Kushtrim Kryeziu

  • Project group leader; Researcher; PhD
  • +47 22781737

ORCID: 0000-0002-6633-4818

Biosketch

Molecular cell biologist with expertise in establishing patient-derived tumor organoid (PDO) models and executing mechanistic and functional studies integrated with genomics. My research focuses on understanding tumor heterogeneity and identifying personalized cancer therapies to improve patient outcomes.

Current Position

  • Project group leader in functional precision oncology, Oslo University Hospital (OUH), Department of Molecular Oncology, Norway

Education

  • 2016: PhD in Malignant Diseases: Medical University of Vienna, Austria
  • 2012: Mag.rer.nat in Genetics and Microbiology, University of Vienna, Austria

Research interests

  • Patient-derived tumor organoids (PDOs): Developing and characterizing these models to understand cancer biology and drug response.
  • Personalized cancer therapy: Using PDOs to predict individual patients´ response to specific treatments.
  • PARP inhibitor efficacy in colorectal cancer: Investigating and improving the effectiveness of this drug class in treating colorectal cancer.
  • Mechanisms of drug resistance: Understanding how tumors develop resistance to treatment, including both intrinsic and acquired mechanisms.

Fellowships and Awards

  • 2023: Early Career Award, Oslo University Hospital
  • 2022: Researcher of the Year, Institute for Cancer Research and the Norwegian Radium Hospital Legacy, OUH
  • 2022: BBA - Reviews on Cancer, selected journal front cover for the 2022 calendar year
  • 2016: Marie SkÅ‚odowska-Curie fellowship for developing talents (Scientia Fellows), European Commission and the University of Oslo

Funding

  • 2024-2027: Unleashing the potential of PARP inhibitors against colorectal cancer. South-Eastern Norway Regional Health Authorities
  • 2024: Co-culture assay for modeling the activity of immune checkpoint inhibitors in colorectal cancer, Familien Blix Fond
  • 2016-2018: Marie SkÅ‚odowska-Curie mobility grant, European Commission and the University of Oslo

Invited presentations at national and international scientific meetings

  • 2024: Norway Life Science 2024 (Microphysiological systems, organoids and organ on a chip technology, NOR_MPS symposium), Oslo. “Heterogeneity of tumor organoids derived from patients with colorectal cancer liver metastases”
  • 2023: EACR-OECI Molecular Pathology Approach to Cancer, Bergamo, Italy. Oral presentation: “Immunohistopathology of organoids derived from multifocal colorectal cancer liver metastases“.
  • 2022: The 7th international Conference on Cancer Research & Drug Development, Baltimore, USA. “Ex vivo treatment modeling of metastatic colorectal cancers in the context of tumor heterogeneity“.
  • 2018: American Association for Cancer Research, Special Conference on Intestinal stem cells and colon cancer: Biology to Therapy, Washington, DC, USA. Oral presentation: “Ex vivo pharmacogenomic heterogeneity of colorectal liver metastases”.

Public engagement

Complete publication list

 

Publications 2021

Kryeziu K, Moosavi SH, Bergsland CH, Guren MG, Eide PW, Totland MZ, Lassen K, Abildgaard A, Nesbakken A, Sveen A, Lothe RA (2021)
Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases
J. Transl. Med., 19 (1), 384
DOI 10.1186/s12967-021-03062-3

Sveen A, Johannessen B, Eilertsen IA, Rosok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjornbeth BA, Skotheim RI, Nesbakken A, Lothe RA (2021)
The expressed mutational landscape of microsatellite stable colorectal cancers
Genome Med., 13 (1), 142
DOI 10.1186/s13073-021-00955-2

Publications 2020

Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Rosok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjornbeth BA, Sveen A, Lothe RA (2020)
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity
Clin. Cancer Res., 26 (15), 4107-4119
DOI 10.1158/1078-0432.CCR-19-3637

Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A (2020)
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
EBioMedicine, 59, 102923
DOI 10.1016/j.ebiom.2020.102923

Publications 2019

Kryeziu K, Bruun J, Guren TK, Sveen A, Lothe RA (2019)
Combination therapies with HSP90 inhibitors against colorectal cancer
Biochim. Biophys. Acta-Rev. Cancer, 1871 (2), 240-247
DOI 10.1016/j.bbcan.2019.01.002

Publications 2018

Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumagi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2018)
Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
Clin. Cancer Res., 24 (4), 794-806
DOI 10.1158/1078-0432.CCR-17-1234

Publications 2017

Traxl A, Beikbaghban T, Wanek T, Kryeziu K, Pirker C, Mairinger S, Stanek J, Filip T, Sauberer M, Kuntner C, Berger W, Langer O (2017)
[C-11]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice
Nucl. Med. Biol., 52, 7-15
DOI 10.1016/j.nucmedbio.2017.05.007

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