Publications 2024

Monshaugen I, Luna L, Rhodes J, Kristiansen FIS, Lång A, Bøe SO, Dutta A, Su Z, Klungland A, Ougland R (2024)
Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer
Front Oncol, 13, 1334112
DOI 10.3389/fonc.2023.1334112, PubMed 38304034

Publications 2023

Li Y, Wang Y, Vera-Rodriguez M, Lindeman LC, Skuggen LE, Rasmussen EMK, Jermstad I, Khan S, Fosslie M, Skuland T, Indahl M, Khodeer S, Klemsdal EK, Jin KX, Dalen KT, Fedorcsak P, Greggains GD, Lerdrup M, Klungland A, Au KF, Dahl JA (2023)
Single-cell m⁶A mapping in vivo using picoMeRIP-seq
Nat Biotechnol, 42 (4), 591-596
DOI 10.1038/s41587-023-01831-7, PubMed 37349523

Lier S, Lund SO, Lipsa A, Frauenknecht KBM, Rein ID, Jain P, Lång AU, Lång EH, Meyer N, Datta A, Anand S, Nesse GJ, Forstrøm RJ, Klungland A, Rinholm JE, Bøe SO, Anands A, Pollard SM, Niclou SP, Lerdrup M, Pandey DP (2023)
CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival
BioRxiv, 2023, 110-113
DOI 10.1101/2023.07.14.548985v1, PublikaID 442

Wang Y, Li Y, Skuland T, Zhou C, Li A, Hashim A, Jermstad I, Khan S, Dalen KT, Greggains GD, Klungland A, Dahl JA, Au KF (2023)
The RNA m⁶A landscape of mouse oocytes and preimplantation embryos
Nat Struct Mol Biol, 30 (5), 703-709
DOI 10.1038/s41594-023-00969-x, PubMed 37081317

Publications 2022

Khodeer S, Klungland A, Dahl JA (2022)
ALKBH5 regulates somatic cell reprogramming in a phase-specific manner
J Cell Sci, 135 (11)
DOI 10.1242/jcs.259824, PubMed 35552718

Li M, Klungland A, Dalhus B (2022)
Studies on Protein-RNA:DNA Hybrid Interactions by Microscale Thermophoresis (MST)
Methods Mol Biol, 2528, 239-251
DOI 10.1007/978-1-0716-2477-7_15, PubMed 35704195

Lång E, Pedersen C, Lång A, Blicher P, Klungland A, Carlson A, Bøe SO (2022)
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
Proc Natl Acad Sci U S A, 119 (32), e2201328119
DOI 10.1073/pnas.2201328119, PubMed 35914175

Su Z, Monshaugen I, Klungland A, Ougland R, Dutta A (2022)
Characterization of novel small non-coding RNAs and their modifications in bladder cancer using an updated small RNA-seq workflow
Front Mol Biosci, 9, 887686
DOI 10.3389/fmolb.2022.887686, PubMed 35923465

Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A (2022)
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer
Nat Commun, 13 (1), 2165
DOI 10.1038/s41467-022-29790-8, PubMed 35444240

Sui X, Klungland A, Gao L (2022)
RNA m6A modifications in mammalian gametogenesis and pregnancy
Reproduction, 165 (1), R1-R8
DOI 10.1530/REP-22-0112, PubMed 36194446

Zhao X, Hendriks IA, Le Gras S, Ye T, Ramos-Alonso L, Nguéa P A, Lien GF, Ghasemi F, Klungland A, Jost B, Enserink JM, Nielsen ML, Chymkowitch P (2022)
Waves of sumoylation support transcription dynamics during adipocyte differentiation
Nucleic Acids Res, 50 (3), 1351-1369
DOI 10.1093/nar/gkac027, PubMed 35100417

Publications 2021

Alexeeva M, Moen MN, Xu XM, Rasmussen A, Leiros I, Kirpekar F, Klungland A, Alsøe L, Nilsen H, Bjelland S (2021)
Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification
Front Immunol, 12, 762032
DOI 10.3389/fimmu.2021.762032, PubMed 35003074

Hildrestrand GA, Rolseth V, Kunath N, Suganthan R, Jensen V, Bugaj AM, Fernandez-Berrocal MS, Sikko SB, Vetlesen S, Kuśnierczyk A, Olsen AK, Gützkow KB, Rowe AD, Wang W, Moldestad O, Syrstad MD, Slupphaug G, Eide L, Klungland A, Sætrom P, Luna L, Ye J, Scheffler K, Bjørås M (2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879

Jin KX, Zuo R, Anastassiadis K, Klungland A, Marr C, Filipczyk A (2021)
N6-methyladenosine (m⁶A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells
Proc Natl Acad Sci U S A, 118 (51)
DOI 10.1073/pnas.2105192118, PubMed 34921114

Tesfahun AN, Alexeeva M, Tomkuvienė M, Arshad A, Guragain P, Klungland A, Klimašauskas S, Ruoff P, Bjelland S (2021)
Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein
Front Microbiol, 12, 608839
DOI 10.3389/fmicb.2021.608839, PubMed 34276575

Zhang LS, Xiong QP, Peña Perez S, Liu C, Wei J, Le C, Zhang L, Harada BT, Dai Q, Feng X, Hao Z, Wang Y, Dong X, Hu L, Wang ED, Pan T, Klungland A, Liu RJ, He C (2021)
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Nat Cell Biol, 23 (7), 684-691
DOI 10.1038/s41556-021-00709-7, PubMed 34253897

Publications 2020

Grøsvik K, Tesfahun AN, Muruzábal-Lecumberri I, Haugland GT, Leiros I, Ruoff P, Kvaløy JT, Knævelsrud I, Ånensen H, Alexeeva M, Sato K, Matsuda A, Alseth I, Klungland A, Bjelland S (2020)
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
Front Microbiol, 11, 263
DOI 10.3389/fmicb.2020.00263, PubMed 32158436

Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vågbø C, Suganthan R, Segers F, Holm S, Quiles-Jiménez A, Gregersen I, Fladeby C, Aukrust P, Bjørås M, Klungland A, Halvorsen B, Alseth I (2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667

Li M, Klungland A (2020)
Modifications and interactions at the R-loop
DNA Repair (Amst), 96, 102958
DOI 10.1016/j.dnarep.2020.102958, PubMed 32961406

Sankar A, Lerdrup M, Manaf A, Johansen JV, Gonzalez JM, Borup R, Blanshard R, Klungland A, Hansen K, Andersen CY, Dahl JA, Helin K, Hoffmann ER (2020)
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
Nat Cell Biol, 22 (4), 380-388
DOI 10.1038/s41556-020-0494-z, PubMed 32231309

Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476

Publications 2019

Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A (2019)
N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Nat Genet, 52 (1), 48-55
DOI 10.1038/s41588-019-0549-x, PubMed 31844323

Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S (2019)
Excision of uracil from DNA by hSMUG1 includes strand incision and processing
Nucleic Acids Res, 47 (2), 779-793
DOI 10.1093/nar/gky1184, PubMed 30496516

Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, Ougland R (2019)
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
Clin Epigenetics, 11 (1), 135
DOI 10.1186/s13148-019-0718-x, PubMed 31519213

Pilžys T, Marcinkowski M, Kukwa W, Garbicz D, Dylewska M, Ferenc K, Mieczkowski A, Kukwa A, Migacz E, Wołosz D, Mielecki D, Klungland A, Piwowarski J, Poznański J, Grzesiuk E (2019)
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
Sci Rep, 9 (1), 13249
DOI 10.1038/s41598-019-49550-x, PubMed 31519943

Prikrylova T, Robertson J, Ferrucci F, Konorska D, Aanes H, Manaf A, Zhang B, Vågbø CB, Kuśnierczyk A, Gilljam KM, Løvkvam-Køster C, Otterlei M, Dahl JA, Enserink J, Klungland A, Robertson AB (2019)
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131

Zhang Z, Manaf A, Li Y, Perez SP, Suganthan R, Dahl JA, Bjørås M, Klungland A (2019)
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
DOI 10.1007/s12035-019-01777-5, PubMed 31654318

Publications 2018

Alexeeva M, Guragain P, Tesfahun AN, Tomkuvienė M, Arshad A, Gerasimaitė R, Rukšėnaitė A, Urbanavičiūtė G, Bjørås M, Laerdahl JK, Klungland A, Klimašauskas S, Bjelland S (2018)
Excision of the doubly methylated base N⁴,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
Philos Trans R Soc Lond B Biol Sci, 373 (1748)
DOI 10.1098/rstb.2017.0337, PubMed 29685966

Askeland G, Dosoudilova Z, Rodinova M, Klempir J, Liskova I, Kuśnierczyk A, Bjørås M, Nesse G, Klungland A, Hansikova H, Eide L (2018)
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Sci Rep, 8 (1), 9817
DOI 10.1038/s41598-018-27985-y, PubMed 29959348

Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L (2018)
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Dis Model Mech, 11 (10)
DOI 10.1242/dmm.035949, PubMed 30254085

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422

Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I et al. (2018)
Positioning Europe for the EPITRANSCRIPTOMICS challenge
RNA Biol, 15 (6), 829-831
DOI 10.1080/15476286.2018.1460996, PubMed 29671387

Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A (2018)
Ythdf2-mediated m⁶A mRNA clearance modulates neural development in mice
Genome Biol, 19 (1), 69
DOI 10.1186/s13059-018-1436-y, PubMed 29855337

Ma C, Chang M, Lv H, Zhang ZW, Zhang W, He X, Wu G, Zhao S, Zhang Y, Wang D, Teng X, Liu C, Li Q, Klungland A, Niu Y, Song S, Tong WM (2018)
RNA m⁶A methylation participates in regulation of postnatal development of the mouse cerebellum
Genome Biol, 19 (1), 68
DOI 10.1186/s13059-018-1435-z, PubMed 29855379

Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A, Jia G, Chen J, He C (2018)
Differential m⁶A, m⁶A_m, and m¹A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
Mol Cell, 71 (6), 973-985.e5
DOI 10.1016/j.molcel.2018.08.011, PubMed 30197295

Publications 2017

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404

Chymkowitch P, P AN, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2017)
Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 27 (2), 334
DOI 10.1101/gr.218370.116, PubMed 28148563

Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D (2017)
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage
Cell Death Dis, 8 (7), e2947
DOI 10.1038/cddis.2017.343, PubMed 28726787

Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A (2017)
Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia
Mol Med Rep, 15 (4), 1513-1526
DOI 10.3892/mmr.2017.6185, PubMed 28259955

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Pawar T, Bjørås M, Klungland A, Eide L (2017)
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B (2017)
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
DNA Repair (Amst), 58, 13-20
DOI 10.1016/j.dnarep.2017.08.005, PubMed 28843610

Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W (2017)
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells
Proc Natl Acad Sci U S A, 115 (2), E325-E333
DOI 10.1073/pnas.1717794115, PubMed 29279410

Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A (2017)
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
PLoS One, 12 (3), e0168182
DOI 10.1371/journal.pone.0168182, PubMed 28288181

Publications 2016

A Alemu E, He C, Klungland A (2016)
ALKBHs-facilitated RNA modifications and de-modifications
DNA Repair (Amst), 44, 87-91
DOI 10.1016/j.dnarep.2016.05.026, PubMed 27237585

Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A (2016)
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377

Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A (2016)
Reversible RNA modifications in meiosis and pluripotency
Nat Methods, 14 (1), 18-22
DOI 10.1038/nmeth.4111, PubMed 28032624

Klungland A, Robertson AB (2016)
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
Free Radic Biol Med, 107, 62-68
DOI 10.1016/j.freeradbiomed.2016.11.038, PubMed 27890639

Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P (2016)
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
Fertil Steril, 105 (5), 1170-1179.e5
DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768

Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH (2016)
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Neurobiol Aging, 48, 34-47
DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell, 167 (3), 816-828.e16
DOI 10.1016/j.cell.2016.09.038, PubMed 27745969

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell, 167 (7), 1897
DOI 10.1016/j.cell.2016.11.045, PubMed 27984735

Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L (2016)
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
PLoS Curr, 8
DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492

Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E (2016)
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells
Cell Physiol Biochem, 38 (1), 173-84
DOI 10.1159/000438619, PubMed 26765775

Rasmussen E, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA (2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
Biochemistry and Biophysics Reports, 6, 9-15
DOI 10.1016/j.bbrep.2016.02.011, PublikaID 234

Rasmussen EMK, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA (2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
Biochem Biophys Rep, 6, 9-15
DOI 10.1016/j.bbrep.2016.02.011, PubMed 28955859

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA (2016)
Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation
Mol Cell Neurosci, 77, 47-52
DOI 10.1016/j.mcn.2016.10.004, PubMed 27751903

Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P (2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
Nat Commun, 7, 10806
DOI 10.1038/ncomms10806, PubMed 26932196

Publications 2015

Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M (2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335

Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
DOI 10.1101/gr.185793.114, PubMed 25800674

Dahl JA, Klungland A (2015)
Micro chromatin immunoprecipitation (μChIP) from early mammalian embryos
Methods Mol Biol, 1222, 227-45
DOI 10.1007/978-1-4939-1594-1_17, PubMed 25287350

Fusser M, Kernstock S, Aileni VK, Egge-Jacobsen W, Falnes PØ, Klungland A (2015)
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
PLoS One, 10 (11), e0141472
DOI 10.1371/journal.pone.0141472, PubMed 26544960

Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE, Darnell RB (2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation
Genes Dev, 29 (19), 2037-53
DOI 10.1101/gad.269415.115, PubMed 26404942

Klungland A, Yang YG (2015)
Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015
Genomics Proteomics Bioinformatics, 14 (3), 122-125
DOI 10.1016/j.gpb.2015.11.001, PubMed 26689322

Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793

Mi S, Klungland A, Yang YG (2015)
Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015
Sci China Life Sci, 59 (1), 89-92
DOI 10.1007/s11427-015-4983-4, PubMed 26676642

Mi S, Klungland A, Yang YG (2015)
Base-excision repair and beyond —A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015
Science China Life Sciences, 59 (1), 89-92
DOI 10.1007/s11427-015-4983-4, PublikaID 237

Ougland R, Rognes T, Klungland A, Larsen E (2015)
Non-homologous functions of the AlkB homologs
J Mol Cell Biol, 7 (6), 494-504
DOI 10.1093/jmcb/mjv029, PubMed 26003568

Publications 2014

Klungland A, Dahl JA (2014)
Dynamic RNA modifications in disease
Curr Opin Genet Dev, 26, 47-52
DOI 10.1016/j.gde.2014.05.006, PubMed 25005745

Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A (2014)
ALKBH4 depletion in mice leads to spermatogenic defects
PLoS One, 9 (8), e105113
DOI 10.1371/journal.pone.0105113, PubMed 25153837

Robertson AB, Dahl JA, Klungland A (2014)
DNA metabolism: bases of DNA repair and regulation
Nat Chem Biol, 10 (7), 487-8
DOI 10.1038/nchembio.1553, PubMed 24937064

Robertson AB, Robertson J, Fusser M, Klungland A (2014)
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
Nucleic Acids Res, 42 (21), 13280-93
DOI 10.1093/nar/gku1032, PubMed 25355512

Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ (2014)
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
PLoS One, 9 (6), e98729
DOI 10.1371/journal.pone.0098729, PubMed 24914785

Publications 2013

Furu K, Klungland A (2013)
Tzfp represses the androgen receptor in mouse testis
PLoS One, 8 (4), e62314
DOI 10.1371/journal.pone.0062314, PubMed 23634227

Jonson I, Ougland R, Klungland A, Larsen E (2013)
Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells
Stem Cell Res, 11 (3), 1264-71
DOI 10.1016/j.scr.2013.08.010, PubMed 24041806

Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG (2013)
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
Nat Commun, 4, 1832
DOI 10.1038/ncomms2863, PubMed 23673617

Solberg A, Robertson AB, Aronsen JM, Rognmo Ø, Sjaastad I, Wisløff U, Klungland A (2013)
Deletion of mouse Alkbh7 leads to obesity
J Mol Cell Biol, 5 (3), 194-203
DOI 10.1093/jmcb/mjt012, PubMed 23572141

Zheng G, Dahl JA, Niu Y, Fu Y, Klungland A, Yang YG, He C (2013)
Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases
RNA Biol, 10 (6), 915-8
DOI 10.4161/rna.24711, PubMed 23619745

Publications 2012

Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD (2012)
DNA repair is indispensable for survival after acute inflammation
J Clin Invest, 122 (7), 2680-9
DOI 10.1172/JCI63338, PubMed 22684101

Kleppa L, Mari PO, Larsen E, Lien GF, Godon C, Theil AF, Nesse GJ, Wiksen H, Vermeulen W, Giglia-Mari G, Klungland A (2012)
Kinetics of endogenous mouse FEN1 in base excision repair
Nucleic Acids Res, 40 (18), 9044-59
DOI 10.1093/nar/gks673, PubMed 22810208

Meza TJ, Moen MN, Vågbø CB, Krokan HE, Klungland A, Grini PE, Falnes PØ (2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
Nucleic Acids Res, 40 (14), 6620-31
DOI 10.1093/nar/gks327, PubMed 22532610

Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM, Bjørås M, Klungland A (2012)
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
Hum Mol Genet, 21 (22), 4939-47
DOI 10.1093/hmg/dds337, PubMed 22914735

Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A (2012)
Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes
Nucleic Acids Res, 40 (21), 10950-63
DOI 10.1093/nar/gks839, PubMed 22965116

Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E (2012)
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation
Stem Cells, 30 (12), 2672-82
DOI 10.1002/stem.1228, PubMed 22961808

Robertson AB, Dahl JA, Ougland R, Klungland A (2012)
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads
Nat Protoc, 7 (2), 340-50
DOI 10.1038/nprot.2011.443, PubMed 22281869

Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE et al. (2012)
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
Mol Cell, 49 (1), 18-29
DOI 10.1016/j.molcel.2012.10.015, PubMed 23177736

Publications 2011

Haj-Yasein NN, Jensen V, Vindedal GF, Gundersen GA, Klungland A, Ottersen OP, Hvalby O, Nagelhus EA (2011)
Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)
Glia, 59 (11), 1635-42
DOI 10.1002/glia.21205, PubMed 21748805

Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA (2011)
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
Proc Natl Acad Sci U S A, 108 (43), 17815-20
DOI 10.1073/pnas.1110655108, PubMed 21990350

Lauritzen KH, Cheng C, Wiksen H, Bergersen LH, Klungland A (2011)
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses
DNA Repair (Amst), 10 (6), 639-53
DOI 10.1016/j.dnarep.2011.04.011, PubMed 21550321

Lauritzen KH, Dalhus B, Storm JF, Bjørås M, Klungland A (2011)
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
Mech Ageing Dev, 132 (8-9), 424-8
DOI 10.1016/j.mad.2011.02.006, PubMed 21354441

Moen MN, Knævelsrud I, Haugland GT, Grøsvik K, Birkeland NK, Klungland A, Bjelland S (2011)
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair
J Bacteriol, 193 (17), 4495-508
DOI 10.1128/JB.00233-11, PubMed 21665970

Robertson AB, Dahl JA, Vågbø CB, Tripathi P, Krokan HE, Klungland A (2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
Nucleic Acids Res, 39 (8), e55
DOI 10.1093/nar/gkr051, PubMed 21300643

Robertson J, Robertson AB, Klungland A (2011)
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
Biochem Biophys Res Commun, 411 (1), 40-3
DOI 10.1016/j.bbrc.2011.06.077, PubMed 21703242

Strømme P, Dobrenis K, Sillitoe RV, Gulinello M, Ali NF, Davidson C, Micsenyi MC, Stephney G, Ellevog L, Klungland A, Walkley SU (2011)
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction
Brain, 134 (Pt 11), 3369-83
DOI 10.1093/brain/awr250, PubMed 21964919

van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ (2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
Nat Commun, 2, 172
DOI 10.1038/ncomms1173, PubMed 21285950

Publications 2010

Dahl JA, Reiner AH, Klungland A, Wakayama T, Collas P (2010)
Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos
PLoS One, 5 (2), e9150
DOI 10.1371/journal.pone.0009150, PubMed 20161773

Fusser M, Nesse GJ, Khobta A, Xia N, Li H, Klungland A, Epe B (2010)
Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol
Carcinogenesis, 32 (1), 80-5
DOI 10.1093/carcin/bgq196, PubMed 21062970

Knævelsrud I, Moen MN, Grøsvik K, Haugland GT, Birkeland NK, Klungland A, Leiros I, Bjelland S (2010)
The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement
J Bacteriol, 192 (21), 5755-66
DOI 10.1128/JB.00135-10, PubMed 20453094

Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A (2010)
Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
Mol Cell Biol, 30 (6), 1357-67
DOI 10.1128/MCB.01149-09, PubMed 20065039

Møllersen L, Rowe AD, Larsen E, Rognes T, Klungland A (2010)
Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice
PLoS Genet, 6 (12), e1001242
DOI 10.1371/journal.pgen.1001242, PubMed 21170307

Nordstrand LM, Svärd J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A (2010)
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects
PLoS One, 5 (11), e13827
DOI 10.1371/journal.pone.0013827, PubMed 21072209

Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A (2010)
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding
Mol Cell Biol, 30 (7), 1814-27
DOI 10.1128/MCB.01602-09, PubMed 20123966

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA (2010)
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
Proc Natl Acad Sci U S A, 108 (2), 846-51
DOI 10.1073/pnas.1015217108, PubMed 21187412

Publications 2009

Robertson AB, Klungland A, Rognes T, Leiros I (2009)
DNA repair in mammalian cells: Base excision repair: the long and short of it
Cell Mol Life Sci, 66 (6), 981-93
DOI 10.1007/s00018-009-8736-z, PubMed 19153658

van den Born E, Bekkelund A, Moen MN, Omelchenko MV, Klungland A, Falnes PØ (2009)
Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
Nucleic Acids Res, 37 (21), 7124-36
DOI 10.1093/nar/gkp774, PubMed 19786499

Publications 2008

Larsen E, Kleppa L, Meza TJ, Meza-Zepeda LA, Rada C, Castellanos CG, Lien GF, Nesse GJ, Neuberger MS, Laerdahl JK, William Doughty R, Klungland A (2008)
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants
Cancer Res, 68 (12), 4571-9
DOI 10.1158/0008-5472.CAN-08-0168, PubMed 18559501

Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A (2008)
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
Cancer Res, 68 (11), 4142-9
DOI 10.1158/0008-5472.CAN-08-0796, PubMed 18519673

Saxowsky TT, Meadows KL, Klungland A, Doetsch PW (2008)
8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells
Proc Natl Acad Sci U S A, 105 (48), 18877-82
DOI 10.1073/pnas.0806464105, PubMed 19020090

Publications 2007

Klungland A, Andersson KB (2007)
[Nobel Prize for genetic modification]
Tidsskr Nor Laegeforen, 127 (23), 3054
PubMed 18049491

Klungland A, Lærdahl JK, Rognes T (2007)
OGG1: From Structural Analysis to the Knockout Mouse
In Oxidative Damage to Nucleic Acids (Evans MD, Cooke MS, eds.), Landes Bioscience and Springer Science+Business Media, 67-80
DOI 10.1007/978-0-387-72974-9_5, PublikaID 44, ISBN 978-0-387-72973-2

Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT (2007)
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Nature, 447 (7143), 447-52
DOI 10.1038/nature05778, PubMed 17450122

Larsen E, Meza TJ, Kleppa L, Klungland A (2007)
Organ and cell specificity of base excision repair mutants in mice
Mutat Res, 614 (1-2), 56-68
DOI 10.1016/j.mrfmmm.2006.01.023, PubMed 16765995

Leiros I, Nabong MP, Grøsvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knaevelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S (2007)
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA
EMBO J, 26 (8), 2206-17
DOI 10.1038/sj.emboj.7601662, PubMed 17396151

Nordstrand LM, Ringvoll J, Larsen E, Klungland A (2007)
Genome instability and DNA damage accumulation in gene-targeted mice
Neuroscience, 145 (4), 1309-17
DOI 10.1016/j.neuroscience.2006.10.059, PubMed 17218062

Ringvoll J, Uldal L, Roed MA, Reite K, Baynton K, Klungland A, Eide L (2007)
Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
FEMS Yeast Res, 7 (6), 848-59
DOI 10.1111/j.1567-1364.2007.00248.x, PubMed 17506834

Risom L, Dybdahl M, Møller P, Wallin H, Haug T, Vogel U, Klungland A, Loft S (2007)
Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
Free Radic Res, 41 (2), 172-81
DOI 10.1080/10715760601024122, PubMed 17364943

Trapp C, Reite K, Klungland A, Epe B (2007)
Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice
Oncogene, 26 (27), 4044-8
DOI 10.1038/sj.onc.1210167, PubMed 17213818

Publications 2006

Falnes PØ, Klungland A, Alseth I (2006)
Repair of methyl lesions in DNA and RNA by oxidative demethylation
Neuroscience, 145 (4), 1222-32
DOI 10.1016/j.neuroscience.2006.11.018, PubMed 17175108

Kleppa L, Kanavin ØJ, Klungland A, Strømme P (2006)
A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome
Neuroscience, 145 (4), 1397-406
DOI 10.1016/j.neuroscience.2006.09.025, PubMed 17084038

Klungland A, Bjelland S (2006)
Oxidative damage to purines in DNA: role of mammalian Ogg1
DNA Repair (Amst), 6 (4), 481-8
DOI 10.1016/j.dnarep.2006.10.012, PubMed 17127104

Larsen E, Reite K, Nesse G, Gran C, Seeberg E, Klungland A (2006)
Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
Oncogene, 25 (17), 2425-32
DOI 10.1038/sj.onc.1209284, PubMed 16369492

Ringvoll J, Nordstrand LM, Vågbø CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjørk A, Doughty RW, Falnes PØ, Krokan HE, Klungland A (2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
EMBO J, 25 (10), 2189-98
DOI 10.1038/sj.emboj.7601109, PubMed 16642038

Touati E, Michel V, Thiberge JM, Avé P, Huerre M, Bourgade F, Klungland A, Labigne A (2006)
Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
Helicobacter, 11 (5), 494-505
DOI 10.1111/j.1523-5378.2006.00442.x, PubMed 16961812

Publications 2005

Holen T, Moe SE, Sørbø JG, Meza TJ, Ottersen OP, Klungland A (2005)
Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo
Nucleic Acids Res, 33 (15), 4704-10
DOI 10.1093/nar/gki785, PubMed 16113241

Rozalski R, Siomek A, Gackowski D, Foksinski M, Gran C, Klungland A, Olinski R (2005)
Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice
Int J Biochem Cell Biol, 37 (6), 1331-6
DOI 10.1016/j.biocel.2005.01.001, PubMed 15778095

Publications 2004

Foksinski M, Rozalski R, Guz J, Ruszkowska B, Sztukowska P, Piwowarski M, Klungland A, Olinski R (2004)
Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species
Free Radic Biol Med, 37 (9), 1449-54
DOI 10.1016/j.freeradbiomed.2004.07.014, PubMed 15454284

Larsen E, Kwon K, Coin F, Egly JM, Klungland A (2004)
Transcription activities at 8-oxoG lesions in DNA
DNA Repair (Amst), 3 (11), 1457-68
DOI 10.1016/j.dnarep.2004.06.008, PubMed 15380101

Rozalski R, Siomek A, Gackowski D, Foksinski M, Gran C, Klungland A, Olinski R (2004)
Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine
Free Radic Res, 38 (11), 1201-5
DOI 10.1080/10715760400017350, PubMed 15621697

Publications 2003

Dantzer F, Bjørås M, Luna L, Klungland A, Seeberg E (2003)
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
DNA Repair (Amst), 2 (6), 707-18
DOI 10.1016/s1568-7864(03)00041-7, PubMed 12767349

Larsen E, Gran C, Saether BE, Seeberg E, Klungland A (2003)
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
Mol Cell Biol, 23 (15), 5346-53
DOI 10.1128/MCB.23.15.5346-5353.2003, PubMed 12861020

Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjørås M, Seeberg E, Rognes T, Klungland A (2003)
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
DOI 10.1093/nar/gkg472, PubMed 12853604

Rogers PA, Eide L, Klungland A, Ding H (2003)
Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
DNA Repair (Amst), 2 (7), 809-17
DOI 10.1016/s1568-7864(03)00065-x, PubMed 12826281

Seeberg E, Klungland A (2003)
Better late than never for repair of miscoding lesions within a transcribed template
Mol Cell, 12 (4), 799-800
DOI 10.1016/s1097-2765(03)00403-9, PubMed 14580331

Publications 2002

Birkeland NK, Anensen H, Knaevelsrud I, Kristoffersen W, Bjørås M, Robb FT, Klungland A, Bjelland S (2002)
Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus
Biochemistry, 41 (42), 12697-705
DOI 10.1021/bi020334w, PubMed 12379112

Osterod M, Larsen E, Le Page F, Hengstler JG, Van Der Horst GT, Boiteux S, Klungland A, Epe B (2002)
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
Oncogene, 21 (54), 8232-9
DOI 10.1038/sj.onc.1206027, PubMed 12447686

Publications 2001

de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA (2001)
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice
Cancer Res, 61 (14), 5378-81
PubMed 11454679

Klungland A (2001)
[Life without DNA repair]
Tidsskr Nor Laegeforen, 121 (1), 41-9
PubMed 12013614

Klungland A, Paulsen R, Rolseth V, Yamada Y, Ueno Y, Wiik P, Matsuda A, Seeberg E, Bjelland S (2001)
5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism
Toxicol Lett, 119 (1), 71-8
DOI 10.1016/s0378-4274(00)00308-8, PubMed 11275423

Knaevelsrud I, Ruoff P, Anensen H, Klungland A, Bjelland S, Birkeland NK (2001)
Excision of uracil from DNA by the hyperthermophilic Afung protein is dependent on the opposite base and stimulated by heat-induced transition to a more open structure
Mutat Res, 487 (3-4), 173-90
DOI 10.1016/s0921-8777(01)00115-x, PubMed 11738943

Publications 2000

Le Page F, Klungland A, Barnes DE, Sarasin A, Boiteux S (2000)
Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences
Proc Natl Acad Sci U S A, 97 (15), 8397-402
DOI 10.1073/pnas.140137297, PubMed 10890888

Seeberg E, Luna L, Morland I, Eide L, Johnsen B, Larsen E, Alseth I, Dantzer F, Baynton K, Aamodt R, Kristiansen KI, Rognes T, Klungland A, Bjørås M (2000)
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028

Publications 1999

Klungland A, Höss M, Gunz D, Constantinou A, Clarkson SG, Doetsch PW, Bolton PH, Wood RD, Lindahl T (1999)
Base excision repair of oxidative DNA damage activated by XPG protein
Mol Cell, 3 (1), 33-42
DOI 10.1016/s1097-2765(00)80172-0, PubMed 10024877

Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, Epe B, Seeberg E, Lindahl T, Barnes DE (1999)
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Proc Natl Acad Sci U S A, 96 (23), 13300-5
DOI 10.1073/pnas.96.23.13300, PubMed 10557315

Publications 1997

Klungland A, Lindahl T (1997)
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
EMBO J, 16 (11), 3341-8
DOI 10.1093/emboj/16.11.3341, PubMed 9214649

Lindahl T, Barnes DE, Klungland A, Mackenney VJ, Schär P (1997)
Repair and processing events at DNA ends
Ciba Found Symp, 211, 198-205; discussion 205-8
DOI 10.1002/9780470515433.ch13, PubMed 9524759

Roldán-Arjona T, Wei YF, Carter KC, Klungland A, Anselmino C, Wang RP, Augustus M, Lindahl T (1997)
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
Proc Natl Acad Sci U S A, 94 (15), 8016-20
DOI 10.1073/pnas.94.15.8016, PubMed 9223306

Publications 1996

Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE, Lindahl T (1996)
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein
EMBO J, 15 (23), 6662-70
PubMed 8978692

Publications 1995

Bjørås M, Klungland A, Johansen RF, Seeberg E (1995)
Purification and properties of the alkylation repair DNA glycosylase encoded the MAG gene from Saccharomyces cerevisiae
Biochemistry, 34 (14), 4577-82
DOI 10.1021/bi00014a010, PubMed 7718559

Klungland A, Laake K, Hoff E, Seeberg E (1995)
Spectrum of mutations induced by methyl and ethyl methanesulfonate at the hprt locus of normal and tag expressing Chinese hamster fibroblasts
Carcinogenesis, 16 (6), 1281-5
DOI 10.1093/carcin/16.6.1281, PubMed 7788844

Lindahl T, Satoh MS, Poirier GG, Klungland A (1995)
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
Trends Biochem Sci, 20 (10), 405-11
DOI 10.1016/s0968-0004(00)89089-1, PubMed 8533153

Publications 1994

Klungland A (1994)
Properties and biological effects of alkylbase DNA glycosylases
Norwegian Cancer Society : Biotechnology Centre of Oslo and Department of Biology, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 942916395, ISBN 82-91493-00-6

Klungland A, Bjørås M, Hoff E, Seeberg E (1994)
Increased removal of 3-alkyladenine reduces the frequencies of hprt mutations induced by methyl- and ethylmethanesulfonate in Chinese hamster fibroblast cells
Nucleic Acids Res, 22 (9), 1670-4
DOI 10.1093/nar/22.9.1670, PubMed 8202370

Publications 1992

Klungland A, Fairbairn L, Watson AJ, Margison GP, Seeberg E (1992)
Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents
EMBO J, 11 (12), 4439-44
DOI 10.1002/j.1460-2075.1992.tb05544.x, PubMed 1425578

Publications 1988

Klungland A (1988)
Virkning av gibrellinsyre (GA3) i normale og mutante byggfrø (Hordeum) vulgare L.) under spiring
A. Klungland, Oslo, 137 s.
BIBSYS 961060832