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ORAACLE – Asthma and Allergy in Children, the Lung and Environment

The overall objective for ORAACLE is to provide research aiming at reducing the burden of allergic and lung-diseases in children and adolescents.

About the group

Through high-quality prospective cohort studies, randomized controlled studies and cross-sectional studies the group targets identification of risk factors, understanding mechanisms, optimising diagnostics and management, as well as preventing development of allergic diseases, asthma and other chronic lung diseases.

Through collaboration with basic research environments in and outside Norway, we work within translational aspects of early origins of non-communicable diseases, including targeted areas such as microbiota, environment, immune-function development, nutrients, as well as fetal- and pregnancy-related factors that may impact later disease. 

ORAACLE, formally established in 2005, includes senior researchers/project managers, PhD students and others with collaboration across professions, institutions, nationally and internationally.  

Through large, prospective cohorts, including birth cohorts, the group has generated vast databases focusing on the detailed information from early life, available to researchers across studies and projects. ORAACLE is based within the Department of child and adolescent allergy and pulmonology,  division of child and adolescent medicine, OUS/UiO.

Projects

Central ongoing research projects originating from ORAACE include:

  • PreventADALL (Preventing Atopic Dermatitis and ALLergies in children)
  • NAPiC (Norwegian Antibiotics for Pneumonia in Children)
  • Take-away peanut allergy study
  • Primary ciliary dyskinesia prevalence and diagnostics
  • Mechanical cough assistance in children with neurodisabilities
  • SPACE (Severe Pediatric Asthma Collaborative in Europe)

The group also participates in (or collaborates with) multi-center trials nationally and internationally.

Cooperation

The ORAACLE collaboration extends nationally and internationally across health professions, basic research and public, including information from national, international as well as local quality registers.

Recent dissertations

  • 2022-12-09: Morten Nilsen: “The gut microbiota from the general population during the first year of life”, The Norwegian University of Life Sciences, Norway
  • 2022-10-14: Sandra Tedner: “Specific IgE-profiles and allergy prediction”, Karolinska Institute, Sweden
  • 2023-01-23: Caroline Alexi Olsson Mägi: “Maternal stress and allergic disease in offspring”, Karolinska Institute, Sweden
  • 2023-03-09: Kim Magnus Advocaat Sandberg Endre: “Atopic dermatitis in infancy”, University of Oslo, Norway
  • 2023-06-20: Åshild Wik Despriee: “Infant colic and pain up to 3 months of age – prevalence perinatal risk factors and infant multimorbidities”, University of Oslo, Norway
  • 2023-09-19: Martin Färdig: “Preschool asthma: infant lung Function, inflammation and skin Barrier function in early life”, Karolinska Insitute, Sweden
  • 2023-09-26: Anine Lie: Is primary prevention of food allergy and asthma possible by early food introduction and skin emollients in infancy?», University of Olso, Norway

Recent publications

  • Sundet, BK ; Lødrup Carlsen, KC ; Haugen, G. ; Hedlin, G. ; Hilde, K. ; Jonassen, C.M; Nordlund, B. ; Rehbinder, EM ; Rueegg, CS ; Sjøborg, K. ; Skjerven, HO ; Söderhäll, C. ; Vettukattil, R. ; Værnesbranden, MR ; Wiik, J. ; Staff, AC ; Sugulle, M. (2023). Adverse pregnancy outcomes and placental dysfunction assessed by maternal midpregnancy angiogenic factors. Pregnancy hypertension, 2023, Vol.33, p.e33-e34
  • Halvorsen, K. ; Sugulle, M. ; Rehbinder, EM ; Sundet, BK ; Lødrup Carlsen, KC ; Haugen, G. ; Hedlin, G. ; Hilde, K. ; Jonassen, C.M ; Nordlund, B. ; Rueegg, CS ; Sjøborg, K. ; Skjerven, HO ; Söderhäll, C. ; Vettukattil, R. ; Værnesbranden, MR ; Wiik, J. ; Staff, AC (2023). Association of maternal asthma and other allergic diseases with placental dysfunction and adverse obstetric outcome. Pregnancy hypertension, 2023, Vol.33, p.e30-e31
  • Hilde K, Gudmundsdóttir HK, Stensby Bains KE, Färdig M, Lødrup Carlsen KC, Jonassen CM, Kreyberg I, Nordlund B, Rehbinder EM, Paasche Roland MC, Skjerven HO, Staff AC, Vettukattil R, Haugen G (2023). Fetal pulmonary artery Doppler blood flow velocity measures and early infant lung function. A prospective cohort study. J Matern Fetal Neonatal Med, 36 (1), 2213796
  • Despriee ÅW, Småstuen MC, Glavin K, Lødrup Carlsen KC, Magi CAO, Söderhäll C, Hedlin G, Nordhagen L, Jonassen CM, Rehbinder EM, Nordlund B, Skjerven H (2023). Infant colic and abdominal pain; associations with infant multimorbidity and maternal perceived stress up to 3 months postpartum-A cross-sectional/cohort study in the PreventADALL study. J Clin Nurs, 32 (19-20), 7605-7617
  • Nilsen M, Rehbinder EM, Lødrup Carlsen KC, Haugen G, Hedlin G, Jonassen CM, Killingstad ME, Nordlund B, Ormaasen I, Skjerven HO, Snipen L, Staff AC, Söderhäll C, Sørensen R, Vettukattil R, Wilborn LM, Rudi K (2023). A Globally Distributed Bacteroides caccae Strain Is the Most Prevalent Mother-Child Shared Bacteroidaceae Strain in a Large Scandinavian Cohort. Appl Environ Microbiol, 89 (7), e0078923
  • Saunders CM, Rehbinder EM, Carlsen KCL, Jonassen CM, LeBlanc M, Nordlund B, Skjerven HO, Söderhäll C, Vettukattil R, Carlsen MH (2023). Feeding Practices and Dietary Diversity in the First Year of Life: PreventADALL, a Scandinavian Randomized Controlled Trial and Birth Cohort Study. J Nutr, 153 (8), 2463-2471
  • Hilde K, Gudmundsdóttir HK, Bains KES, Carlsen KCL, Färdig M, Jonassen CM, Kreyberg I, LeBlanc M, Nordlund B, Rehbinder EM, Roland MCP, Skjerven HO, Staff AC, Vettukattil R, Haugen G (2023). Third trimester fetal lung volume, thoracic circumference, and early infant lung function. Pediatr Pulmonol, 58 (7), 2050-2058
  • Hoel ST, Wiik J, Carlsen KCL, Endre KMA, Gudmundsdóttir HK, Haugen G, Hoyer A, Jonassen CM, LeBlanc M, Nordlund B, Rudi K, Skjerven HO, Staff AC, Hedlin G, Söderhäll C, Vettukattil R, Aaneland H, Rehbinder EM (2023). Birth mode is associated with development of atopic dermatitis in infancy and early childhood. J Allergy Clin Immunol Glob, 2 (3), 100104
  • Rapin A, Rehbinder EM, Macowan M, Pattaroni C, Lødrup Carlsen KC, Harris NL, Jonassen CM, Landrø L, Lossius AH, Nordlund B, Rudi K, Skjerven HO, Cathrine Staff A, Söderhäll C, Ubags N, Vettukattil R, Marsland BJ (2023). The skin microbiome in the first year of life and its association with atopic dermatitis. Allergy, 78 (7), 1949-1963
  • Wiik J, Vaernesbranden MR, Jonassen CM, Staff AC, Carlsen KCL, Granum B, Haugen G, Hedlin G, Hilde K, Jacobsson B, Nilsson S, Nordlund B, Rangberg A, Rehbinder EM, Sengpiel V, Skjerven H, Sundet BK, Söderhäll C, Vettukattil R, Sjøborg K (2023). Maternal human papillomavirus infection during pregnancy and preterm delivery: A mother-child cohort study in Norway and Sweden. Acta Obstet Gynecol Scand, 102 (3), 344-354
  • Brinchmann BC, Vist GE, Becher R, Grimsrud TK, Elvsaas IØ, Underland V, Holme JA, Carlsen KCL, Kreyberg I, Nordhagen LS, Bains KES, Carlsen KH, Alexander J, Valen H (2023). Use of Swedish smokeless tobacco during pregnancy: A systematic review of pregnancy and early life health risk. Addiction, 118 (5), 789-803
  • Goutaki M, Lam YT, Alexandru M, Anagiotos A, Armengot M, Boon M, Burgess A, Caversaccio N, Crowley S, Dheyauldeen SAD, Emiralioglu N, Erdem E, van Gogh C, Gunaydin O, Haarman EG, Harris A, Hayn I, Ismail-Koch H, Karadag B, Kempeneers C, Kim S, Lorent N, Ozcelik U, Pioch C, Poirrier AML et al. (2023). Characteristics of Otologic Disease Among Patients With Primary Ciliary Dyskinesia. JAMA Otolaryngol Head Neck Surg, 149 (7), 587-596
  • Lam YT, Papon JF, Alexandru M, Anagiotos A, Armengot M, Boon M, Burgess A, Crowley S, Dheyauldeen SAD, Emiralioglu N, Erdem Eralp E, van Gogh C, Gokdemir Y, Gunaydın O, Haarman EG, Harris A, Hayn I, Ismail-Koch H, Karadag B, Kempeneers C, Kim S, Latzin P, Lorent N, Ozcelik U, Pioch C et al. (2023). Sinonasal disease among patients with primary ciliary dyskinesia: an international study. ERJ Open Res, 9 (3)
  • Hov B, Andersen T, Toussaint M, Mikalsen IB, Vollsaeter M, Markussen H, Indrekvam S, Hovland V (2023). User-perceived impact of long-term mechanical assisted cough in paediatric neurodisability. Dev Med Child Neurol, 65 (5), 655-663
Published Oct. 18, 2023 11:07 AM - Last modified Oct. 18, 2023 11:07 AM

Contact

Participants

  • Karin Cecilie Lødrup Carlsen University of Oslo
  • Hrefna Katrín Gudmundsdottir University of Oslo
  • Brit Hov University of Oslo
  • Anine Lie University of Oslo
  • Anita Christine Senstad Wathne University of Oslo
  • Sigve Ådalen University of Oslo
  • Eilif Folland Lønnebakke University of Oslo
  • Vibeke Østberg Landaas University of Oslo
  • Åshild Wik Despriee
  • Geir Håland
  • Berit Brunstad Granum
  • Egil Bakkeheim
  • Unni Nygaard
  • Karen Eline Stensby Bains
  • Vegard Hovland
  • Riyas Vettukattil
  • Håvard Ove Skjerven
  • Iren Matthews
  • Suzanne Crowley
  • Per Kristian Knudsen
  • Eva Marie Rehbinder
  • Carina Madelen Saunders
  • Kim Endre
  • Tonje Reier-Nilsen
  • Lotte Marie Stangeland Haavik
  • Marius Skram
  • Synne Sperstad Kennelly
  • Runa Kaldestad
  • Hilde Aandeland
  • Yucheng Chen
Detailed list of participants

 

 

 
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