About the group

Through high-quality prospective cohort studies, randomized controlled studies and cross-sectional studies the group targets identification of risk factors, understanding mechanisms, optimising diagnostics and management, as well as preventing development of allergic diseases, asthma and other chronic lung diseases.

Through collaboration with basic research environments in and outside Norway, we work within translational aspects of early origins of non-communicable diseases, including targeted areas such as microbiota, environment, immune-function development, nutrients, as well as fetal- and pregnancy-related factors that may impact later disease. 

ORAACLE, formally established in 2005, includes senior researchers/project managers, PhD students and others with collaboration across professions, institutions, nationally and internationally.  

Through large, prospective cohorts, including birth cohorts, the group has generated vast databases focusing on the detailed information from early life, available to researchers across studies and projects. ORAACLE is based within the Department of child and adolescent allergy and pulmonology,  division of child and adolescent medicine, OUS/UiO.

Projects

Central ongoing research projects originating from ORAACE include:

  • PreventADALL (Preventing Atopic Dermatitis and ALLergies in children)
  • NAPiC (Norwegian Antibiotics for Pneumonia in Children)
  • Take-away peanut allergy study
  • Primary ciliary dyskinesia prevalence and diagnostics
  • Mechanical cough assistance in children with neurodisabilities
  • SPACE (Severe Pediatric Asthma Collaborative in Europe)
  • INSTAR-study: a randomized, double-blind study on preventing astma in children
  • AMIC-study (Antibiotics, Microbiology and Immunology in Children with Chronic wet Cough)

The group also participates in (or collaborates with) multi-center trials nationally and internationally.

Cooperation

The ORAACLE collaboration extends nationally and internationally across health professions, basic research and public, including information from national, international as well as local quality registers.

Recent dissertations

  • June 2024: Carina S. Saunders. Can maternal-infant diet Prevent Allergic Diseases in Children? Supervisors: Karin C. Lødrup Carlsen, Eva Maria Rehbinder, Monica Hauger Carlsen (UiO, ernæringsinstituttet), Knut Rudi (NMBU)
  • May 2024: Katarina Hilde. Fetal lung growth. Supervisors: Guttorm Haugen, Karin C. Lødrup Carlsen og Marie Cecilie Paasche
  • April 2024: Brit Hov. Mekanisk hostestøtte hos barn med NIV og nedsatt hostefunksjon. Supervisors: Vegard Hovland, Karin C. Lødrup Carlsen, Tiina Andersen (Bergen University), Michael Touissaint (ULB, Belgium)

Recent publications

  • Kennelly SS, Hovland V, Matthews IL, Reinholt FP, Skjerven H, Heimdal K, Crowley S (2024) Tracheobronchomalacia is common in children with primary ciliary dyskinesia-A case note review Pediatr Pulmonol, 59 (12), 3560-3568
  • Färdig M, Hoyer A, Almqvist C, Bains KES, Carlsen KCL, Gudmundsdóttir HK, Granum B, Haugen GN, Hedlin G, Jonassen CM, Konradsen JR, Lie A, Rehbinder EM, Skjerven HO, Staff AC, Vettukattil R, Söderhäll C, Nordlund B (2024) Infant lung function and early skin barrier impairment in the development of asthma at age 3 years Allergy, 79 (3), 667-678
  • Rehbinder EM, Wärnberg Gerdin S, Hoyer A, Bradley M, Lødrup Carlsen KC, Granum B, Hedlin G, Jonassen CM, Leblanc M, Nordlund B, Rudi K, Skjerven HO, Staff AC, Vettukattil R, Söderhäll C (2024) Frequent oil baths and skin barrier during infancy in the PreventADALL study Br J Dermatol, 191 (1), 49-57
  • Bains KES, Kreyberg I, Färdig M, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Hilde K, Jonassen CM, Nordlund B, Rehbinder EM, Rueegg CS, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Carlsen KCL (2024) Maternal use of snus as smokeless tobacco in pregnancy and infant lung function ERJ Open Res, 10 (4)
  • Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG et al. (2022)
    Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial
    Lancet, 399 (10344), 2398-2411
  • Skjerven HO, Rehbinder EM, Vettukattil R, LeBlanc M, Granum B, Haugen G, Hedlin G, Landrø L, Marsland BJ, Rudi K, Sjøborg KD, Söderhäll C, Staff AC, Carlsen KH, Asarnoj A, Bains KES, Carlsen OCL, Endre KMA, Granlund PA, Hermansen JU, Gudmundsdóttir HK, Hilde K, Håland G, Kreyberg I, Olsen IC et al. (2020). Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial
    Lancet, 395 (10228), 951-961
  • Skjerven HO, Rolfsjord LB, Berents TL, Engen H, Dizdarevic E, Midgaard C, Kvenshagen B, Aas MH, Hunderi JOG, Stensby Bains KE, Mowinckel P, Carlsen KH, Lødrup Carlsen KC (2015). Allergic diseases and the effect of inhaled epinephrine in children with acute bronchiolitis: follow-up from the randomised, controlled, double-blind, Bronchiolitis ALL trial. Lancet Respir Med, 3 (9), 702-708
  • Skjerven HO, Hunderi JO, Brügmann-Pieper SK, Brun AC, Engen H, Eskedal L, Haavaldsen M, Kvenshagen B, Lunde J, Rolfsjord LB, Siva C, Vikin T, Mowinckel P, Carlsen KH, Lødrup Carlsen KC (2013). Racemic adrenaline and inhalation strategies in acute bronchiolitis. N Engl J Med, 368 (24), 2286-93
  • Håland G, Carlsen KC, Sandvik L, Devulapalli CS, Munthe-Kaas MC, Pettersen M, Carlsen KH, ORAACLE (2006). Reduced lung function at birth and the risk of asthma at 10 years of age. N Engl J Med, 355 (16), 1682-9