Publications 2022
AKAP18 delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ.Res., 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976
Publications 2021
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front. Cardiovasc. Med., 7, 623922
DOI 10.3389/fcvm.2020.623922
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front. Physiol., 12, 744730
DOI 10.3389/fphys.2021.744730
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
Front. Pharmacol., 12, 638646
DOI 10.3389/fphar.2021.638646
Publications 2020
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc. Res., 116 (1), 78-90
DOI 10.1093/cvr/cvz087
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ.Res., 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641
Publications 2019
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc. Res., 115 (4), 752-764
DOI 10.1093/cvr/cvy257
Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes
Am. J. Physiol.-Heart Circul. Physiol., 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018
Publications 2018
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
eLife, 7, e39427
DOI 10.7554/eLife.39427
Publications 2017
Regional Dysfunction After Myocardial Infarction in Rats
Circ.-Cardiovasc. Imaging, 10 (9), e005997
DOI 10.1161/CIRCIMAGING.116.005997
Mapping the in vitro interactome of cardiac sodium (Na+)-calcium (Ca2+) exchanger 1 (NCX1)
Proteomics, 17 (17-18), 1600417
DOI 10.1002/pmic.201600417
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc. Res., 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087
Publications 2016
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc. Res., 112 (1), 443-451
DOI 10.1093/cvr/cvw111
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylatedPhospholemman
J. Biol. Chem., 291 (9), 4561-4579
DOI 10.1074/jbc.M115.677898
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle
PHYSIOL. REP., 4 (18), e12896
DOI 10.14814/phy2.12896
Ca2+-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Front. Physiol., 7, 197
DOI 10.3389/fphys.2016.00197
Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
Biochem. J., 473, 2413-2423
DOI 10.1042/BCJ20160465
Publications 2015
Hypokalaemia induces Ca2+ overload and Ca2+ waves in ventricular myocytes by reducing Na+, K+-ATPase alpha(2) activity
J. Physiol.-London, 593 (6), 1509-1521
DOI 10.1113/jphysiol.2014.279893
Deranged sodium to sudden death
J. Physiol.-London, 593 (6), 1331-1345
DOI 10.1113/jphysiol.2014.281204
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
PHYSIOL. REP., 3 (2), e12285
DOI 10.14814/phy2.12285
Publications 2014
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am. J. Physiol.-Heart Circul. Physiol., 306 (7), H1018-H1024
DOI 10.1152/ajpheart.00741.2013
Variable t-tubule organization and Ca2+ homeostasis across the atria
Am. J. Physiol.-Heart Circul. Physiol., 307 (4), H609-H620
DOI 10.1152/ajpheart.00295.2014
Molecular Basis of Calpain Cleavage and Inactivation of the Sodium-Calcium Exchanger 1 in Heart Failure
J. Biol. Chem., 289 (49), 33984-33998
DOI 10.1074/jbc.M114.602581
Publications 2013
Cardiac sodium transport and excitation-contraction coupling
J. Mol. Cell. Cardiol., 61, 11-19
DOI 10.1016/j.yjmcc.2013.06.003
Improved MR phase-contrast velocimetry using a novel nine-point balanced motion-encoding scheme with increased robustness to eddy current effects
Magn. Reson. Med., 69 (1), 48-61
DOI 10.1002/mrm.24226
Multiple Causes of Fatigue during Shortening Contractions in Rat Slow Twitch Skeletal Muscle
PLoS One, 8 (8), e71700
DOI 10.1371/journal.pone.0071700
Beta-Adrenergic Stimulation Maintains Cardiac Function in Serca2 Knockout Mice
Biophys. J., 104 (6), 1349-1356
DOI 10.1016/j.bpj.2013.01.042
Integrating multi-scale data to create a virtual physiological mouse heart
Interface Focus, 3 (2), 20120076
DOI 10.1098/rsfs.2012.0076
Slow Ca2+ sparks de-synchronize Ca2+ release in failing cardiomyocytes: Evidence for altered configuration of Ca2+ release units?
J. Mol. Cell. Cardiol., 58, 41-52
DOI 10.1016/j.yjmcc.2013.01.014
Synchrony of Cardiomyocyte Ca2+ Release is Controlled by t-tubule Organization, SR Ca2+ Content, and Ryanodine Receptor Ca2+ Sensitivity
Biophys. J., 104 (8), 1685-1697
DOI 10.1016/j.bpj.2013.03.022
Normal training response in skeletal muscle of post-infarction heart failure patients
Eur. J. Sport Sci., 13 (2), 231-239
DOI 10.1080/17461391.2011.624197
I-CaL inhibition prevents arrhythmogenic Ca2+ waves caused by abnormal Ca2+ sensitivity of RyR or SR Ca2+ accumulation
Cardiovasc. Res., 98 (2), 315-325
DOI 10.1093/cvr/cvt037
Publications 2012
ROS-Mediated Decline in Maximum Ca2+-Activated Force in Rat Skeletal Muscle Fibers following In Vitro and In Vivo Stimulation
PLoS One, 7 (5), e35226
DOI 10.1371/journal.pone.0035226
An analysis of deformation-dependent electromechanical coupling in the mouse heart
J. Physiol.-London, 590 (18), 4553-4569
DOI 10.1113/jphysiol.2012.231928
Sodium Accumulation in SERCA Knockout-Induced Heart Failure
Biophys. J., 102 (9), 2039-2048
DOI 10.1016/j.bpj.2012.03.045
No Rest for the Weary: Diastolic Calcium Homeostasis in the Normal and Failing Myocardium
Physiology, 27 (5), 308-323
DOI 10.1152/physiol.00021.2012
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?
Heart Fail. Rev., 17 (3), 421-436
DOI 10.1007/s10741-011-9289-4
Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients
Scand. J. Med. Sci. Sports, 22 (2), 199-206
DOI 10.1111/j.1600-0838.2010.01226.x
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout
Proc. Natl. Acad. Sci. U. S. A., 109 (10), 3997-4001
DOI 10.1073/pnas.1120172109
Publications 2011
Calcium Dynamics in the Ventricular Myocytes of SERCA2 Knockout Mice: A Modeling Study
Biophys. J., 100 (2), 322-331
DOI 10.1016/j.bpj.2010.11.048
Attenuated Fatigue in Slow Twitch Skeletal Muscle during Isotonic Exercise in Rats with Chronic Heart Failure
PLoS One, 6 (7), e22695
DOI 10.1371/journal.pone.0022695
Calcium controls cardiac function - by all means!
J. Physiol.-London, 589 (12), 2919-2920
DOI 10.1113/jphysiol.2011.210989
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle
J. Physiol.-London, 589 (24), 6139-6155
DOI 10.1113/jphysiol.2011.211987
Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content
Cardiovasc. Res., 90 (3), 503-512
DOI 10.1093/cvr/cvr013
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A
Am. J. Physiol.-Cell Physiol., 300 (5), C989-C997
DOI 10.1152/ajpcell.00196.2010
Publications 2010
Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies
BMC Mol. Biol., 11, 22
DOI 10.1186/1471-2199-11-22
High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2
J. Appl. Physiol., 108 (5), 1311-1320
DOI 10.1152/japplphysiol.01133.2009
Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice
J. Appl. Physiol., 109 (6), 1749-1755
DOI 10.1152/japplphysiol.00282.2010
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alpha MHC-MerCreMer) mice
Am. J. Physiol.-Heart Circul. Physiol., 299 (5), H1671-H1678
DOI 10.1152/ajpheart.01155.2009
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 298 (3), R808-R814
DOI 10.1152/ajpregu.00250.2009
Control of Ca2+ Release by Action Potential Configuration in Normal and Failing Murine Cardiomyocytes
Biophys. J., 99 (5), 1377-1386
DOI 10.1016/j.bpj.2010.06.055
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J. Physiol.-London, 588 (3), 465-478
DOI 10.1113/jphysiol.2009.183517
There Goes the Neighborhood: Pathological Alterations in T-Tubule Morphology and Consequences for Cardiomyocyte Ca2+ Handling
J. Biomed. Biotechnol., 503906
DOI 10.1155/2010/503906
Training Effects on Skeletal Muscle Calcium Handling in Human Chronic Heart Failure
Med. Sci. Sports Exerc., 42 (5), 847-855
DOI 10.1249/MSS.0b013e3181c29ec1
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc. Res., 86 (1), 63-71
DOI 10.1093/cvr/cvp401
Functional coupling of alpha(2)-isoform Na+/K+-ATPase and Ca2+ extrusion through the Na+/Ca2+-exchanger in cardiomyocytes
Cell Calcium, 48 (1), 54-60
DOI 10.1016/j.ceca.2010.06.006
Publications 2009
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
J. Mol. Cell. Cardiol., 47 (2), 180-187
DOI 10.1016/j.yjmcc.2009.03.013
Mice carrying a conditional Serca2(flox) allele for the generation of Ca2+ handling-deficient mouse models
Cell Calcium, 46 (3), 219-225
DOI 10.1016/j.ceca.2009.07.004
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice
Am. J. Physiol.-Heart Circul. Physiol., 296 (4), H1069-H1079
DOI 10.1152/ajpheart.01009.2008
Causes of fatigue in slow-twitch rat skeletal muscle during dynamic activity
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 297 (3), R900-R910
DOI 10.1152/ajpregu.91043.2008
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 297 (1), R26-R33
DOI 10.1152/ajpregu.90617.2008
Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance
Am. J. Physiol.-Heart Circul. Physiol., 296 (3), H787-H795
DOI 10.1152/ajpheart.00796.2008
Publications 2008
Slow contractions characterize failing rat hearts
Basic Res. Cardiol., 103 (4), 328-344
DOI 10.1007/s00395-008-0719-y
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha(2)-isoform in heart failure
Cardiovasc. Res., 78 (1), 71-78
DOI 10.1093/cvr/cvn013
Altered Na(+)/Ca(2+)-exchanger activity due to downregulation of Na(+)/K(+)-ATPase alpha(2)-isoform in heart failure (vol 78, pg 71, 2008)
Cardiovasc. Res., 79 (2), 352
DOI 10.1093/cvr/cvn147
Publications 2007
Effects of treatment with a 5-HT4 receptor antagonist in heart failure
Br. J. Pharmacol., 150 (2), 143-152
DOI 10.1038/sj.bjp.0706966
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes
Am. J. Physiol.-Heart Circul. Physiol., 293 (4), H2367-H2376
DOI 10.1152/ajpheart.01375.2006
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
J. Mol. Cell. Cardiol., 43 (6), 767-779
DOI 10.1016/j.yjmcc.2007.08.019
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure
J. Mol. Cell. Cardiol., 43 (2), 177-186
DOI 10.1016/j.yjmcc.2007.05.004
The Na+/K+-ATPase alpha(2)-isoform regulates cardiac contractility in rat cardiomyocytes
Cardiovasc. Res., 75 (1), 109-117
DOI 10.1016/j.cardiores.2007.03.017
Publications 2006
Contribution of the Na2+/Ca2+ exchanger to rapid Ca2+ release in cardiomyocytes
Biophys. J., 91 (3), 779-792
DOI 10.1529/biophysj.105.072447
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction
J. Physiol.-London, 574 (2), 519-533
DOI 10.1113/jphysiol.2006.107227
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue
Circ.Res., 98 (12), 1514-1519
DOI 10.1161/01.RES.0000226529.66545.e5
Slow diffusion of K+ in the T tubules of rat cardiomyocytes
J. Appl. Physiol., 101 (4), 1170-1176
DOI 10.1152/japplphysiol.00297.2006
Publications 1996
K⁺ balance of the quadriceps muscle during dynamic exercise with and without β-adrenoceptor blockade
In Journal of applied physiology, The Society, Bethesda, Md., 78(1995)nr 5, S. 513-523
BIBSYS 961484284
Fuzzy space and control of Na⁺, K⁺-pump rate in heart and skeletal muscle
In Acta physiologica Scandinavica, Blackwell, for Scandinavian Physiological Society., London, 156(1996)nr 3, S. 213-225
BIBSYS 961350792
Publications 1986
Exercise in human physiology: international symposium in memory of Lars Hermansen
Blackwell Scientific Publ., [Oxford], 167 s.
BIBSYS 942805232, ISBN 82-90688-00-8
Publications 1978
Function of na-K-ATPase in renal sodium reabsorption
University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, Oslo, l b. (fl. pag.)
BIBSYS 823074072, ISBN 82-90246-00-5