
Lars N.G. Nilsson
- Professor
- +47 22840221
Publications 2020
A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
Alzheimers Dement (Amst), 12 (1), e12128
DOI 10.1002/dad2.12128, PubMed 33313376
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
Cereb Cortex, 30 (4), 2295-2306
DOI 10.1093/cercor/bhz240, PubMed 31812991
Analyzing microglial-associated Aβ in Alzheimer's disease transgenic mice with a novel mid-domain Aβ-antibody
Sci Rep, 10 (1), 10590
DOI 10.1038/s41598-020-67419-2, PubMed 32601313
Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
Sci Rep, 10 (1), 15886
DOI 10.1038/s41598-020-72878-8, PubMed 32985583
Publications 2019
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
Sci Rep, 9 (1), 4600
DOI 10.1038/s41598-019-40999-4, PubMed 30872722
Glial activation and inflammation along the Alzheimer's disease continuum
J Neuroinflammation, 16 (1), 46
DOI 10.1186/s12974-019-1399-2, PubMed 30791945
Publications 2018
CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
J Neuroinflammation, 15 (1), 304
DOI 10.1186/s12974-018-1331-1, PubMed 30390679
Risk of malignancy in resected pancreatic mucinous cystic neoplasms
Br J Surg, 105 (4), 439-446
DOI 10.1002/bjs.10787, PubMed 29488646
Publications 2017
The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
J Neuroinflammation, 14 (1), 59
DOI 10.1186/s12974-017-0835-4, PubMed 28320424
An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells
J Pharmacol Toxicol Methods, 90, 67-75
DOI 10.1016/j.vascn.2017.11.004, PubMed 29203451
Publications 2016
Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease
Alzheimers Res Ther, 8 (1), 17
DOI 10.1186/s13195-016-0182-1, PubMed 27121148
Publications 2015
Isobaric Quantification of Cerebrospinal Fluid Amyloid-β Peptides in Alzheimer's Disease: C-Terminal Truncation Relates to Early Measures of Neurodegeneration
J Proteome Res, 14 (11), 4834-43
DOI 10.1021/acs.jproteome.5b00668, PubMed 26452689
Identification of amyloid beta mid-domain fragments in human cerebrospinal fluid
Biochimie, 113, 86-92
DOI 10.1016/j.biochi.2015.03.022, PubMed 25866191
Publications 2014
Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice
J Biol Chem, 290 (8), 5053-64
DOI 10.1074/jbc.M114.600569, PubMed 25548284
Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer's disease transgenic mice
PLoS One, 9 (8), e103607
DOI 10.1371/journal.pone.0103607, PubMed 25089901
Publications 2013
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease
J Alzheimers Dis, 33 (3), 699-713
DOI 10.3233/JAD-2012-121357, PubMed 23001711
Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
BMC Neurosci, 14, 148
DOI 10.1186/1471-2202-14-148, PubMed 24261309
The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ
Acta Neuropathol Commun, 1, 60
DOI 10.1186/2051-5960-1-60, PubMed 24252272
Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice
Neurobiol Aging, 35 (3), 556-64
DOI 10.1016/j.neurobiolaging.2013.09.013, PubMed 24126157
Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model
Mech Ageing Dev, 134 (10), 467-77
DOI 10.1016/j.mad.2013.09.002, PubMed 24121118
Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain
J Alzheimers Dis, 37 (1), 29-40
DOI 10.3233/JAD-130029, PubMed 23780660
Publications 2012
USE OF FUSED CIRCULATIONS TO INVESTIGATE THE ROLE OF APOLIPOPROTEIN E AS AMYLOID CATALYST AND PERIPHERAL SINK IN ALZHEIMER'S DISEASE
Technol Innov, 14 (2), 199-208
DOI 10.3727/194982412X13462021398010, PubMed 23626867
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain
Acta Neuropathol, 124 (4), 465-78
DOI 10.1007/s00401-012-0997-1, PubMed 22692572
Publications 2011
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease
Am J Pathol, 178 (5), 2286-98
DOI 10.1016/j.ajpath.2011.01.052, PubMed 21514441
The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ
Neurobiol Aging, 33 (5), 1010.e1-13
DOI 10.1016/j.neurobiolaging.2011.10.022, PubMed 22118948
The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
J Neuroinflammation, 8, 34
DOI 10.1186/1742-2094-8-34, PubMed 21492414
Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease
J Alzheimers Dis, 27 (4), 711-22
DOI 10.3233/JAD-2011-110725, PubMed 21891870
Publications 2010
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
Int J Alzheimers Dis, 2011, 936580
DOI 10.4061/2011/936580, PubMed 21234373
Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study
Behav Brain Res, 215 (1), 83-94
DOI 10.1016/j.bbr.2010.06.034, PubMed 20615433
Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice
J Neurotrauma, 27 (7), 1297-309
DOI 10.1089/neu.2009.1255, PubMed 20486800
Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders
Eur J Neurosci, 31 (5), 852-63
DOI 10.1111/j.1460-9568.2010.07105.x, PubMed 20374285
Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease
BMC Neurosci, 11, 124
DOI 10.1186/1471-2202-11-124, PubMed 20923550
Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease
Nutr Rev, 68 Suppl 2, S128-34
DOI 10.1111/j.1753-4887.2010.00347.x, PubMed 21091946
Animal models of amyloid-beta-related pathologies in Alzheimer's disease
FEBS J, 277 (6), 1389-409
DOI 10.1111/j.1742-4658.2010.07564.x, PubMed 20136653
Publications 2009
[Rare mutations aim toward future treatment]
Lakartidningen, 106 (20), 1396-400
PubMed 19585838
Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice
FEBS J, 276 (4), 995-1006
DOI 10.1111/j.1742-4658.2008.06836.x, PubMed 19215301
An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease
Neurobiol Dis, 36 (3), 425-34
DOI 10.1016/j.nbd.2009.08.007, PubMed 19703562
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice
FEBS Lett, 583 (18), 3021-6
DOI 10.1016/j.febslet.2009.08.009, PubMed 19683527
Publications 2008
Local impact of perivascular plaques on cerebral blood flow dynamics in a transgenic mouse model of Alzheimer's disease
PROC SPIE, 6860, 686022
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells
Brain Pathol, 18 (4), 548-61
DOI 10.1111/j.1750-3639.2008.00152.x, PubMed 18422760
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice
Neurobiol Aging, 30 (9), 1393-405
DOI 10.1016/j.neurobiolaging.2007.11.022, PubMed 18192084
Publications 2007
Sensitive ELISA detection of amyloid-beta protofibrils in biological samples
J Neurochem, 103 (1), 334-45
DOI 10.1111/j.1471-4159.2007.04759.x, PubMed 17623042
Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes
ACS Chem Biol, 2 (8), 553-60
DOI 10.1021/cb700116u, PubMed 17672509
[Don't underestimate the value of transgenic animal models of Alzheimer disease]
Lakartidningen, 104 (10), 798-9; discussion 799-800
PubMed 17432800
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase
J Neurochem, 101 (3), 854-62
DOI 10.1111/j.1471-4159.2006.04443.x, PubMed 17448150
Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease
Eur J Neurosci, 26 (4), 882-9
DOI 10.1111/j.1460-9568.2007.05719.x, PubMed 17714184
Publications 2005
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
Neurobiol Aging, 27 (1), 67-77
DOI 10.1016/j.neurobiolaging.2004.12.007, PubMed 16298242
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay
Ann Neurol, 58 (1), 147-50
DOI 10.1002/ana.20524, PubMed 15984012
Publications 2004
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease
J Alzheimers Dis, 6 (5), 509-14
DOI 10.3233/jad-2004-6508, PubMed 15505373
Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
Behav Brain Res, 153 (1), 107-21
DOI 10.1016/j.bbr.2003.11.004, PubMed 15219712
Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
Neurobiol Aging, 25 (9), 1153-67
DOI 10.1016/j.neurobiolaging.2003.12.011, PubMed 15312961
Publications 2001
Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
J Neurosci, 21 (5), 1444-51
PubMed 11222634
Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease
Neurochem Int, 39 (5-6), 361-70
DOI 10.1016/s0197-0186(01)00043-2, PubMed 11578771
The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation
Neurobiol Aging, 22 (6), 923-30
DOI 10.1016/s0197-4580(01)00308-6, PubMed 11755000
Publications 1999
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
J Biol Chem, 274 (10), 6421-31
DOI 10.1074/jbc.274.10.6421, PubMed 10037734
Publications 1993
Effects of nucleus basalis lesion on muscarinic receptor subtypes
Exp Brain Res, 97 (2), 225-32
DOI 10.1007/BF00228691, PubMed 8150042
Decrease of somatostatin receptor binding in the rat cerebral cortex after ibotenic acid lesion of the nucleus basalis magnocellularis: a quantitative autoradiographic study
Brain Res, 628 (1-2), 31-8
DOI 10.1016/0006-8993(93)90934-f, PubMed 8313162