Geir Christensen
- Professor emeritus; MD, PhD
- +47 23016793
Publications 2022
AKAP18 delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ.Res., 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement
Front Mol Med, 2, 1-14
DOI 10.3389/fmmed.2022.980717, PublikaID 435
Publications 2021
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study
Clin. Biochem., 88, 30-36
DOI 10.1016/j.clinbiochem.2020.11.009
Performance of a Novel Research-Use-Only Secretoneurin ELISA in Patients with Suspected Acute Coronary Syndrome: Comparison with an Established Secretoneurin Radioimmunoassay
Cardiology, 146 (5), 566-574
DOI 10.1159/000517444
Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
ESC Heart Fail., 8 (2), 918-927
DOI 10.1002/ehf2.13177
Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study
Clin. Chem., 67 (6), 889-898
DOI 10.1093/clinchem/hvab030
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGF beta signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
DOI 10.1038/s41598-021-99032-2
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis
Clin. Biochem., 98, 74-77
DOI 10.1016/j.clinbiochem.2021.09.014
Publications 2020
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J. Am. Heart Assoc., 9 (3), e013518
DOI 10.1161/JAHA.119.013518
The Cardiac Syndecan-2 Interactome
Front. Cell. Dev. Biol., 8, 792
DOI 10.3389/fcell.2020.00792
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 145 (3), 187-198
DOI 10.1159/000505318
Syndecan-4(-/-)Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
Front. Cell. Dev. Biol., 8, 730
DOI 10.3389/fcell.2020.00730
Publications 2019
Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis
Clin. Biochem., 71, 17-23
DOI 10.1016/j.clinbiochem.2019.06.008
Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study
Crit. Care Med., 47 (5), E412-E419
DOI 10.1097/CCM.0000000000003670
Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease
Matrix Biol., 75-76, 286-299
DOI 10.1016/j.matbio.2018.01.001
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J. Physiol.-London, 597 (7), 1833-1853
DOI 10.1113/JP277273
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J. Biol. Chem., 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9, 9206
DOI 10.1038/s41598-019-45651-9
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ.-Arrhythmia Electrophysiol., 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc. Res., 115 (4), 752-764
DOI 10.1093/cvr/cvy257
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am. J. Physiol.-Lung Cell. Mol. Physiol., 316 (6), L999-L1012
DOI 10.1152/ajplung.00322.2018
Publications 2018
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422
Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study
Clin. Biochem., 59, 62-68
DOI 10.1016/j.clinbiochem.2018.07.006
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001
Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study
Clin. Biochem., 52, 41-47
DOI 10.1016/j.clinbiochem.2017.10.015
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc. Res., 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study
Biomarkers, 23 (7), 654-663
DOI 10.1080/1354750X.2018.1474258
Overexpression of integrin alpha 11 induces cardiac fibrosis in mice
Acta Physiol., 222 (2), e12932
DOI 10.1111/apha.12932
Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study
Crit. Care Med., 46 (5), E404-E410
DOI 10.1097/CCM.0000000000003050
Publications 2017
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7, 3490
DOI 10.1038/s41598-017-03625-9
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J. Mol. Med., 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediat. Inflamm., 2017, 9450439
DOI 10.1155/2017/9450439
The Soft-and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart
J. Clin. Med., 6 (5), 53
DOI 10.3390/jcm6050053
Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study
Biomarkers, 22 (8), 775-781
DOI 10.1080/1354750X.2016.1269200
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J. Cardiovasc. Transl. Res., 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Reports, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009
Glycosylated Chromogranin A in Heart Failure Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ.-Heart Fail., 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675
Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study
Clin. Biochem., 50 (7-8), 394-400
DOI 10.1016/j.clinbiochem.2016.12.010
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study
Respir. Res., 18, 184
DOI 10.1186/s12931-017-0665-z
Publications 2016
Seasonal variation in accumulation of persistent organic pollutants in an Arctic marine benthic food web
Sci. Total Environ., 542, 108-120
DOI 10.1016/j.scitotenv.2015.10.092
The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study
Biomarkers, 21 (2), 173-179
DOI 10.3109/1354750X.2015.1126645
Syndecans in heart fibrosis
Cell Tissue Res., 365 (3), 539-552
DOI 10.1007/s00441-016-2454-2
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079
Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study
Clin. Chem., 62 (10), 1380-1389
DOI 10.1373/clinchem.2016.258764
Prognostic Value of Secretoneurin in Critically III Patients With Infections
Crit. Care Med., 44 (10), 1882-1890
DOI 10.1097/CCM.0000000000001832
Prevalence and Prognostic Significance of Hyponatremia in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination (ACE) 2 Study
PLoS One, 11 (8), e0161232
DOI 10.1371/journal.pone.0161232
Publications 2015
Diagnostic accuracy for heart failure- data from Akershus heart survey 2
Tidsskr. Nor. Laegeforen., 135 (19), 1738-1744
DOI 10.4045/tidsskr.14.1174
Current status, between-year comparisons and maternal transfer of organohalogenated compounds (OHCs) in Arctic char (Salvelinus alpinus) from Bjornoya, Svalbard (Norway)
Sci. Total Environ., 521, 421-430
DOI 10.1016/j.scitotenv.2015.03.104
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
Am. J. Physiol.-Lung Cell. Mol. Physiol., 309 (4), L378-L387
DOI 10.1152/ajplung.00342.2014
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715
Psychological distress and mortality in patients with acute dyspnea: data from the Akershus Cardiac Examination (ACE) 2 Study
Gen. Hosp. Psych., 37 (6), 548-553
DOI 10.1016/j.genhosppsych.2015.07.007
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Cardiovasc. Res., 106 (2), 217-226
DOI 10.1093/cvr/cvv002
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice
Acta Physiol., 213 (2), 492-504
DOI 10.1111/apha.12376
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
Nat. Commun., 6, 7229
DOI 10.1038/ncomms8229
Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling
J. Cardiovasc. Surg., 56 (3), 483-492
Secretoneurin Is a Novel Prognostic Cardiovascular Biomarker Associated With Cardiomyocyte Calcium Handling
J. Am. Coll. Cardiol., 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065
Influence of Glycosylation on Diagnostic and Prognostic Accuracy of N-Terminal Pro-B-Type Natriuretic Peptide in Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study
Clin. Chem., 61 (8), 1087-1097
DOI 10.1373/clinchem.2015.239673
Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
Cardiovasc. Res., 106 (1), 32-42
DOI 10.1093/cvr/cvv041
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice
J. Mol. Cell. Cardiol., 88, 133-144
DOI 10.1016/j.yjmcc.2015.10.003
In memory of Guro Valen (1960-2014)
J. Mol. Cell. Cardiol., 79, 254-255
DOI 10.1016/j.yjmcc.2014.11.026
Publications 2014
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
J. Intern. Med., 275 (6), 621-630
DOI 10.1111/joim.12175
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am. J. Physiol.-Heart Circul. Physiol., 306 (7), H1018-H1024
DOI 10.1152/ajpheart.00741.2013
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
J. Mol. Cell. Cardiol., 76, 148-157
DOI 10.1016/j.yjmcc.2014.08.008
The Homeostatic Chemokine CCL21 Predicts Mortality in Aortic Stenosis Patients and Modulates Left Ventricular Remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172
A Dominant STIM1 Mutation Causes Stormorken Syndrome
Hum. Mutat., 35 (5), 556-564
DOI 10.1002/humu.22544
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115
Prognostic Value of Circulating MicroRNA-210 Levels in Patients with Moderate to Severe Aortic Stenosis
PLoS One, 9 (3), e91812
DOI 10.1371/journal.pone.0091812
Increased Levels of Eotaxin and MCP-1 in Juvenile Dermatomyositis Median 16.8 Years after Disease Onset; Associations with Disease Activity, Duration and Organ Damage
PLoS One, 9 (3), e92171
DOI 10.1371/journal.pone.0092171
In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction
RHEUMATOLOGY, 53 (12), 2214-2222
DOI 10.1093/rheumatology/keu256
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding
PLoS One, 9 (3), e89621
DOI 10.1371/journal.pone.0089621
Publications 2013
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli
FEBS J., 280 (10), 2382-2398
DOI 10.1111/febs.12235
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse
J. Appl. Physiol., 114 (8), 988-997
DOI 10.1152/japplphysiol.00793.2012
Prominent Heart Organ-Level Performance Deficits in a Genetic Model of Targeted Severe and Progressive SERCA2 Deficiency
PLoS One, 8 (11), e79609
DOI 10.1371/journal.pone.0079609
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress
J. Mol. Cell. Cardiol., 54, 73-81
DOI 10.1016/j.yjmcc.2012.11.006
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene
J. Appl. Physiol., 115 (10), 1572-1580
DOI 10.1152/japplphysiol.01044.2012
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br. J. Pharmacol., 170 (2), 366-379
DOI 10.1111/bph.12282
Synchrony of Cardiomyocyte Ca2+ Release is Controlled by t-tubule Organization, SR Ca2+ Content, and Ryanodine Receptor Ca2+ Sensitivity
Biophys. J., 104 (8), 1685-1697
DOI 10.1016/j.bpj.2013.03.022
Effect of short- and long-term physical activities on circulating granin protein levels
Regul. Pept., 185, 14-19
DOI 10.1016/j.regpep.2013.06.003
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury
Cardiovasc. Res., 99 (1), 164-174
DOI 10.1093/cvr/cvt091
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload
Matrix Biol., 32 (2), 133-142
DOI 10.1016/j.matbio.2012.11.011
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart
FEBS J., 280 (10), 2228-2247
DOI 10.1111/febs.12161
Lack of pro-inflammatory cytokine mobilization predicts poor prognosis in patients with acute heart failure
Cytokine, 61 (3), 962-969
DOI 10.1016/j.cyto.2013.01.006
Publications 2012
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovasc. Res., 93 (1), 100-110
DOI 10.1093/cvr/cvr294
A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta
Acta Physiol., 205 (1), 92-102
DOI 10.1111/j.1748-1716.2011.02369.x
IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung
Exp. Lung Res., 38 (8), 406-419
DOI 10.3109/01902148.2012.716903
Dephosphorylation of cardiac proteins in vitro - a matter of phosphatase specificity
Proteomics, 12 (7), 973-978
DOI 10.1002/pmic.201100116
Sodium Accumulation in SERCA Knockout-Induced Heart Failure
Biophys. J., 102 (9), 2039-2048
DOI 10.1016/j.bpj.2012.03.045
No Rest for the Weary: Diastolic Calcium Homeostasis in the Normal and Failing Myocardium
Physiology, 27 (5), 308-323
DOI 10.1152/physiol.00021.2012
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure
Physiol. Genomics, 44 (2), 162-172
DOI 10.1152/physiolgenomics.00016.2011
Endothelin-1 in the Human Myocardium and Circulating Plasma: Evaluation before, during and after Correction of Aortic Stenosis with Aortic Valve Replacement
Cardiology, 123 (1), 1-10
DOI 10.1159/000339756
Secretogranin II; a Protein Increased in the Myocardium and Circulation in Heart Failure with Cardioprotective Properties
PLoS One, 7 (5), e37401
DOI 10.1371/journal.pone.0037401
Calcium release units in heart failure: that's about the size of it
Cardiovasc. Res., 95 (4), 397-398
DOI 10.1093/cvr/cvs241
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout
Proc. Natl. Acad. Sci. U. S. A., 109 (10), 3997-4001
DOI 10.1073/pnas.1120172109
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
J. Appl. Physiol., 112 (8), 1372-1382
DOI 10.1152/japplphysiol.01350.2011
The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038
Publications 2011
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur. Heart J., 32 (2), 236-245
DOI 10.1093/eurheartj/ehq166
Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302
Cortisol response to stress is associated with myocardial remodeling in salmonid fishes
J. Exp. Biol., 214 (8), 1313-1321
DOI 10.1242/jeb.053058
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation
Am. J. Physiol.-Lung Cell. Mol. Physiol., 301 (1), L50-L59
DOI 10.1152/ajplung.00048.2010
Calcium Dynamics in the Ventricular Myocytes of SERCA2 Knockout Mice: A Modeling Study
Biophys. J., 100 (2), 322-331
DOI 10.1016/j.bpj.2010.11.048
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis
Cell Calcium, 49 (4), 201-207
DOI 10.1016/j.ceca.2010.09.009
Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes
J. Appl. Physiol., 111 (5), 1278-1289
DOI 10.1152/japplphysiol.01383.2010
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle
J. Physiol.-London, 589 (24), 6139-6155
DOI 10.1113/jphysiol.2011.211987
Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content
Cardiovasc. Res., 90 (3), 503-512
DOI 10.1093/cvr/cvr013
Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668
Publications 2010
High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2
J. Appl. Physiol., 108 (5), 1311-1320
DOI 10.1152/japplphysiol.01133.2009
Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice
J. Appl. Physiol., 109 (6), 1749-1755
DOI 10.1152/japplphysiol.00282.2010
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alpha MHC-MerCreMer) mice
Am. J. Physiol.-Heart Circul. Physiol., 299 (5), H1671-H1678
DOI 10.1152/ajpheart.01155.2009
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 298 (3), R808-R814
DOI 10.1152/ajpregu.00250.2009
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J. Physiol.-London, 588 (3), 465-478
DOI 10.1113/jphysiol.2009.183517
Plasma IL-18 and IL-18BP are altered differently in reverse remodeling following aortic valve replacement
Scand. Cardiovasc. J., 44 (2), 113-118
DOI 10.3109/14017430903426902
Chromogranin B in Heart Failure A Putative Cardiac Biomarker Expressed in the Failing Myocardium
Circ.-Heart Fail., 3 (4), 503-U84
DOI 10.1161/CIRCHEARTFAILURE.109.867747
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc. Res., 86 (1), 63-71
DOI 10.1093/cvr/cvp401
Multiple cytokine biomarkers in heart failure
Expert Rev. Mol. Diagn., 10 (2), 147-157
DOI 10.1586/ERM.10.3
Circulating cytokine levels in mice with heart failure are etiology dependent
J. Appl. Physiol., 108 (5), 1357-1364
DOI 10.1152/japplphysiol.01084.2009
Publications 2009
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
J. Mol. Cell. Cardiol., 47 (2), 180-187
DOI 10.1016/j.yjmcc.2009.03.013
Mice carrying a conditional Serca2(flox) allele for the generation of Ca2+ handling-deficient mouse models
Cell Calcium, 46 (3), 219-225
DOI 10.1016/j.ceca.2009.07.004
Increased Production of CXCL16 in Experimental and Clinical Heart Failure A Possible Role in Extracellular Matrix Remodeling
Circ.-Heart Fail., 2 (6), 624-632
DOI 10.1161/CIRCHEARTFAILURE.108.821074
Cardiac Troponin I Degradation in Serum of Patients with Hypertrophic Obstructive Cardiomyopathy Undergoing Percutaneous Septal Ablation
Cardiology, 114 (3), 167-173
DOI 10.1159/000226596
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur. Heart J., 30 (10), 1229-1236
DOI 10.1093/eurheartj/ehp088
Elevated levels of activin A in clinical and experimental pulmonary hypertension
J. Appl. Physiol., 106 (4), 1356-1364
DOI 10.1152/japplphysiol.90719.2008
Publications 2008
Alterations in circulating activin A, GDF-15, TGF-beta 3 and MMP-2,-3, and-9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis
Eur. J. Heart Fail., 10 (12), 1201-1207
DOI 10.1016/j.ejheart.2008.09.010
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
J. Mol. Cell. Cardiol., 45 (2), 261-269
DOI 10.1016/j.yjmcc.2008.05.009
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc. Res., 80 (1), 47-54
DOI 10.1093/cvr/cvn180
Publications 2007
Goose-mediated nutrient enrichment and planktonic grazer control in arctic freshwater ponds
Oecologia, 153 (3), 653-662
DOI 10.1007/s00442-007-0770-7
Publications 2006
Regulation of neuronal type genes in congestive heart failure rats
Acta Physiol., 186 (1), 17-27
DOI 10.1111/j.1748-1716.2005.01503.x
Activin A inhibits organization of sarcomeric proteins in cardiomyocytes induced by leukemia inhibitory factor
J. Mol. Cell. Cardiol., 41 (4), 689-697
DOI 10.1016/j.yjmcc.2006.07.009
Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure
Diabetologia, 49 (4), 724-731
DOI 10.1007/s00125-006-0150-6
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice
Am. J. Physiol.-Heart Circul. Physiol., 291 (2), H507-H516
DOI 10.1152/ajpheart.00862.2005
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue
Circ.Res., 98 (12), 1514-1519
DOI 10.1161/01.RES.0000226529.66545.e5
Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction - The ASSENT-2 troponin substudy
Circ.Res., 99 (10), 1141-1147
DOI 10.1161/01.RES.0000249531.23654.e1
Publications 2005
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse
J. Appl. Physiol., 98 (2), 680-689
DOI 10.1152/japplphysiol.00924.2004
Reduced immune responses to an aseptic inflammation in mice with congestive heart failure
Eur. J. Haematol., 75 (2), 156-163
DOI 10.1111/j.1600-0609.2005.00440.x
Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure
Circulation, 111 (19), 2461-2468
DOI 10.1161/01.CIR.0000165119.62099.14
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice
Am. J. Physiol.-Heart Circul. Physiol., 289 (2), H708-H714
DOI 10.1152/ajpheart.01179.2004
Publications 2004
Comparison of nonviral transfection and adeno-associated viral transduction on cardiomyocytes
Mol. Biotechnol., 28 (1), 21-31
DOI 10.1385/MB:28:1:21
Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling
Physiol. Genomics, 16 (3), 301-308
DOI 10.1152/physiolgenomics.00144.2002
Leukaemia inhibitory factor alters expression of genes involved in rat cardiomyocyte energy metabolism
Acta Physiol. Scand., 180 (2), 133-142
DOI 10.1046/j.0001-6772.2003.01245.x
Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes
J. Mol. Cell. Cardiol., 37 (6), 1183-1193
DOI 10.1016/j.yjmcc.2004.09.008
Elevated levels of activin A in heart failure - Potential role in myocardial remodeling
Circulation, 109 (11), 1379-1385
DOI 10.1161/01.CIR.0000120704.97934.41
Publications 2003
Radionuclide speciation in effluent from La Hague reprocessing plant in France
Health Phys., 85 (3), 311-322
DOI 10.1097/00004032-200309000-00007
Cardiopulmonary alterations in mRNA expression for interteukin-1 beta, the interleukin-6 superfamity and CXC-chemokines during development of postischaemic heart failure in the rat
Clin. Physiol. Funct. Imaging, 23 (5), 263-268
DOI 10.1046/j.1475-097X.2003.00503.x
Evaluation of a new fiber-optic pressure recording system for cardiovascular measurements in mice
Am. J. Physiol.-Heart Circul. Physiol., 285 (5), H2233-H2239
DOI 10.1152/ajpheart.01123.2002
Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction
Cardiovasc. Res., 59 (1), 122-131
DOI 10.1016/S0008-6363(03)00339-0
Publications 2002
Leukotriene antagonism reduces the generation of endothelin-l and interferon-gamma and inhibits eosinophilic airway inflammation
Respir. Med., 96 (11), 901-906
DOI 10.1053/rmed.2002.1375
Decreased hematopoiesis in bone marrow of mice with congestive heart failure
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 282 (1), R166-R172
DOI 10.1152/ajpregu.2002.282.1.R166
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Cardiovasc. Res., 53 (2), PII S0008-6363(01)00489-8-391
DOI 10.1016/S0008-6363(01)00489-8
Surgical manipulation, but not moderate exercise, is associated with increased cytokine mRNA expression in the rat soleus muscle
Acta Physiol. Scand., 175 (3), 219-226
DOI 10.1046/j.1365-201X.2002.00990.x
Gene expression of colony-stimulating factors and stem cell factor after myocardial infarction in the mouse
Acta Physiol. Scand., 175 (3), 173-181
DOI 10.1046/j.1365-201X.2002.00989.x
Publications 2001
Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes
Basic Res. Cardiol., 96 (4), 345-352
DOI 10.1007/s003950170042
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Eur. J. Clin. Invest., 31 (5), 389-397
DOI 10.1046/j.1365-2362.2001.00795.x
Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation
Am. J. Physiol.-Lung Cell. Mol. Physiol., 280 (4), L659-L665
DOI 10.1152/ajplung.2001.280.4.L659
Quantitative assessment of myocardial perfusion during graded coronary artery stenoses by intravenous myocardial contrast echocardiography
J. Am. Coll. Cardiol., 37 (2), 624-631
DOI 10.1016/S0735-1097(00)01127-X
Publications 2000
High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates
Circulation, 101 (2), 178-184
DOI 10.1161/01.CIR.101.2.178
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Cardiovasc. Res., 47 (4), 778-787
DOI 10.1016/S0008-6363(00)00142-5
Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation
Eur. Resp. J., 15 (4), 743-750
DOI 10.1034/j.1399-3003.2000.15d19.x
Cardiac endothelin-like immunoreactivity and preproendothelin-1 mRNA expression in human heart failure
Scand. Cardiovasc. J., 34 (1), 21-27
Publications 1999
Thyroid hormone control of contraction and the Ca2+-ATPase/phospholamban complex in adult rat ventricular myocytes
J. Mol. Cell. Cardiol., 31 (3), 645-656
DOI 10.1006/jmcc.1998.0900
Publications 1998
Associations between behavioural indicators of 'stress' in weaner pigs and respiratory lesions at slaughter
Prev. Vet. Med., 34 (2-3), 175-190
DOI 10.1016/S0167-5877(97)00074-3
Increased synthesis and release of endothelin-1 during the initial phase of airway inflammation
Am. J. Respir. Crit. Care Med., 158 (5), 1600-1606
DOI 10.1164/ajrccm.158.5.9707082
Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats
J. Mol. Cell. Cardiol., 30 (8), 1581-1593
DOI 10.1006/jmcc.1998.0724
Reduced myocardial Na+, K+-pump capacity in congestive heart failure following myocardial infarction in rats
J. Mol. Cell. Cardiol., 30 (7), 1311-1328
Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats. Localization of preproendothelin-1 mRNA and endothelin peptide
Cardiovasc. Res., 39 (3), 633-643
DOI 10.1016/S0008-6363(98)00156-4
Publications 1997
Atrial systolic pressure, as well as stretch, is a principal stimulus for release of ANF
Am. J. Physiol.-Heart Circul. Physiol., 272 (2), H820-H826
DOI 10.1152/ajpheart.1997.272.2.H820
Endothelin production and effects of endothelin antagonism during experimental airway inflammation
Am. J. Respir. Crit. Care Med., 155 (4), 1404-1412
DOI 10.1164/ajrccm.155.4.9105086
Transient Ca2+ overload alters Ca2+ handling in rat cardiomyocytes: effects on shortening and relaxation
Am. J. Physiol.-Heart Circul. Physiol., 273 (2), H573-H582
DOI 10.1152/ajpheart.1997.273.2.H573
Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling
Basic Res. Cardiol., 92 (5), 289-298
DOI 10.1007/s003950050038
Transient, isopeptide-specific induction of myocardial endothelin-1 mRNA in congestive heart failure in rats
Am. J. Physiol.-Heart Circul. Physiol., 273 (4), H1727-H1736
Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats
Cardiovasc. Res., 33 (3), 601-610
DOI 10.1016/S0008-6363(96)00266-0
Publications 1996
Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644
Circulation, 93 (9), 1747-1754
DOI 10.1161/01.CIR.93.9.1747
Lack of inhibitory effect of atrial natriuretic factor on renin release induced by renal hypotension
Scand. J. Clin. Lab. Invest., 56 (7), 665-670
DOI 10.3109/00365519609090603
Inhibition of granulocyte-derived proteases reduces the increase in plasma endothelin associated with myocardial ischemia in the pig
Basic Res. Cardiol., 91 (4), 289-295
DOI 10.1007/BF00789301
Publications 1995
INCREASED IN-VIVO EXPRESSION AND PRODUCTION OF ENDOTHELIN-1 BY PORCINE CARDIOMYOCYTES SUBJECTED TO ISCHEMIA
Circ.Res., 76 (5), 767-772
Endothelin release associated with splanchnic ischemia is abolished by inhibition of leukocyte-derived proteases
Endothelium, 3, 225-234
DOI 10.3109/10623329509024668, PublikaID 318
Publications 1994
PACSUS - PACS for Ullevål sykehus
Trondheim
BIBSYS 952210738
Internprising for bedre økonomisk styring: internprisingspraksis i fire bilfirma sammenlignet med teorien på området
[Forfatterne], Bergen, 53 bl.
BIBSYS 942419294
CARDIAC CONTRACTILE FUNCTION FOLLOWING REPETITIVE BRIEF ISCHEMIA - EFFECTS OF NUCLEOSIDE TRANSPORT INHIBITION
Am. J. Physiol., 267 (1), H57-H65
DOI 10.1152/ajpheart.1994.267.1.H57
SURVEY OF ARTIFICIAL RADIONUCLIDES IN THE BARENTS SEA AND THE KARA SEA
J. Environ. Radioact., 25 (1-2), 99-112
DOI 10.1016/0265-931X(94)90010-8
ENDOTHELIN SECRETION BY ENDOCARDIAL ENDOTHELIAL-CELLS - RESPONSE
Cardiovasc. Res., 28 (5), 722
DOI 10.1093/cvr/28.5.722a
Publications 1993
RELEASE OF ATRIAL-NATRIURETIC-FACTOR
Scand. J. Clin. Lab. Invest., 53 (2), 91-100
DOI 10.3109/00365519309088395
CARDIOVASCULAR AND RENAL EFFECTS OF ATRIAL-NATRIURETIC-FACTOR
Scand. J. Clin. Lab. Invest., 53 (3), 203-209
DOI 10.3109/00365519309088410
ATRIAL-NATRIURETIC-FACTOR (ANF) DOES NOT AFFECT ION-TRANSPORT IN HUMAN INTESTINE BUT DOES IN PORCINE INTESTINE
Acta Physiol. Scand., 147 (4), 417-429
DOI 10.1111/j.1748-1716.1993.tb09517.x
ATRIAL-NATRIURETIC-FACTOR INCREASES PERITONEAL-FLUID FORMATION IN THE PIG
Acta Physiol. Scand., 149 (1), 121-122
DOI 10.1111/j.1748-1716.1993.tb09601.x
ATRIAL CONTRACTILE PERFORMANCE AFTER CESSATION OF ATRIAL-FIBRILLATION
Am. J. Physiol., 264 (1), H104-H109
DOI 10.1152/ajpheart.1993.264.1.H104
EFFECTS OF ATRIAL-FIBRILLATION ON LEFT AND RIGHT ATRIAL DIMENSIONS, PRESSURES, AND COMPLIANCES
Am. J. Physiol., 264 (4), H1093-H1097
SIGNIFICANCE OF INCREASED ATRIAL PRESSURE ON STROKE VOLUME DURING ATRIAL-FIBRILLATION IN ANESTHETIZED PIGS
Acta Physiol. Scand., 149 (2), 157-161
DOI 10.1111/j.1748-1716.1993.tb09608.x
INHIBITORY EFFECT OF ENDOTHELIN ON RENIN RELEASE IN DOG KIDNEYS
Acta Physiol. Scand., 148 (2), 131-136
DOI 10.1111/j.1748-1716.1993.tb09542.x
EFFECT ON RENIN RELEASE OF INHIBITING RENAL NITRIC-OXIDE SYNTHESIS IN ANESTHETIZED DOGS
Acta Physiol. Scand., 148 (2), 137-142
DOI 10.1111/j.1748-1716.1993.tb09543.x
ALTERATIONS IN PLASMA ENDOTHELIN DURING PASSAGE THROUGH THE LEFT-HEART CHAMBERS BEFORE AND AFTER BRIEF MYOCARDIAL-ISCHEMIA
Cardiovasc. Res., 27 (12), 2160-2163
DOI 10.1093/cvr/27.12.2160
RELEASE OF ENDOTHELIN FROM THE PORCINE HEART AFTER SHORT-TERM CORONARY-ARTERY OCCLUSION
Cardiovasc. Res., 27 (8), 1482-1485
DOI 10.1093/cvr/27.8.1482
ENDOTHELIN IS RELEASED FROM THE PORCINE CORONARY CIRCULATION AFTER SHORT-TERM ISCHEMIA
J. Cardiovasc. Pharmacol., 22 8, S313-S316
DOI 10.1097/00005344-199322008-00082
Publications 1992
CHARACTERISTICS AND DEVELOPMENT OF MYOCARDIAL STUNNING IN THE PIG
Am. J. Physiol., 263 (2), H544-H551
DOI 10.1152/ajpheart.1992.263.2.H544
Atrial natriuretic factor: an experimental study on release mechanisms and on cardiovascular and renal effects
[Universitetet i Oslo, Institutt for eksperiementell medisinsk forskning], Oslo, 1 b. (flere pag.)
BIBSYS 930211189, ISBN 82-90246-39-0
ATRIAL-NATRIURETIC-FACTOR AND RENAL SODIUM-EXCRETION DURING VENTILATION WITH PEEP IN HYPERVOLEMIC DOGS
J. Appl. Physiol., 72 (3), 993-997
DOI 10.1152/jappl.1992.72.3.993
IMPORTANCE OF NITRIC-OXIDE IN CANINE FEMORAL CIRCULATION - COMPARISON OF 2 NO INHIBITORS
Cardiovasc. Res., 26 (4), 357-361
DOI 10.1093/cvr/26.4.357
EFFECT OF ATRIAL-NATRIURETIC-FACTOR ON RENAL PROSTAGLANDIN-E2 RELEASE IN THE ANESTHETIZED DOG
Acta Physiol. Scand., 145 (4), 369-375
DOI 10.1111/j.1748-1716.1992.tb09377.x
INHIBITION OF RENAL NITRIC-OXIDE SYNTHESIS WITH N(G)-MONOMETHYL-L-ARGININE AND N(G)-NITRO-L-ARGININE
Am. J. Physiol., 262 (6), F939-F942
DOI 10.1152/ajprenal.1992.262.6.F939
Publications 1991
RELEASE OF ATRIAL-NATRIURETIC-FACTOR DURING SELECTIVE CARDIAC ALPHA-ADRENERGIC AND BETA-ADRENERGIC STIMULATION, INTRACORONARY CA2+ INFUSION, AND AORTIC CONSTRICTION IN PIGS
Circ.Res., 68 (3), 638-644
DOI 10.1161/01.RES.68.3.638
RENAL UPTAKE AND DEGRADATION OF TRAPPED-LABEL CALCITONIN
Biochem. Pharmacol., 41 (8), 1119-1126
DOI 10.1016/0006-2952(91)90649-P
RIGHT AND LEFT ATRIAL DIAMETERS DURING INCREMENTAL ATRIAL-PACING IN PIGS
Am. J. Physiol., 260 (3), H973-H978
DOI 10.1152/ajpheart.1991.260.3.H973
ATRIAL-NATRIURETIC-FACTOR REDUCES RENIN RELEASE BY OPPOSING ALPHA-ADRENOCEPTOR ACTIVITY
Am. J. Physiol., 261 (2), E240-E245
DOI 10.1152/ajpendo.1991.261.2.E240
Publications 1990
INFLUENCE OF ANGIOTENSIN ON TOTAL INTRAVASCULAR CAPACITY IN THE ANESTHETIZED PIG
Acta Physiol. Scand., 139 (4), 569-573
DOI 10.1111/j.1748-1716.1990.tb08960.x
Publications 1989
ATRIAL NATRIURETIC FACTOR INDUCES NATRIURESIS DURING PACING TACHYCARDIA IN DOGS
Am. J. Physiol., 256 (6), R1245-R1249
RELEASE OF ATRIAL NATRIURETIC FACTOR DURING INFUSION OF ISOPROTERENOL AND ANGIOTENSIN-II
Am. J. Physiol., 257 (4), R896-R900
DOI 10.1152/ajpregu.1989.257.4.R896
Publications 1988
THE RELEASE MECHANISM FOR ATRIAL NATRIURETIC FACTOR DURING BLOOD-VOLUME EXPANSION AND TACHYCARDIA IN DOGS
Acta Physiol. Scand., 134 (2), 263-270
DOI 10.1111/j.1748-1716.1988.tb08487.x