Lars Christian Haugli Bråten

  • PhD student; MD
  • +47 22 11 77 94 / 992 99 034

Lars Christian Bråten has a medical degree from University of Dundee in Scotland from 2005. He has been working with internal medicine, with a special interest in infectious diseases, until he started as a PhD-student in 2015.

Research Project 
Lars Christian Bråten is currently doing his PhD on clinical outcomes of the AIM-study (Antibiotics in Modic changes) – a randomized trial testing antibiotic treatment in patients with chronic low back pain and Modic changes. He is also working on the Backtobasic-study – a randomized trial testing TNF-α inhibitors in patients with chronic low back pain and Modic changes.

Main supervisor/Co supervisor: Kjersti Storheim, John-Anker Zwart, Elina Schistad and Jens Ivar Brox.

Methodology and interests
Lars Christian Bråten has a strong interest in clinical trials and back pain research, and is also involved in radiological and biomedical changes in patients with chronic back pain. He also has a special interest in research on microbiota of the gut and the sputum. He is a member of the National research school in population based epidemiology (EPINOR).

 

Publications 2023

Bråten LCH, Gjefsen E, Gervin K, Pripp AH, Skouen JS, Schistad E, Pedersen LM, Wigemyr M, Selmer KK, Aass HCD, Goll G, Brox JI, Espeland A, Grøvle L, Zwart JA, Storheim K, AIM-study group (2023)
Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study)
J Pain Res, 16, 1713-1724
DOI 10.2147/JPR.S406079, PubMed 37252109

Espeland A, Kristoffersen PM, Bråten LCH, Grøvle L, Grotle M, Haugen AJ, Rolfsen MP, Hellum C, Zwart JA, Storheim K, Assmus J, Vetti N (2023)
Longitudinal Relationship between Reduced Modic change Edema and Disability and Pain in Patients with Chronic Low Back Pain
Spine (Phila Pa 1976) (in press)
DOI 10.1097/BRS.0000000000004837, PubMed 37759351

Vigeland MD, Flåm ST, Vigeland MD, Espeland A, Zucknick M, Wigemyr M, Bråten LCH, Gjefsen E, Zwart JA, Storheim K, Pedersen LM, Selmer K, Lie BA, Gervin K, The Aim Study Group (2023)
Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
Antibiotics (Basel), 12 (7)
DOI 10.3390/antibiotics12071217, PubMed 37508313

Publications 2022

Bråten LCH, Grøvle L, Wigemyr M, Wilhelmsen M, Gjefsen E, Espeland A, Haugen AJ, Skouen JS, Brox JI, Zwart JA, Storheim K, Ostelo RW, Grotle M (2022)
Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain
J Clin Epidemiol, 151, 75-87
DOI 10.1016/j.jclinepi.2022.07.012, PubMed 35926821

Vigeland MD, Flåm ST, Vigeland MD, Espeland A, Kristoffersen PM, Vetti N, Wigemyr M, Bråten LCH, Gjefsen E, Schistad EI, Haugen AJ, Froholdt A, Skouen JS, Zwart JA, Storheim K, Pedersen LM, Lie BA, AIM Study Group (2022)
Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement
Sci Rep, 12 (1), 215
DOI 10.1038/s41598-021-04189-5, PubMed 34997115

Publications 2021

Bråten LCH, Storheim K, AIM study group (2021)
Letter to the Editor regarding, "Chronic low back pain, bacterial infection, and treatment with antibiotics"
Spine J, 21 (7), 1229-1230
DOI 10.1016/j.spinee.2021.03.034, PubMed 34243895

Gjefsen E, Gervin K, Goll G, Bråten LCH, Wigemyr M, Aass HCD, Vigeland MD, Schistad E, Pedersen LM, Pripp AH, Storheim K, Selmer KK, Zwart JA (2021)
Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes
RMD Open, 7 (2)
DOI 10.1136/rmdopen-2021-001726, PubMed 34344830

Johnsen MB, Roos E, Grønne DT, Bråten LCH, Skou ST (2021)
Impact of educational level and employment status on short-term and long-term pain relief from supervised exercise therapy and education: an observational study of 22 588 patients with knee and hip osteoarthritis
BMJ Open, 11 (4), e045156
DOI 10.1136/bmjopen-2020-045156, PubMed 33853803

Publications 2020

Bråten LCH, Grøvle L, Espeland A, Pripp AH, Grotle M, Helllum C, Haugen AJ, Froholdt A, Rolfsen MP, Nygaard ØP, Lutro O, Kristoffersen PM, Anke A, Schistad EI, Skouen JS, Brox JI, Zwart JA, Storheim K, AIM-study group (2020)
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study)
BMC Musculoskelet Disord, 21 (1), 458
DOI 10.1186/s12891-020-03422-y, PubMed 32660517

Bråten LCH, Schistad EI, Espeland A, Kristoffersen PM, Haugen AJ, Marchand GH, Vetti N, Pripp AH, Kadar TI, Skouen JS, Grotle M, Grøvle L, Zwart JA, Brox JI, Storheim K, AIM-study group (2020)
Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study
BMC Musculoskelet Disord, 21 (1), 368
DOI 10.1186/s12891-020-03381-4, PubMed 32522268

Gjefsen E, Bråten LCH, Goll GL, Wigemyr M, Bolstad N, Valberg M, Schistad EI, Marchand GH, Granviken F, Selmer KK, Froholdt A, Haugen AJ, Dagestad MH, Vetti N, Bakland G, Lie BA, Haavardsholm EA, Nilsen AT, Holmgard TE, Kadar TI, Kvien T, Skouen JS, Grøvle L, Brox JI, Espeland A et al. (2020)
The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial
BMC Musculoskelet Disord, 21 (1), 698
DOI 10.1186/s12891-020-03720-5, PubMed 33087100

Grotle M, Bråten LC, Brox JI, Espeland A, Zolic-Karlsson Z, Munk Killingmo R, Tingulstad A, Grøvle L, Froholdt A, Kristoffersen PM, Wigemyr M, van Tulder MW, Storheim K, Zwart JA, AIM-study group (2020)
Cost-utility analysis of antibiotic treatment in patients with chronic low back pain and Modic changes: results from a randomised, placebo-controlled trial in Norway (the AIM study)
BMJ Open, 10 (6), e035461
DOI 10.1136/bmjopen-2019-035461, PubMed 32546490

Kristoffersen PM, Bråten LCH, Vetti N, Grøvle L, Hellum C, Storheim K, Zwart JA, Assmus J, Espeland A (2020)
Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes-subgroup analysis of a randomized trial
Eur Radiol, 31 (6), 4285-4297
DOI 10.1007/s00330-020-07542-w, PubMed 33247344

Kristoffersen PM, Vetti N, Storheim K, Bråten LC, Rolfsen MP, Assmus J, Espeland A (2020)
Short tau inversion recovery MRI of Modic changes: a reliability study
Acta Radiol Open, 9 (1), 2058460120902402
DOI 10.1177/2058460120902402, PubMed 32064122

Publications 2019

Bråten LCH, Rolfsen MP, Espeland A, Wigemyr M, Aßmus J, Froholdt A, Haugen AJ, Marchand GH, Kristoffersen PM, Lutro O, Randen S, Wilhelmsen M, Winsvold BS, Kadar TI, Holmgard TE, Vigeland MD, Vetti N, Nygaard ØP, Lie BA, Hellum C, Anke A, Grotle M, Schistad EI, Skouen JS, Grøvle L et al. (2019)
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
BMJ, 367, l5654
DOI 10.1136/bmj.l5654, PubMed 31619437

Publications 2016

Bråten LC, Reikvam DH (2016)
[A man in his 30s with fever after a safari in South Africa]
Tidsskr Nor Laegeforen, 136 (4), 328-30
DOI 10.4045/tidsskr.15.0431, PubMed 26905848

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