Maren-Helene Langeland Degnes

  • Postdoc; PhD
My PhD research focused on biostatistical analyses of large-scale proteomics plasma in samples from pregnant women. We investigated the uptake and release of proteins by the placenta into maternal and fetal circulations, utilizing samples collected via the 4-vessel sampling method. Additionally, we examined protein trajectories throughout gestation using data from the longitudinal STORK cohort. Our primary goal was to identify potential biomarkers for preeclampsia.
 
Post doctor work:
Uptake and release of proteins from placenta between genders.
Movement of fatty acids between mother, placenta and the fetus utilizing the 4-vessel samples.
Validation of suggested biomarkers of preeclampsia
 
Github page
 

Publications 2024

Andresen IJ, Zucknick M, Degnes ML, Angst MS, Aghaeepour N, Romero R, Roland MCP, Tarca AL, Westerberg AC, Michelsen TM (2024)
Prediction of late-onset preeclampsia using plasma proteomics: a longitudinal multi-cohort study
Sci Rep, 14 (1), 30813
DOI 10.1038/s41598-024-81277-2, PubMed 39730472

Degnes ML, Westerberg AC, Andresen IJ, Henriksen T, Roland MCP, Zucknick M, Michelsen TM (2024)
Protein biomarker signatures of preeclampsia - a longitudinal 5000-multiplex proteomics study
Sci Rep, 14 (1), 23654
DOI 10.1038/s41598-024-73796-9, PubMed 39390022

Westerberg AC, Degnes ML, Andresen IJ, Roland MCP, Michelsen TM (2024)
Angiogenic and vasoactive proteins in the maternal-fetal interface in healthy pregnancies and preeclampsia
Am J Obstet Gynecol, 231 (5), 550.e1-550.e22
DOI 10.1016/j.ajog.2024.03.012, PubMed 38494070

Publications 2022

Degnes ML, Westerberg AC, Zucknick M, Powell TL, Jansson T, Henriksen T, Roland MCP, Michelsen TM (2022)
Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?
BMC Med, 20 (1), 227
DOI 10.1186/s12916-022-02415-z, PubMed 35773701

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