Publications from OUS - Dept. of Microbiology, Klungland - Lab for dynamic gene regulation
167 publications found
Publications 2024
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The balance between intrinsic and ecological fitness defines new regimes in eco-evolutionary population dynamics
bioRxiv
DOI 10.1101/2023.03.15.532871, PubMed 36993598 -
Epigenetic aging of human blood cells is influenced by the age of the host body
Aging Cell, 23 (5), e14112
DOI 10.1111/acel.14112, PubMed 38439206
Publications 2023
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Optimized synthesis of polyacrylic acid-coated magnetic nanoparticles for high-efficiency DNA isolation and size selection
RSC Adv, 13 (42), 29109-29120
DOI 10.1039/d3ra04687g, PubMed 37800135 -
The Role of Non-Coding RNAs in Epigenetic Dysregulation in Glioblastoma Development
Int J Mol Sci, 24 (22)
DOI 10.3390/ijms242216320, PubMed 38003512 -
Single-cell m6A mapping in vivo using picoMeRIP-seq
Nat Biotechnol, 42 (4), 591-596
DOI 10.1038/s41587-023-01831-7, PubMed 37349523 -
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA
Sci Rep, 13 (1), 20836
DOI 10.1038/s41598-023-46868-5, PubMed 38012172 -
Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Nat Commun, 14 (1), 1767
DOI 10.1038/s41467-023-37488-8, PubMed 36997540 -
The RNA m6A landscape of mouse oocytes and preimplantation embryos
Nat Struct Mol Biol, 30 (5), 703-709
DOI 10.1038/s41594-023-00969-x, PubMed 37081317
Publications 2022
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The use of public transport and contraction of SARS-CoV-2 in a large prospective cohort in Norway
BMC Infect Dis, 22 (1), 252
DOI 10.1186/s12879-022-07233-5, PubMed 35287611 -
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
Sci Adv, 8 (11), eabf8627
DOI 10.1126/sciadv.abf8627, PubMed 35302840 -
Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease
Clin Epigenetics, 14 (1), 128
DOI 10.1186/s13148-022-01350-3, PubMed 36242045 -
ALKBH5 regulates somatic cell reprogramming in a phase-specific manner
J Cell Sci, 135 (11)
DOI 10.1242/jcs.259824, PubMed 35552718 -
Studies on Protein-RNA:DNA Hybrid Interactions by Microscale Thermophoresis (MST)
Methods Mol Biol, 2528, 239-251
DOI 10.1007/978-1-0716-2477-7_15, PubMed 35704195 -
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
Proc Natl Acad Sci U S A, 119 (32), e2201328119
DOI 10.1073/pnas.2201328119, PubMed 35914175 -
CompAIRR: ultra-fast comparison of adaptive immune receptor repertoires by exact and approximate sequence matching
Bioinformatics, 38 (17), 4230-4232
DOI 10.1093/bioinformatics/btac505, PubMed 35852318 -
MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions
Genome Biol, 23 (1), 247
DOI 10.1186/s13059-022-02815-7, PubMed 36451166 -
Characterization of novel small non-coding RNAs and their modifications in bladder cancer using an updated small RNA-seq workflow
Front Mol Biosci, 9, 887686
DOI 10.3389/fmolb.2022.887686, PubMed 35923465 -
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer
Nat Commun, 13 (1), 2165
DOI 10.1038/s41467-022-29790-8, PubMed 35444240 -
RNA m6A modifications in mammalian gametogenesis and pregnancy
Reproduction, 165 (1), R1-R8
DOI 10.1530/REP-22-0112, PubMed 36194446 -
Waves of sumoylation support transcription dynamics during adipocyte differentiation
Nucleic Acids Res, 50 (3), 1351-1369
DOI 10.1093/nar/gkac027, PubMed 35100417
Publications 2021
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Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification
Front Immunol, 12, 762032
DOI 10.3389/fimmu.2021.762032, PubMed 35003074 -
Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells
Scand J Immunol, 94 (1), e13050
DOI 10.1111/sji.13050, PubMed 34643957 -
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879 -
Evaluation of diagnostic factors used to refer children with constipation for rectal biopsies
Int J Colorectal Dis, 37 (3), 597-605
DOI 10.1007/s00384-021-04069-4, PubMed 34882271 -
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483 -
N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells
Proc Natl Acad Sci U S A, 118 (51)
DOI 10.1073/pnas.2105192118, PubMed 34921114 -
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
BMC Cancer, 21 (1), 930
DOI 10.1186/s12885-021-08640-8, PubMed 34407780 -
Swarm v3: towards tera-scale amplicon clustering
Bioinformatics, 38 (1), 267-269
DOI 10.1093/bioinformatics/btab493, PubMed 34244702 -
Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
Cell Rep, 35 (7), 109154
DOI 10.1016/j.celrep.2021.109154, PubMed 34010660 -
Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein
Front Microbiol, 12, 608839
DOI 10.3389/fmicb.2021.608839, PubMed 34276575 -
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Nat Cell Biol, 23 (7), 684-691
DOI 10.1038/s41556-021-00709-7, PubMed 34253897
Publications 2020
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Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390 -
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Comput Struct Biotechnol J, 18, 2877-2889
DOI 10.1016/j.csbj.2020.09.038, PubMed 33163148 -
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
Front Microbiol, 11, 263
DOI 10.3389/fmicb.2020.00263, PubMed 32158436 -
NucBreak: location of structural errors in a genome assembly by using paired-end Illumina reads
BMC Bioinformatics, 21 (1), 66
DOI 10.1186/s12859-020-3414-0, PubMed 32085722 -
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667 -
Modifications and interactions at the R-loop
DNA Repair (Amst), 96, 102958
DOI 10.1016/j.dnarep.2020.102958, PubMed 32961406 -
Analysis of epigenetic aging in vivo and in vitro: Factors controlling the speed and direction
Exp Biol Med (Maywood), 245 (17), 1543-1551
DOI 10.1177/1535370220947015, PubMed 32762265 -
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
Nat Cell Biol, 22 (4), 380-388
DOI 10.1038/s41556-020-0494-z, PubMed 32231309 -
The DIRAC code for relativistic molecular calculations
J Chem Phys, 152 (20), 204104
DOI 10.1063/5.0004844, PubMed 32486677 -
Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function
Nucleic Acids Res, 48 (7), 3962-3974
DOI 10.1093/nar/gkaa117, PubMed 32095813 -
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476 -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Sci Adv, 6 (37)
DOI 10.1126/sciadv.abc0367, PubMed 32917713
Publications 2019
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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Nat Genet, 52 (1), 48-55
DOI 10.1038/s41588-019-0549-x, PubMed 31844323 -
Excision of uracil from DNA by hSMUG1 includes strand incision and processing
Nucleic Acids Res, 47 (2), 779-793
DOI 10.1093/nar/gky1184, PubMed 30496516 -
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097 -
Going low to reach high: Small-scale ChIP-seq maps new terrain
Wiley Interdiscip Rev Syst Biol Med, 12 (1), e1465
DOI 10.1002/wsbm.1465, PubMed 31478357 -
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
Clin Epigenetics, 11 (1), 135
DOI 10.1186/s13148-019-0718-x, PubMed 31519213 -
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533 -
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
Sci Rep, 9 (1), 13249
DOI 10.1038/s41598-019-49550-x, PubMed 31519943 -
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131 -
Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein
Proteins, 88 (3), 440-448
DOI 10.1002/prot.25821, PubMed 31587363 -
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Aging Cell, 18 (2), e12897
DOI 10.1111/acel.12897, PubMed 30712319 -
Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
Hum Mol Genet, 28 (18), 3043-3052
DOI 10.1093/hmg/ddz114, PubMed 31131398 -
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
DOI 10.1007/s12035-019-01777-5, PubMed 31654318
Publications 2018
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Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
Philos Trans R Soc Lond B Biol Sci, 373 (1748)
DOI 10.1098/rstb.2017.0337, PubMed 29685966 -
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Sci Rep, 8 (1), 9817
DOI 10.1038/s41598-018-27985-y, PubMed 29959348 -
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Dis Model Mech, 11 (10)
DOI 10.1242/dmm.035949, PubMed 30254085 -
Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity
Mol Cancer, 17 (1), 171
DOI 10.1186/s12943-018-0918-6, PubMed 30526604 -
How low can you go? Pushing the limits of low-input ChIP-seq
Brief Funct Genomics, 17 (2), 89-95
DOI 10.1093/bfgp/elx037, PubMed 29087438 -
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422 -
Positioning Europe for the EPITRANSCRIPTOMICS challenge
RNA Biol, 15 (6), 829-831
DOI 10.1080/15476286.2018.1460996, PubMed 29671387 -
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
Genome Biol, 19 (1), 69
DOI 10.1186/s13059-018-1436-y, PubMed 29855337 -
RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum
Genome Biol, 19 (1), 68
DOI 10.1186/s13059-018-1435-z, PubMed 29855379 -
Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring
Sci Rep, 8 (1), 3055
DOI 10.1038/s41598-018-21211-5, PubMed 29445184 -
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
Mol Cell, 71 (6), 973-985.e5
DOI 10.1016/j.molcel.2018.08.011, PubMed 30197295 -
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445
Publications 2017
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TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404 -
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage
Cell Death Dis, 8 (7), e2947
DOI 10.1038/cddis.2017.343, PubMed 28726787 -
Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia
Mol Med Rep, 15 (4), 1513-1526
DOI 10.3892/mmr.2017.6185, PubMed 28259955 -
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766 -
Loss of prion protein induces a primed state of type I interferon-responsive genes
PLoS One, 12 (6), e0179881
DOI 10.1371/journal.pone.0179881, PubMed 28651013 -
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262 -
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634 -
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564 -
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
DNA Repair (Amst), 58, 13-20
DOI 10.1016/j.dnarep.2017.08.005, PubMed 28843610 -
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells
Proc Natl Acad Sci U S A, 115 (2), E325-E333
DOI 10.1073/pnas.1717794115, PubMed 29279410 -
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
PLoS One, 12 (3), e0168182
DOI 10.1371/journal.pone.0168182, PubMed 28288181
Publications 2016
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ALKBHs-facilitated RNA modifications and de-modifications
DNA Repair (Amst), 44, 87-91
DOI 10.1016/j.dnarep.2016.05.026, PubMed 27237585 -
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377 -
Reversible RNA modifications in meiosis and pluripotency
Nat Methods, 14 (1), 18-22
DOI 10.1038/nmeth.4111, PubMed 28032624 -
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
Free Radic Biol Med, 107, 62-68
DOI 10.1016/j.freeradbiomed.2016.11.038, PubMed 27890639 -
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
Fertil Steril, 105 (5), 1170-1179.e5
DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768 -
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Neurobiol Aging, 48, 34-47
DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119 -
Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease
Mol Brain, 9 (1), 61
DOI 10.1186/s13041-016-0237-z, PubMed 27234294 -
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell, 167 (3), 816-828.e16
DOI 10.1016/j.cell.2016.09.038, PubMed 27745969 -
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell, 167 (7), 1897
DOI 10.1016/j.cell.2016.11.045, PubMed 27984735 -
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
PLoS Curr, 8
DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492 -
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells
Cell Physiol Biochem, 38 (1), 173-84
DOI 10.1159/000438619, PubMed 26765775 -
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
Biochem Biophys Rep, 6, 9-15
DOI 10.1016/j.bbrep.2016.02.011, PubMed 28955859 -
Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
Sci Rep, 6, 34535
DOI 10.1038/srep34535, PubMed 27731423 -
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783 -
Effect of Hydroxymethylcytosine on the Structure and Stability of Holliday Junctions
Biochemistry, 55 (41), 5781-5789
DOI 10.1021/acs.biochem.6b00801, PubMed 27653243 -
Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation
Mol Cell Neurosci, 77, 47-52
DOI 10.1016/j.mcn.2016.10.004, PubMed 27751903 -
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
Nat Commun, 7, 10806
DOI 10.1038/ncomms10806, PubMed 26932196
Publications 2015
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Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335 -
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
DOI 10.1101/gr.185793.114, PubMed 25800674 -
Micro chromatin immunoprecipitation (μChIP) from early mammalian embryos
Methods Mol Biol, 1222, 227-45
DOI 10.1007/978-1-4939-1594-1_17, PubMed 25287350 -
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
PLoS One, 10 (11), e0141472
DOI 10.1371/journal.pone.0141472, PubMed 26544960 -
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation
Genes Dev, 29 (19), 2037-53
DOI 10.1101/gad.269415.115, PubMed 26404942 -
Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015
Genomics Proteomics Bioinformatics, 14 (3), 122-125
DOI 10.1016/j.gpb.2015.11.001, PubMed 26689322 -
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793 -
Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015
Sci China Life Sci, 59 (1), 89-92
DOI 10.1007/s11427-015-4983-4, PubMed 26676642 -
Non-homologous functions of the AlkB homologs
J Mol Cell Biol, 7 (6), 494-504
DOI 10.1093/jmcb/mjv029, PubMed 26003568
Publications 2014
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Dynamic RNA modifications in disease
Curr Opin Genet Dev, 26, 47-52
DOI 10.1016/j.gde.2014.05.006, PubMed 25005745 -
ALKBH4 depletion in mice leads to spermatogenic defects
PLoS One, 9 (8), e105113
DOI 10.1371/journal.pone.0105113, PubMed 25153837 -
DNA metabolism: bases of DNA repair and regulation
Nat Chem Biol, 10 (7), 487-8
DOI 10.1038/nchembio.1553, PubMed 24937064 -
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
Nucleic Acids Res, 42 (21), 13280-93
DOI 10.1093/nar/gku1032, PubMed 25355512 -
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
PLoS One, 9 (6), e98729
DOI 10.1371/journal.pone.0098729, PubMed 24914785
Publications 2013
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Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells
Stem Cell Res, 11 (3), 1264-71
DOI 10.1016/j.scr.2013.08.010, PubMed 24041806 -
DNA repair mechanisms in Huntington's disease
Mol Neurobiol, 47 (3), 1093-102
DOI 10.1007/s12035-013-8409-7, PubMed 23361256 -
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
Nat Commun, 4, 1832
DOI 10.1038/ncomms2863, PubMed 23673617 -
Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation
Cancer Res, 73 (20), 6323-33
DOI 10.1158/0008-5472.CAN-12-4660, PubMed 23943798 -
Deletion of mouse Alkbh7 leads to obesity
J Mol Cell Biol, 5 (3), 194-203
DOI 10.1093/jmcb/mjt012, PubMed 23572141 -
Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases
RNA Biol, 10 (6), 915-8
DOI 10.4161/rna.24711, PubMed 23619745
Publications 2012
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DNA repair is indispensable for survival after acute inflammation
J Clin Invest, 122 (7), 2680-9
DOI 10.1172/JCI63338, PubMed 22684101 -
Kinetics of endogenous mouse FEN1 in base excision repair
Nucleic Acids Res, 40 (18), 9044-59
DOI 10.1093/nar/gks673, PubMed 22810208 -
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
Hum Mol Genet, 21 (22), 4939-47
DOI 10.1093/hmg/dds337, PubMed 22914735
Publications 2011
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Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation
BioData Min, 4 (1), 15
DOI 10.1186/1756-0381-4-15, PubMed 21672238 -
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair
J Bacteriol, 193 (17), 4495-508
DOI 10.1128/JB.00233-11, PubMed 21665970 -
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
Nucleic Acids Res, 39 (8), e55
DOI 10.1093/nar/gkr051, PubMed 21300643 -
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
Biochem Biophys Res Commun, 411 (1), 40-3
DOI 10.1016/j.bbrc.2011.06.077, PubMed 21703242 -
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction
Brain, 134 (Pt 11), 3369-83
DOI 10.1093/brain/awr250, PubMed 21964919
Publications 2010
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The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement
J Bacteriol, 192 (21), 5755-66
DOI 10.1128/JB.00135-10, PubMed 20453094 -
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding
Mol Cell Biol, 30 (7), 1814-27
DOI 10.1128/MCB.01602-09, PubMed 20123966
Publications 2009
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DNA repair in mammalian cells: Base excision repair: the long and short of it
Cell Mol Life Sci, 66 (6), 981-93
DOI 10.1007/s00018-009-8736-z, PubMed 19153658
Publications 2008
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Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells
Endocrinology, 149 (8), 3799-808
DOI 10.1210/en.2008-0117, PubMed 18467441 -
HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea
J Bacteriol, 191 (4), 1191-9
DOI 10.1128/JB.01013-08, PubMed 19060138 -
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants
Cancer Res, 68 (12), 4571-9
DOI 10.1158/0008-5472.CAN-08-0168, PubMed 18559501
Publications 2007
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[Nobel Prize for genetic modification]
Tidsskr Nor Laegeforen, 127 (23), 3054
PubMed 18049491 -
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Nature, 447 (7143), 447-52
DOI 10.1038/nature05778, PubMed 17450122 -
Organ and cell specificity of base excision repair mutants in mice
Mutat Res, 614 (1-2), 56-68
DOI 10.1016/j.mrfmmm.2006.01.023, PubMed 16765995 -
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA
EMBO J, 26 (8), 2206-17
DOI 10.1038/sj.emboj.7601662, PubMed 17396151 -
Genome instability and DNA damage accumulation in gene-targeted mice
Neuroscience, 145 (4), 1309-17
DOI 10.1016/j.neuroscience.2006.10.059, PubMed 17218062 -
Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
FEMS Yeast Res, 7 (6), 848-59
DOI 10.1111/j.1567-1364.2007.00248.x, PubMed 17506834 -
Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
Free Radic Res, 41 (2), 172-81
DOI 10.1080/10715760601024122, PubMed 17364943 -
Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice
Oncogene, 26 (27), 4044-8
DOI 10.1038/sj.onc.1210167, PubMed 17213818
Publications 2006
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Repair of methyl lesions in DNA and RNA by oxidative demethylation
Neuroscience, 145 (4), 1222-32
DOI 10.1016/j.neuroscience.2006.11.018, PubMed 17175108 -
Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli
Nucleic Acids Res, 34 (20), 5915-22
DOI 10.1093/nar/gkl750, PubMed 17065468 -
CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells
Nat Biotechnol, 24 (3), 351-7
DOI 10.1038/nbt1197, PubMed 16501577 -
A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome
Neuroscience, 145 (4), 1397-406
DOI 10.1016/j.neuroscience.2006.09.025, PubMed 17084038 -
Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
Oncogene, 25 (17), 2425-32
DOI 10.1038/sj.onc.1209284, PubMed 16369492 -
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
EMBO J, 25 (10), 2189-98
DOI 10.1038/sj.emboj.7601109, PubMed 16642038 -
Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
Helicobacter, 11 (5), 494-505
DOI 10.1111/j.1523-5378.2006.00442.x, PubMed 16961812
Publications 2005
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Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo
Nucleic Acids Res, 33 (15), 4704-10
DOI 10.1093/nar/gki785, PubMed 16113241 -
Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice
Int J Biochem Cell Biol, 37 (6), 1331-6
DOI 10.1016/j.biocel.2005.01.001, PubMed 15778095
Publications 2004
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Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species
Free Radic Biol Med, 37 (9), 1449-54
DOI 10.1016/j.freeradbiomed.2004.07.014, PubMed 15454284 -
Transcription activities at 8-oxoG lesions in DNA
DNA Repair (Amst), 3 (11), 1457-68
DOI 10.1016/j.dnarep.2004.06.008, PubMed 15380101 -
Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine
Free Radic Res, 38 (11), 1201-5
DOI 10.1080/10715760400017350, PubMed 15621697
Publications 2003
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Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
DNA Repair (Amst), 2 (6), 707-18
DOI 10.1016/s1568-7864(03)00041-7, PubMed 12767349 -
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
Mol Cell Biol, 23 (15), 5346-53
DOI 10.1128/MCB.23.15.5346-5353.2003, PubMed 12861020 -
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
DOI 10.1093/nar/gkg472, PubMed 12853604 -
Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
DNA Repair (Amst), 2 (7), 809-17
DOI 10.1016/s1568-7864(03)00065-x, PubMed 12826281 -
Better late than never for repair of miscoding lesions within a transcribed template
Mol Cell, 12 (4), 799-800
DOI 10.1016/s1097-2765(03)00403-9, PubMed 14580331
Publications 2002
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Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus
Biochemistry, 41 (42), 12697-705
DOI 10.1021/bi020334w, PubMed 12379112 -
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
Oncogene, 21 (54), 8232-9
DOI 10.1038/sj.onc.1206027, PubMed 12447686
Publications 2001
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Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice
Cancer Res, 61 (14), 5378-81
PubMed 11454679 -
[Life without DNA repair]
Tidsskr Nor Laegeforen, 121 (1), 41-9
PubMed 12013614 -
5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism
Toxicol Lett, 119 (1), 71-8
DOI 10.1016/s0378-4274(00)00308-8, PubMed 11275423 -
Excision of uracil from DNA by the hyperthermophilic Afung protein is dependent on the opposite base and stimulated by heat-induced transition to a more open structure
Mutat Res, 487 (3-4), 173-90
DOI 10.1016/s0921-8777(01)00115-x, PubMed 11738943
Publications 2000
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Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences
Proc Natl Acad Sci U S A, 97 (15), 8397-402
DOI 10.1073/pnas.140137297, PubMed 10890888 -
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028
Publications 1997
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Repair and processing events at DNA ends
Ciba Found Symp, 211, 198-205; discussion 205-8
DOI 10.1002/9780470515433.ch13, PubMed 9524759 -
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
Proc Natl Acad Sci U S A, 94 (15), 8016-20
DOI 10.1073/pnas.94.15.8016, PubMed 9223306
Publications 1996
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Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein
EMBO J, 15 (23), 6662-70
PubMed 8978692
Publications 1995
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Purification and properties of the alkylation repair DNA glycosylase encoded the MAG gene from Saccharomyces cerevisiae
Biochemistry, 34 (14), 4577-82
DOI 10.1021/bi00014a010, PubMed 7718559 -
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
Trends Biochem Sci, 20 (10), 405-11
DOI 10.1016/s0968-0004(00)89089-1, PubMed 8533153