, Smiseth OA, Flachskampf FA (2020)
Myocardial Efficiency A Fundamental Physiological Concept on the Verge of Clinical Impact
JACC-Cardiovasc. Imag., 13 (7), 1564-1576
DOI 10.1016/j.jcmg.2019.08.030

Storsten P, Aalen JM, Boe E, Remme EW, Gjesdal O, Larsen CK, Andersen OS, Eriksen M, Kongsgaard E, Duchenne J, Voigt JU, Smiseth OA, Skulstad H (2020)
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy
JACC-Cardiovasc. Imag., 13 (7), 1475-1484
DOI 10.1016/j.jcmg.2019.11.016

Aalen JM, Donal E, Larsen CK, Duchenne J, Lederlin M, Cvijic M, Hubert A, Voros G, Leclercq C, Bogaert J, Hopp E, Fjeld JG, Penicka M, Linde C, Aalen OO, Kongsgard E, Galli E, Voigt JU, Smiseth OA (2020)
Imaging predictors of response to cardiac resynchronization therapy: left ventricular work asymmetry by echocardiography and septal viability by cardiac magnetic resonance
Eur. Heart J., 41 (39), 3813-3823
DOI 10.1093/eurheartj/ehaa603

Aalen JM, Smiseth OA (2020)
Editorial commentary: Septal flash - what is behind the flashy name?
Trends Cardiovasc. Med., 30 (2), 123-124
DOI 10.1016/j.tcm.2019.04.003

Publications 2019

Boe E, Smiseth OA, Storsten P, Andersen OS, Aalen J, Eriksen M, Krogh MR, Kongsgaard E, Remme EW, Skulstad H (2019)
Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study
Europace, 21 (2), 347-355
DOI 10.1093/europace/euy221

Kvale KF, Bersvendsen J, Remme EW, Salles S, Aalen JM, Brekke PH, Edvardsen T, Samset E (2019)
Detection of Regional Mechanical Activation of the Left Ventricular Myocardium Using High Frame Rate Ultrasound Imaging
IEEE Trans. Med. Imaging, 38 (11), 2665-2675
DOI 10.1109/TMI.2019.2909358

Kvale KF, Salles S, Brekke PH, Remme EW, Aalen JM, Edvardsen T, Samset E (2019)
Comparison of two methods for mechanical activation detection using high frame rate ultrasound imaging
IEEE INT ULTRA SYM, 1410-1413

Smiseth OA, Aalen JM (2019)
Mechanism of harm from left bundle branch block
Trends Cardiovasc. Med., 29 (6), 335-342
DOI 10.1016/j.tcm.2018.10.012

Stensrud MJ, Aalen JM, Aalen OO, Valberg M (2019)
Limitations of hazard ratios in clinical trials
Eur. Heart J., 40 (17), 1378-1383
DOI 10.1093/eurheartj/ehy770

Aalen J, Storsten P, Remme EW, Sirnes PA, Gjesdal O, Larsen CK, Kongsgaard E, Boe E, Skulstad H, Hisdal J, Smiseth OA (2019)
Afterload Hypersensitivity in Patients With Left Bundle Branch Block
JACC-Cardiovasc. Imag., 12 (6), 967-977
DOI 10.1016/j.jcmg.2017.11.025

Aalen JM, Remme EW, Larsen CK, Andersen OS, Krogh M, Duchenne J, Hopp E, Ross S, Beela AS, Kongsgaard E, Bergsland J, Odland HH, Skulstad H, Opdahl A, Voigt JU, Smiseth OA (2019)
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block Role of Left Ventricular Wall Interactions and Myocardial Scar
JACC-Cardiovasc. Imag., 12 (12), 2402-2413
DOI 10.1016/j.jcmg.2018.11.030

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