Publications 2024

Kildal W, Cyll K, Kalsnes J, Islam R, Julbø FM, Pradhan M, Ersvær E, Shepherd N, Vlatkovic L, OSBREAC, Tekpli X, Garred Ø, Kristensen GB, Askautrud HA, Hveem TS, Danielsen HE, OSBREAC - Oslo Breast Cancer Consortium (2024)
Deep learning for automated scoring of immunohistochemically stained tumour tissue sections - Validation across tumour types based on patient outcomes
Heliyon, 10 (13), e32529
DOI 10.1016/j.heliyon.2024.e32529, PubMed 39040241

Publications 2022

Brunetti M, Panagopoulos I, Vitelli V, Andersen K, Hveem TS, Davidson B, Eriksson AGZ, Trent PKB, Heim S, Micci F (2022)
Endometrial Carcinoma: Molecular Cytogenetics and Transcriptomic Profile
Cancers (Basel), 14 (14)
DOI 10.3390/cancers14143536, PubMed 35884597

Gorunova L, Boye K, Panagopoulos I, Berner JM, Bjerkehagen B, Hompland I, Lobmaier I, Hølmebakk T, Hveem TS, Heim S, Micci F (2022)
Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity
Oncotarget, 13, 508-517
DOI 10.18632/oncotarget.28209, PubMed 35284037

Kleppe A, Skrede OJ, De Raedt S, Hveem TS, Askautrud HA, Jacobsen JE, Church DN, Nesbakken A, Shepherd NA, Novelli M, Kerr R, Liestøl K, Kerr DJ, Danielsen HE (2022)
A clinical decision support system optimising adjuvant chemotherapy for colorectal cancers by integrating deep learning and pathological staging markers: a development and validation study
Lancet Oncol, 23 (9), 1221-1232
DOI 10.1016/S1470-2045(22)00391-6, PubMed 35964620

Publications 2021

Cyll K, Kleppe A, Kalsnes J, Vlatkovic L, Pradhan M, Kildal W, Tobin KAR, Reine TM, Wæhre H, Brennhovd B, Askautrud HA, Skaaheim Haug E, Hveem TS, Danielsen HE (2021)
PTEN and DNA Ploidy Status by Machine Learning in Prostate Cancer
Cancers (Basel), 13 (17)
DOI 10.3390/cancers13174291, PubMed 34503100

Jiang D, Hveem TS, Glaire M, Church DN, Kerr DJ, Yang L, Danielsen HE (2021)
Automated assessment of CD8⁺ T-lymphocytes and stroma fractions complement conventional staging of colorectal cancer
EBioMedicine, 71, 103547
DOI 10.1016/j.ebiom.2021.103547, PubMed 34479131

Publications 2020

Ersvaer E, Hveem TS, Vlatkovic L, Brennhovd B, Kleppe A, Tobin KAR, Pradhan M, Cyll K, Waehre H, Kerr DJ, Danielsen HE (2020)
Prognostic value of DNA ploidy and automated assessment of stroma fraction in prostate cancer
Int J Cancer, 147 (4), 1228-1234
DOI 10.1002/ijc.32832, PubMed 31846064

Skrede OJ, De Raedt S, Kleppe A, Hveem TS, Liestøl K, Maddison J, Askautrud HA, Pradhan M, Nesheim JA, Albregtsen F, Farstad IN, Domingo E, Church DN, Nesbakken A, Shepherd NA, Tomlinson I, Kerr R, Novelli M, Kerr DJ, Danielsen HE (2020)
Deep learning for prediction of colorectal cancer outcome: a discovery and validation study
Lancet, 395 (10221), 350-360
DOI 10.1016/S0140-6736(19)32998-8, PubMed 32007170

Publications 2019

Ersvær E, Kildal W, Vlatkovic L, Cyll K, Pradhan M, Kleppe A, Hveem TS, Askautrud HA, Novelli M, Wæhre H, Liestøl K, Danielsen HE (2019)
Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer
Mod Pathol, 33 (5), 905-915
DOI 10.1038/s41379-019-0418-2, PubMed 31801961

Panagopoulos I, Brunetti M, Stoltenberg M, Strandabø RAU, Staurseth J, Andersen K, Kostolomov I, Hveem TS, Lorenz S, Nystad TA, Flægstad T, Micci F, Heim S (2019)
Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype
Exp Hematol Oncol, 8, 12
DOI 10.1186/s40164-019-0136-y, PubMed 31161074

Publications 2018

Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2018)
Prognostic markers for colorectal cancer: estimating ploidy and stroma
Ann Oncol, 29 (3), 616-623
DOI 10.1093/annonc/mdx794, PubMed 29293881

Kleppe A, Albregtsen F, Vlatkovic L, Pradhan M, Nielsen B, Hveem TS, Askautrud HA, Kristensen GB, Nesbakken A, Trovik J, Wæhre H, Tomlinson I, Shepherd NA, Novelli M, Kerr DJ, Danielsen HE (2018)
Chromatin organisation and cancer prognosis: a pan-cancer study
Lancet Oncol, 19 (3), 356-369
DOI 10.1016/S1470-2045(17)30899-9, PubMed 29402700

Nielsen B, Kleppe A, Hveem TS, Pradhan M, Syvertsen RA, Nesheim JA, Kristensen GB, Trovik J, Kerr DJ, Albregtsen F, Danielsen HE (2018)
Association Between Proportion of Nuclei With High Chromatin Entropy and Prognosis in Gynecological Cancers
J Natl Cancer Inst, 110 (12), 1400-1408
DOI 10.1093/jnci/djy063, PubMed 29684152

Publications 2017

Cyll K, Ersvær E, Vlatkovic L, Pradhan M, Kildal W, Avranden Kjær M, Kleppe A, Hveem TS, Carlsen B, Gill S, Löffeler S, Haug ES, Wæhre H, Sooriakumaran P, Danielsen HE (2017)
Tumour heterogeneity poses a significant challenge to cancer biomarker research
Br J Cancer, 117 (3), 367-375
DOI 10.1038/bjc.2017.171, PubMed 28618431

Publications 2016

Hveem TS, Kleppe A, Vlatkovic L, Ersvær E, Wæhre H, Nielsen B, Kjær MA, Pradhan M, Syvertsen RA, Nesheim JA, Liestøl K, Albregtsen F, Danielsen HE (2016)
Chromatin changes predict recurrence after radical prostatectomy
Br J Cancer, 114 (11), 1243-50
DOI 10.1038/bjc.2016.96, PubMed 27124335

Hveem TS, Njølstad TS, Nielsen B, Syvertsen RA, Nesheim JA, Kjæreng ML, Kildal W, Pradhan M, Marcickiewicz J, Tingulstad S, Staff AC, Haugland HK, Eraker R, Oddenes K, Rokne JA, Tjugum J, Lode MS, Amant F, Werner HM, Bjørge L, Albregtsen F, Liestøl K, Salvesen HB, Trovik J, Danielsen HE et al. (2016)
Changes in Chromatin Structure in Curettage Specimens Identifies High-Risk Patients in Endometrial Cancer
Cancer Epidemiol Biomarkers Prev, 26 (1), 61-67
DOI 10.1158/1055-9965.EPI-16-0215, PubMed 27587790

Silva MP, Barros-Silva JD, Ersvær E, Kildal W, Hveem TS, Pradhan M, Vieira J, Teixeira MR, Danielsen HE (2016)
Cancer Prognosis Defined by the Combined Analysis of 8q, PTEN and ERG
Transl Oncol, 9 (6), 575-582
DOI 10.1016/j.tranon.2016.08.005, PubMed 27916292

Publications 2015

Blaker YN, Brodtkorb M, Maddison J, Hveem TS, Nesheim JA, Mohn HM, Kolstad A, Geisler CH, Liestøl K, Smeland EB, Holte H, Delabie J, Danielsen H (2015)
Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma
Histopathology, 67 (1), 62-9
DOI 10.1111/his.12624, PubMed 25431344

Njølstad TS, Trovik J, Hveem TS, Kjæreng ML, Kildal W, Pradhan M, Marcickiewicz J, Tingulstad S, Staff AC, Haugland HK, Eraker R, Oddenes K, Rokne JA, Tjugum J, Lode MS, ENITEC Network/MoMaTEC Study Group, Amant F, Werner HM, Salvesen HB, Danielsen HE (2015)
DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer
Br J Cancer, 112 (10), 1656-64
DOI 10.1038/bjc.2015.123, PubMed 25897678

Publications 2014

Hveem TS, Merok MA, Pretorius ME, Novelli M, Bævre MS, Sjo OH, Clinch N, Liestøl K, Svindland A, Lothe RA, Nesbakken A, Danielsen HE (2014)
Prognostic impact of genomic instability in colorectal cancer
Br J Cancer, 110 (8), 2159-64
DOI 10.1038/bjc.2014.133, PubMed 24642618

Nielsen B, Hveem TS, Kildal W, Abeler VM, Kristensen GB, Albregtsen F, Danielsen HE (2014)
Entropy-based adaptive nuclear texture features are independent prognostic markers in a total population of uterine sarcomas
Cytometry A, 87 (4), 315-25
DOI 10.1002/cyto.a.22601, PubMed 25483227

Publications 2013

Domingo E, Ramamoorthy R, Oukrif D, Rosmarin D, Presz M, Wang H, Pulker H, Lockstone H, Hveem T, Cranston T, Danielsen H, Novelli M, Davidson B, Xu ZZ, Molloy P, Johnstone E, Holmes C, Midgley R, Kerr D, Sieber O, Tomlinson I (2013)
Use of multivariate analysis to suggest a new molecular classification of colorectal cancer
J Pathol, 229 (3), 441-8
DOI 10.1002/path.4139, PubMed 23165447

Publications 2011

Dunn JM, Hveem T, Pretorius M, Oukrif D, Nielsen B, Albregtsen F, Lovat LB, Novelli MR, Danielsen HE (2011)
Comparison of nuclear texture analysis and image cytometric DNA analysis for the assessment of dysplasia in Barrett's oesophagus
Br J Cancer, 105 (8), 1218-23
DOI 10.1038/bjc.2011.353, PubMed 21934680