Publications published since 2003 from OUS - Dept. of Microbiology, Lab for genome repair and regulation (Klungland)

121 publications found

Publications 2019

  1. Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S (2019)
    Excision of uracil from DNA by hSMUG1 includes strand incision and processing
    Nucleic Acids Res, 47 (2), 779-793
    DOI 10.1093/nar/gky1184, PubMed 30496516
  2. Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S (2019)
    Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
    Aging Cell, 18 (2), e12897
    DOI 10.1111/acel.12897, PubMed 30712319

Publications 2018

  1. Alexeeva M, Guragain P, Tesfahun AN, Tomkuvienė M, Arshad A, Gerasimaitė R, Rukšėnaitė A, Urbanavičiūtė G, Bjørås M, Laerdahl JK, Klungland A, Klimašauskas S, Bjelland S (2018)
    Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
    Philos Trans R Soc Lond B Biol Sci, 373 (1748)
    DOI 10.1098/rstb.2017.0337, PubMed 29685966
  2. Askeland G, Dosoudilova Z, Rodinova M, Klempir J, Liskova I, Kuśnierczyk A, Bjørås M, Nesse G, Klungland A, Hansikova H, Eide L (2018)
    Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
    Sci Rep, 8 (1), 9817
    DOI 10.1038/s41598-018-27985-y, PubMed 29959348
  3. Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L (2018)
    A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
    Dis Model Mech, 11 (10)
    DOI 10.1242/dmm.035949, PubMed 30254085
  4. Bagger SO, Hopkinson BM, Pandey DP, Bak M, Brydholm AV, Villadsen R, Helin K, Rønnov-Jessen L, Petersen OW, Kim J (2018)
    Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity
    Mol Cancer, 17 (1), 171
    DOI 10.1186/s12943-018-0918-6, PubMed 30526604
  5. Dahl JA, Gilfillan GD (2018)
    How low can you go? Pushing the limits of low-input ChIP-seq
    Brief Funct Genomics, 17 (2), 89-95
    DOI 10.1093/bfgp/elx037, PubMed 29087438
  6. Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
    STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
    Cell Calcium, 76, 87-100
    DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422
  7. Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I et al. (2018)
    Positioning Europe for the EPITRANSCRIPTOMICS challenge
    RNA Biol, 15 (6), 829-831
    DOI 10.1080/15476286.2018.1460996, PubMed 29671387
  8. Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A (2018)
    Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
    Genome Biol, 19 (1), 69
    DOI 10.1186/s13059-018-1436-y, PubMed 29855337
  9. Ma C, Chang M, Lv H, Zhang ZW, Zhang W, He X, Wu G, Zhao S, Zhang Y, Wang D, Teng X, Liu C, Li Q, Klungland A, Niu Y, Song S, Tong WM (2018)
    RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum
    Genome Biol, 19 (1), 68
    DOI 10.1186/s13059-018-1435-z, PubMed 29855379
  10. Skjærven KH, Jakt LM, Fernandes JMO, Dahl JA, Adam AC, Klughammer J, Bock C, Espe M (2018)
    Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring
    Sci Rep, 8 (1), 3055
    DOI 10.1038/s41598-018-21211-5, PubMed 29445184
  11. Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A, Jia G, Chen J, He C (2018)
    Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
    Mol Cell, 71 (6), 973-985.e5
    DOI 10.1016/j.molcel.2018.08.011, PubMed 30197295

Publications 2017

  1. Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
    TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
    Proc Natl Acad Sci U S A, 114 (5), 1039-1044
    DOI 10.1073/pnas.1615093114, PubMed 28096404
  2. Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D (2017)
    ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage
    Cell Death Dis, 8 (7), e2947
    DOI 10.1038/cddis.2017.343, PubMed 28726787
  3. Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A (2017)
    Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia
    Mol Med Rep, 15 (4), 1513-1526
    DOI 10.3892/mmr.2017.6185, PubMed 28259955
  4. Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
    Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
    Cell Discov, 3, 17013
    DOI 10.1038/celldisc.2017.13, PubMed 28529766
  5. Malachin G, Reiten MR, Salvesen Ø, Aanes H, Kamstra JH, Skovgaard K, Heegaard PMH, Ersdal C, Espenes A, Tranulis MA, Bakkebø MK (2017)
    Loss of prion protein induces a primed state of type I interferon-responsive genes
    PLoS One, 12 (6), e0179881
    DOI 10.1371/journal.pone.0179881, PubMed 28651013
  6. Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
    NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
    Cell Rep, 18 (1), 82-92
    DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
  7. Pawar T, Bjørås M, Klungland A, Eide L (2017)
    Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
    Mitochondrion, 40, 16-28
    DOI 10.1016/j.mito.2017.09.002, PubMed 28893634
  8. Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
    No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
    Sci Rep, 7 (1), 4384
    DOI 10.1038/s41598-017-04472-4, PubMed 28663564
  9. Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B (2017)
    Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
    DNA Repair (Amst), 58, 13-20
    DOI 10.1016/j.dnarep.2017.08.005, PubMed 28843610
  10. Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W (2017)
    ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells
    Proc Natl Acad Sci U S A, 115 (2), E325-E333
    DOI 10.1073/pnas.1717794115, PubMed 29279410
  11. Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A (2017)
    Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
    PLoS One, 12 (3), e0168182
    DOI 10.1371/journal.pone.0168182, PubMed 28288181

Publications 2016

  1. A Alemu E, He C, Klungland A (2016)
    ALKBHs-facilitated RNA modifications and de-modifications
    DNA Repair (Amst), 44, 87-91
    DOI 10.1016/j.dnarep.2016.05.026, PubMed 27237585
  2. Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A (2016)
    Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
    Nature, 537 (7621), 548-552
    DOI 10.1038/nature19360, PubMed 27626377
  3. Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A (2016)
    Reversible RNA modifications in meiosis and pluripotency
    Nat Methods, 14 (1), 18-22
    DOI 10.1038/nmeth.4111, PubMed 28032624
  4. Klungland A, Robertson AB (2016)
    Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
    Free Radic Biol Med, 107, 62-68
    DOI 10.1016/j.freeradbiomed.2016.11.038, PubMed 27890639
  5. Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P (2016)
    Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
    Fertil Steril, 105 (5), 1170-1179.e5
    DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768
  6. Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH (2016)
    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
    Neurobiol Aging, 48, 34-47
    DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119
  7. Lillenes MS, Rabano A, Støen M, Riaz T, Misaghian D, Møllersen L, Esbensen Y, Günther CC, Selnes P, Stenset VT, Fladby T, Tønjum T (2016)
    Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease
    Mol Brain, 9 (1), 61
    DOI 10.1186/s13041-016-0237-z, PubMed 27234294
  8. Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
    ALKBH1-Mediated tRNA Demethylation Regulates Translation
    Cell, 167 (3), 816-828.e16
    DOI 10.1016/j.cell.2016.09.038, PubMed 27745969
  9. Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
    ALKBH1-Mediated tRNA Demethylation Regulates Translation
    Cell, 167 (7), 1897
    DOI 10.1016/j.cell.2016.11.045, PubMed 27984735
  10. Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L (2016)
    Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
    PLoS Curr, 8
    DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492
  11. Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E (2016)
    Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells
    Cell Physiol Biochem, 38 (1), 173-84
    DOI 10.1159/000438619, PubMed 26765775
  12. Rasmussen EMK, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA (2016)
    DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
    Biochem Biophys Rep, 6, 9-15
    DOI 10.1016/j.bbrep.2016.02.011, PubMed 28955859
  13. Skjærven KH, Jakt LM, Dahl JA, Espe M, Aanes H, Hamre K, Fernandes JM (2016)
    Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
    Sci Rep, 6, 34535
    DOI 10.1038/srep34535, PubMed 27731423
  14. Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
    Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
    Epigenetics Chromatin, 9, 21
    DOI 10.1186/s13072-016-0070-8, PubMed 27252783
  15. Vander Zanden CM, Rowe RK, Broad AJ, Robertson AB, Ho PS (2016)
    Effect of Hydroxymethylcytosine on the Structure and Stability of Holliday Junctions
    Biochemistry, 55 (41), 5781-5789
    DOI 10.1021/acs.biochem.6b00801, PubMed 27653243
  16. Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA (2016)
    Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation
    Mol Cell Neurosci, 77, 47-52
    DOI 10.1016/j.mcn.2016.10.004, PubMed 27751903
  17. Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P (2016)
    Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
    Nat Commun, 7, 10806
    DOI 10.1038/ncomms10806, PubMed 26932196

Publications 2015

  1. Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M (2015)
    Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
    Cell Rep, 13 (12), 2671-8
    DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335
  2. Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
    Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
    Genome Res, 25 (6), 897-906
    DOI 10.1101/gr.185793.114, PubMed 25800674
  3. Dahl JA, Klungland A (2015)
    Micro chromatin immunoprecipitation (μChIP) from early mammalian embryos
    Methods Mol Biol, 1222, 227-45
    DOI 10.1007/978-1-4939-1594-1_17, PubMed 25287350
  4. Fusser M, Kernstock S, Aileni VK, Egge-Jacobsen W, Falnes PØ, Klungland A (2015)
    Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
    PLoS One, 10 (11), e0141472
    DOI 10.1371/journal.pone.0141472, PubMed 26544960
  5. Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE, Darnell RB (2015)
    A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation
    Genes Dev, 29 (19), 2037-53
    DOI 10.1101/gad.269415.115, PubMed 26404942
  6. Klungland A, Yang YG (2015)
    Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015
    Genomics Proteomics Bioinformatics, 14 (3), 122-125
    DOI 10.1016/j.gpb.2015.11.001, PubMed 26689322
  7. Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
    Am J Physiol Heart Circ Physiol, 309 (3), H434-49
    DOI 10.1152/ajpheart.00253.2014, PubMed 26055793
  8. Mi S, Klungland A, Yang YG (2015)
    Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015
    Sci China Life Sci, 59 (1), 89-92
    DOI 10.1007/s11427-015-4983-4, PubMed 26676642
  9. Ougland R, Rognes T, Klungland A, Larsen E (2015)
    Non-homologous functions of the AlkB homologs
    J Mol Cell Biol, 7 (6), 494-504
    DOI 10.1093/jmcb/mjv029, PubMed 26003568

Publications 2014

  1. Klungland A, Dahl JA (2014)
    Dynamic RNA modifications in disease
    Curr Opin Genet Dev, 26, 47-52
    DOI 10.1016/j.gde.2014.05.006, PubMed 25005745
  2. Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A (2014)
    ALKBH4 depletion in mice leads to spermatogenic defects
    PLoS One, 9 (8), e105113
    DOI 10.1371/journal.pone.0105113, PubMed 25153837
  3. Robertson AB, Dahl JA, Klungland A (2014)
    DNA metabolism: bases of DNA repair and regulation
    Nat Chem Biol, 10 (7), 487-8
    DOI 10.1038/nchembio.1553, PubMed 24937064
  4. Robertson AB, Robertson J, Fusser M, Klungland A (2014)
    Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
    Nucleic Acids Res, 42 (21), 13280-93
    DOI 10.1093/nar/gku1032, PubMed 25355512
  5. Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ (2014)
    Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
    PLoS One, 9 (6), e98729
    DOI 10.1371/journal.pone.0098729, PubMed 24914785

Publications 2013

  1. Furu K, Klungland A (2013)
    Tzfp represses the androgen receptor in mouse testis
    PLoS One, 8 (4), e62314
    DOI 10.1371/journal.pone.0062314, PubMed 23634227
  2. Jonson I, Ougland R, Klungland A, Larsen E (2013)
    Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells
    Stem Cell Res, 11 (3), 1264-71
    DOI 10.1016/j.scr.2013.08.010, PubMed 24041806
  3. Jonson I, Ougland R, Larsen E (2013)
    DNA repair mechanisms in Huntington's disease
    Mol Neurobiol, 47 (3), 1093-102
    DOI 10.1007/s12035-013-8409-7, PubMed 23361256
  4. Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG (2013)
    ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
    Nat Commun, 4, 1832
    DOI 10.1038/ncomms2863, PubMed 23673617
  5. Malatesta M, Steinhauer C, Mohammad F, Pandey DP, Squatrito M, Helin K (2013)
    Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation
    Cancer Res, 73 (20), 6323-33
    DOI 10.1158/0008-5472.CAN-12-4660, PubMed 23943798
  6. Solberg A, Robertson AB, Aronsen JM, Rognmo Ø, Sjaastad I, Wisløff U, Klungland A (2013)
    Deletion of mouse Alkbh7 leads to obesity
    J Mol Cell Biol, 5 (3), 194-203
    DOI 10.1093/jmcb/mjt012, PubMed 23572141
  7. Zheng G, Dahl JA, Niu Y, Fu Y, Klungland A, Yang YG, He C (2013)
    Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases
    RNA Biol, 10 (6), 915-8
    DOI 10.4161/rna.24711, PubMed 23619745

Publications 2012

  1. Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD (2012)
    DNA repair is indispensable for survival after acute inflammation
    J Clin Invest, 122 (7), 2680-9
    DOI 10.1172/JCI63338, PubMed 22684101
  2. Kleppa L, Mari PO, Larsen E, Lien GF, Godon C, Theil AF, Nesse GJ, Wiksen H, Vermeulen W, Giglia-Mari G, Klungland A (2012)
    Kinetics of endogenous mouse FEN1 in base excision repair
    Nucleic Acids Res, 40 (18), 9044-59
    DOI 10.1093/nar/gks673, PubMed 22810208
  3. Meza TJ, Moen MN, Vågbø CB, Krokan HE, Klungland A, Grini PE, Falnes PØ (2012)
    The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
    Nucleic Acids Res, 40 (14), 6620-31
    DOI 10.1093/nar/gks327, PubMed 22532610
  4. Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM, Bjørås M, Klungland A (2012)
    Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
    Hum Mol Genet, 21 (22), 4939-47
    DOI 10.1093/hmg/dds337, PubMed 22914735
  5. Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A (2012)
    Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes
    Nucleic Acids Res, 40 (21), 10950-63
    DOI 10.1093/nar/gks839, PubMed 22965116
  6. Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E (2012)
    ALKBH1 is a histone H2A dioxygenase involved in neural differentiation
    Stem Cells, 30 (12), 2672-82
    DOI 10.1002/stem.1228, PubMed 22961808
  7. Robertson AB, Dahl JA, Ougland R, Klungland A (2012)
    Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads
    Nat Protoc, 7 (2), 340-50
    DOI 10.1038/nprot.2011.443, PubMed 22281869
  8. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE et al. (2012)
    ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
    Mol Cell, 49 (1), 18-29
    DOI 10.1016/j.molcel.2012.10.015, PubMed 23177736

Publications 2011

  1. Echeverría PC, Forafonov F, Pandey DP, Mühlebach G, Picard D (2011)
    Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation
    BioData Min, 4 (1), 15
    DOI 10.1186/1756-0381-4-15, PubMed 21672238
  2. Haj-Yasein NN, Jensen V, Vindedal GF, Gundersen GA, Klungland A, Ottersen OP, Hvalby O, Nagelhus EA (2011)
    Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)
    Glia, 59 (11), 1635-42
    DOI 10.1002/glia.21205, PubMed 21748805
  3. Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA (2011)
    Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
    Proc Natl Acad Sci U S A, 108 (43), 17815-20
    DOI 10.1073/pnas.1110655108, PubMed 21990350
  4. Lauritzen KH, Cheng C, Wiksen H, Bergersen LH, Klungland A (2011)
    Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses
    DNA Repair (Amst), 10 (6), 639-53
    DOI 10.1016/j.dnarep.2011.04.011, PubMed 21550321
  5. Lauritzen KH, Dalhus B, Storm JF, Bjørås M, Klungland A (2011)
    Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
    Mech Ageing Dev, 132 (8-9), 424-8
    DOI 10.1016/j.mad.2011.02.006, PubMed 21354441
  6. Moen MN, Knævelsrud I, Haugland GT, Grøsvik K, Birkeland NK, Klungland A, Bjelland S (2011)
    Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair
    J Bacteriol, 193 (17), 4495-508
    DOI 10.1128/JB.00233-11, PubMed 21665970
  7. Robertson AB, Dahl JA, Vågbø CB, Tripathi P, Krokan HE, Klungland A (2011)
    A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
    Nucleic Acids Res, 39 (8), e55
    DOI 10.1093/nar/gkr051, PubMed 21300643
  8. Robertson J, Robertson AB, Klungland A (2011)
    The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
    Biochem Biophys Res Commun, 411 (1), 40-3
    DOI 10.1016/j.bbrc.2011.06.077, PubMed 21703242
  9. Strømme P, Dobrenis K, Sillitoe RV, Gulinello M, Ali NF, Davidson C, Micsenyi MC, Stephney G, Ellevog L, Klungland A, Walkley SU (2011)
    X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction
    Brain, 134 (Pt 11), 3369-83
    DOI 10.1093/brain/awr250, PubMed 21964919
  10. van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ (2011)
    ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
    Nat Commun, 2, 172
    DOI 10.1038/ncomms1173, PubMed 21285950

Publications 2010

  1. Dahl JA, Reiner AH, Klungland A, Wakayama T, Collas P (2010)
    Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos
    PLoS One, 5 (2), e9150
    DOI 10.1371/journal.pone.0009150, PubMed 20161773
  2. Fusser M, Nesse GJ, Khobta A, Xia N, Li H, Klungland A, Epe B (2010)
    Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol
    Carcinogenesis, 32 (1), 80-5
    DOI 10.1093/carcin/bgq196, PubMed 21062970
  3. Knævelsrud I, Moen MN, Grøsvik K, Haugland GT, Birkeland NK, Klungland A, Leiros I, Bjelland S (2010)
    The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement
    J Bacteriol, 192 (21), 5755-66
    DOI 10.1128/JB.00135-10, PubMed 20453094
  4. Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A (2010)
    Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
    Mol Cell Biol, 30 (6), 1357-67
    DOI 10.1128/MCB.01149-09, PubMed 20065039
  5. Møllersen L, Rowe AD, Larsen E, Rognes T, Klungland A (2010)
    Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice
    PLoS Genet, 6 (12), e1001242
    DOI 10.1371/journal.pgen.1001242, PubMed 21170307
  6. Nordstrand LM, Svärd J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A (2010)
    Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects
    PLoS One, 5 (11), e13827
    DOI 10.1371/journal.pone.0013827, PubMed 21072209
  7. Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A (2010)
    Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding
    Mol Cell Biol, 30 (7), 1814-27
    DOI 10.1128/MCB.01602-09, PubMed 20123966
  8. Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA (2010)
    Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
    Proc Natl Acad Sci U S A, 108 (2), 846-51
    DOI 10.1073/pnas.1015217108, PubMed 21187412

Publications 2009

  1. Robertson AB, Klungland A, Rognes T, Leiros I (2009)
    DNA repair in mammalian cells: Base excision repair: the long and short of it
    Cell Mol Life Sci, 66 (6), 981-93
    DOI 10.1007/s00018-009-8736-z, PubMed 19153658
  2. van den Born E, Bekkelund A, Moen MN, Omelchenko MV, Klungland A, Falnes PØ (2009)
    Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
    Nucleic Acids Res, 37 (21), 7124-36
    DOI 10.1093/nar/gkp774, PubMed 19786499

Publications 2008

  1. Albanito L, Sisci D, Aquila S, Brunelli E, Vivacqua A, Madeo A, Lappano R, Pandey DP, Picard D, Mauro L, Andò S, Maggiolini M (2008)
    Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells
    Endocrinology, 149 (8), 3799-808
    DOI 10.1210/en.2008-0117, PubMed 18467441
  2. Jørgensen MG, Pandey DP, Jaskolska M, Gerdes K (2008)
    HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea
    J Bacteriol, 191 (4), 1191-9
    DOI 10.1128/JB.01013-08, PubMed 19060138
  3. Larsen E, Kleppa L, Meza TJ, Meza-Zepeda LA, Rada C, Castellanos CG, Lien GF, Nesse GJ, Neuberger MS, Laerdahl JK, William Doughty R, Klungland A (2008)
    Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants
    Cancer Res, 68 (12), 4571-9
    DOI 10.1158/0008-5472.CAN-08-0168, PubMed 18559501
  4. Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A (2008)
    AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
    Cancer Res, 68 (11), 4142-9
    DOI 10.1158/0008-5472.CAN-08-0796, PubMed 18519673
  5. Saxowsky TT, Meadows KL, Klungland A, Doetsch PW (2008)
    8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells
    Proc Natl Acad Sci U S A, 105 (48), 18877-82
    DOI 10.1073/pnas.0806464105, PubMed 19020090

Publications 2007

  1. Klungland A, Andersson KB (2007)
    [Nobel Prize for genetic modification]
    Tidsskr Nor Laegeforen, 127 (23), 3054
    PubMed 18049491
  2. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT (2007)
    OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
    Nature, 447 (7143), 447-52
    DOI 10.1038/nature05778, PubMed 17450122
  3. Larsen E, Meza TJ, Kleppa L, Klungland A (2007)
    Organ and cell specificity of base excision repair mutants in mice
    Mutat Res, 614 (1-2), 56-68
    DOI 10.1016/j.mrfmmm.2006.01.023, PubMed 16765995
  4. Leiros I, Nabong MP, Grøsvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knaevelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S (2007)
    Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA
    EMBO J, 26 (8), 2206-17
    DOI 10.1038/sj.emboj.7601662, PubMed 17396151
  5. Nordstrand LM, Ringvoll J, Larsen E, Klungland A (2007)
    Genome instability and DNA damage accumulation in gene-targeted mice
    Neuroscience, 145 (4), 1309-17
    DOI 10.1016/j.neuroscience.2006.10.059, PubMed 17218062
  6. Ringvoll J, Uldal L, Roed MA, Reite K, Baynton K, Klungland A, Eide L (2007)
    Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
    FEMS Yeast Res, 7 (6), 848-59
    DOI 10.1111/j.1567-1364.2007.00248.x, PubMed 17506834
  7. Risom L, Dybdahl M, Møller P, Wallin H, Haug T, Vogel U, Klungland A, Loft S (2007)
    Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
    Free Radic Res, 41 (2), 172-81
    DOI 10.1080/10715760601024122, PubMed 17364943
  8. Trapp C, Reite K, Klungland A, Epe B (2007)
    Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice
    Oncogene, 26 (27), 4044-8
    DOI 10.1038/sj.onc.1210167, PubMed 17213818

Publications 2006

  1. Falnes PØ, Klungland A, Alseth I (2006)
    Repair of methyl lesions in DNA and RNA by oxidative demethylation
    Neuroscience, 145 (4), 1222-32
    DOI 10.1016/j.neuroscience.2006.11.018, PubMed 17175108
  2. Faridani OR, Nikravesh A, Pandey DP, Gerdes K, Good L (2006)
    Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli
    Nucleic Acids Res, 34 (20), 5915-22
    DOI 10.1093/nar/gkl750, PubMed 17065468
  3. Kleppa L, Kanavin ØJ, Klungland A, Strømme P (2006)
    A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome
    Neuroscience, 145 (4), 1397-406
    DOI 10.1016/j.neuroscience.2006.09.025, PubMed 17084038
  4. Klungland A, Bjelland S (2006)
    Oxidative damage to purines in DNA: role of mammalian Ogg1
    DNA Repair (Amst), 6 (4), 481-8
    DOI 10.1016/j.dnarep.2006.10.012, PubMed 17127104
  5. Larsen E, Reite K, Nesse G, Gran C, Seeberg E, Klungland A (2006)
    Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
    Oncogene, 25 (17), 2425-32
    DOI 10.1038/sj.onc.1209284, PubMed 16369492
  6. Ringvoll J, Nordstrand LM, Vågbø CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjørk A, Doughty RW, Falnes PØ, Krokan HE, Klungland A (2006)
    Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
    EMBO J, 25 (10), 2189-98
    DOI 10.1038/sj.emboj.7601109, PubMed 16642038
  7. Touati E, Michel V, Thiberge JM, Avé P, Huerre M, Bourgade F, Klungland A, Labigne A (2006)
    Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
    Helicobacter, 11 (5), 494-505
    DOI 10.1111/j.1523-5378.2006.00442.x, PubMed 16961812

Publications 2005

  1. Holen T, Moe SE, Sørbø JG, Meza TJ, Ottersen OP, Klungland A (2005)
    Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo
    Nucleic Acids Res, 33 (15), 4704-10
    DOI 10.1093/nar/gki785, PubMed 16113241
  2. Rozalski R, Siomek A, Gackowski D, Foksinski M, Gran C, Klungland A, Olinski R (2005)
    Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice
    Int J Biochem Cell Biol, 37 (6), 1331-6
    DOI 10.1016/j.biocel.2005.01.001, PubMed 15778095

Publications 2004

  1. Foksinski M, Rozalski R, Guz J, Ruszkowska B, Sztukowska P, Piwowarski M, Klungland A, Olinski R (2004)
    Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species
    Free Radic Biol Med, 37 (9), 1449-54
    DOI 10.1016/j.freeradbiomed.2004.07.014, PubMed 15454284
  2. Larsen E, Kwon K, Coin F, Egly JM, Klungland A (2004)
    Transcription activities at 8-oxoG lesions in DNA
    DNA Repair (Amst), 3 (11), 1457-68
    DOI 10.1016/j.dnarep.2004.06.008, PubMed 15380101
  3. Ougland R, Zhang CM, Liiv A, Johansen RF, Seeberg E, Hou YM, Remme J, Falnes PØ (2004)
    AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
    Mol Cell, 16 (1), 107-16
    DOI 10.1016/j.molcel.2004.09.002, PubMed 15469826
  4. Rozalski R, Siomek A, Gackowski D, Foksinski M, Gran C, Klungland A, Olinski R (2004)
    Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine
    Free Radic Res, 38 (11), 1201-5
    DOI 10.1080/10715760400017350, PubMed 15621697

Publications 2003

  1. Dantzer F, Bjørås M, Luna L, Klungland A, Seeberg E (2003)
    Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
    DNA Repair (Amst), 2 (6), 707-18
    DOI 10.1016/S1568-7864(03)00041-7, PubMed 12767349
  2. Larsen E, Gran C, Saether BE, Seeberg E, Klungland A (2003)
    Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
    Mol Cell Biol, 23 (15), 5346-53
    DOI 10.1128/MCB.23.15.5346-5353.2003, PubMed 12861020
  3. Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjørås M, Seeberg E, Rognes T, Klungland A (2003)
    Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
    Nucleic Acids Res, 31 (14), 3893-900
    DOI 10.1093/nar/gkg472, PubMed 12853604
  4. Rogers PA, Eide L, Klungland A, Ding H (2003)
    Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
    DNA Repair (Amst), 2 (7), 809-17
    DOI 10.1016/S1568-7864(03)00065-X, PubMed 12826281
  5. Seeberg E, Klungland A (2003)
    Better late than never for repair of miscoding lesions within a transcribed template
    Mol Cell, 12 (4), 799-800
    DOI 10.1016/S1097-2765(03)00403-9, PubMed 14580331

 
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