Publications 2024

Lindeman I, Høydahl LS, Christophersen A, Risnes LF, Jahnsen J, Lundin KEA, Sollid LM, Iversen R (2024)
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease
Cell Rep, 43 (4), 114045
DOI 10.1016/j.celrep.2024.114045, PubMed 38578826

Risnes LF, Reims HM, Doyle RM, Qiao SW, Sollid LM, Lundin KEA, Christophersen A (2024)
Gluten-Free Diet Induces Rapid Changes in Phenotype and Survival Properties of Gluten-Specific T Cells in Celiac Disease
Gastroenterology, 167 (2), 250-263
DOI 10.1053/j.gastro.2024.03.027, PubMed 38552723

Publications 2022

Christophersen A, Zühlke S, Lund EG, Snir O, Dahal-Koirala S, Risnes LF, Jahnsen J, Lundin KEA, Sollid LM (2022)
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv Sci (Weinh), 9 (34), e2205912
DOI 10.1002/advs.202205912, PubMed 36482157

Risnes LF, Chlubnová M, Magistrelli E, Kemppainen E, Hervonen K, Mansikka E, Lindfors K, Salmi T, Dahal-Koirala S, Sollid LM (2022)
Phenotypic Analysis of Disease-Relevant T Cells in Dermatitis Herpetiformis
J Invest Dermatol, 143 (1), 163-166.e2
DOI 10.1016/j.jid.2022.07.007, PubMed 35961617

Publications 2021

Christophersen A, Zühlke S, Lund EG, Snir O, Dahal-Koirala S, Risnes LF, Jahnsen J, Lundin KEA, Sollid LM (2021)
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv Sci (Weinh), 8 (21), e2102778
DOI 10.1002/advs.202102778, PubMed 34495570

Dahal-Koirala S, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Sandve GK, Qiao SW, Sollid LM (2021)
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front Immunol, 12, 639672
DOI 10.3389/fimmu.2021.639672, PubMed 33927715

Eggesbø LM, Risnes LF, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2021)
Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8⁺ αβ T lymphocytes in untreated celiac disease
Eur J Immunol, 51 (6), 1542-1545
DOI 10.1002/eji.202048974, PubMed 33559929

Risnes LF, Eggesbø LM, Christophersen A, Sollid LM (2021)
Response to: "Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease"
Mucosal Immunol, 14 (5), 1216-1217
DOI 10.1038/s41385-021-00422-6, PubMed 34108593

Risnes LF, Eggesbø LM, Zühlke S, Dahal-Koirala S, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2021)
Circulating CD103⁺ γδ and CD8⁺ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Mucosal Immunol, 14 (4), 842-851
DOI 10.1038/s41385-021-00385-8, PubMed 33654213

Publications 2019

Bartolomé-Casado R, Landsverk OJB, Chauhan SK, Richter L, Phung D, Greiff V, Risnes LF, Yao Y, Neumann RS, Yaqub S, Øyen O, Horneland R, Aandahl EM, Paulsen V, Sollid LM, Qiao SW, Baekkevold ES, Jahnsen FL (2019)
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737

Christophersen A, Risnes LF, Dahal-Koirala S, Sollid LM (2019)
Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond
Trends Mol Med, 25 (10), 836-852
DOI 10.1016/j.molmed.2019.05.009, PubMed 31331739

Eggesbø LM, Risnes LF, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2019)
Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease
Mucosal Immunol, 13 (2), 313-321
DOI 10.1038/s41385-019-0222-9, PubMed 31728027

Frick R, Gunnarsen KS, Dahal-Koirala S, Risnes LF, Sollid LM, Sandlie I, Høydahl LS, Løset GÅ (2019)
A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease
Eur J Immunol, 50 (1), 142-145
DOI 10.1002/eji.201948235, PubMed 31580480

Zühlke S, Risnes LF, Dahal-Koirala S, Christophersen A, Sollid LM, Lundin KE (2019)
CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease
United European Gastroenterol J, 7 (10), 1337-1344
DOI 10.1177/2050640619874183, PubMed 31839959

Publications 2018

Dahal-Koirala S, Ciacchi L, Petersen J, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Reid HH, Qiao SW, Rossjohn J, Sollid LM (2018)
Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes
J Biol Chem, 294 (3), 941-952
DOI 10.1074/jbc.RA118.005736, PubMed 30455354

Risnes LF, Christophersen A, Dahal-Koirala S, Neumann RS, Sandve GK, Sarna VK, Lundin KE, Qiao SW, Sollid LM (2018)
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
J Clin Invest, 128 (6), 2642-2650
DOI 10.1172/JCI98819, PubMed 29757191

Publications 2017

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121

Sarna VK, Skodje GI, Reims HM, Risnes LF, Dahal-Koirala S, Sollid LM, Lundin KEA (2017)
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Gut, 67 (9), 1606-1613
DOI 10.1136/gutjnl-2017-314461, PubMed 28779027

Publications 2016

Bryson S, Thomson CA, Risnes LF, Dasgupta S, Smith K, Schrader JW, Pai EF (2016)
Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation
J Immunol, 196 (11), 4723-30
DOI 10.4049/jimmunol.1402890, PubMed 27183571

Christophersen A, Risnes LF, Bergseng E, Lundin KE, Sollid LM, Qiao SW (2016)
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834

Dahal-Koirala S, Risnes LF, Christophersen A, Sarna VK, Lundin KE, Sollid LM, Qiao SW (2016)
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage
Mucosal Immunol, 9 (3), 587-96
DOI 10.1038/mi.2015.147, PubMed 26838051