Publication in Nature Immunology from Malmberg group
A paper entitled "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping" was published in the highly ranked journal Nature Immunology on July 2. This work will be an important resource when designing new NK cell therapies.
The authors have been analyzing transcriptional data from 427 patients and 39 datasets, including 7 solid tumor types (lung, brain, skin, pancreas, prostate, breast, sarcoma). They could identify 6 different functional states of tumor-infiltrating NK cells, and the state of the NK cells correlate with survival for cancer patients.
This work can be used as a reference map and extended to interrogate new data sets from different disease conditions and experimental perturbations. This resource can also guide us to design new and better NK cell therapies.
Links:
The Nature Immunology publication:
Netskar H, Pfefferle A, Goodridge JP, Sohlberg E, Dufva O, Teichmann SA, Brownlie D, Michaëlsson J, Marquardt N, Clancy T, Horowitz A, Malmberg KJ (2024)
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Nat Immunol (in press)
DOI 10.1038/s41590-024-01884-z, PubMed 38956379
Original news article from the PRIMA homepage:
Publication in Nature Immunology from Malmberg group - PRIMA (uio.no)
Comprehensive article about the findings from the Institute of Clinical Medicine, UiO (in Norwegian):
Kan naturlige dreperceller bidra til bedre behandling av kreft? - Institutt for klinisk medisin (uio.no)
Home page of the"Natural Killer Cell Biology and Cell Therapy" research group - led by Karl Johan Malmberg