Publications 2022

Karlsen TH, Sheron N, Zelber-Sagi S, Carrieri P, Dusheiko G, Bugianesi E, Pryke R, Hutchinson SJ, Sangro B, Martin NK, Cecchini M, Dirac MA, Belloni A, Serra-Burriel M, Ponsioen CY, Sheena B, Lerouge A, Devaux M, Scott N, Hellard M, Verkade HJ, Sturm E, Marchesini G, Yki-Jarvinen H, Byrne CD et al. (2022)
The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality
Lancet, 399 (10319), 61-116
DOI 10.1016/S0140-6736(21)01701-3

Vedeld HM, Grimsrud MM, Andresen K, Pharo HD, von Seth E, Karlsen TH, Honne H, Paulsen V, Farkkila MA, Bergquist A, Jeanmougin M, Aabakken L, Boberg KM, Folseraas T, Lind GE (2022)
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
Hepatology, 75 (1), 59-73
DOI 10.1002/hep.32125

Publications 2021

Bossen L, Vesterhus M, Hov JR, Farkkila M, Rosenberg WM, Moller HJ, Boberg KM, Karlsen TH, Gronbaek H (2021)
Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis
Clin. Transl. Gastroenterol., 12 (3), e00315
DOI 10.14309/ctg.0000000000000315

Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hubenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang SK, Ye BD, Cheon JH, Datta LW, Daryani NE, Ellul P, Esaki M, Fuyuno Y, McGovern DPB, Haritunians T, Hong M, Juyal G et al. (2021)
Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations
Hum. Mol. Genet., 30 (5), 356-369
DOI 10.1093/hmg/ddab017

Dhillon AK, Rupp C, Bergquist A, Voitl R, Folseraas T, Troseid M, Midttun O, Ueland PM, Karlsen TH, Vesterhus M, Kummen M, Hov JR (2021)
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand. J. Gastroenterol., 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627

Fossdal G, Mjelle AB, Wiencke K, Bjork I, Gilja OH, Folseraas T, Karlsen TH, Rosenberg W, Giil LM, Vesterhus M (2021)
Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF
JHEP Rep., 3 (5), 100328
DOI 10.1016/j.jhepr.2021.100328

Jiang XJ, Bergquist A, Loscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skanland SS, Maleki KT, Cornillet M, Tasken K, Franke A, Karlsen TH, Bjorkstrom NK, Melum E (2021)
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci. Transl. Med., 13 (582), eabb0036
DOI 10.1126/scitranslmed.abb0036

Kummen M, Thingholm LB, Ruhlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun O, McCann A, Ueland PM, Hoivik ML, Vesterhus M, Troseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR (2021)
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798
DOI 10.1053/j.gastro.2020.12.058

Mousa OY, Juran BD, McCauley BM, Vesterhus MN, Folseraas T, Turgeon CT, Ali AH, Schlicht EM, Atkinson EJ, Hu C, Harnois D, Carey EJ, Gossard AA, Oglesbee D, Eaton JE, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN (2021)
Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation
Hepatology, 74 (1), 281-295
DOI 10.1002/hep.31652

Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi MEK, Palom A, Ellinghaus D, Khan A, Martinez-Bueno M, Rolker S, Amitrano S, Tato LR, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernandez-Cadenas I, Holter JC, Banales JM et al. (2021)
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
J. Clin. Invest., 131 (23)
DOI 10.1172/JCI152386

Pagano E, Elias JE, Schneditz G, Saveljeva S, Holland LM, Borrelli F, Karlsen TH, Kaser A, Kaneider NC (2021)
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment
Gut
DOI 10.1136/gutjnl-2020-323363

Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Hohne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, Garcia-Beccaria M, Gabernet G, Nahnsen S, Mallm JP et al. (2021)
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
J. Hepatol., 75 (3), 634-646
DOI 10.1016/j.jhep.2021.03.029

Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlstrom A, Mohs A, Zuhlke S, Liao LJ, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Galvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A et al. (2021)
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
Nat. Metab., 3 (9), 1228-+
DOI 10.1038/s42255-021-00452-1

Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2021)
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin. Exp. Immunol., 203 (2), 304-314
DOI 10.1111/cei.13541

Vesterhus M, Nielsen MJ, Hov JR, Saffioti F, Manon-Jensen T, Leeming DJ, Moum B, Boberg KM, Pinzani M, Karlsen TH, Karsdal MA, Thorburn D (2021)
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep., 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178

Zheng TH, Ellinghaus D, Juzenas S, Cossais F, Burmeister G, Mayr G, Jorgensen IF, Teder-Laving M, Skogholt AH, Chen SS, Strege PR, Ito G, Banasik K, Becker T, Bokelmann F, Brunak S, Buch S, Clausnitzer H, Datz C, Degenhardt F, Doniec M, Erikstrup C, Esko T, Forster M, Frey N et al. (2021)
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Gut, 70 (8), 1538-1549
DOI 10.1136/gutjnl-2020-323868

Publications 2020

Deeb M, Karlsen TH, Hirschfield GM (2020)
The 6 C's of primary sclerosing cholangitis
J. Hepatol., 73 (5), 1255-1256
DOI 10.1016/j.jhep.2020.06.033

Eaton JE, Vesterhus M, McCauley BM, Atkinson EJ, Schlicht EM, Juran BD, Gossard AA, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN (2020)
Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning
Hepatology, 71 (1), 214-224
DOI 10.1002/hep.30085

Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernandez J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kassens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng TH, Yi XL, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F et al. (2020)
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N. Engl. J. Med., 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283

Goeppert B, Folseraas T, Roessler S, Kloor M, Volckmar AL, Endris V, Buchhalter I, Stenzinger A, Grzyb K, Grimsrud MM, Gornicka B, von Seth E, Reynolds GM, Franke A, Gotthardt DN, Mehrabi A, Cheung A, Verheij J, Arola J, Makisalo H, Eide TJ, Weidemann S, Cheville JC, Mazza G, Hirschfield GM et al. (2020)
Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Hepatology, 72 (4), 1253-1266
DOI 10.1002/hep.31110

Kummen M, Solberg OG, Storm-Larsen C, Holm K, Ragnarsson A, Troseid M, Vestad B, Skardal R, Yndestad A, Ueland T, Svardal A, Berge RK, Seljeflot I, Gullestad L, Karlsen TH, Aaberge L, Aukrust P, Hov JR (2020)
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y

Liwinski T, Zenouzi R, John C, Ehlken H, Ruhlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rosch T, Lohse AW, Heeren J, Franke A, Schramm C (2020)
Alterations of the bile microbiome in primary sclerosing cholangitis
Gut, 69 (4), 665-672
DOI 10.1136/gutjnl-2019-318416

Lohse AW, Sebode M, Jorgensen MH, Ytting H, Karlsen TH, Kelly D, Manns MP, Vesterhus M, European Reference Network Hepatol Int Autoimmune Hepatitis Grp IAIHG (2020)
Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group
J. Hepatol., 73 (6), 1496-1506
DOI 10.1016/j.jhep.2020.07.023

Thaventhiran JED, Allen HL, Burren OS, Rae W, Greene D, Staples E, Zhang ZN, Farmery JHR, Simeoni I, Rivers E, Maimaris J, Penkett CJ, Stephens J, Deevi SVV, Sanchis-Juan A, Gleadall NS, Thomas MJ, Sargur RB, Gordins P, Baxendale HE, Brown M, Tuijnenburg P, Worth A, Hanson S, Linger RJ et al. (2020)
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Nature, 583 (7814), 90-+
DOI 10.1038/s41586-020-2265-1

Vesterhus M, Karlsen TH (2020)
Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities
J. Gastroenterol., 55 (6), 588-614
DOI 10.1007/s00535-020-01681-z

Publications 2019

Carpino G, Cardinale V, Folseraas T, Overi D, Grzyb K, Costantini D, Berloco PB, Di Matteo S, Karlsen TH, Alvaro D, Gaudio E (2019)
Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Hepatology, 69 (2), 622-638
DOI 10.1002/hep.30210

Colombo M, Karlsen TH (2019)
The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother
J. Hepatol., 70 (3), 339-342
DOI 10.1016/j.jhep.2018.11.017

Cornberg M, Tacke F, Karlsen TH, European Assoc Study Liver (2019)
Clinical Practice Guidelines of the European Association for the study of the Liver - Advancing methodology but preserving practicability
J. Hepatol., 70 (1), 5-7
DOI 10.1016/j.jhep.2018.10.011

Dhillon AK, Kremer AE, Kummen M, Boberg KM, Elferink RPO, Karlsen TH, Beuers U, Vesterhus M, Hov JR (2019)
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
Sci Rep, 9, 8450
DOI 10.1038/s41598-019-44762-7

Dhillon AK, Kummen M, Troseid M, Akra S, Liaskou E, Moum B, Vesterhus M, Karlsen TH, Seljeflot I, Hov JR (2019)
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Liver Int., 39 (2), 371-381
DOI 10.1111/liv.13979

Goode EC, Clark AB, Mells GF, Srivastava B, Spiess K, Gelson WTH, Trivedi PJ, Lynch KD, Castren E, Vesterhus MN, Karlsen TH, Ji S, Anderson CA, Thorburn D, Hudson M, Heneghan MA, Aldersley MA, Bathgate A, Sandford RN, Alexander GJ, Chapman RW, Walmsley M, Hirschfield GM, Rushbrook SM, UK-PSC Consortium (2019)
Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System
Hepatology, 69 (5), 2120-2135
DOI 10.1002/hep.30479

Jorgensen SF, Macpherson ME, Bjornetro T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Troseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2019)
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9, 167
DOI 10.1038/s41598-018-35367-7

Karlsen TH, Newsome PN (2019)
The dawn of a new EASL - A new chapter in the history of the European Association for the Study of the liver
J. Hepatol., 71 (1), 5-8
DOI 10.1016/j.jhep.2019.03.010

Melum E, Jiang XJ, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan JJ, Karlsen TH, Exley MA, Schutze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS (2019)
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Nat. Immunol., 20 (12), 1644-+
DOI 10.1038/s41590-019-0504-0

Schneditz G, Elias JE, Pagano E, Cader MZ, Saveljeva S, Long K, Mukhopadhyay S, Arasteh M, Lawley TD, Dougan G, Bassett A, Karlsen TH, Kaser A, Kaneider NC (2019)
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
Sci. Signal., 12 (562), 9048
DOI 10.1126/scisignal.aau9048

Thingholm LB, Ruhlemann MC, Koch M, Fuqua B, Laucke G, Boehm R, Bang C, Franzosa EA, Hubenthal M, Rahnavard A, Frosts F, Lloyd-Price J, Schirmer M, Lusis AJ, Vulpe CD, Lerch MM, Homuth G, Kacprowski T, Schmidt CO, Nothlings U, Karlsen TH, Lieb W, Laudes M, Franke A, Huttenhower C (2019)
Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition
Cell Host Microbe, 26 (2), 252-+
DOI 10.1016/j.chom.2019.07.004

Publications 2018

Aberg F, Isoniemi H, Pukkala E, Jalanko H, Rasmussen A, Storm HH, Schultz N, Bennet W, Ekvall N, Ericzon BG, Malenicka S, Tretli S, Line PD, Boberg KM, Ostensen A, Karlsen TH, Nordin A (2018)
Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries
Liver Transplant., 24 (9), 1252-1259
DOI 10.1002/lt.25305

Alberts R, de Vries EMG, Goode EC, Jiang XJ, Sampaziotis F, Rombouts K, Bottcher K, Folseraas T, Weismuller TJ, Mason AL, Wang WW, Alexander G, Alvaro D, Bergquist A, Bjorkstrom NK, Beuers U, Bjornsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouilleres O, Cheung A, Dalekos G, Eaton J et al. (2018)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598

Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E (2018)
Natural killer T cells mediate inflammation in the bile ducts
Mucosal Immunol., 11 (6), 1582-1590
DOI 10.1038/s41385-018-0066-8

Berntsen NL, Fosby B, Valestrand L, Tan C, Reims HM, Schrumpf E, Karlsen TH, Line PD, Melum E (2018)
Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree
Am. J. Physiol.-Gastroint. Liver Physiol., 314 (3), G349-G359
DOI 10.1152/ajpgi.00124.2017

Broce I, Karch CM, Wen N, Fan CC, Wang YP, Tan CH, Kouri N, Ross OA, Hoglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL et al. (2018)
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
PLos Med., 15 (1), e1002487
DOI 10.1371/journal.pmed.1002487

Carpino G, Cardinale V, Folseraas T, Overi D, Floreani A, Franchitto A, Onori P, Cazzagon N, Berloco PB, Karlsen TH, Alvaro D, Gaudio E (2018)
Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
Am. J. Pathol., 188 (3), 627-639
DOI 10.1016/j.ajpath.2017.11.010

Chung BK, Henriksen EKK, Jorgensen KK, Karlsen TH, Hirschfield GM, Liaskou E (2018)
Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease
Hepatol. Commun., 2 (8), 960-971
DOI 10.1002/hep4.1200

Chung BK, Karlsen TH, Folseraas T (2018)
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma
Biochim. Biophys. Acta-Mol. Basis Dis., 1864 (4), 1390-1400
DOI 10.1016/j.bbadis.2017.08.020

Karlsen TH, Tacke F (2018)
"The times they are a'changin'" - Positioning the European Association for the Study of the Liver in the changing landscape of hepatology
J. Hepatol., 68 (5), 873-875
DOI 10.1016/j.jhep.2018.02.001

Momozawa Y, Dmitrieva J, Theatre E, Deffontaine V, Rahmouni S, Charloteaux B, Crins F, Docampo E, Elansary M, Gori AS, Lecut C, Mariman R, Mni M, Oury C, Altukhov I, Alexeev D, Aulchenko Y, Amininejad L, Bouma G, Hoentjen F, Lowenberg M, Oldenburg B, Pierik MJ, vander Meulen-de Jong AE, van der Woude CJ et al. (2018)
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
Nat. Commun., 9, 2427
DOI 10.1038/s41467-018-04365-8

Nielsen MJ, Thorburn D, Leeming DJ, Hov JR, Nygard S, Moum B, Saffioti F, Gilja OH, Boberg KM, Mazza G, Rosjo H, Pinzani M, Karlsen TH, Karsdal MA, Vesterhus M (2018)
Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis
Aliment. Pharmacol. Ther., 48 (2), 179-189
DOI 10.1111/apt.14806

Nordin A, Aberg F, Pukkala E, Pedersen CR, Storm HH, Rasmussen A, Bennet W, Olausson M, Wilczek H, Ericzon BG, Tretli S, Line PD, Karlsen TH, Boberg KM, Isoniemi H (2018)
Decreasing incidence of cancer after liver transplantationA Nordic population-based study over 3 decades
Am. J. Transplant., 18 (4), 952-963
DOI 10.1111/ajt.14507

Pollheimer MJ, Racedo S, Mikels-Vigdal A, Marshall D, Bowlus C, Lackner C, Madl T, Karlsen TH, Hov JR, Lyman SK, Adamkewicz J, Smith V, Moreau E, Zollner G, Eide TJ, Stojakovic T, Scharnagl H, Gruber HJ, Stauber RE, Trauner M, Fickert P (2018)
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
J. Hepatol., 69 (2), 368-377
DOI 10.1016/j.jhep.2018.04.009

Ruhlemann MC, Degenhardt F, Thingholm LB, Wang J, Skieceviciene J, Rausch P, Hov JR, Lieb W, Karlsen TH, Laudes M, Baines JF, Heinsen FA, Franke A (2018)
Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979

Tronstad RR, Polushina T, Brattbakk HR, Stansberg C, von Volkmann HL, Hanevik K, Ellinghaus E, Jorgensen SF, Ersland KM, Pham KDC, Gilja OH, Hovdenak N, Hausken T, Vatn MH, Franke A, Knappskog PM, Le Hellard S, Karlsen TH, Fiskerstrand T (2018)
Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea
Scand. J. Gastroenterol., 53 (10-11), 1264-1273
DOI 10.1080/00365521.2018.1521867

Publications 2017

Chung BK, Guevel BT, Reynolds GM, Udatha DBRKG, Henriksen EKK, Stamataki Z, Hirschfield GM, Karlsen TH, Liaskou E (2017)
Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
J. Autoimmun., 77, 45-54
DOI 10.1016/j.jaut.2016.10.003

Chung BK, Karlsen TH (2017)
Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease
Dig. Dis., 35 (4), 323-333
DOI 10.1159/000456583

Claussen JC, Skieceviciene J, Wang J, Rausch P, Karlsen TH, Lieb W, Baines JF, Franke A, Hutt MT (2017)
Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome
PLoS Comput. Biol., 13 (6), e1005361
DOI 10.1371/journal.pcbi.1005361

de Vries EM, Farkkila M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouilleres O, Pares A, Nygard S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Rosjo H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int., 37 (10), 1554-1561
DOI 10.1111/liv.13402

Henriksen EKK, Jorgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KEA, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E (2017)
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J. Hepatol., 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002

Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouilleres O, Farkkila M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D, Yu L et al. (2017)
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076

Hov JR, Boberg KM, Taraldsrud E, Vesterhus M, Boyadzhieva M, Solberg IC, Schrumpf E, Vatn MH, Lie BA, Molberg O, Karlsen TH (2017)
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int., 37 (3), 458-465
DOI 10.1111/liv.13238

Hov JR, Karlsen TH (2017)
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Semin. Liver Dis., 37 (4), 314-331
DOI 10.1055/s-0037-1608801

Jendrek ST, Gotthardt D, Nitzsche T, Widmann L, Korf T, Michaels MA, Weiss KH, Liaskou E, Vesterhus M, Karlsen TH, Mindorf S, Schemmer P, Bar F, Teegen B, Schroeder T, Ehlers M, Hammers CM, Komorowski L, Lehnert H, Fellermann K, Derer S, Hov JR, Sina C (2017)
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Gut, 66 (1), 137-144
DOI 10.1136/gutjnl-2016-311739

Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Muller T, Schramm C, Sterneck M, Weismuller TJ, Gotthardt DN, Ellinghaus D, Braun F et al. (2017)
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Nature Genet., 49 (2), 269-273
DOI 10.1038/ng.3745

Jiang XJ, Karlsen TH (2017)
Genetics of primary sclerosing cholangitis and pathophysiological implications
Nat. Rev. Gastroenterol. Hepatol., 14 (5), 279-295
DOI 10.1038/nrgastro.2016.154

Jorgensen SF, Macpherson ME, Bjoro K, Karlsen TH, Reims HM, Grzyb K, Fosby B, Fevang B, Aukrust P, Nordoy I (2017)
Liver transplantation in patients with primary antibody deficiency
J. Allergy Clin. Immunol., 139 (5), 1708-+
DOI 10.1016/j.jaci.2016.10.025

Karlsen TH, Folseraas T, Thorburn D, Vesterhus M (2017)
Primary sclerosing cholangitis - a comprehensive review
J. Hepatol., 67 (6), 1298-1323
DOI 10.1016/j.jhep.2017.07.022

Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, Pick J, Markus MRP, Hopfner T, Jacobs G, Siegert S, Artati A, Kastenmuller G, Romisch-Margl W, Adamski J, Illig T, Nothnagel M, Karlsen TH, Schreiber S, Franke A, Krawczak M, Nothlings U, Lieb W (2017)
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur. J. Clin. Nutr., 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43

Kummen M, Holm K, Anmarkrud JA, Nygard S, Vesterhus M, Hoivik ML, Troseid M, Marschall HU, Schrumpf E, Moum B, Rosjo H, Aukrust P, Karlsen TH, Hov JR (2017)
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500

Kummen M, Vesterhus M, Troseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR (2017)
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol. J., 5 (4), 532-541
DOI 10.1177/2050640616663453

Malenicka S, Ericzon BG, Jorgensen MH, Isoniemi H, Karlsen TH, Krantz M, Naeser V, Olausson M, Rasmussen A, Ronnholm K, Sanengen T, Scholz T, Fischler B, Nemeth A (2017)
Impaired intention-to-treat survival after listing for liver transplantation in children with biliary atresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries
Pediatr. Transplant., 21 (2), e12851
DOI 10.1111/petr.12851

Maroni L, Agostinelli L, Saccomanno S, Pinto C, Giordano DM, Rychiicki C, De Minicis S, Trozzi L, Banales JM, Melum E, Karlsen TH, Benedetti A, Baroni GS, Marzioni M (2017)
NLrp3 Activation Induces IL-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes
Am. J. Pathol., 187 (2), 366-376
DOI 10.1016/j.ajpath.2016.10.010

Maroni L, Hohenester SD, de Graaf SFJV, Tolenaars D, van Lienden K, Verheij J, Marzioni M, Karlsen TH, Elferink RPJO, Beuers U (2017)
Knockout of the Primary Sclerosing Cholangitis-Risk Gene Fut2 Causes Liver Disease in Mice
Hepatology, 66 (2), 542-554
DOI 10.1002/hep.29029

O'Hara SP, Karlsen TH, LaRusso NF (2017)
Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?
Gut, 66 (11), 1873-1877
DOI 10.1136/gutjnl-2017-314249

Rosati E, Dowds CM, Liaskou E, Henriksen EKK, Karlsen TH, Franke A (2017)
Overview of methodologies for T-cell receptor repertoire analysis
BMC Biotechnol., 17, 61
DOI 10.1186/s12896-017-0379-9

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gomez-Vazquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu WM et al. (2017)
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Nat. Med., 23 (8), 954-+
DOI 10.1038/nm.4360

Schrumpf E, Jiang XJ, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E (2017)
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
PHYSIOL. REP., 5 (4), e13117
DOI 10.14814/phy2.13117

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Backhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E (2017)
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J. Hepatol., 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020

Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Hoivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR (2017)
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm. Bowel Dis., 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264

Vesterhus M, Holm A, Hov JR, Nygard S, Schrumpf E, Melum E, Thorbjornsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Rosjo H, Moum B, Ponsioen CY, Boberg KM, Farkkila M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J. Hepatol., 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019

Weismuller TJ, Trivedi PJ, Bergquist A, Imam M, Lenzen H, Ponsioen CY, Holm K, Gotthardt D, Farkkila MA, Marschall HU, Thorburn D, Weersma RK, Fevery J, Mueller T, Chazouilleres O, Schulze K, Lazaridis KN, Almer S, Pereira SP, Levy C, Mason A, Naess S, Bowlus CL, Floreani A, Halilbasic E et al. (2017)
Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis
Gastroenterology, 152 (8), 1975-+
DOI 10.1053/j.gastro.2017.02.038

Publications 2016

D'Agnolo HMA, Kievit W, Andrade RJ, Karlsen TH, Wedemeyer H, Drenth JPH (2016)
Creating an effective clinical registry for rare diseases
United European Gastroenterol. J., 4 (3), 333-338
DOI 10.1177/2050640615618042

Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hubenthal M, Folseraas T, Wang YP, Esko T, Metspalu A, Westra HJ, Franke L, Pers TH, Weersma RK, Collij V, D'Amato M, Halfvarson J, Jensen AB, Lieb W, Degenhardt F, Forstner AJ et al. (2016)
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Nature Genet., 48 (5), 510-+
DOI 10.1038/ng.3528

Harbord M, Annese V, Vavricka SR, Allez M, Barreiro-de Acosta M, Boberg KM, Burisch J, De Vos M, De Vries AM, Dick AD, Juillerat P, Karlsen TH, Koutroubakis I, Lakatos PL, Orchard T, Papay P, Raine T, Reinshagen M, Thaci D, Tilg H, Carbonnel F, European Crohn's Colitis Org ECCO (2016)
The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease
J. Crohns Colitis, 10 (3), 239-254
DOI 10.1093/ecco-jcc/jjv213

Jorgensen SF, Reims HM, Frydenlund D, Holm K, Paulsen V, Michelsen AE, Jorgensen KK, Osnes LT, Bratlie J, Eide TJ, Dahl CP, Holter E, Tronstad RR, Hanevik K, Brattbakk HR, Kaveh F, Fiskerstrand T, Kran AMB, Ueland T, Karlsen TH, Aukrust P, Lundin KEA, Fevang B (2016)
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am. J. Gastroenterol., 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329

Jorgensen SF, Troseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Hoivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KEA, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol., 9 (6), 1455-1465
DOI 10.1038/mi.2016.18

Karlsen TH (2016)
Primary sclerosing cholangitis: 50 years of a gut-liver relationship and still no love?
Gut, 65 (10), 1579-1581
DOI 10.1136/gutjnl-2016-312137

Kevans D, Tyler AD, Holm K, Jorgensen KK, Vatn MH, Karlsen TH, Kaplan GG, Eksteen B, Gevers D, Hov JR, Silverberg MS (2016)
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
J. Crohns Colitis, 10 (3), 330-337
DOI 10.1093/ecco-jcc/jjv204

Liaskou E, Henriksen EKK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2016)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-1619
DOI 10.1002/hep.28116

Lunder AK, Hov JR, Borthne A, Gleditsch J, Johannesen G, Tveit K, Viktil E, Henriksen M, Hovde O, Huppertz-Hauss G, Hoie O, Hoivik ML, Monstad I, Solberg IC, Jahnsen J, Karlsen TH, Moum B, Vatn M, Negard A (2016)
Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease
Gastroenterology, 151 (4), 660-+
DOI 10.1053/j.gastro.2016.06.021

Ponsioen CY, Chapman RW, Chazouilleres O, Hirschfield GM, Karlsen TH, Lohse AW, Pinzani M, Schrumpf E, Trauner M, Gores GJ (2016)
Surrogate Endpoints for Clinical Trials in Primary Sclerosing Cholangitis: Review and Results From an International PSC Study Group Consensus Process
Hepatology, 63 (4), 1357-1367
DOI 10.1002/hep.28256

Skagen K, Troseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JER, Halvorsen B, Skjelland M (2016)
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-69
DOI 10.1016/j.atherosclerosis.2016.01.033

Saadati HR, Wittig M, Helbig I, Hasler R, Anderson CA, Mathew CG, Kupcinskas L, Parkes M, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2016)
Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci
BMC Med. Genet., 17, 26
DOI 10.1186/s12881-016-0289-z

Wang J, Thingholm LB, Skieceviciene J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Ruhlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hubenthal M, Koch M, Schwarz K, Rimbach G, Hubbe P et al. (2016)
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Nature Genet., 48 (11), 1396-1406
DOI 10.1038/ng.3695

Yokoyama JS, Wang YP, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH et al. (2016)
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
JAMA Neurol., 73 (6), 691-697
DOI 10.1001/jamaneurol.2016.0150

Zenouzi R, Weismuller TJ, Jorgensen KK, Bubenheim M, Lenzen H, Hubener P, Schulze K, Weiler-Normann C, Sebode M, Ehlken H, Pannicke N, Hartl J, Peiseler M, Hubener S, Karlsen TH, Boberg KM, Manns MP, Lohse AW, Schramm C (2016)
No Evidence That Azathioprine Increases Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis
Clin. Gastroenterol. Hepatol., 14 (12), 1806-1812
DOI 10.1016/j.cgh.2016.07.032

Zweers SJ, Shiryaev A, Komuta M, Vesterhus M, Hov JR, Perugorria MJ, de Waart DR, Chang JC, Tol S, Velde AAT, de Jonge WJ, Banales JM, Roskams T, Beuers U, Karlsen TH, Jansen PL, Schaap FG (2016)
Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
Liver Int., 36 (9), 1370-1377
DOI 10.1111/liv.13092

Publications 2015

Aberg F, Gissler M, Karlsen TH, Ericzon BG, Foss A, Rasmussen A, Bennet W, Olausson M, Line PD, Nordin A, Bergquist A, Boberg KM, Castedal M, Pedersen CR, Isoniemi H (2015)
Differences in Long-Term Survival Among Liver Transplant Recipients and the General Population: A Population-Based Nordic Study
Hepatology, 61 (2), 668-677
DOI 10.1002/hep.27538

Andersen IM, Fosby B, Boberg KM, Clausen OPF, Jebsen P, Melum E, Line PD, Foss A, Schrumpf E, Karlsen TH (2015)
Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway
Transplant. Direct., 1 (9), e39
DOI 10.1097/TXD.0000000000000548

Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills I, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM (2015)
Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
PLoS One, 10 (4), e0123057
DOI 10.1371/journal.pone.0123057

Andreassen OA, Desikan RS, Wang YP, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM (2015)
Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms (vol 10, e0123057, 2015)
PLoS One, 10 (5), e0128048
DOI 10.1371/journal.pone.0128048

Berntsen NL, Klingenberg O, Juran BD, de Valle MB, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR (2015)
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Gastroenterology, 148 (5), 924-U355
DOI 10.1053/j.gastro.2015.01.041

Carpino G, Cardinale V, Renzi A, Hov JR, Berloco PB, Rossi M, Karlsen TH, Alvaro D, Gaudio E (2015)
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
J. Hepatol., 63 (5), 1220-1228
DOI 10.1016/j.jhep.2015.06.018

Folseraas T, Liaskou E, Anderson CA, Karlsen TH (2015)
Genetics in PSC: What Do the "Risk Genes" Teach Us?
Clin. Rev. Allergy Immunol., 48 (2-3), 154-164
DOI 10.1007/s12016-014-8417-z

Fosby B, Melum E, Bjoro K, Bennet W, Rasmussen A, Andersen IM, Castedal M, Olausson M, Wibeck C, Gotlieb M, Gjertsen H, Toivonen L, Foss S, Makisalo H, Nordin A, Sanengen T, Bergquist A, Larsson ME, Soderdahl G, Nowak G, Boberg KM, Isoniemi H, Keiding S, Foss A, Line PD et al. (2015)
Liver transplantation in the Nordic countries - An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013
Scand. J. Gastroenterol., 50 (6), 797-808
DOI 10.3109/00365521.2015.1036359

Hov JR, Zhong HZ, Qin BC, Anmarkrud JA, Holm K, Franke A, Lie BA, Karlsen TH (2015)
The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
PLoS One, 10 (7), e0133804
DOI 10.1371/journal.pone.0133804

Karlsen TH, Chung BK (2015)
Genetic Risk and the Development of Autoimmune Liver Disease
Dig. Dis., 33 2, 13-24
DOI 10.1159/000440706

Karlsen TH, Lammert F, Thompson RJ (2015)
Genetics of liver disease: From pathophysiology to clinical practice
J. Hepatol., 62 1, S6-S14
DOI 10.1016/j.jhep.2015.02.025

Li J, Jorgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, Videm V, Folseraas T, Atschekzei F, Elder JT, Nair RP, Winkelmann J, Gieger C, Nothen MM, Buning C, Brand S et al. (2015)
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat. Commun., 6, 6804
DOI 10.1038/ncomms7804

Maggadottir SM, Li J, Glessner JT, Li YR, Wei Z, Chang X, Mentch FD, Thomas KA, Kim CE, Zhao Y, Hou CP, Wang FX, Jorgensen SF, Perez EE, Sullivan KE, Orange JS, Karlsen TH, Chapel H, Cunningham-Rundles C, Hakonarson H (2015)
Rare variants at 16p11.2 are associated with common variable immunodeficiency
J. Allergy Clin. Immunol., 135 (6), 1569-1577
DOI 10.1016/j.jaci.2014.12.1939

Olin P, Hausken J, Foss A, Karlsen TH, Melum E, Haugaa H (2015)
Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation
Scand. J. Gastroenterol., 50 (9), 1127-1134
DOI 10.3109/00365521.2015.1027262

Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015)
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
Nat. Biotechnol., 33 (8), 845-+
DOI 10.1038/nbt.3275

Schrumpf E, Boberg KM, Karlsen TH (2015)
Primary sclerosing cholangitis - the Norwegian experience
Scand. J. Gastroenterol., 50 (6), 781-796
DOI 10.3109/00365521.2015.1028996

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Bjorkstrom NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E (2015)
The biliary epithelium presents antigens to and activates natural killer T cells
Hepatology, 62 (4), 1249-1259
DOI 10.1002/hep.27840

Thorsen T, Dahlgren US, Aandahl EM, Grzyb K, Karlsen TH, Boberg KM, Rydberg L, Naper C, Foss A, Bennet W (2015)
Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications
Transpl. Int., 28 (7), 800-812
DOI 10.1111/tri.12552

Thorsen T, Aandahl EM, Bennet W, Olausson M, Ericzon BG, Nowak G, Duraj F, Isoniemi H, Rasmussen A, Karlsen TH, Foss A (2015)
Transplantation With Livers From Deceased Donors Older Than 75 Years
Transplantation, 99 (12), 2534-2542
DOI 10.1097/TP.0000000000000728

Troseid M, Ueland T, Hov JR, Svardal A, Gregersen I, Dahl CP, Aakhus S, Gude E, Bjorndal B, Halvorsen B, Karlsen TH, Aukrust P, Gullestad L, Berge RK, Yndestad A (2015)
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
J. Intern. Med., 277 (6), 717-726
DOI 10.1111/joim.12328

Vesterhus M, Hov JR, Holm A, Schrumpf E, Nygard S, Godang K, Andersen IM, Naess S, Thorburn D, Saffioti F, Vatn M, Gilja OH, Lund-Johansen F, Syversveen T, Brabrand K, Pares A, Ponsioen CY, Pinzani M, Farkkila M, Moum B, Ueland T, Rosjo H, Rosenberg W, Boberg KM, Karlsen TH (2015)
Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
Hepatology, 62 (1), 188-197
DOI 10.1002/hep.27825

Vukcevic D, Traherne JA, Naess S, Ellinghaus E, Kamatani Y, Dilthey A, Lathrop M, Karlsen TH, Franke A, Moffatt M, Cookson W, Trowsdale J, McVean G, Sawcer S, Leslie S (2015)
Imputation of KIR Types from SNP Variation Data
Am. J. Hum. Genet., 97 (4), 593-607
DOI 10.1016/j.ajhg.2015.09.005

Wittig M, Anmarkrud JA, Kassens JC, Koch S, Forster M, Ellinghaus E, Hov JR, Sauer S, Schimmler M, Ziemann M, Gorg S, Jacob F, Karlsen TH, Franke A (2015)
Development of a high-resolution NGS-based HLA-typing and analysis pipeline
Nucleic Acids Res., 43 (11), E70-U11
DOI 10.1093/nar/gkv184

Publications 2014

Andersen IM, Tengesdal G, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis
Clin. Gastroenterol. Hepatol., 12 (6), 1019-1028
DOI 10.1016/j.cgh.2013.09.024

Andreassen OA, McEvoy LK, Thompson WK, Wang YP, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM, Int Consortium Blood Pressure Genetic Factors Osteoporosis (2014)
Identifying Common Genetic Variants in Blood Pressure Due to Polygenic Pleiotropy With Associated Phenotypes
Hypertension, 63 (4), 819-826
DOI 10.1161/HYPERTENSIONAHA.113.02077

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M, Int PSC Study Grp IPSCSG (2014)
Characterization of animal models for primary sclerosing cholangitis (PSC)
J. Hepatol., 60 (6), 1290-1303
DOI 10.1016/j.jhep.2014.02.006

Flachsbart F, Caliebe A, Heinsen FA, Hemming-Karlsen T, Schreiber S, Franke A, Nebel A (2014)
Investigation of Complement Component C4 Copy Number Variation in Human Longevity
PLoS One, 9 (1), e86188
DOI 10.1371/journal.pone.0086188

Fosby B, Naess S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH (2014)
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation vs
World J. Gastroenterol., 20 (14), 3986-4000
DOI 10.3748/wjg.v20.i14.3986

Henriksen EKK, Melum E, Karlsen TH (2014)
Update on primary sclerosing cholangitis genetics
Curr. Opin. Gastroenterol., 30 (3), 310-319
DOI 10.1097/MOG.0000000000000052

Hirschfield GM, Karlsen TH (2014)
Genetic Risks Link Autoimmune Hepatitis to Other Autoimmune Liver Disease
Gastroenterology, 147 (2), 270-273
DOI 10.1053/j.gastro.2014.06.020

Karlsen TH, Vesterhus M, Boberg KM (2014)
Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis
Aliment. Pharmacol. Ther., 39 (3), 282-301
DOI 10.1111/apt.12581

Naess S, Bjornsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SGE, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int., 34 (10), 1488-1495
DOI 10.1111/liv.12492

Naess S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJP, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH (2014)
Refinement of the MHC Risk Map in a Scandinavian Primary Sclerosing Cholangitis Population
PLoS One, 9 (12), e114486
DOI 10.1371/journal.pone.0114486

Publications 2013

Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismuller TJ, Schramm C, Wittig M, Bergquist A, Bjornsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al. (2013)
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis and Ulcerative Colitis Identifies Risk Loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-1083
DOI 10.1002/hep.25977

Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, Stade B, Bromberg Y, Ellinghaus E, Keller A, Rivas MA, Skieceviciene J, Doncheva NT, Liu X, Liu Q, Jiang FM, Forster M, Mayr G, Albrecht M, Hasler R, Boehm BO, Goodall J, Berzuini CR, Lee J, Andersen V et al. (2013)
Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies
Gastroenterology, 145 (2), 339-347
DOI 10.1053/j.gastro.2013.04.040

Friedrich K, Rupp C, Hov JR, Steinebrunner N, Weiss KH, Stiehl A, Brune M, Schaefer PKY, Schemmer P, Sauer P, Schirmacher P, Runz H, Karlsen TH, Stremmel W, Gotthardt DN (2013)
A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis
PLoS One, 8 (3), e58734
DOI 10.1371/journal.pone.0058734

Hirschfield GM, Chapman RW, Karlsen TH, Lammert F, Lazaridis KN, Mason AL (2013)
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Gastroenterology, 144 (7), 1357-1374
DOI 10.1053/j.gastro.2013.03.053

Hirschfield GM, Karlsen TH, Lindor KD, Adams DH (2013)
Primary sclerosing cholangitis
Lancet, 382 (9904), 1587-1599
DOI 10.1016/S0140-6736(13)60096-3

Jorgensen KK, Lindstrom L, Cvancarova M, Karlsen TH, Castedal M, Friman S, Schrumpf E, Foss A, Isoniemi H, Nordin A, Holte K, Rasmussen A, Bergquist A, Vatn MH, Boberg KM (2013)
Immunosuppression After Liver Transplantation for Primary Sclerosing Cholangitis Influences Activity of Inflammatory Bowel Disease
Clin. Gastroenterol. Hepatol., 11 (5), 517-523
DOI 10.1016/j.cgh.2012.12.027

Karlsen TH, Boberg KM (2013)
Update on primary sclerosing cholangitis
J. Hepatol., 59 (3), 571-582
DOI 10.1016/j.jhep.2013.03.015

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismuller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Muller T, Srivastava B, Dalekos G, Nothen MM, Herms S et al. (2013)
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nature Genet., 45 (6), 670-+
DOI 10.1038/ng.2616

Mells GF, Kaser A, Karlsen TH (2013)
Novel insights into autoimmune liver diseases provided by genome-wide association studies
J. Autoimmun., 46, 41-54
DOI 10.1016/j.jaut.2013.07.004

Metzger J, Negm AA, Plentz RR, Weismuller TJ, Wedemeyer J, Karlsen TH, Dakna M, Mullen W, Mischak H, Manns MP, Lankisch TO (2013)
Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders
Gut, 62 (1), 122-130
DOI 10.1136/gutjnl-2012-302047

Wannhoff A, Hov JR, Folseraas T, Rupp C, Friedrich K, Anmarkrud JA, Weiss KH, Sauer P, Schirmacher P, Boberg KM, Stremmel W, Karlsen TH, Gotthardt DN (2013)
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J. Hepatol., 59 (6), 1278-1284
DOI 10.1016/j.jhep.2013.08.005

Publications 2012

Andresen K, Boberg KM, Vedeld HM, Honne H, Hektoen M, Wadsworth CA, Clausen OP, Karlsen TH, Foss A, Mathisen O, Schrumpf E, Lothe RA, Lind GE (2012)
Novel target genes and a valid biomarker panel identified for cholangiocarcinoma
Epigenetics, 7 (11), 1249-1257
DOI 10.4161/epi.22191

Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismuller TJ, Gotthard DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Bjornsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J. Hepatol., 57 (2), 366-375
DOI 10.1016/j.jhep.2012.03.031

Fosby B, Karlsen TH, Melum E (2012)
Recurrence and rejection in liver transplantation for primary sclerosing cholangitis
World J. Gastroenterol., 18 (1), 1-15
DOI 10.3748/wjg.v18.i1.1

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V et al. (2012)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature, 491 (7422), 119-124
DOI 10.1038/nature11582

Karlsen TH (2012)
A Lecture on the Genetics of Primary Sclerosing Cholangitis
Dig. Dis., 30 1, 32-38
DOI 10.1159/000341122

Naess S, Shiryaev A, Hov JR, Franke A, Karlsen TH (2012)
Genetics in primary sclerosing cholangitis
Clin. Res. Hepatol. Gastroenterol., 36 (4), 325-333
DOI 10.1016/j.clinre.2012.02.003

Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E, UK-PSC Consortium (2012)
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis
Scand. J. Gastroenterol., 47 (7), 820-826
DOI 10.3109/00365521.2012.682090

Publications 2011

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagace C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C et al. (2011)
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Nature Genet., 43 (3), 246-U94
DOI 10.1038/ng.764

Folseraas T, Karlsen TH (2011)
To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?
Liver Int., 31 (6), 751-754
DOI 10.1111/j.1478-3231.2011.02471.x

Folseraas T, Melum E, Franke A, Karlsen TH (2011)
Genetics in primary sclerosing cholangitis
Best Pract. Res. Clin. Gastroenterol., 25 (6), 713-726
DOI 10.1016/j.bpg.2011.09.010

Friman S, Foss A, Isoniemi H, Olausson M, Hockerstedt K, Yamamoto S, Karlsen TH, Rizell M, Ericzon BG (2011)
Liver transplantation for cholangiocarcinoma: Selection is essential for acceptable results
Scand. J. Gastroenterol., 46 (3), 370-375
DOI 10.3109/00365521.2010.533384

Hov JR, Keitel V, Schrumpf E, Haussinger D, Karlsen TH (2011)
TGR5 Sequence Variation in Primary Sclerosing Cholangitis
Dig. Dis., 29 (1), 78-84
DOI 10.1159/000324138

Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH (2011)
Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis
Hepatology, 53 (6), 1967-1976
DOI 10.1002/hep.24299

Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Boberg KM, Melum E, Folseraas T, Schrumpf E, Bergquist A, Bjornsson E, Fu JY, Westra HJ, Groen HJM, Fehrmann RSN, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismuller TJ, Wedemeyer J, Schramm C, Sterneck M, Gunther R, Braun F et al. (2011)
Three Ulcerative Colitis Susceptibility Loci Are Associated with Primary Sclerosing Cholangitis and Indicate a Role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-1985
DOI 10.1002/hep.24307

Karlsen TH, Kaser A (2011)
Deciphering the Genetic Predisposition to Primary Sclerosing Cholangitis
Semin. Liver Dis., 31 (2), 188-207
DOI 10.1055/s-0031-1276647

Karlsen TH, Lazaridis KN (2011)
At the End of the Beginning FOREWORD
Semin. Liver Dis., 31 (2), 111-113
DOI 10.1055/s-0031-1276640

Melum E, Franke A, Schramm C, Weismuller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Bjornsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2011)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nature Genet., 43 (1), 17-19
DOI 10.1038/ng.728

Publications 2010

Bowlus CL, Li CS, Karlsen TH, Lie BA, Selmi C (2010)
Primary Sclerosing Cholangitis in Genetically Diverse Populations Listed for Liver Transplantation: Unique Clinical and Human Leukocyte Antigen Associations
Liver Transplant., 16 (11), 1324-1330
DOI 10.1002/lt.22161

Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G et al. (2010)
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Nature Genet., 42 (11), 991-U113
DOI 10.1038/ng.689

Franke A, Balschun T, Sina C, Ellinghaus D, Hasler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH, Krawczak M, Rosenstiel P et al. (2010)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
Nature Genet., 42 (4), 292-294
DOI 10.1038/ng.553

Holm K, Melum E, Franke A, Karlsen TH (2010)
SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
BMC Bioinformatics, 11, 600
DOI 10.1186/1471-2105-11-600

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismuller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
PLoS One, 5 (8), e12403
DOI 10.1371/journal.pone.0012403

Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P (2010)
Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C
J. Hepatol., 52 (5), 712-717
DOI 10.1016/j.jhep.2009.11.029

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismuller TJ, Gotthardt D, Rust C, Philipp EER, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2010)
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Gastroenterology, 138 (3), 1102-1111
DOI 10.1053/j.gastro.2009.11.046

Karlsen TH, Hov JR (2010)
Genetics of cholestatic liver disease in 2010
Curr. Opin. Gastroenterol., 26 (3), 251-258
DOI 10.1097/MOG.0b013e328336807d

Karlsen TH, Melum E, Franke A (2010)
The Utility of Genome-Wide Association Studies in Hepatology
Hepatology, 51 (5), 1833-1842
DOI 10.1002/hep.23564

Karlsen TH, Schrumpf E, Boberg KM (2010)
Update on primary sclerosing cholangitis
Dig. Liver Dis., 42 (6), 390-400
DOI 10.1016/j.dld.2010.01.011

Karlsen TH, Schrumpf E, Boberg KM (2010)
Primary sclerosing cholangitis
Best Pract. Res. Clin. Gastroenterol., 24 (5), 655-666
DOI 10.1016/j.bpg.2010.07.005

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J. Neuroimmunol., 226 (1-2), 194-197
DOI 10.1016/j.jneuroim.2010.07.003

Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2010)
SNP Discovery Performance of Two Second-Generation Sequencing Platforms in the NOD2 Gene Region
Hum. Mutat., 31 (7), 875-885
DOI 10.1002/humu.21276

Publications 2009

Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjoras M, Boberg KM, Alseth I (2009)
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-1154
DOI 10.1093/carcin/bgp118

Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF (2009)
Killer Immunoglobulin-like Receptor Ligand HLA-Bw4 Protects Against Multiple Sclerosis
Ann. Neurol., 65 (6), 658-666
DOI 10.1002/ana.21695

Melum E, Franke A, Karlsen TH (2009)
Genome-wide association studies - A summary for the clinical gastroenterologist
World J. Gastroenterol., 15 (43), 5377-5396
DOI 10.3748/wjg.15.5377

Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen TH, Boberg KM, Bergquist A, Kunz M, Witte T, Gross WL, Epplen JT, Alarcon-Riquelme ME, Schreiber S, Ibrahim SM (2009)
Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases
Genes Immun., 10 (6), 601-605
DOI 10.1038/gene.2009.29

Publications 2008

Eike MC, Nordang GBN, Karlsen TH, Boberg KM, Vatn MH, Dahl-Jorgensen K, Ronningen KS, Joner G, Flato B, Bergquist A, Thorsby E, Forre O, Kvien TK, Undlien DE, Lie BA, IBSEN Study Grp (2008)
The FCRL3-169T > C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases
Ann. Rheum. Dis., 67 (9), 1287-1291
DOI 10.1136/ard.2007.077826

Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S (2008)
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Nature Genet., 40 (6), 713-715
DOI 10.1038/ng.148

Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PCF, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, Mathew CG, Schreiber S et al. (2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Nature Genet., 40 (11), 1319-1323
DOI 10.1038/ng.221

Hov JR, Boberg KM, Karlsen TH (2008)
Autoantibodies in primary sclerosing cholangitis
World J. Gastroenterol., 14 (24), 3781-3791
DOI 10.3748/wjg.14.3781

Karlsen TH, Schrumpf E, Boberg KM (2008)
Gallbladder polyps in primary sclerosing cholangitis: not so benign
Curr. Opin. Gastroenterol., 24 (3), 395-399
DOI 10.1097/MOG.0b013e3282f5727a

Melum E, Buch S, Schafmayer C, Kalthoff H, Tepel J, Schreiber S, Karlsen TH, Hampe J (2008)
Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
Int. J. Cancer, 123 (1), 241-242
DOI 10.1002/ijc.23517

Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM (2008)
An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
Am. J. Gastroenterol., 103 (4), 1045
DOI 10.1111/j.1572-0241.2007.01772_5.x

Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA (2008)
Cholanglocarcinoma in primary sclerosing cholangitis is associated with NKG2D Polymorphisms
Hepatology, 47 (1), 90-96
DOI 10.1002/hep.21964

Publications 2007

Franke A, Rosenstiel P, Balschun T, von Kampen O, Schreiber S, Sina C, Hampe J, Karlsen TH, Vatn MH, Solberg C, IBSEN Study Grp (2007)
No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample
Gastroenterology, 132 (5), 2080-2081
DOI 10.1053/j.gastro.2007.03.087

Karlsen TH (2007)
On the genetic influence on disease susceptibility and disease progression in primary sclerosing cholangitis
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 534, 1 b. (flere pag.)
BIBSYS 071323686, ISBN 978-82-8072-709-1

Karlsen TH, Boberg KM, Olsson M, Sun JY, Senitzer D, Bergquist A, Schrumpf E, Thorsby E, Lie BA (2007)
Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
J. Hepatol., 46 (5), 899-906
DOI 10.1016/j.jhep.2007.01.032

Karlsen TH, Hampe J, Wiencke K, Schrumpf E, Thorsby E, Lie BA, Broome U, Schreiber S, Boberg KM (2007)
Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis
Am. J. Gastroenterol., 102 (1), 115-121
DOI 10.1111/j.1572-0241.2006.00928.x

Karlsen TH, Schrumpf E, Boberg KM (2007)
Genetic epidemiology of primary sclerosing cholangitis
World J. Gastroenterol., 13 (41), 5421-5431
DOI 10.3748/wjg.v13.i41.5421

Wiencke K, Karlsen TH, Boberg KM, Thorsby E, Schrumpf E, Lie BA, Spurkland A (2007)
Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes
Tissue Antigens, 69 (2), 161-169
DOI 10.1111/j.1399-0039.2006.00738.x

Publications 2006

Bowlus CL, Karlsen TH, Broome U, Thorsby E, Vatn M, Schrumpf E, Lie BA, Boberg KM, IBSEN study grp (2006)
Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
J. Hepatol., 45 (5), 704-710
DOI 10.1016/j.jhep.2006.03.012

Franke A, Ruether A, Wedemeyer N, Karlsen TH, Nebel A, Schreiber S (2006)
No association between the functional CARD4 insertion/deletion polymorphism and inflammatory bowel diseases in the German population
Gut, 55 (11), 1679-1680
DOI 10.1136/gut.2006.104646

Karlsen TH, Lie BA, Froslie KF, Thorsby E, Broome U, Schrumpf E, Boberg KM (2006)
Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
Gastroenterology, 131 (3), 781-787
DOI 10.1053/j.gastro.2006.05.057

Melum E, Karlsen TH, Broome U, Thorsby E, Schrumpf E, Boberg KM, Lie BA (2006)
The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta 32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
Tissue Antigens, 68 (1), 78-81
DOI 10.1111/j.1399-0039.2006.00604.x

Publications 2002

Karlsen TH (2002)
Forslag vedrørende fremtidige arbeidsprosesser i medisinsk avdeling, Aust-Agder sykehus HF
In Organisasjonsutvikling og gevinstrealisering knyttet til elektronisk pasientjournal ved medisinsk avdeling, Aust-Agdersykehus HF: sluttrapport, Aust-Agder sykehus HF, Arendal, Vedlegg 3, 60 s.
BIBSYS 080931561

Karlsen TH, Eikestad V (2002)
Organisasjonsutvikling og gevinstrealisering knyttet til elektronisk pasientjournal ved medisinsk avdeling, Aust-Agdersykehus HF: sluttrapport
Aust-Agder sykehus HF, Arendal, 31 s.
BIBSYS 080931464

Karlsen TH, Eikestad V (2002)
Karlegging av arbeidsprosesser i medisinsk avdeling, Aust-Agder sykehus HF
In Organisasjonsutvikling og gevinstrealisering knyttet til elektronisk pasientjournal ved medisinsk avdeling, Aust-Agdersykehus HF: sluttrapport, Aust-Agder sykehus HF, Arendal, Vedlegg 2, 66 s.
BIBSYS 080931618