Per Kristian Lunde

  • Researcher
  • +47 230 16808

Publications 2023

Lunde PK, Manfra O, Støle TP, Lunde M, Martinsen M, Carlson CR, Louch WE (2023)
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
DOI 10.3390/cells12192358, PubMed 37830576

Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM (2023)
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
DOI 10.1161/CIRCULATIONAHA.121.054168, PubMed 36876489

Publications 2022

Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
DOI 10.3389/fcell.2022.908126, PubMed 36092718

Publications 2021

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703

Mengeste AM, Lund J, Katare P, Ghobadi R, Bakke HG, Lunde PK, Eide L, Mahony GO, Göpel S, Peng XR, Kase ET, Thoresen GH, Rustan AC (2021)
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
Curr Res Pharmacol Drug Discov, 2, 100060
DOI 10.1016/j.crphar.2021.100060, PubMed 34909682

Publications 2020

Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR (2020)
Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis
Pediatr Cardiol, 41 (8), 1675-1688
DOI 10.1007/s00246-020-02427-7, PubMed 32770262

Publications 2019

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Publications 2018

Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE (2018)
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974

Publications 2016

Hortemo KH, Lunde PK, Anonsen JH, Kvaløy H, Munkvik M, Rehn TA, Sjaastad I, Lunde IG, Aronsen JM, Sejersted OM (2016)
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle
Physiol Rep, 4 (18)
DOI 10.14814/phy2.12896, PubMed 27664189

Publications 2015

Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR (2015)
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322

Hortemo KH, Aronsen JM, Lunde IG, Sjaastad I, Lunde PK, Sejersted OM (2015)
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
Physiol Rep, 3 (2)
DOI 10.14814/phy2.12285, PubMed 25713325

Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bjørnstad JL, Tønnessen T (2015)
Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
Cardiovasc Res, 106 (1), 32-42
DOI 10.1093/cvr/cvv041, PubMed 25694587

Publications 2013

Hortemo KH, Munkvik M, Lunde PK, Sejersted OM (2013)
Multiple causes of fatigue during shortening contractions in rat slow twitch skeletal muscle
PLoS One, 8 (8), e71700
DOI 10.1371/journal.pone.0071700, PubMed 23977116

Slettalokken G, Rehn TA, Munkvik M, Rud B, Nymark BS, Lunde PK, Sjaastad I, Sejersted OM, Hallen J (2013)
Normal training response in skeletal muscle of post-infarction heart failure patients
Eur. J. Sport Sci., 13 (2), 231-239
DOI 10.1080/17461391.2011.624197

Publications 2012

Dutka TL, Verburg E, Larkins N, Hortemo KH, Lunde PK, Sejersted OM, Lamb GD (2012)
ROS-mediated decline in maximum Ca2+-activated force in rat skeletal muscle fibers following in vitro and in vivo stimulation
PLoS One, 7 (5), e35226
DOI 10.1371/journal.pone.0035226, PubMed 22629297

Rehn TA, Munkvik M, Lunde PK, Sjaastad I, Sejersted OM (2012)
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?
Heart Fail Rev, 17 (3), 421-36
DOI 10.1007/s10741-011-9289-4, PubMed 21996779

Publications 2011

Munkvik M, Lunde PK, Aronsen JM, Birkeland JA, Sjaastad I, Sejersted OM (2011)
Attenuated fatigue in slow twitch skeletal muscle during isotonic exercise in rats with chronic heart failure
PLoS One, 6 (7), e22695
DOI 10.1371/journal.pone.0022695, PubMed 21799933

Sjåland C, Lunde PK, Swift F, Munkvik M, Ericsson M, Lunde M, Boye S, Christensen G, Ellingsen Ø, Sejersted OM, Andersson KB (2011)
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle
J Physiol, 589 (Pt 24), 6139-55
DOI 10.1113/jphysiol.2011.211987, PubMed 21946846

Wanichawan P, Louch WE, Hortemo KH, Austbø B, Lunde PK, Scott JD, Sejersted OM, Carlson CR (2011)
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A
Am J Physiol Cell Physiol, 300 (5), C989-97
DOI 10.1152/ajpcell.00196.2010, PubMed 21289289

Publications 2010

Munkvik M, Rehn TA, Slettaløkken G, Hasic A, Hallén J, Sjaastad I, Sejersted OM, Lunde PK (2010)
Training effects on skeletal muscle calcium handling in human chronic heart failure
Med Sci Sports Exerc, 42 (5), 847-55
DOI 10.1249/MSS.0b013e3181c29ec1, PubMed 19996998

Slettaløkken G, Rehn TA, Munkvik M, Rud B, Sökjer-Petersen M, Lunde PK, Sjaastad I, Sejersted OM, Hallén J (2010)
Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients
Scand J Med Sci Sports, 22 (2), 199-206
DOI 10.1111/j.1600-0838.2010.01226.x, PubMed 20874858

Publications 2009

Munkvik M, Lunde PK, Sejersted OM (2009)
Causes of fatigue in slow-twitch rat skeletal muscle during dynamic activity
Am J Physiol Regul Integr Comp Physiol, 297 (3), R900-10
DOI 10.1152/ajpregu.91043.2008, PubMed 19625691

Rehn TA, Borge BA, Lunde PK, Munkvik M, Sneve ML, Grøndahl F, Aronsen JM, Sjaastad I, Prydz K, Kolset SO, Wiig H, Sejersted OM, Iversen PO (2009)
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats
Am J Physiol Regul Integr Comp Physiol, 297 (1), R26-33
DOI 10.1152/ajpregu.90617.2008, PubMed 19339678

Publications 2007

Birkeland JA, Swift F, Tovsrud N, Enger U, Lunde PK, Qvigstad E, Levy FO, Sejersted OM, Sjaastad I (2007)
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes
Am J Physiol Heart Circ Physiol, 293 (4), H2367-76
DOI 10.1152/ajpheart.01375.2006, PubMed 17660386

Publications 2006

Lunde PK, Sejersted OM, Thorud HM, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J (2006)
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue
Circ Res, 98 (12), 1514-9
DOI 10.1161/01.RES.0000226529.66545.e5, PubMed 16690878

Publications 2005

Schiøtz Thorud HM, Stranda A, Birkeland JA, Lunde PK, Sjaastad I, Kolset SO, Sejersted OM, Iversen PO (2005)
Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure
Am J Physiol Regul Integr Comp Physiol, 289 (2), R389-R394
DOI 10.1152/ajpregu.00067.2005, PubMed 15802562

Tavi P, Sjögren M, Lunde PK, Zhang SJ, Abbate F, Vennström B, Westerblad H (2005)
Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1
J Mol Cell Cardiol, 38 (4), 655-63
DOI 10.1016/j.yjmcc.2005.02.008, PubMed 15808842

Thorud HM, Verburg E, Lunde PK, Strømme TA, Sjaastad I, Sejersted OM (2005)
Temperature-dependent skeletal muscle dysfunction in rats with congestive heart failure
J Appl Physiol (1985), 99 (4), 1500-7
DOI 10.1152/japplphysiol.00807.2004, PubMed 15932960

Woldbaek PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T (2005)
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice
Am J Physiol Heart Circ Physiol, 289 (2), H708-14
DOI 10.1152/ajpheart.01179.2004, PubMed 15821032

Publications 2004

Florholmen G, Aas V, Rustan AC, Lunde PK, Straumann N, Eid H, Odegaard A, Dishington H, Andersson KB, Christensen G (2004)
Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes
J Mol Cell Cardiol, 37 (6), 1183-93
DOI 10.1016/j.yjmcc.2004.09.008, PubMed 15572048

Schiøtz Thorud HM, Lunde PK, Nicolaysen G, Nicolaysen A, Helge JW, Nilsson GE, Sejersted OM (2004)
Muscle dysfunction during exercise of a single skeletal muscle in rats with congestive heart failure is not associated with reduced muscle blood supply
Acta Physiol Scand, 181 (2), 173-81
DOI 10.1111/j.1365-201X.2004.01285.x, PubMed 15180789

Publications 2003

Johansson C, Lunde PK, Gothe S, Lannergren J, Westerblad H (2003)
Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors
J Physiol, 547 (Pt 3), 789-96
DOI 10.1113/jphysiol.2002.032086, PubMed 12562961

Woldbaek PR, Tønnessen T, Henriksen UL, Florholmen G, Lunde PK, Lyberg T, Christensen G (2003)
Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction
Cardiovasc Res, 59 (1), 122-31
DOI 10.1016/s0008-6363(03)00339-0, PubMed 12829183

Publications 2002

Lunde PK, Verburg E, Eriksen M, Sejersted OM (2002)
Contractile properties of in situ perfused skeletal muscles from rats with congestive heart failure
J Physiol, 540 (Pt 2), 571-80
DOI 10.1113/jphysiol.2001.013324, PubMed 11956344

Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T, Holt E, Lunde PK, Christensen G (2002)
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Cardiovasc Res, 53 (2), 382-91
DOI 10.1016/s0008-6363(01)00489-8, PubMed 11827689

Schiøtz Thorud HM, Wisløff U, Lunde PK, Christensen G, Ellingsen Ø, Sejersted OM (2002)
Surgical manipulation, but not moderate exercise, is associated with increased cytokine mRNA expression in the rat soleus muscle
Acta Physiol Scand, 175 (3), 219-26
DOI 10.1046/j.1365-201X.2002.00990.x, PubMed 12100361

Publications 2001

Jóhannsson E, Lunde PK, Heddle C, Sjaastad I, Thomas MJ, Bergersen L, Halestrap AP, Blackstad TW, Ottersen OP, Sejersted OM (2001)
Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure
Circulation, 104 (6), 729-34
DOI 10.1161/hc3201.092286, PubMed 11489783

Lunde PK, Dahlstedt AJ, Bruton JD, Lännergren J, Thorén P, Sejersted OM, Westerblad H (2001)
Contraction and intracellular Ca(2+) handling in isolated skeletal muscle of rats with congestive heart failure
Circ Res, 88 (12), 1299-305
DOI 10.1161/hh1201.092041, PubMed 11420307

Lunde PK, Sjaastad I, Schiøtz Thorud HM, Sejersted OM (2001)
Skeletal muscle disorders in heart failure
Acta Physiol Scand, 171 (3), 277-94
DOI 10.1046/j.1365-201x.2001.00830.x, PubMed 11412140

Skeie GO, Lunde PK, Sejersted OM, Mygland A, Aarli JA, Gilhus NE (2001)
Autoimmunity against the ryanodine receptor in myasthenia gravis
Acta Physiol Scand, 171 (3), 379-84
DOI 10.1046/j.1365-201x.2001.00841.x, PubMed 11412151

Publications 2000

Johansson C, Lännergren J, Lunde PK, Vennström B, Thorén P, Westerblad H (2000)
Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha(1)- or -beta-deficient mice
Am J Physiol Regul Integr Comp Physiol, 278 (3), R598-603
DOI 10.1152/ajpregu.2000.278.3.R598, PubMed 10712278

Ortenblad N, Lunde PK, Levin K, Andersen JL, Pedersen PK (2000)
Enhanced sarcoplasmic reticulum Ca(2+) release following intermittent sprint training
Am J Physiol Regul Integr Comp Physiol, 279 (1), R152-60
DOI 10.1152/ajpregu.2000.279.1.R152, PubMed 10896877

Wasserstrom JA, Holt E, Sjaastad I, Lunde PK, Odegaard A, Sejersted OM (2000)
Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI
Am J Physiol Heart Circ Physiol, 279 (2), H798-807
DOI 10.1152/ajpheart.2000.279.2.H798, PubMed 10924080

Publications 1999

Holt E, Sjaastad I, Lunde PK, Christensen G, Sejersted OM (1999)
Thyroid hormone control of contraction and the Ca(2+)-ATPase/phospholamban complex in adult rat ventricular myocytes
J Mol Cell Cardiol, 31 (3), 645-56
DOI 10.1006/jmcc.1998.0900, PubMed 10198194

Sommerschild HT, Lunde PK, Deindl E, Jynge P, Ilebekk A, Kirkebøen KA (1999)
Elevated levels of endogenous adenosine alter metabolism and enhance reduction in contractile function during low-flow ischemia: associated changes in expression of Ca(2+)-ATPase and phospholamban
J Mol Cell Cardiol, 31 (10), 1897-911
DOI 10.1006/jmcc.1999.1022, PubMed 10525427

Publications 1998

Holt E, Tønnessen T, Lunde PK, Semb SO, Wasserstrom JA, Sejersted OM, Christensen G (1998)
Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats
J Mol Cell Cardiol, 30 (8), 1581-93
DOI 10.1006/jmcc.1998.0724, PubMed 9737944

Lunde PK, Verburg E, Vøllestad NK, Sejersted OM (1998)
Skeletal muscle fatigue in normal subjects and heart failure patients. Is there a common mechanism?
Acta Physiol Scand, 162 (3), 215-28
DOI 10.1046/j.1365-201X.1998.0343f.x, PubMed 9578367

Semb SO, Lunde PK, Holt E, Tønnessen T, Christensen G, Sejersted OM (1998)
Reduced myocardial Na+, K(+)-pump capacity in congestive heart failure following myocardial infarction in rats
J Mol Cell Cardiol, 30 (7), 1311-28
DOI 10.1006/jmcc.1998.0696, PubMed 9710800

Skeie GO, Lunde PK, Sejersted OM, Mygland A, Aarli JA, Gilhus NE (1998)
Myasthenia gravis sera containing antiryanodine receptor antibodies inhibit binding of [3H]-ryanodine to sarcoplasmic reticulum
Muscle Nerve, 21 (3), 329-35
DOI 10.1002/(sici)1097-4598(199803)21:3<329::aid-mus6>;2-c, PubMed 9486861

Skeie GO, Lunde PK, Sejersted OM, Mygland A, Aarli JA, Gilhus NE (1998)
Myasthenia gravis-associated ryanodine receptor antibodies inhibit binding of ryanodine to sarcoplasmic reticulum
Ann N Y Acad Sci, 841, 530-3
DOI 10.1111/j.1749-6632.1998.tb10976.x, PubMed 9668288

Tønnessen T, Lunde PK, Giaid A, Sejersted OM, Christensen G (1998)
Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats. Localization of preproendothelin-1 mRNA and endothelin peptide
Cardiovasc Res, 39 (3), 633-43
DOI 10.1016/s0008-6363(98)00156-4, PubMed 9861306

Publications 1997

Holt E, Lunde PK, Sejersted OM, Christensen G (1997)
Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling
Basic Res Cardiol, 92 (5), 289-98
DOI 10.1007/BF00788941, PubMed 9486350

Lunde PK, Sejersted OM (1997)
Intracellular calcium signalling in striated muscle cells
Scand J Clin Lab Invest, 57 (7), 559-68
DOI 10.3109/00365519709055278, PubMed 9397486

Lunde PK, Sejersted OM (1997)
Ryanodine binding sites measured in small skeletal muscle biopsies
Scand J Clin Lab Invest, 57 (7), 569-80
DOI 10.3109/00365519709055279, PubMed 9397487

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