Lars N.G. Nilsson

  • Professor
  • +47 22840221

Original articles

Halaas NB, Henjum K, Blennow K, Dakhil S, Idland AV, Nilsson LN, Sederevicius D, Vidal-Piñeiro D, Walhovd KB, Wyller TB, Zetterberg H, Watne LO, Fjell AM (2019)
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
Cereb Cortex (in press)
DOI 10.1093/cercor/bhz240, PubMed 31812991

Jendresen C, Digre A, Cui H, Zhang X, Vlodavsky I, Li JP, Nilsson LNG (2019)
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
Sci Rep, 9 (1), 4600
DOI 10.1038/s41598-019-40999-4, PubMed 30872722

Nordengen K, Kirsebom BE, Henjum K, Selnes P, Gísladóttir B, Wettergreen M, Torsetnes SB, Grøntvedt GR, Waterloo KK, Aarsland D, Nilsson LNG, Fladby T (2019)
Glial activation and inflammation along the Alzheimer's disease continuum
J Neuroinflammation, 16 (1), 46
DOI 10.1186/s12974-019-1399-2, PubMed 30791945

Henjum K, Quist-Paulsen E, Zetterberg H, Blennow K, Nilsson LNG, Watne LO (2018)
CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
J Neuroinflammation, 15 (1), 304
DOI 10.1186/s12974-018-1331-1, PubMed 30390679

Keane MG, Shamali A, Nilsson LN, Antila A, Millastre Bocos J, Marijinissen Van Zanten M, Verdejo Gil C, Maisonneuve P, Vaalavuo Y, Hoskins T, Robinson S, Ceyhan GO, Abu Hilal M, Pereira SP, Laukkarinen J, Del Chiaro M (2018)
Risk of malignancy in resected pancreatic mucinous cystic neoplasms
Br J Surg, 105 (4), 439-446
DOI 10.1002/bjs.10787, PubMed 29488646

Jendresen C, Daws MR, Nilsson LNG (2017)
An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells
J Pharmacol Toxicol Methods, 90, 67-75
DOI 10.1016/j.vascn.2017.11.004, PubMed 29203451

Jendresen C, Årskog V, Daws MR, Nilsson LN (2017)
The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
J Neuroinflammation, 14 (1), 59
DOI 10.1186/s12974-017-0835-4, PubMed 28320424

Henjum K, Almdahl IS, Årskog V, Minthon L, Hansson O, Fladby T, Nilsson LN (2016)
Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease
Alzheimers Res Ther, 8 (1), 17
DOI 10.1186/s13195-016-0182-1, PubMed 27121148

Rogeberg M, Almdahl IS, Wettergreen M, Nilsson LN, Fladby T (2015)
Isobaric Quantification of Cerebrospinal Fluid Amyloid-β Peptides in Alzheimer's Disease: C-Terminal Truncation Relates to Early Measures of Neurodegeneration
J Proteome Res, 14 (11), 4834-43
DOI 10.1021/acs.jproteome.5b00668, PubMed 26452689

Rogeberg M, Wettergreen M, Nilsson LN, Fladby T (2015)
Identification of amyloid beta mid-domain fragments in human cerebrospinal fluid
Biochimie, 113, 86-92
DOI 10.1016/j.biochi.2015.03.022, PubMed 25866191

Jendresen CB, Cui H, Zhang X, Vlodavsky I, Nilsson LN, Li JP (2014)
Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice
J Biol Chem, 290 (8), 5053-64
DOI 10.1074/jbc.M114.600569, PubMed 25548284

Nuruddin S, Syverstad GH, Lillehaug S, Leergaard TB, Nilsson LN, Ropstad E, Krogenæs A, Haraldsen IR, Torp R (2014)
Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer's disease transgenic mice
PLoS One, 9 (8), e103607
DOI 10.1371/journal.pone.0103607, PubMed 25089901

Gumucio A, Lannfelt L, Nilsson LN (2013)
Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
BMC Neurosci, 14, 148
DOI 10.1186/1471-2202-14-148, PubMed 24261309

Lillehaug S, Syverstad GH, Nilsson LN, Bjaalie JG, Leergaard TB, Torp R (2013)
Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice
Neurobiol Aging, 35 (3), 556-64
DOI 10.1016/j.neurobiolaging.2013.09.013, PubMed 24126157

Lillenes MS, Støen M, Gómez-Muñoz M, Torp R, Günther CC, Nilsson LN, Tønjum T (2013)
Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model
Mech Ageing Dev, 134 (10), 467-77
DOI 10.1016/j.mad.2013.09.002, PubMed 24121118

Kalimo H, Lalowski M, Bogdanovic N, Philipson O, Bird TD, Nochlin D, Schellenberg GD, Brundin R, Olofsson T, Soliymani R, Baumann M, Wirths O, Bayer TA, Nilsson LN, Basun H, Lannfelt L, Ingelsson M (2013)
The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ
Acta Neuropathol Commun, 1, 60
DOI 10.1186/2051-5960-1-60, PubMed 24252272

Gu GJ, Wu D, Lund H, Sunnemark D, Kvist AJ, Milner R, Eckersley S, Nilsson LN, Agerman K, Landegren U, Kamali-Moghaddam M (2013)
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease
J Alzheimers Dis, 33 (3), 699-713
DOI 10.3233/JAD-2012-121357, PubMed 23001711

Magnusson K, Sehlin D, Syvänen S, Svedberg MM, Philipson O, Söderberg L, Tegerstedt K, Holmquist M, Gellerfors P, Tolmachev V, Antoni G, Lannfelt L, Hall H, Nilsson LN (2013)
Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain
J Alzheimers Dis, 37 (1), 29-40
DOI 10.3233/JAD-130029, PubMed 23780660

Zhang X, Wang B, O'Callaghan P, Hjertström E, Jia J, Gong F, Zcharia E, Nilsson LN, Lannfelt L, Vlodavsky I, Lindahl U, Li JP (2012)
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain
Acta Neuropathol, 124 (4), 465-78
DOI 10.1007/s00401-012-0997-1, PubMed 22692572

Nilsson LN, Gografe S, Costa DA, Hughes T, Dressler D, Potter H (2012)
Technol Innov, 14 (2), 199-208
DOI 10.3727/194982412X13462021398010, PubMed 23626867

Philipson O, Lord A, Lalowski M, Soliymani R, Baumann M, Thyberg J, Bogdanovic N, Olofsson T, Tjernberg LO, Ingelsson M, Lannfelt L, Kalimo H, Nilsson LN (2011)
The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ
Neurobiol Aging, 33 (5), 1010.e1-13
DOI 10.1016/j.neurobiolaging.2011.10.022, PubMed 22118948

Lord A, Philipson O, Klingstedt T, Westermark G, Hammarström P, Nilsson KP, Nilsson LN (2011)
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease
Am J Pathol, 178 (5), 2286-98
DOI 10.1016/j.ajpath.2011.01.052, PubMed 21514441

Ramberg V, Tracy LM, Samuelsson M, Nilsson LN, Iverfeldt K (2011)
The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
J Neuroinflammation, 8, 34
DOI 10.1186/1742-2094-8-34, PubMed 21492414

Yang J, Lunde LK, Nuntagij P, Oguchi T, Camassa LM, Nilsson LN, Lannfelt L, Xu Y, Amiry-Moghaddam M, Ottersen OP, Torp R (2011)
Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease
J Alzheimers Dis, 27 (4), 711-22
DOI 10.3233/JAD-2011-110725, PubMed 21891870

Blom ES, Wang Y, Skoglund L, Hansson AC, Ubaldi M, Lourdusamy A, Sommer WH, Mielke M, Hyman BT, Heilig M, Lannfelt L, Nilsson LN, Ingelsson M (2010)
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
Int J Alzheimers Dis, 2011, 936580
DOI 10.4061/2011/936580, PubMed 21234373

Kamali-Moghaddam M, Pettersson FE, Wu D, Englund H, Darmanis S, Lord A, Tavoosidana G, Sehlin D, Gustafsdottir S, Nilsson LN, Lannfelt L, Landegren U (2010)
Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease
BMC Neurosci, 11, 124
DOI 10.1186/1471-2202-11-124, PubMed 20923550

Codita A, Gumucio A, Lannfelt L, Gellerfors P, Winblad B, Mohammed AH, Nilsson LN (2010)
Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study
Behav Brain Res, 215 (1), 83-94
DOI 10.1016/j.bbr.2010.06.034, PubMed 20615433

Hånell A, Clausen F, Björk M, Jansson K, Philipson O, Nilsson LN, Hillered L, Weinreb PH, Lee D, McIntosh TK, Gimbel DA, Strittmatter SM, Marklund N (2010)
Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice
J Neurotrauma, 27 (7), 1297-309
DOI 10.1089/neu.2009.1255, PubMed 20486800

Israelsson C, Bengtsson H, Lobell A, Nilsson LN, Kylberg A, Isaksson M, Wootz H, Lannfelt L, Kullander K, Hillered L, Ebendal T (2010)
Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders
Eur J Neurosci, 31 (5), 852-63
DOI 10.1111/j.1460-9568.2010.07105.x, PubMed 20374285

Lord A, Gumucio A, Englund H, Sehlin D, Sundquist VS, Söderberg L, Möller C, Gellerfors P, Lannfelt L, Pettersson FE, Nilsson LN (2009)
An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease
Neurobiol Dis, 36 (3), 425-34
DOI 10.1016/j.nbd.2009.08.007, PubMed 19703562

Philipson O, Lannfelt L, Nilsson LN (2009)
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice
FEBS Lett, 583 (18), 3021-6
DOI 10.1016/j.febslet.2009.08.009, PubMed 19683527

Ingelsson M, Basun H, Pettersson FE, Kilander L, Nilsson LN, Lannfelt L (2009)
[Rare mutations aim toward future treatment]
Lakartidningen, 106 (20), 1396-400
PubMed 19585838

Lord A, Englund H, Söderberg L, Tucker S, Clausen F, Hillered L, Gordon M, Morgan D, Lannfelt L, Pettersson FE, Nilsson LN (2009)
Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice
FEBS J, 276 (4), 995-1006
DOI 10.1111/j.1742-4658.2008.06836.x, PubMed 19215301

O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X (2008)
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells
Brain Pathol, 18 (4), 548-61
DOI 10.1111/j.1750-3639.2008.00152.x, PubMed 18422760

Philipson O, Hammarström P, Nilsson KP, Portelius E, Olofsson T, Ingelsson M, Hyman BT, Blennow K, Lannfelt L, Kalimo H, Nilsson LN (2008)
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice
Neurobiol Aging, 30 (9), 1393-405
DOI 10.1016/j.neurobiolaging.2007.11.022, PubMed 18192084

Nase G, Helm PJ, Oguchi T, Nilsson LNG, Lannfelt L, Ottersen OP, Torp R (2008)
Local impact of perivascular plaques on cerebral blood flow dynamics in a transgenic mouse model of Alzheimer's disease
PROC SPIE, 6860, 686022

Nilsson KP, Aslund A, Berg I, Nyström S, Konradsson P, Herland A, Inganäs O, Stabo-Eeg F, Lindgren M, Westermark GT, Lannfelt L, Nilsson LN, Hammarström P (2007)
Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes
ACS Chem Biol, 2 (8), 553-60
DOI 10.1021/cb700116u, PubMed 17672509

Sahlin C, Pettersson FE, Nilsson LN, Lannfelt L, Johansson AS (2007)
Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease
Eur J Neurosci, 26 (4), 882-9
DOI 10.1111/j.1460-9568.2007.05719.x, PubMed 17714184

Englund H, Sehlin D, Johansson AS, Nilsson LN, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE (2007)
Sensitive ELISA detection of amyloid-beta protofibrils in biological samples
J Neurochem, 103 (1), 334-45
DOI 10.1111/j.1471-4159.2007.04759.x, PubMed 17623042

Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN (2007)
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase
J Neurochem, 101 (3), 854-62
DOI 10.1111/j.1471-4159.2006.04443.x, PubMed 17448150

Stenh C, Englund H, Lord A, Johansson AS, Almeida CG, Gellerfors P, Greengard P, Gouras GK, Lannfelt L, Nilsson LN (2005)
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay
Ann Neurol, 58 (1), 147-50
DOI 10.1002/ana.20524, PubMed 15984012

Lord A, Kalimo H, Eckman C, Zhang XQ, Lannfelt L, Nilsson LN (2005)
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
Neurobiol Aging, 27 (1), 67-77
DOI 10.1016/j.neurobiolaging.2004.12.007, PubMed 16298242

Nilsson LN, Arendash GW, Leighty RE, Costa DA, Low MA, Garcia MF, Cracciolo JR, Rojiani A, Wu X, Bales KR, Paul SM, Potter H (2004)
Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
Neurobiol Aging, 25 (9), 1153-67
DOI 10.1016/j.neurobiolaging.2003.12.011, PubMed 15312961

Costa DA, Nilsson LN, Bales KR, Paul SM, Potter H (2004)
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease
J Alzheimers Dis, 6 (5), 509-14
DOI 10.3233/jad-2004-6508, PubMed 15505373

Leighty RE, Nilsson LN, Potter H, Costa DA, Low MA, Bales KR, Paul SM, Arendash GW (2004)
Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
Behav Brain Res, 153 (1), 107-21
DOI 10.1016/j.bbr.2003.11.004, PubMed 15219712

Nilsson LN, Das S, Potter H (2001)
Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease
Neurochem Int, 39 (5-6), 361-70
DOI 10.1016/s0197-0186(01)00043-2, PubMed 11578771

Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H (2001)
Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
J Neurosci, 21 (5), 1444-51
PubMed 11222634

Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN (1999)
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
J Biol Chem, 274 (10), 6421-31
DOI 10.1074/jbc.274.10.6421, PubMed 10037734

Bogdanovic N, Nilsson L, Adem A, Winblad B, Bergström L (1993)
Decrease of somatostatin receptor binding in the rat cerebral cortex after ibotenic acid lesion of the nucleus basalis magnocellularis: a quantitative autoradiographic study
Brain Res, 628 (1-2), 31-8
DOI 10.1016/0006-8993(93)90934-f, PubMed 8313162

Bogdanovic N, Islam A, Nilsson L, Bergström L, Winblad B, Adem A (1993)
Effects of nucleus basalis lesion on muscarinic receptor subtypes
Exp Brain Res, 97 (2), 225-32
DOI 10.1007/bf00228691, PubMed 8150042

Review articles

Lannfelt L, Pettersson FE, Nilsson LN (2010)
Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease
Nutr Rev, 68 Suppl 2, S128-34
DOI 10.1111/j.1753-4887.2010.00347.x, PubMed 21091946

Philipson O, Lord A, Gumucio A, O'Callaghan P, Lannfelt L, Nilsson LN (2010)
Animal models of amyloid-beta-related pathologies in Alzheimer's disease
FEBS J, 277 (6), 1389-409
DOI 10.1111/j.1742-4658.2010.07564.x, PubMed 20136653

Potter H, Wefes IM, Nilsson LN (2001)
The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation
Neurobiol Aging, 22 (6), 923-30
DOI 10.1016/s0197-4580(01)00308-6, PubMed 11755000

Other articles

Nilsson LN, Lannfelt L, Basun H, Nordberg A, Winblad B (2007)
[Don't underestimate the value of transgenic animal models of Alzheimer disease]
Lakartidningen, 104 (10), 798-9; discussion 799-800
PubMed 17432800

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