Publications 2024

Randsborg PH, Brinchmann JE, Owesen C, Engebretsen L, Birkenes T, Hanvold HA, Benth JŠ, Årøen A (2024)
Autologous Chondrocyte Implantation Is Not Better Than Arthroscopic Debridement for the Treatment of Symptomatic Cartilage Lesions of the Knee: Two-Year Results From a Randomized-Controlled Trial
Arthrosc Sports Med Rehabil, 6 (2), 100909
DOI 10.1016/j.asmr.2024.100909, PubMed 38495635

Publications 2023

Frerker N, Karlsen TA, Stensland M, Nyman TA, Rayner S, Brinchmann JE (2023)
Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants
Front Bioeng Biotechnol, 11, 1116513
DOI 10.3389/fbioe.2023.1116513, PubMed 36896010

Publications 2022

Brinchmann BC, Holme JA, Frerker N, Rambøl MH, Karlsen T, Brinchmann JE, Kubátová A, Kukowski K, Skuland T, Øvrevik J (2022)
Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells
Basic Clin Pharmacol Toxicol, 132 (1), 83-97
DOI 10.1111/bcpt.13805, PubMed 36214226

Publications 2021

Al-Modawi RN, Brinchmann JE, Karlsen TA (2021)
Extensive downregulation of immune gene expression by microRNA-140-3p 5' isomiR in an in vitro model of osteoarthritis
Osteoarthr Cartil Open, 3 (3), 100189
DOI 10.1016/j.ocarto.2021.100189, PubMed 36474808

Frerker N, Karlsen TA, Lilledahl MB, Brorson SH, Tibballs JE, Brinchmann JE (2021)
Scaffold-Free Engineering of Human Cartilage Implants
Cartilage, 13 (1_suppl), 1237S-1249S
DOI 10.1177/19476035211007923, PubMed 33858229

Publications 2019

Al-Modawi RN, Brinchmann JE, Karlsen TA (2019)
Multi-pathway Protective Effects of MicroRNAs on Human Chondrocytes in an In Vitro Model of Osteoarthritis
Mol Ther Nucleic Acids, 17, 776-790
DOI 10.1016/j.omtn.2019.07.011, PubMed 31446120

Karlsen TA, Sundaram AYM, Brinchmann JE (2019)
Single-Cell RNA Sequencing of In Vitro Expanded Chondrocytes: MSC-Like Cells With No Evidence of Distinct Subsets
Cartilage, 13 (2_suppl), 774S-784S
DOI 10.1177/1947603519847746, PubMed 31072202

Karlsen TA, Aae TF, Brinchmann JE (2019)
Robust profiling of microRNAs and isomiRs in human plasma exosomes across 46 individuals
Sci Rep, 9 (1), 19999
DOI 10.1038/s41598-019-56593-7, PubMed 31882820

Kosik-Kozioł A, Costantini M, Mróz A, Idaszek J, Heljak M, Jaroszewicz J, Kijeńska E, Szöke K, Frerker N, Barbetta A, Brinchmann JE, Święszkowski W (2019)
3D bioprinted hydrogel model incorporating β-tricalcium phosphate for calcified cartilage tissue engineering
Biofabrication, 11 (3), 035016
DOI 10.1088/1758-5090/ab15cb, PubMed 30943457

Suliman S, Ali HRW, Karlsen TA, Amiaud J, Mohamed-Ahmed S, Layrolle P, Costea DE, Brinchmann JE, Mustafa K (2019)
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells
Sci Rep, 9 (1), 16031
DOI 10.1038/s41598-019-52442-9, PubMed 31690774

Aae TF, Karlsen TA, Haugen IK, Risberg MA, Lian ØB, Brinchmann JE (2019)
Evaluating plasma extracellular vesicle microRNAs as possible biomarkers for osteoarthritis
Osteoarthr Cartil Open, 1 (3-4), 100018
DOI 10.1016/j.ocarto.2019.100018, PubMed 36475003

Publications 2018

Brinchmann BC, Skuland T, Rambøl MH, Szoke K, Brinchmann JE, Gutleb AC, Moschini E, Kubátová A, Kukowski K, Le Ferrec E, Lagadic-Gossmann D, Schwarze PE, Låg M, Refsnes M, Øvrevik J, Holme JA (2018)
Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)
Part Fibre Toxicol, 15 (1), 21
DOI 10.1186/s12989-018-0257-1, PubMed 29751765

Karlsen TA, Brinchmann JE (2018)
Expression of inflammatory cytokines in mesenchymal stromal cells is sensitive to culture conditions and simple cell manipulations
Exp Cell Res, 374 (1), 122-127
DOI 10.1016/j.yexcr.2018.11.014, PubMed 30496759

Rambøl MH, Hisdal J, Sundhagen JO, Brinchmann JE, Rosales A (2018)
Recellularization of Decellularized Venous Grafts Using Peripheral Blood: A Critical Evaluation
EBioMedicine, 32, 215-222
DOI 10.1016/j.ebiom.2018.05.012, PubMed 29779699

Publications 2017

Szoke K, Dankova J, Buzgo M, Amler E, Brinchmann JE, Ostrup E (2017)
The effect of medium composition on deposition of collagen type 1 and expression of osteogenic genes in mesenchymal stem cells derived from human adipose tissue and bone marrow
Process Biochem., 59, 321-328
DOI 10.1016/j.procbio.2016.10.011

Wollert KC, Meyer GP, Müller-Ehmsen J, Tschöpe C, Bonarjee V, Larsen AI, May AE, Empen K, Chorianopoulos E, Tebbe U, Waltenberger J, Mahrholdt H, Ritter B, Pirr J, Fischer D, Korf-Klingebiel M, Arseniev L, Heuft HG, Brinchmann JE, Messinger D, Hertenstein B, Ganser A, Katus HA, Felix SB, Gawaz MP et al. (2017)
Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial
Eur Heart J, 38 (39), 2936-2943
DOI 10.1093/eurheartj/ehx188, PubMed 28431003

Publications 2016

Behnan J, Stangeland B, Hosainey SA, Joel M, Olsen TK, Micci F, Glover JC, Isakson P, Brinchmann JE (2016)
Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency
Oncogene, 36 (4), 570-584
DOI 10.1038/onc.2016.230, PubMed 27345406

Behnan J, Stangeland B, Langella T, Finocchiaro G, Murrell W, Brinchmann JE (2016)
Ultrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells
Sci Rep, 6, 32788
DOI 10.1038/srep32788, PubMed 27605047

Costantini M, Idaszek J, Szöke K, Jaroszewicz J, Dentini M, Barbetta A, Brinchmann JE, Święszkowski W (2016)
3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation
Biofabrication, 8 (3), 035002
DOI 10.1088/1758-5090/8/3/035002, PubMed 27431574

Foldager CB, Bendtsen M, Berg LC, Brinchmann JE, Brittberg M, Bunger C, Canseco J, Chen L, Christensen BB, Colombier P, Deleuran BW, Edwards J, Elmengaard B, Farr J, Gatenholm B, Gomoll AH, Hui JH, Jakobsen RB, Joergensen NL, Kassem M, Koch T, Kold S, Krogsgaard MR, Lauridsen H, Le D et al. (2016)
Aarhus Regenerative Orthopaedics Symposium (AROS)
Acta Orthop, 87 (sup363), 1-5
DOI 10.1080/17453674.2017.1297918, PubMed 28271925

Karlsen TA, de Souza GA, Ødegaard B, Engebretsen L, Brinchmann JE (2016)
microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1β-induced Osteoarthritis
Mol Ther Nucleic Acids, 5 (10), e373
DOI 10.1038/mtna.2016.64, PubMed 27727249

Publications 2015

Hart ML, Izeta A, Herrera-Imbroda B, Amend B, Brinchmann JE (2015)
Cell Therapy for Stress Urinary Incontinence
Tissue Eng Part B Rev, 21 (4), 365-76
DOI 10.1089/ten.TEB.2014.0627, PubMed 25789845

Pullisaar H, Verket A, Szoke K, Tiainen H, Haugen HJ, Brinchmann JE, Reseland JE, Østrup E (2015)
Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds
J Tissue Eng, 6, 2041731415575870
DOI 10.1177/2041731415575870, PubMed 26090086

Szöke K, Reinisch A, Østrup E, Reinholt FP, Brinchmann JE (2015)
Autologous cell sources in therapeutic vasculogenesis: In vitro and in vivo comparison of endothelial colony-forming cells from peripheral blood and endothelial cells isolated from adipose tissue
Cytotherapy, 18 (2), 242-52
DOI 10.1016/j.jcyt.2015.10.009, PubMed 26669908

Publications 2014

Herlofsen SR, Høiby T, Cacchiarelli D, Zhang X, Mikkelsen TS, Brinchmann JE (2014)
Brief report: importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells
Stem Cells, 32 (6), 1629-35
DOI 10.1002/stem.1642, PubMed 24449344

Jakobsen RB, Shahdadfar A, Reinholt FP, Brinchmann JE (2014)
Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue (vol 18, pg 1407, 2010)
Knee Surg. Sports Traumatol. Arthrosc., 22 (7), 1711-1714
DOI 10.1007/s00167-014-2938-0

Jakobsen RB, Østrup E, Zhang X, Mikkelsen TS, Brinchmann JE (2014)
Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling
PLoS One, 9 (5), e96615
DOI 10.1371/journal.pone.0096615, PubMed 24816923

Klein G, Hart ML, Brinchmann JE, Rolauffs B, Stenzl A, Sievert KD, Aicher WK (2014)
Mesenchymal stromal cells for sphincter regeneration
Adv Drug Deliv Rev, 82-83, 123-36
DOI 10.1016/j.addr.2014.10.026, PubMed 25451135

Olderøy MØ, Lilledahl MB, Beckwith MS, Melvik JE, Reinholt F, Sikorski P, Brinchmann JE (2014)
Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels
PLoS One, 9 (3), e91662
DOI 10.1371/journal.pone.0091662, PubMed 24626259

Pullisaar H, Reseland JE, Haugen HJ, Brinchmann JE, Ostrup E (2014)
Simvastatin coating of TiO₂ scaffold induces osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells
Biochem Biophys Res Commun, 447 (1), 139-44
DOI 10.1016/j.bbrc.2014.03.133, PubMed 24704451

Publications 2013

Fernandes AM, Herlofsen SR, Karlsen TA, Küchler AM, Fløisand Y, Brinchmann JE (2013)
Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage
PLoS One, 8 (5), e62994
DOI 10.1371/journal.pone.0062994, PubMed 23671648

Herlofsen SR, Bryne JC, Høiby T, Wang L, Issner R, Zhang X, Coyne MJ, Boyle P, Gu H, Meza-Zepeda LA, Collas P, Mikkelsen TS, Brinchmann JE (2013)
Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells
BMC Genomics, 14, 105
DOI 10.1186/1471-2164-14-105, PubMed 23414147

Karlsen TA, Brinchmann JE (2013)
Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I
Mol Ther, 21 (6), 1169-81
DOI 10.1038/mt.2013.55, PubMed 23568258

Karlsen TA, Jakobsen RB, Mikkelsen TS, Brinchmann JE (2013)
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN
Stem Cells Dev, 23 (3), 290-304
DOI 10.1089/scd.2013.0209, PubMed 24063364

Rohban R, Reinisch A, Etchart N, Schallmoser K, Hofmann NA, Szoke K, Brinchmann JE, Bonyadi Rad E, Rohde E, Strunk D (2013)
Identification of an effective early signaling signature during neo-vasculogenesis in vivo by ex vivo proteomic profiling
PLoS One, 8 (6), e66909
DOI 10.1371/journal.pone.0066909, PubMed 23826172

Vik-Mo EO, Nyakas M, Mikkelsen BV, Moe MC, Due-Tønnesen P, Suso EM, Sæbøe-Larssen S, Sandberg C, Brinchmann JE, Helseth E, Rasmussen AM, Lote K, Aamdal S, Gaudernack G, Kvalheim G, Langmoen IA (2013)
Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
Cancer Immunol Immunother, 62 (9), 1499-509
DOI 10.1007/s00262-013-1453-3, PubMed 23817721

Publications 2012

Otto Beitnes J, Oie E, Shahdadfar A, Karlsen T, Müller RM, Aakhus S, Reinholt FP, Brinchmann JE (2012)
Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function
Cell Transplant, 21 (8), 1697-709
DOI 10.3727/096368911X627462, PubMed 22410280

Szöke K, Beckstrøm KJ, Brinchmann JE (2012)
Ectopic expression of CDX4 in human mesenchymal stem cells does not affect HOX gene expression or induce hematopoietic reprogramming
Stem Cell Res, 9 (2), 135-42
DOI 10.1016/j.scr.2012.05.006, PubMed 22721648

Szöke K, Brinchmann JE (2012)
Concise review: therapeutic potential of adipose tissue-derived angiogenic cells
Stem Cells Transl Med, 1 (9), 658-67
DOI 10.5966/sctm.2012-0069, PubMed 23197872

Publications 2011

Beitnes JO, Lunde K, Brinchmann JE, Aakhus S (2011)
Stem cells for cardiac repair in acute myocardial infarction
Expert Rev Cardiovasc Ther, 9 (8), 1015-25
DOI 10.1586/erc.11.108, PubMed 21878046

Duggal S, Brinchmann JE (2011)
Importance of serum source for the in vitro replicative senescence of human bone marrow derived mesenchymal stem cells
J Cell Physiol, 226 (11), 2908-15
DOI 10.1002/jcp.22637, PubMed 21302288

Herlofsen SR, Küchler AM, Melvik JE, Brinchmann JE (2011)
Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in self-gelling alginate discs reveals novel chondrogenic signature gene clusters
Tissue Eng Part A, 17 (7-8), 1003-13
DOI 10.1089/ten.TEA.2010.0499, PubMed 21087199

Karlsen TA, Mirtaheri P, Shahdadfar A, Fløisand Y, Brinchmann JE (2011)
Effect of three-dimensional culture and incubator gas concentration on phenotype and differentiation capability of human mesenchymal stem cells
J Cell Biochem, 112 (2), 684-93
DOI 10.1002/jcb.22978, PubMed 21268090

Szöke K, Beckstrøm KJ, Brinchmann JE (2011)
Human adipose tissue as a source of cells with angiogenic potential
Cell Transplant, 21 (1), 235-50
DOI 10.3727/096368911X580518, PubMed 21669039

Publications 2010

Karlsen TA, Shahdadfar A, Brinchmann JE (2010)
Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype
Tissue Eng Part C Methods, 17 (2), 219-27
DOI 10.1089/ten.TEC.2010.0200, PubMed 20799885

Publications 2009

Beitnes JO, Hopp E, Lunde K, Solheim S, Arnesen H, Brinchmann JE, Forfang K, Aakhus S (2009)
Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study
Heart, 95 (24), 1983-9
DOI 10.1136/hrt.2009.178913, PubMed 19833610

Duggal S, Frønsdal KB, Szöke K, Shahdadfar A, Melvik JE, Brinchmann JE (2009)
Phenotype and gene expression of human mesenchymal stem cells in alginate scaffolds
Tissue Eng Part A, 15 (7), 1763-73
DOI 10.1089/ten.tea.2008.0306, PubMed 19115828

Hildrestrand GA, Duggal S, Bjørås M, Luna L, Brinchmann JE (2009)
Modulation of DNA glycosylase activities in mesenchymal stem cells
Exp Cell Res, 315 (15), 2558-67
DOI 10.1016/j.yexcr.2009.05.017, PubMed 19477173

Jakobsen RB, Shahdadfar A, Reinholt FP, Brinchmann JE (2009)
Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue
Knee Surg Sports Traumatol Arthrosc, 18 (10), 1407-16
DOI 10.1007/s00167-009-1017-4, PubMed 20020100

Koga H, Engebretsen L, Brinchmann JE, Muneta T, Sekiya I (2009)
Mesenchymal stem cell-based therapy for cartilage repair: a review
Knee Surg Sports Traumatol Arthrosc, 17 (11), 1289-97
DOI 10.1007/s00167-009-0782-4, PubMed 19333576

Publications 2008

Dahl JA, Duggal S, Coulston N, Millar D, Melki J, Shahdadfar A, Brinchmann JE, Collas P (2008)
Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum
Int J Dev Biol, 52 (8), 1033-42
DOI 10.1387/ijdb.082663jd, PubMed 18956336

Løken S, Jakobsen RB, Arøen A, Heir S, Shahdadfar A, Brinchmann JE, Engebretsen L, Reinholt FP (2008)
Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model
Knee Surg Sports Traumatol Arthrosc, 16 (10), 896-903
DOI 10.1007/s00167-008-0566-2, PubMed 18592218

Shahdadfar A, Løken S, Dahl JA, Tunheim SH, Collas P, Reinholt FP, Engebretsen L, Brinchmann JE (2008)
Persistence of collagen type II synthesis and secretion in rapidly proliferating human articular chondrocytes in vitro
Tissue Eng Part A, 14 (12), 1999-2007
DOI 10.1089/ten.tea.2007.0344, PubMed 18636947

Wester T, Jørgensen JJ, Stranden E, Sandbaek G, Tjønnfjord G, Bay D, Kollerøs D, Kroese AJ, Brinchmann JE (2008)
Treatment with autologous bone marrow mononuclear cells in patients with critical lower limb ischaemia. A pilot study
Scand J Surg, 97 (1), 56-62
DOI 10.1177/145749690809700108, PubMed 18450207

Publications 2007

Brinchmann JE (2007)
Expanding autologous multipotent mesenchymal bone marrow stromal cells
J Neurol Sci, 265 (1-2), 127-30
DOI 10.1016/j.jns.2007.05.006, PubMed 17560612

Egeland T, Brinchmann JE (2007)
The REPAIR-AMI and ASTAMI trials: cell isolation procedures
Eur Heart J, 28 (17), 2174-5; author reply 2175
DOI 10.1093/eurheartj/ehm240, PubMed 17673446

Egeland T, Brinchmann JE (2007)
Cell quality in the ASTAMI study
Eur Heart J, 28 (17), 2172; author reply 2173-4
DOI 10.1093/eurheartj/ehm125, PubMed 17675309

Publications 2006

Boquest AC, Shahdadfar A, Brinchmann JE, Collas P (2006)
Isolation of stromal stem cells from human adipose tissue
Methods Mol Biol, 325, 35-46
DOI 10.1385/1-59745-005-7:35, PubMed 16761717

Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, Endresen K, Ilebekk A, Mangschau A, Fjeld JG, Smith HJ, Taraldsrud E, Grøgaard HK, Bjørnerheim R, Brekke M, Müller C, Hopp E, Ragnarsson A, Brinchmann JE, Forfang K (2006)
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
N Engl J Med, 355 (12), 1199-209
DOI 10.1056/NEJMoa055706, PubMed 16990383

Publications 2005

Boquest AC, Shahdadfar A, Frønsdal K, Sigurjonsson O, Tunheim SH, Collas P, Brinchmann JE (2005)
Isolation and transcription profiling of purified uncultured human stromal stem cells: alteration of gene expression after in vitro cell culture
Mol Biol Cell, 16 (3), 1131-41
DOI 10.1091/mbc.e04-10-0949, PubMed 15635089

Dalgaard J, Beckstrøm KJ, Jahnsen FL, Brinchmann JE (2005)
Differential capability for phagocytosis of apoptotic and necrotic leukemia cells by human peripheral blood dendritic cell subsets
J Leukoc Biol, 77 (5), 689-98
DOI 10.1189/jlb.1204711, PubMed 15728242

Hedfors IA, Beckstrøm KJ, Benati C, Bonini C, Brinchmann JE (2005)
Retrovirus mediated gene transduction of human T-cell subsets
Cancer Immunol Immunother, 54 (8), 759-68
DOI 10.1007/s00262-004-0647-0, PubMed 15655695

Kvale EØ, Dalgaard J, Lund-Johansen F, Rollag H, Farkas L, Midtvedt K, Jahnsen FL, Brinchmann JE, Olweus J (2005)
CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection
Blood, 107 (5), 2022-9
DOI 10.1182/blood-2005-05-2016, PubMed 16269620

Shahdadfar A, Frønsdal K, Haug T, Reinholt FP, Brinchmann JE (2005)
In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability
Stem Cells, 23 (9), 1357-66
DOI 10.1634/stemcells.2005-0094, PubMed 16081661

Publications 2003

Dalgaard J, Beckstrøm KJ, Brinchmann JE (2003)
Uptake of Apoptotic K562 Leukaemia Cells by Immature Dendritic Cells is Greatly Facilitated by Serum
Scand J Immunol, 58 (5), 541-9
DOI 10.1046/j.1365-3083.2003.01332.x, PubMed 14629626

Hedfors IA, Brinchmann JE (2003)
Polyclonal T-cell activation protocol stimulates preferential expansion of EBV-specific T-cell clones in vitro
Cancer Immunol Immunother, 53 (5), 439-44
DOI 10.1007/s00262-003-0462-z, PubMed 14624314

Hedfors IA, Brinchmann JE (2003)
Long-term proliferation and survival of in vitro-activated T cells is dependent on Interleukin-2 receptor signalling but not on the high-affinity IL-2R
Scand J Immunol, 58 (5), 522-32
DOI 10.1046/j.1365-3083.2003.01338.x, PubMed 14629624

Wester TS, Jørgensen JJ, Stranden E, Bay D, Sandbæk G, Kollerøs D, Tjønnfjord GE, Brinchmann JE, Kroese A (2003)
Behandling av pasienter med kritisk iskemi (KI) i underekstremitene med transplantasjon av autologe stamceller: en pilotstudie
In Vitenskapelige forhandlinger, Norsk kirurgisk forening., [Oslo], 2003, Abstrakt 283
BIBSYS 041735749

Publications 2000

Brinchmann JE (2000)
Differential responses of T cell subsets: possible role in the immunopathogenesis of AIDS
AIDS, 14 (12), 1689-700
DOI 10.1097/00002030-200008180-00002, PubMed 10985304

Publications 1999

Mugnaini EN, Egeland T, Spurkland A, Brinchmann JE (1999)
The T cell receptor repertoire of CD8+CD28- T lymphocytes is dominated by expanded clones that persist over time
Clin Exp Immunol, 117 (2), 298-303
DOI 10.1046/j.1365-2249.1999.00980.x, PubMed 10444261

Mugnaini EN, Egeland T, Syversen AM, Spurkland A, Brinchmann JE (1999)
Molecular analysis of the complementarity determining region 3 of the human T cell receptor beta chain. Establishment of a reference panel of CDR3 lengths from phytohaemagglutinin activated lymphocytes
J Immunol Methods, 223 (2), 207-16
DOI 10.1016/s0022-1759(99)00004-6, PubMed 10089099

Mugnaini EN, Haaheim LL, Sannes M, Brinchmann JE (1999)
In vivo expansion coincident with excessive in vitro cell death within the memory subset of CD8+ T cells in HIV type 1 infection
AIDS Res Hum Retroviruses, 15 (3), 265-72
DOI 10.1089/088922299311448, PubMed 10052757

Mugnaini EN, Syversen AM, Sannes M, Freng A, Brinchmann JE (1999)
Normal CD4 T-cell receptor repertoire in tonsillar tissue despite perturbed repertoire in peripheral blood in HIV-1 infected individuals
AIDS, 13 (18), 2507-13
DOI 10.1097/00002030-199912240-00003, PubMed 10630519

Publications 1998

Brinchmann JE, Røsok BI, Spurkland A (1998)
Activation and proliferation of CD8+ T cells in lymphoid tissues of HIV-1-infected individuals in the absence of the high-affinity IL-2 receptor
J Acquir Immune Defic Syndr Hum Retrovirol, 19 (4), 332-8
DOI 10.1097/00042560-199812010-00003, PubMed 9833741

Mugnaini EN, Spurkland A, Egeland T, Sannes M, Brinchmann JE (1998)
Demonstration of identical expanded clones within both CD8+CD28+ and CD8+CD28- T cell subsets in HIV type 1-infected individuals
Eur J Immunol, 28 (5), 1738-42
DOI 10.1002/(sici)1521-4141(199805)28:05<1738::aid-immu1738>3.0.co;2-s, PubMed 9603481

Reisaeter AV, Thorsby E, Brinchmann JE (1998)
Allospecific helper T-lymphocyte repertoire in monozygotic twins
Scand J Immunol, 47 (4), 381-7
DOI 10.1046/j.1365-3083.1998.00308.x, PubMed 9600321

Røsok BI, Brinchmann JE, Stent G, Bjerknes R, Voltersvik P, Olofsson J, Asjö B (1998)
Correlates of apoptosis of CD4+ and CD8+ T cells in tonsillar tissue in HIV type 1 infection
AIDS Res Hum Retroviruses, 14 (18), 1635-43
DOI 10.1089/aid.1998.14.1635, PubMed 9870316

Spurkland A, Brinchmann JE, Markussen G, Pedeutour F, Munthe E, Lea T, Vartdal F, Aasheim HC (1998)
Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites
J Biol Chem, 273 (8), 4539-46
DOI 10.1074/jbc.273.8.4539, PubMed 9468509

Publications 1997

Rosok B, Brinchmann JE, Voltersvik P, Olofsson J, Bostad L, Asjö B (1997)
Correlates of latent and productive HIV type-1 infection in tonsillar CD4(+) T cells
Proc Natl Acad Sci U S A, 94 (17), 9332-6
DOI 10.1073/pnas.94.17.9332, PubMed 9256482

Røsok B, Voltersvik P, Larsson BM, Albert J, Brinchmann JE, Asjö B (1997)
CD8+ T cells from HIV type 1-seronegative individuals suppress virus replication in acutely infected cells
AIDS Res Hum Retroviruses, 13 (1), 79-85
DOI 10.1089/aid.1997.13.79, PubMed 8989430

Publications 1996

Brinchmann JE, Janson CH, Klem LB, Haaheim LL, Spurkland A (1996)
Strict adherence to a common rank order of T-cell receptor V beta usage in human leucocyte antigen disparate individuals
Scand J Immunol, 44 (2), 179-84
DOI 10.1046/j.1365-3083.1996.d01-294.x, PubMed 8711432

Reisaeter AV, Brinchmann JE, Lundin KE, Thorsby E (1996)
Monozygotic twins display differences in their allospecific cytotoxic T-cell repertoire
Scand J Immunol, 44 (6), 638-42
DOI 10.1046/j.1365-3083.1996.d01-357.x, PubMed 8972747

Reisaeter AV, Thorsby E, Brinchmann JE (1996)
Analysis of alloreactive helper T lymphocyte precursor frequencies. Influence of interleukin-2 produced by the stimulating cells
J Immunol Methods, 189 (1), 65-72
DOI 10.1016/0022-1759(95)00230-8, PubMed 8576581

Røsok BI, Bostad L, Voltersvik P, Bjerknes R, Olofsson J, Asjö B, Brinchmann JE (1996)
Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection
AIDS, 10 (10), F35-8
PubMed 8874620

Publications 1994

Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T (1994)
Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations
J Infect Dis, 169 (4), 730-8
DOI 10.1093/infdis/169.4.730, PubMed 7907640

Lundin KE, Brinchmann JE, Hansen T (1994)
Interactions between staphylococcal superantigens and human T-cell clones are predominantly but not exclusively governed by their T-cell receptor V beta usage
Scand J Immunol, 39 (4), 387-94
DOI 10.1111/j.1365-3083.1994.tb03390.x, PubMed 8146598

Publications 1992

Brinchmann JE (1992)
[Factors influencing the development of the HIV pandemic]
Tidsskr Nor Laegeforen, 112 (17), 2231-4
PubMed 1523666

Brinchmann JE (1992)
[HIV pandemic--history, present, future]
Tidsskr Nor Laegeforen, 112 (17), 2268-71
PubMed 1523672

Brinchmann JE, Gaudernack G, Thorsby E, Vartdal F (1992)
Staphylococcal exotoxin superantigens induce human immunodeficiency virus type 1 expression in naturally infected CD4+ T cells
J Virol, 66 (10), 5924-8
DOI 10.1128/JVI.66.10.5924-5928.1992, PubMed 1356159

Publications 1991

Brinchmann JE (1991)
Human immunodeficiency virus infection: immunological and virological studies
The Norwegian Cancer Society, Oslo, 1 b. (flere pag.)
BIBSYS 911109366, ISBN 82-90187-82-3

Brinchmann JE, Albert J, Vartdal F (1991)
Few infected CD4+ T cells but a high proportion of replication-competent provirus copies in asymptomatic human immunodeficiency virus type 1 infection
J Virol, 65 (4), 2019-23
DOI 10.1128/JVI.65.4.2019-2023.1991, PubMed 1672165

Brinchmann JE, Gaudernack G, Vartdal F (1991)
In vitro replication of HIV-1 in naturally infected CD4+ T cells is inhibited by rIFN alpha 2 and by a soluble factor secreted by activated CD8+ T cells, but not by rIFN beta, rIFN gamma, or recombinant tumor necrosis factor-alpha
J Acquir Immune Defic Syndr (1988), 4 (5), 480-8
PubMed 1673156

Brinchmann JE, Vartdal F, Thorsby E, Bucher A, Frøland SS, Kittelsen P, Kristoffersen J, Baklien K (1991)
[Quantification of T-lymphocyte subpopulations. Immunological marker in human immunodeficiency virus infections]
Tidsskr Nor Laegeforen, 111 (4), 440-3
PubMed 2006482

Publications 1990

Brinchmann JE, Gaudernack G, Vartdal F (1990)
CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. Evidence for a soluble inhibitor
J Immunol, 144 (8), 2961-6
PubMed 1969879

Publications 1989

Brinchmann JE, Gaudernack G, Thorsby E, Jonassen TO, Vartdal F (1989)
Reliable isolation of human immunodeficiency virus from cultures of naturally infected CD4+ T cells
J Virol Methods, 25 (3), 293-300
DOI 10.1016/0166-0934(89)90056-6, PubMed 2573612

Brinchmann JE, Leivestad T, Vartdal F (1989)
Quantification of lymphocyte subsets based on positive immunomagnetic selection of cells directly from blood
J Immunogenet, 16 (2), 177-83
DOI 10.1111/j.1744-313x.1989.tb00460.x, PubMed 2687388

Brinchmann JE, Vartdal F, Thorsby E (1989)
T lymphocyte subset changes in human immunodeficiency virus infection
J Acquir Immune Defic Syndr (1988), 2 (4), 398-403
PubMed 2526872

Publications 1988

Brinchmann JE, Vartdal F, Forset KL, Thorsby E (1988)
A comparison of serial E-RFC monitoring and immunomagnetic quantitation of CD2+ cells in RATG-treated transplant recipients
Transplantation, 45 (4), 804-5
PubMed 2895968

Brinchmann JE, Vartdal F, Forset KL, Thorsby E (1988)
Immunologic monitoring of rabbit antithymocyte globulin-treated transplant recipients: a comparison of serial E-RFC and immunomagnetic quantitation of CD2+ cells
Transplant Proc, 20 (3), 390-1
PubMed 3289168

Brinchmann JE, Vartdal F, Gaudernack G, Markussen G, Funderud S, Ugelstad J, Thorsby E (1988)
Direct immunomagnetic quantification of lymphocyte subsets in blood
Clin Exp Immunol, 71 (1), 182-6
PubMed 3349645

Publications 1983

Brinchmann JE, Haukås G (1983)
[Unusual manifestations of syphilis]
Tidsskr Nor Laegeforen, 103 (13), 1058-60
PubMed 6879544