OUH - Group members

Ina Skaara Brorson

PhD student; MSc
+47 230 79025

PhD thesis entitled 'Genome-wide DNA methylation and gene expression profiling of multiple sclerosis CD4+ and CD8+T cells', supervised by Steffan D. Bos (MSc, PhD) and co-supervised by Tone Berge (MSc, Phd) and Hanne Harbo (MD, PhD)

Current research interests is to gain better insight in the involved immune cells in MS pathological processes by the use of single cell multiome ATAC + RNA sequencing to create a high-resolution map of the immune cell composition and epigenetic fingerprint of the immune cells.

Publications 2020

Brorson IS, Eriksson AM, Leikfoss IS, Vitelli V, Celius EG, Lüders T, Berge T, Harbo HF, Nilsen H, Bos SD (2020)
CD8⁺ T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls
Mult Scler J Exp Transl Clin, 6 (4), 2055217320978511
DOI 10.1177/2055217320978511, PubMed 33343920

Publications 2019

Berge T, Eriksson A, Brorson IS, Høgestøl EA, Berg-Hansen P, Døskeland A, Mjaavatten O, Bos SD, Harbo HF, Berven F (2019)
Quantitative proteomic analyses of CD4⁺ and CD8⁺ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
Clin Proteomics, 16, 19
DOI 10.1186/s12014-019-9241-5, PubMed 31080378

Brorson IS, Eriksson A, Leikfoss IS, Celius EG, Berg-Hansen P, Barcellos LF, Berge T, Harbo HF, Bos SD (2019)
No differential gene expression for CD4⁺ T cells of MS patients and healthy controls
Mult Scler J Exp Transl Clin, 5 (2), 2055217319856903
DOI 10.1177/2055217319856903, PubMed 31223483

Publications 2018

Rhead B, Brorson IS, Berge T, Adams C, Quach H, Moen SM, Berg-Hansen P, Celius EG, Sangurdekar DP, Bronson PG, Lea RA, Burnard S, Maltby VE, Scott RJ, Lechner-Scott J, Harbo HF, Bos SD, Barcellos LF (2018)
Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients
PLoS One, 13 (10), e0206511
DOI 10.1371/journal.pone.0206511, PubMed 30379917

Publications 2016

Berge T, Leikfoss IS, Brorson IS, Bos SD, Page CM, Gustavsen MW, Bjølgerud A, Holmøy T, Celius EG, Damoiseaux J, Smolders J, Harbo HF, Spurkland A (2016)
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
Genes Immun, 17 (2), 118-27
DOI 10.1038/gene.2015.61, PubMed 26765264

Publications 2015

Leikfoss IS, Keshari PK, Gustavsen MW, Bjølgerud A, Brorson IS, Celius EG, Spurkland A, Bos SD, Harbo HF, Berge T (2015)
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
PLoS One, 10 (7), e0132957
DOI 10.1371/journal.pone.0132957, PubMed 26203907