Publications by Fredrik Hellem Schjesvold
87 publications found
Publications 2024
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Advances and challenges in anti-cancer vaccines for multiple myeloma
Front Immunol, 15, 1411352
DOI 10.3389/fimmu.2024.1411352, PubMed 39161773 -
Estimated Financial Savings From Clinical Studies at Oslo Myeloma Center in the Period 2015-2021
Clin Lymphoma Myeloma Leuk (in press)
DOI 10.1016/j.clml.2024.07.015, PubMed 39191633 -
Consensus guidelines and recommendations for the management and response assessment of chimeric antigen receptor T-cell therapy in clinical practice for relapsed and refractory multiple myeloma: a report from the International Myeloma Working Group Immunotherapy Committee
Lancet Oncol, 25 (8), e374-e387
DOI 10.1016/S1470-2045(24)00094-9, PubMed 38821074 -
In multiple myeloma, monthly treatment with zoledronic acid beyond two years offers sustained protection against progressive bone disease
Blood Cancer J, 14 (1), 65
DOI 10.1038/s41408-024-01046-2, PubMed 38622134 -
Health-related quality of life and quality-adjusted progression free survival for carfilzomib and dexamethasone maintenance following salvage autologous stem-cell transplantation in patients with multiple myeloma: a randomized phase 2 trial by the Nordic Myeloma Study Group
J Patient Rep Outcomes, 8 (1), 15
DOI 10.1186/s41687-024-00691-2, PubMed 38315268 -
VRD versus VCD as induction therapy before autologous stem cell transplantation in multiple myeloma: a nationwide population-based study
Blood Cancer J, 14 (1), 60
DOI 10.1038/s41408-024-01047-1, PubMed 38594252 -
Ixazomib, Lenalidomide, and Dexamethasone (IRD) Treatment with Cytogenetic Risk-Based Maintenance in Transplant-Eligible Myeloma: A Phase 2 Multicenter Study by the Nordic Myeloma Study Group
Cancers (Basel), 16 (5)
DOI 10.3390/cancers16051024, PubMed 38473382 -
Progression-free survival as a surrogate endpoint in myeloma clinical trials: an evolving paradigm
Blood Cancer J, 14 (1), 134
DOI 10.1038/s41408-024-01109-4, PubMed 39134544 -
Efficacy and safety of melflufen plus daratumumab and dexamethasone in relapsed/refractory multiple myeloma: results from the randomized, open-label, phase III LIGHTHOUSE study
Haematologica, 109 (3), 895-905
DOI 10.3324/haematol.2023.283509, PubMed 37646660 -
Isatuximab-pomalidomide-dexamethasone versus pomalidomide-dexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis
Haematologica, 109 (7), 2239-2249
DOI 10.3324/haematol.2023.284325, PubMed 38299578 -
Health-related quality of life in relapsed/refractory multiple myeloma treated with melflufen and dexamethasone: analyses from the phase III OCEAN study
Haematologica, 109 (7), 2331-2336
DOI 10.3324/haematol.2023.284635, PubMed 38426292 -
A plain language summary of the PERSEUS study of daratumumab plus bortezomib, lenalidomide, and dexamethasone for treating newly diagnosed multiple myeloma
Future Oncol, 1-21 (in press)
DOI 10.1080/14796694.2024.2394323, PubMed 39287147
Publications 2023
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Bone scintigraphy reduces the need for biopsy in suspected cardiac amyloidosis
Tidsskr Nor Laegeforen, 143 (9)
DOI 10.4045/tidsskr.22.0644, PubMed 37341415 -
Ixazomib-Thalidomide-Dexamethasone Induction Followed by Ixazomib or Placebo Maintenance in Nontransplant Eligible Newly Diagnosed Multiple Myeloma Patients: Long-term Results of HOVON-126/NMSG 21.13
Hemasphere, 7 (9), e940
DOI 10.1097/HS9.0000000000000940, PubMed 37663673 -
Potential value of pre-planned imaging of bone disease in multiple myeloma
Blood Cancer J, 13 (1), 105
DOI 10.1038/s41408-023-00880-0, PubMed 37419876 -
Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data
Cell Rep Methods, 3 (3), 100417
DOI 10.1016/j.crmeth.2023.100417, PubMed 37056380 -
Prevention and management of adverse events during treatment with bispecific antibodies and CAR T cells in multiple myeloma: a consensus report of the European Myeloma Network
Lancet Oncol, 24 (6), e255-e269
DOI 10.1016/S1470-2045(23)00159-6, PubMed 37269857 -
Intensifying treatment in PET-positive multiple myeloma patients after upfront autologous stem cell transplantation
Leukemia, 37 (10), 2107-2114
DOI 10.1038/s41375-023-01998-7, PubMed 37568010 -
Pomalidomide, Bortezomib, and Dexamethasone in Lenalidomide-Pretreated Multiple Myeloma: A Subanalysis of OPTIMISMM by Frailty and Bortezomib Dose Adjustment
Clin Lymphoma Myeloma Leuk, 24 (3), 165-176.e4
DOI 10.1016/j.clml.2023.10.009, PubMed 38072743 -
Phase I Study of Safety and Pharmacokinetics of RO7297089, an Anti-BCMA/CD16a Bispecific Antibody, in Patients with Relapsed, Refractory Multiple Myeloma
Clin Hematol Int, 5 (1), 43-51
DOI 10.1007/s44228-022-00023-5, PubMed 36656461 -
Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody
Leukemia, 37 (6), 1349-1360
DOI 10.1038/s41375-023-01883-3, PubMed 37024520 -
Difficult-to-treat patients with relapsed/refractory multiple myeloma: A review of clinical trial results
EJHaem, 4 (4), 1117-1131
DOI 10.1002/jha2.743, PubMed 38024633 -
Melflufen in relapsed/refractory multiple myeloma refractory to prior alkylators: A subgroup analysis from the OCEAN study
Eur J Haematol, 112 (3), 402-411
DOI 10.1111/ejh.14127, PubMed 37968873 -
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
N Engl J Med, 390 (4), 301-313
DOI 10.1056/NEJMoa2312054, PubMed 38084760 -
Benefit Versus Risk Assessment of Melflufen and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Analyses From Longer Follow-up of the OCEAN and HORIZON Studies
Clin Lymphoma Myeloma Leuk, 23 (9), 687-696
DOI 10.1016/j.clml.2023.05.004, PubMed 37355418 -
Management of patients with multiple myeloma and COVID-19 in the post pandemic era: a consensus paper from the European Myeloma Network (EMN)
Leukemia, 37 (6), 1175-1185
DOI 10.1038/s41375-023-01920-1, PubMed 37142661 -
Treatment of primary plasma cell leukaemia with carfilzomib and lenalidomide-based therapy (EMN12/HOVON-129): final analysis of a non-randomised, multicentre, phase 2 study
Lancet Oncol, 24 (10), 1119-1133
DOI 10.1016/S1470-2045(23)00405-9, PubMed 37717583
Publications 2022
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Corrigendum to "Corrigendum to 'Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up'": [Ann Oncol Volume 33, Issue 1, January 2022, Page 117]
Ann Oncol, 33 (9), 988
DOI 10.1016/j.annonc.2022.05.004, PubMed 35810138 -
Oral ixazomib-dexamethasone vs oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma: a randomized Phase 2 trial
Blood Cancer J, 12 (1), 9
DOI 10.1038/s41408-021-00593-2, PubMed 35075109 -
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically
Mol Oncol, 16 (6), 1241-1258
DOI 10.1002/1878-0261.13191, PubMed 35148457 -
A prospective study of Skeletal survey versus Low-dose whole-body CT for Osteolytic lesions in Multiple Myeloma
Eur J Haematol, 108 (5), 423-429
DOI 10.1111/ejh.13749, PubMed 35113466 -
What matters most to patients with multiple myeloma? A Pan-European patient preference study
Front Oncol, 12, 1027353
DOI 10.3389/fonc.2022.1027353, PubMed 36523996 -
Anti-CD38 antibody therapy for patients with relapsed/refractory multiple myeloma: differential mechanisms of action and recent clinical trial outcomes
Ann Hematol, 101 (10), 2123-2137
DOI 10.1007/s00277-022-04917-5, PubMed 35943588 -
Melflufen for the treatment of multiple myeloma
Expert Rev Clin Pharmacol, 15 (4), 371-382
DOI 10.1080/17512433.2022.2075847, PubMed 35723075 -
Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): follow-up analysis of a randomised, phase 3 study
Lancet Oncol, 23 (3), 416-427
DOI 10.1016/S1470-2045(22)00019-5, PubMed 35151415 -
Cobimetinib Alone and Plus Venetoclax With/Without Atezolizumab in Patients With Relapsed/Refractory Multiple Myeloma
Clin Lymphoma Myeloma Leuk, 23 (1), e59-e70
DOI 10.1016/j.clml.2022.10.006, PubMed 36450626 -
Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis
Haematologica, 107 (3), 774-775
DOI 10.3324/haematol.2021.279160, PubMed 35229573 -
Melflufen in multiple myeloma: the conclusion matters - Authors' reply
Lancet Haematol, 9 (4), e244-e245
DOI 10.1016/S2352-3026(22)00071-0, PubMed 35358436 -
Authors' reply: Perspective: The approval and withdrawal of melphalan flufenamide (melflufen): Implications for the state of the FDA
Transl Oncol, 25, 101528
DOI 10.1016/j.tranon.2022.101528, PubMed 36087383 -
Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study
Lancet Haematol, 9 (2), e98-e110
DOI 10.1016/S2352-3026(21)00381-1, PubMed 35032434 -
Longitudinal minimal residual disease assessment in multiple myeloma patients in complete remission - results from the NMSG flow-MRD substudy within the EMN02/HO95 MM trial
BMC Cancer, 22 (1), 147
DOI 10.1186/s12885-022-09184-1, PubMed 35123422 -
Comparison of [18F]fluciclovine and [18F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients
Mol Imaging Biol, 24 (5), 842-851
DOI 10.1007/s11307-022-01734-0, PubMed 35501622
Publications 2021
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Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up
Hemasphere, 5 (2), e528
DOI 10.1097/HS9.0000000000000528, PubMed 33554050 -
Corrigendum to 'Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up': [Ann Oncol 2021; 32(3): 309-322]
Ann Oncol, 33 (1), 117
DOI 10.1016/j.annonc.2021.10.001, PubMed 34857439 -
Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
Ann Oncol, 32 (3), 309-322
DOI 10.1016/j.annonc.2020.11.014, PubMed 33549387 -
Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
Blood Cancer J, 11 (12), 192
DOI 10.1038/s41408-021-00587-0, PubMed 34857730 -
Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma: A randomised phase 2 trial by the Nordic Myeloma Study Group
Eur J Haematol, 108 (1), 34-44
DOI 10.1111/ejh.13709, PubMed 34536308 -
Correction to: Adverse event management in the TOURMALINE-MM3 study of post-transplant ixazomib maintenance in multiple myeloma
Ann Hematol, 100 (1), 297-302
DOI 10.1007/s00277-020-04302-0, PubMed 33106909 -
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma
Am J Hematol, 96 (4), 418-427
DOI 10.1002/ajh.26083, PubMed 33368455 -
COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network
Lancet Haematol, 8 (12), e934-e946
DOI 10.1016/S2352-3026(21)00278-7, PubMed 34756169 -
Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group
Lancet Oncol, 22 (3), e105-e118
DOI 10.1016/S1470-2045(20)30756-7, PubMed 33662288 -
Isatuximab for relapsed/refractory multiple myeloma: review of key subgroup analyses from the Phase III ICARIA-MM study
Future Oncol, 17 (34), 4797-4812
DOI 10.2217/fon-2021-0568, PubMed 34521277 -
Pomalidomide, bortezomib, and dexamethasone at first relapse in lenalidomide-pretreated myeloma: A subanalysis of OPTIMISMM by clinical characteristics
Eur J Haematol, 108 (1), 73-83
DOI 10.1111/ejh.13706, PubMed 34496096 -
Isatuximab plus pomalidomide and dexamethasone in frail patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis
Am J Hematol, 96 (11), E423-E427
DOI 10.1002/ajh.26319, PubMed 34383345 -
Current and Novel Alkylators in Multiple Myeloma
Cancers (Basel), 13 (10)
DOI 10.3390/cancers13102465, PubMed 34070213 -
Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis
Haematologica, 106 (4), 1182-1187
DOI 10.3324/haematol.2020.253450, PubMed 32586908 -
Treatment of multiple myeloma-related bone disease: recommendations from the Bone Working Group of the International Myeloma Working Group
Lancet Oncol, 22 (3), e119-e130
DOI 10.1016/S1470-2045(20)30559-3, PubMed 33545067 -
Monoclonal gammopathy of clinical importance
Tidsskr. Nor. Laegeforen., 141 (13), 1276-1280 -
[Monoclonal gammopathy of clinical importance]
Tidsskr Nor Laegeforen, 141 (2021-13)
DOI 10.4045/tidsskr.20.0981, PubMed 34596996 -
Efficacy of a novel device for cryoprevention of oral mucositis: a randomized, blinded, multicenter, parallel group, phase 3 trial
Bone Marrow Transplant, 57 (2), 191-197
DOI 10.1038/s41409-021-01512-6, PubMed 34728786
Publications 2020
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Adverse event management in the TOURMALINE-MM3 study of post-transplant ixazomib maintenance in multiple myeloma
Ann Hematol, 99 (8), 1793-1804
DOI 10.1007/s00277-020-04149-5, PubMed 32613281 -
Efficacy and safety of oral panobinostat plus subcutaneous bortezomib and oral dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma (PANORAMA 3): an open-label, randomised, phase 2 study
Lancet Oncol, 22 (1), 142-154
DOI 10.1016/S1470-2045(20)30680-X, PubMed 33301738 -
Melflufen for relapsed and refractory multiple myeloma
Expert Opin Investig Drugs, 29 (10), 1069-1078
DOI 10.1080/13543784.2020.1808884, PubMed 32924646 -
Evolution of diagnostic workup and treatment for multiple myeloma 2013-2019
Eur J Haematol, 105 (4), 434-448
DOI 10.1111/ejh.13464, PubMed 32557833 -
Quality of life is maintained with ixazomib maintenance in post-transplant newly diagnosed multiple myeloma: The TOURMALINE-MM3 trial
Eur J Haematol, 104 (5), 443-458
DOI 10.1111/ejh.13379, PubMed 31880006 -
OCEAN: a randomized Phase III study of melflufen + dexamethasone to treat relapsed refractory multiple myeloma
Future Oncol, 16 (11), 631-641
DOI 10.2217/fon-2020-0024, PubMed 32141766 -
Ixazomib-Thalidomide-low dose dexamethasone induction followed by maintenance therapy with ixazomib or placebo in newly diagnosed multiple myeloma patients not eligible for autologous stem cell transplantation; results from the randomized phase II HOVON-126/NMSG 21.13 trial
Haematologica, 105 (12), 2879-2882
DOI 10.3324/haematol.2019.240374, PubMed 33256392
Publications 2019
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Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study
Lancet, 394 (10214), 2096-2107
DOI 10.1016/S0140-6736(19)32556-5, PubMed 31735560 -
International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders
Lancet Oncol, 20 (6), e302-e312
DOI 10.1016/S1470-2045(19)30309-2, PubMed 31162104 -
Pembrolizumab plus pomalidomide and dexamethasone for patients with relapsed or refractory multiple myeloma (KEYNOTE-183): a randomised, open-label, phase 3 trial
Lancet Haematol, 6 (9), e459-e469
DOI 10.1016/S2352-3026(19)30110-3, PubMed 31327687 -
Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial
Lancet Oncol, 20 (6), 781-794
DOI 10.1016/S1470-2045(19)30152-4, PubMed 31097405 -
Pembrolizumab plus lenalidomide and dexamethasone for patients with treatment-naive multiple myeloma (KEYNOTE-185): a randomised, open-label, phase 3 trial
Lancet Haematol, 6 (9), e448-e458
DOI 10.1016/S2352-3026(19)30109-7, PubMed 31327689
Publications 2018
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Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial
Lancet, 393 (10168), 253-264
DOI 10.1016/S0140-6736(18)33003-4, PubMed 30545780 -
Improved outcome in patients following autologous stem cell transplantation for multiple myeloma in south eastern Norway 2001-2010: a retrospective, population based analysis
BMC Cancer, 18 (1), 801
DOI 10.1186/s12885-018-4722-x, PubMed 30089450 -
In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy
Blood, 132, 4676
DOI 10.1182/blood-2018-99-110357, PublikaID 304 -
Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
Blood, 132, 4677
DOI 10.1182/blood-2018-99-110669, PublikaID 303
Publications 2017
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[Not Available]
Tidsskr Nor Laegeforen, 137 (1), 58
DOI 10.4045/tidsskr.16.0963, PubMed 28073239 -
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice
Leukemia, 31 (10), 2114-2121
DOI 10.1038/leu.2017.69, PubMed 28232741
Publications 2016
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Benzylpenicillin plus an aminoglycoside versus meropenem in neutropenic lymphoma and leukaemia patients with a suspected bacterial infection: a randomized, controlled trial
Clin Microbiol Infect, 23 (3), 179-187
DOI 10.1016/j.cmi.2016.10.019, PubMed 27793737
Publications 2015
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Tumors Escape CD4+ T-cell-Mediated Immunosurveillance by Impairing the Ability of Infiltrating Macrophages to Indirectly Present Tumor Antigens
Cancer Res, 75 (16), 3268-78
DOI 10.1158/0008-5472.CAN-14-3640, PubMed 26038231
Publications 2014
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How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Front Immunol, 5, 174
DOI 10.3389/fimmu.2014.00174, PubMed 24782871 -
Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells
Eur J Immunol, 44 (9), 2625-37
DOI 10.1002/eji.201444659, PubMed 24846412
Publications 2013
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[Investigation of anemia]
Tidsskr Nor Laegeforen, 133 (6), 610
DOI 10.4045/tidsskr.13.0256, PubMed 23552139 -
[Investigation of amyloidosis]
Tidsskr Nor Laegeforen, 133 (3), 266
DOI 10.4045/tidsskr.13.0044, PubMed 23381155
Publications 2012
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A woman in her seventies with reduced general condition, dyspnoea and generalised pain
Tidsskr Nor Laegeforen, 132 (17), 1969-72
DOI 10.4045/tidsskr.11.0608, PubMed 23007363
Publications 2009
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[Erythrocytosis as a problem]
Tidsskr Nor Laegeforen, 129 (22), 2387; author reply 2387
DOI 10.4045/tidsskr.09.1196, PubMed 19935946
Publications 2008
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[High-dose treatment of systemic AL-amyloidosis with autologous stem cell support]
Tidsskr Nor Laegeforen, 128 (12), 1392-6
PubMed 18552900