Current projects

  • Developing novel complement activation assays for application in basic and clinical research
  • Studying the cross-talk between complement and TLRs, in particular to the co-receptor CD14
  • Investigating the effect on inflammation by inhibiting complement activation and CD14 using human whole blood in vitro models and in vivo animal models of human diseases
  • Studying the “Thromboinflammation” and new complex whole blood models to reveal cross-talk between biological systems ex vivo
  • Studying complement activation in patients with diseases being tentative candidates for future complement intervention
  • Develop tools for evaluation of the effect of complement therapy in the clinic
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