Publications 2024

Ruud M, Frisk M, Melleby AO, Norseng PA, Mohamed BA, Li J, Aronsen JM, Setterberg IE, Jakubiczka J, van Hout I, Coffey S, Shen X, Nygård S, Lunde IG, Tønnessen T, Jones PP, Sjaastad I, Gullestad L, Toischer K, Dahl CP, Christensen G, Louch WE (2024)
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
J Physiol, 602 (18), 4487-4510
DOI 10.1113/JP284566, PubMed 38686538

Støle TP, Lunde M, Gehmlich K, Christensen G, Louch WE, Carlson CR (2024)
Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells
Cells, 13 (11)
DOI 10.3390/cells13110947, PubMed 38891079

Udjus C, Halvorsen B, Kong XY, Sagen EL, Martinsen M, Yang K, Løberg EM, Christensen G, Skjønsberg OH, Larsen KO (2024)
Alveolar hypoxia induces organ-specific inflammasome-related inflammation in male mouse lungs
Physiol Rep, 12 (14), e16143
DOI 10.14814/phy2.16143, PubMed 39034131

Publications 2023

Andreassen K, Rixon C, Hansen MH, Hauge-Iversen IM, Zhang L, Sadredini M, Erusappan PM, Sjaastad I, Christensen G, Haugaa KH, Edvardsen T, Lunde IG, Stokke MK (2023)
Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice
Am J Physiol Heart Circ Physiol, 324 (6), H881-H892
DOI 10.1152/ajpheart.00701.2022, PubMed 37115627

Bhatnagar R, Berge K, Røysland R, Høiseth AD, Brynildsen J, Christensen G, Omland T, Røsjø H, Lyngbakken MN (2023)
Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study
Cardiology, 148 (6), 506-516
DOI 10.1159/000533266, PubMed 37544298

Perdreau-Dahl H, Lipsett DB, Frisk M, Kermani F, Carlson CR, Brech A, Shen X, Bergan-Dahl A, Hou Y, Tuomainen T, Tavi P, Jones PP, Lunde M, Wasserstrom JA, Laporte J, Ullrich ND, Christensen G, Morth JP, Louch WE (2023)
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Circ Res, 132 (11), e188-e205
DOI 10.1161/CIRCRESAHA.122.321732, PubMed 37139790

Sasi A, Romaine A, Erusappan PM, Melleby AO, Hasic A, Dahl CP, Broch K, Almaas VM, Puertas RD, Roderick HL, Lunde IG, Sjaastad I, Vistnes M, Christensen G (2023)
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development
Matrix Biol Plus, 19-20, 100135
DOI 10.1016/j.mbplus.2023.100135, PubMed 38076279

Strand ME, Vanhaverbeke M, Henkens MTHM, Sikking MA, Rypdal KB, Braathen B, Almaas VM, Tønnessen T, Christensen G, Heymans S, Lunde IG (2023)
Inflammation and Syndecan-4 Shedding from Cardiac Cells in Ischemic and Non-Ischemic Heart Disease
Biomedicines, 11 (4)
DOI 10.3390/biomedicines11041066, PubMed 37189684

Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G (2023)
Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
Cardiovasc Res, 119 (10), 1915-1927
DOI 10.1093/cvr/cvad078, PubMed 37216909

Publications 2022

Berge K, Brynildsen J, Røysland R, Strand H, Christensen G, Høiseth AD, Omland T, Røsjø H, Lyngbakken MN (2022)
Prognostic value of cardiac biomarkers and National Early Warning Score 2 in acute dyspnoea
Open Heart, 9 (1)
DOI 10.1136/openhrt-2021-001938, PubMed 35387863

Lunde IG, Aronsen JM, Melleby AO, Strand ME, Skogestad J, Bendiksen BA, Ahmed MS, Sjaastad I, Attramadal H, Carlson CR, Christensen G (2022)
Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy
Mol Biol Rep, 49 (12), 11795-11809
DOI 10.1007/s11033-022-07985-y, PubMed 36205855

Lunde IG, Skrbic B, Sjaastad I, Christensen G, Carlson CR, Tønnessen T (2022)
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement
Front Mol Med, 2, 980717
DOI 10.3389/fmmed.2022.980717, PubMed 39086965

Lunde IG, Skrbic B, Sjaastad I, Christensen G, Carlson CR, Tønnessen T (2022)
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement
Front Mol Med, 2, 1-14
DOI 10.3389/fmmed.2022.980717, PublikaID 435

Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG (2022)
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail, 10 (2), 858-871
DOI 10.1002/ehf2.14234, PubMed 36444917

Romaine A, Melleby AO, Alam J, Lobert VH, Lu N, Lockwood FE, Hasic A, Lunde IG, Sjaastad I, Stenmark H, Herum KM, Gullberg D, Christensen G (2022)
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
DOI 10.1152/ajpheart.00635.2021, PubMed 35522553

Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG (2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599

Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)
The female syndecan-4^-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
DOI 10.3389/fcell.2022.908126, PubMed 36092718

Udjus C, Sjaastad I, Hjørnholm U, Tunestveit TK, Hoffmann P, Hinojosa A, Espe EKS, Christensen G, Skjønsberg OH, Larsen KO, Rostrup M (2022)
Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers
Physiol Rep, 10 (3), e15184
DOI 10.14814/phy2.15184, PubMed 35146955

Publications 2021

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703

Myhre PL, Ottesen AH, Faaren AL, Tveit SH, Springett J, Pyylampi J, Stridsberg M, Christensen G, Høiseth AD, Omland T, Røsjø H (2021)
Performance of a Novel Research-Use-Only Secretoneurin ELISA in Patients with Suspected Acute Coronary Syndrome: Comparison with an Established Secretoneurin Radioimmunoassay
Cardiology, 146 (5), 566-574
DOI 10.1159/000517444, PubMed 34284402

Nordén ES, Bendiksen BA, Andresen H, Bergo KK, Espe EK, Hasic A, Hauge-Iversen IM, Veras I, Hussain RI, Sjaastad I, Christensen G, Cataliotti A (2021)
Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
ESC Heart Fail, 8 (2), 918-927
DOI 10.1002/ehf2.13177, PubMed 33497525

Rutkovskiy A, Lyngbakken MN, Dahl MB, Bye A, Pedersen MH, Wisløff U, Christensen G, Høiseth AD, Omland T, Røsjø H (2021)
Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study
Clin Chem, 67 (6), 889-898
DOI 10.1093/clinchem/hvab030, PubMed 33783502

Rypdal KB, Erusappan PM, Melleby AO, Seifert DE, Palmero S, Strand ME, Tønnessen T, Dahl CP, Almaas V, Hubmacher D, Apte SS, Christensen G, Lunde IG (2021)
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
DOI 10.1038/s41598-021-99032-2, PubMed 34611183

Aakre KM, Ottesen AH, Strand H, Faaren AL, Alaour B, Torsvik J, Sylte MS, Marber M, Christensen G, Røsjø H, Omland T (2021)
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis
Clin Biochem, 98, 74-77
DOI 10.1016/j.clinbiochem.2021.09.014, PubMed 34624255

Publications 2020

Alam J, Musiime M, Romaine A, Sawant M, Melleby AO, Lu N, Eckes B, Christensen G, Gullberg D (2020)
Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Matrix Biol Plus, 8, 100045
DOI 10.1016/j.mbplus.2020.100045, PubMed 33543038

Berge K, Lyngbakken MN, Myhre PL, Brynildsen J, Røysland R, Strand H, Christensen G, Høiseth AD, Omland T, Røsjø H (2020)
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study
Clin Biochem, 88, 30-36
DOI 10.1016/j.clinbiochem.2020.11.009, PubMed 33245872

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Mathiesen SB, Lunde M, Stensland M, Martinsen M, Nyman TA, Christensen G, Carlson CR (2020)
The Cardiac Syndecan-2 Interactome
Front Cell Dev Biol, 8, 792
DOI 10.3389/fcell.2020.00792, PubMed 32984315

Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T (2020)
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 145 (3), 187-198
DOI 10.1159/000505318, PubMed 31968347

Rønning SB, Carlson CR, Aronsen JM, Pisconti A, Høst V, Lunde M, Liland KH, Sjaastad I, Kolset SO, Christensen G, Pedersen ME (2020)
Syndecan-4^-/- Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
Front Cell Dev Biol, 8, 730
DOI 10.3389/fcell.2020.00730, PubMed 32850844

Publications 2019

Brynildsen J, Myhre PL, Lyngbakken MN, Klaeboe LG, Stridsberg M, Christensen G, Edvardsen T, Omland T, Røsjø H (2019)
Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis
Clin Biochem, 71, 17-23
DOI 10.1016/j.clinbiochem.2019.06.008, PubMed 31228433

Brynildsen J, Petäjä L, Myhre PL, Lyngbakken MN, Nygård S, Stridsberg M, Christensen G, Ottesen AH, Pettilä V, Omland T, Røsjø H (2019)
Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study
Crit Care Med, 47 (5), e412-e419
DOI 10.1097/CCM.0000000000003670, PubMed 30730440

Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE (2019)
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J Physiol, 597 (7), 1833-1853
DOI 10.1113/JP277273, PubMed 30707448

Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR (2019)
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423, PubMed 30967474

Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T (2019)
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9 (1), 9206
DOI 10.1038/s41598-019-45651-9, PubMed 31235849

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca²⁺-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE (2019)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410

Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO (2019)
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, 316 (6), L999-L1012
DOI 10.1152/ajplung.00322.2018, PubMed 30908936

Publications 2018

Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T (2018)
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422, PubMed 30052659

Berge K, Lyngbakken MN, Einvik G, Winther JA, Brynildsen J, Røysland R, Strand H, Christensen G, Høiseth AD, Omland T, Røsjø H (2018)
Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study
Clin Biochem, 59, 62-68
DOI 10.1016/j.clinbiochem.2018.07.006, PubMed 30028971

Christensen G, Herum KM, Lunde IG (2018)
Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease
Matrix Biol, 75-76, 286-299
DOI 10.1016/j.matbio.2018.01.001, PubMed 29337052

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G (2018)
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141, PubMed 29878127

Pervez MO, Winther JA, Brynildsen J, Strand H, Christensen G, Høiseth AD, Myhre PL, Røysland R, Lyngbakken MN, Omland T, Røsjø H (2018)
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study
Biomarkers, 23 (7), 654-663
DOI 10.1080/1354750X.2018.1474258, PubMed 29733687

Røsjø H, Masson S, Caironi P, Stridsberg M, Magnoli M, Christensen G, Moise G, Urbano MC, Gattinoni L, Pesenti A, Latini R, Omland T, ALBIOS Biomarkers Study Investigators (2018)
Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study
Crit Care Med, 46 (5), e404-e410
DOI 10.1097/CCM.0000000000003050, PubMed 29481425

Publications 2017

Abraityte A, Lunde IG, Askevold ET, Michelsen AE, Christensen G, Aukrust P, Yndestad A, Fiane A, Andreassen A, Aakhus S, Dahl CP, Gullestad L, Broch K, Ueland T (2017)
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7 (1), 3490
DOI 10.1038/s41598-017-03625-9, PubMed 28615692

Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T (2017)
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477

Dhondup Y, Sjaastad I, Sandanger Ø, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang L, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840

Herum KM, Lunde IG, McCulloch AD, Christensen G (2017)
The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart
J Clin Med, 6 (5)
DOI 10.3390/jcm6050053, PubMed 28534817

Lyngbakken MN, Pervez MO, Brynildsen J, Pedersen MH, Sølvernes J, Christensen G, Høiseth AD, Omland T, Røsjø H (2017)
Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study
Clin Biochem, 52, 41-47
DOI 10.1016/j.clinbiochem.2017.10.015, PubMed 29074091

Myhre PL, Stridsberg M, Linko R, Okkonen M, Nygård S, Christensen G, Pettilä V, Omland T, Røsjø H, FINNALI Study Group (2017)
Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study
Biomarkers, 22 (8), 775-781
DOI 10.1080/1354750X.2016.1269200, PubMed 28049363

Norum HM, Broch K, Michelsen AE, Lunde IG, Lekva T, Abraityte A, Dahl CP, Fiane AE, Andreassen AK, Christensen G, Aakhus S, Aukrust P, Gullestad L, Ueland T (2017)
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J Cardiovasc Transl Res, 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y, PubMed 28474304

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Ottesen AH, Carlson CR, Louch WE, Dahl MB, Sandbu RA, Johansen RF, Jarstadmarken H, Bjørås M, Høiseth AD, Brynildsen J, Sjaastad I, Stridsberg M, Omland T, Christensen G, Røsjø H (2017)
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766

Ottesen AH, Christensen G, Omland T, Røsjø H (2017)
Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure
Curr Heart Fail Rep, 14 (6), 478-488
DOI 10.1007/s11897-017-0360-x, PubMed 28975588

Pervez MO, Lyngbakken MN, Myhre PL, Brynildsen J, Langsjøen EC, Høiseth AD, Christensen G, Omland T, Røsjø H (2017)
Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study
Clin Biochem, 50 (7-8), 394-400
DOI 10.1016/j.clinbiochem.2016.12.010, PubMed 28065681

Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D (2017)
Overexpression of integrin α11 induces cardiac fibrosis in mice
Acta Physiol (Oxf), 222 (2)
DOI 10.1111/apha.12932, PubMed 28771943

Winther JA, Brynildsen J, Høiseth AD, Strand H, Følling I, Christensen G, Nygård S, Røsjø H, Omland T (2017)
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study
Respir Res, 18 (1), 184
DOI 10.1186/s12931-017-0665-z, PubMed 29100503

Publications 2016

Høiseth AD, Brynildsen J, Hagve TA, Christensen G, Søyseth V, Omland T, Røsjø H (2016)
The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study
Biomarkers, 21 (2), 173-9
DOI 10.3109/1354750X.2015.1126645, PubMed 26754170

Lunde IG, Herum KM, Carlson CC, Christensen G (2016)
Syndecans in heart fibrosis
Cell Tissue Res, 365 (3), 539-52
DOI 10.1007/s00441-016-2454-2, PubMed 27411689

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG (2016)
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079, PubMed 27768722

Myhre PL, Ottesen AH, Okkonen M, Linko R, Stridsberg M, Nygård S, Christensen G, Pettilä V, Omland T, Røsjø H, FINNALI Laboratory Study Group (2016)
Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study
Clin Chem, 62 (10), 1380-9
DOI 10.1373/clinchem.2016.258764, PubMed 27540029

Røsjø H, Stridsberg M, Ottesen AH, Nygård S, Christensen G, Pettilä V, Linko R, Karlsson S, Varpula T, Ruokonen E, Omland T, FINNSEPSIS and FINNALI Study Groups (2016)
Prognostic Value of Secretoneurin in Critically Ill Patients With Infections
Crit Care Med, 44 (10), 1882-90
DOI 10.1097/CCM.0000000000001832, PubMed 27414477

Winther JA, Brynildsen J, Høiseth AD, Følling I, Brekke PH, Christensen G, Hagve TA, Verbalis JG, Omland T, Røsjø H (2016)
Prevalence and Prognostic Significance of Hyponatremia in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination (ACE) 2 Study
PLoS One, 11 (8), e0161232
DOI 10.1371/journal.pone.0161232, PubMed 27529844

Publications 2015

Brynildsen J, Høiseth AD, Nygård S, Hagve TA, Christensen G, Omland T, Røsjø H (2015)
[Diagnostic accuracy for heart failure – data from the Akershus Cardiac Examination 2 Study]
Tidsskr Nor Laegeforen, 135 (19), 1738-44
DOI 10.4045/tidsskr.14.1174, PubMed 26486668

Bytingsvik J, Frantzen M, Götsch A, Heimstad ES, Christensen G, Evenset A (2015)
Current status, between-year comparisons and maternal transfer of organohalogenated compounds (OHCs) in Arctic char (Salvelinus alpinus) from Bjørnøya, Svalbard (Norway)
Sci Total Environ, 521-522, 421-30
DOI 10.1016/j.scitotenv.2015.03.104, PubMed 25864154

Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH (2015)
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
Am J Physiol Lung Cell Mol Physiol, 309 (4), L378-87
DOI 10.1152/ajplung.00342.2014, PubMed 26071556

Dhondup Y, Sjaastad I, Scott H, Sandanger Ø, Zhang L, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521

Einvik G, Dammen T, Høiseth AD, Brynildsen J, Hagve TA, Christensen G, Omland T, Røsjø H (2015)
Psychological distress and mortality in patients with acute dyspnea: data from the Akershus Cardiac Examination (ACE) 2 Study
Gen Hosp Psychiatry, 37 (6), 548-53
DOI 10.1016/j.genhosppsych.2015.07.007, PubMed 26298205

Evenset A, Hallanger IG, Tessmann M, Warner N, Ruus A, Borgå K, Gabrielsen GW, Christensen G, Renaud PE (2015)
Seasonal variation in accumulation of persistent organic pollutants in an Arctic marine benthic food web
Sci Total Environ, 542 (Pt A), 108-20
DOI 10.1016/j.scitotenv.2015.10.092, PubMed 26519572

Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, Linke WA, Gomez MF, Christensen G (2015)
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Cardiovasc Res, 106 (2), 217-26
DOI 10.1093/cvr/cvv002, PubMed 25587045

Kho C, Lee A, Jeong D, Oh JG, Gorski PA, Fish K, Sanchez R, DeVita RJ, Christensen G, Dahl R, Hajjar RJ (2015)
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
Nat Commun, 6, 7229
DOI 10.1038/ncomms8229, PubMed 26068603

Ottesen AH, Louch WE, Carlson CR, Landsverk OJB, Kurola J, Johansen RF, Moe MK, Aronsen JM, Høiseth AD, Jarstadmarken H, Nygård S, Bjørås M, Sjaastad I, Pettilä V, Stridsberg M, Omland T, Christensen G, Røsjø H (2015)
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832

Røsjø H, Dahl MB, Jørgensen M, Røysland R, Brynildsen J, Cataliotti A, Christensen G, Høiseth AD, Hagve TA, Omland T (2015)
Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study
Clin Chem, 61 (8), 1087-97
DOI 10.1373/clinchem.2015.239673, PubMed 26056354

Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bjørnstad JL, Tønnessen T (2015)
Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
Cardiovasc Res, 106 (1), 32-42
DOI 10.1093/cvr/cvv041, PubMed 25694587

Strand ME, Aronsen JM, Braathen B, Sjaastad I, Kvaløy H, Tønnessen T, Christensen G, Lunde IG (2015)
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice
J Mol Cell Cardiol, 88, 133-44
DOI 10.1016/j.yjmcc.2015.10.003, PubMed 26449522

Publications 2014

Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L, GISSI-HF Investigators, Ueland T (2014)
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
J Intern Med, 275 (6), 621-30
DOI 10.1111/joim.12175, PubMed 24330105

Boardman NT, Aronsen JM, Louch WE, Sjaastad I, Willoch F, Christensen G, Sejersted O, Aasum E (2014)
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am J Physiol Heart Circ Physiol, 306 (7), H1018-24
DOI 10.1152/ajpheart.00741.2013, PubMed 24486508

Engebretsen KV, Skårdal K, Bjørnstad S, Marstein HS, Skrbic B, Sjaastad I, Christensen G, Bjørnstad JL, Tønnessen T (2014)
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
J Mol Cell Cardiol, 76, 148-57
DOI 10.1016/j.yjmcc.2014.08.008, PubMed 25169971

Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A (2014)
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172, PubMed 25398010

Hillestad V, Espe EK, Cero F, Larsen KO, Sjaastad I, Nygård S, Skjønsberg OH, Christensen G (2014)
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice
Acta Physiol (Oxf), 213 (2), 492-504
DOI 10.1111/apha.12376, PubMed 25182570

Majak P, Lunde IG, Hasic AK, Husebye T, Christensen G, Tønnessen T, Bjørnstad JL (2014)
Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling
J Cardiovasc Surg (Torino), 56 (3), 483-92
PubMed 24429804

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930

Nygård S, Reitan T, Clancy T, Nygaard V, Bjørnstad J, Skrbic B, Tønnessen T, Christensen G, Hovig E (2014)
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699

Røsjø H, Dahl MB, Bye A, Andreassen J, Jørgensen M, Wisløff U, Christensen G, Edvardsen T, Omland T (2014)
Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis
PLoS One, 9 (3), e91812
DOI 10.1371/journal.pone.0091812, PubMed 24626394

Sanner H, Schwartz T, Flatø B, Vistnes M, Christensen G, Sjaastad I (2014)
Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage
PLoS One, 9 (3), e92171
DOI 10.1371/journal.pone.0092171, PubMed 24647150

Schwartz T, Sjaastad I, Flatø B, Vistnes M, Christensen G, Sanner H (2014)
In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction
Rheumatology (Oxford), 53 (12), 2214-22
DOI 10.1093/rheumatology/keu256, PubMed 24996906

Vistnes M, Aronsen JM, Lunde IG, Sjaastad I, Carlson CR, Christensen G (2014)
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding
PLoS One, 9 (3), e89621
DOI 10.1371/journal.pone.0089621, PubMed 24595230

Ytrehus K, Larsen T, Christensen G, Stensløkken KO, Levy FO (2014)
In memory of Guro Valen (1960-2014)
J Mol Cell Cardiol, 79, 254-5
DOI 10.1016/j.yjmcc.2014.11.026, PubMed 25490150

Publications 2013

Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T (2013)
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli
FEBS J, 280 (10), 2382-98
DOI 10.1111/febs.12235, PubMed 23480731

Engebretsen KV, Waehre A, Bjørnstad JL, Skrbic B, Sjaastad I, Behmen D, Marstein HS, Yndestad A, Aukrust P, Christensen G, Tønnessen T (2013)
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse
J Appl Physiol (1985), 114 (8), 988-97
DOI 10.1152/japplphysiol.00793.2012, PubMed 23412898

Heinis FI, Andersson KB, Christensen G, Metzger JM (2013)
Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency
PLoS One, 8 (11), e79609
DOI 10.1371/journal.pone.0079609, PubMed 24223976

Hillestad V, Kramer F, Golz S, Knorr A, Andersson KB, Christensen G (2013)
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene
J Appl Physiol (1985), 115 (10), 1572-80
DOI 10.1152/japplphysiol.01044.2012, PubMed 24072410

Land S, Louch WE, Niederer SA, Aronsen JM, Christensen G, Sjaastad I, Sejersted OM, Smith NP (2013)
Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice
Biophys J, 104 (6), 1349-56
DOI 10.1016/j.bpj.2013.01.042, PubMed 23528094

Moltzau LR, Aronsen JM, Meier S, Nguyen CH, Hougen K, Ørstavik Ø, Sjaastad I, Christensen G, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2013)
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br J Pharmacol, 170 (2), 366-79
DOI 10.1111/bph.12282, PubMed 23808942

Røsjø H, Opstad PK, Hoff JE, Godang K, Christensen G, Stridsberg M, Omland T (2013)
Effect of short- and long-term physical activities on circulating granin protein levels
Regul Pept, 185, 14-9
DOI 10.1016/j.regpep.2013.06.003, PubMed 23816467

Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A (2013)
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury
Cardiovasc Res, 99 (1), 164-74
DOI 10.1093/cvr/cvt091, PubMed 23580606

Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG (2013)
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart
FEBS J, 280 (10), 2228-47
DOI 10.1111/febs.12161, PubMed 23374111

Vistnes M, Høiseth AD, Røsjø H, Nygård S, Pettersen E, Søyseth V, Hurlen P, Christensen G, Omland T (2013)
Lack of pro-inflammatory cytokine mobilization predicts poor prognosis in patients with acute heart failure
Cytokine, 61 (3), 962-9
DOI 10.1016/j.cyto.2013.01.006, PubMed 23415671

Øyehaug L, Loose KØ, Jølle GF, Røe ÅT, Sjaastad I, Christensen G, Sejersted OM, Louch WE (2013)
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity
Biophys J, 104 (8), 1685-97
DOI 10.1016/j.bpj.2013.03.022, PubMed 23601316

Publications 2012

Balik S, Hugo G, Weiss E, Jan N, Roman N, Sleeman W, Fatyga M, Christensen G, Murphy M, Lu J, Keall P, Williamson J (2012)
MO-F-BRA-02: Evaluation of 4D CT to 4D Cone-Beam CT Deformable Image Registration for Lung Cancer Adaptive Radiation Therapy
Med Phys, 39 (6Part21), 3875
DOI 10.1118/1.4735821, PubMed 28518270

Cero FT, Hillestad V, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH (2012)
IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung
Exp Lung Res, 38 (8), 406-19
DOI 10.3109/01902148.2012.716903, PubMed 22908875

Ding K, Cao K, Du K, Chen Q, Ennis D, Christensen G, Reinhardt J, Libby B, Benedict S, Sheng K (2012)
SU-E-J-192: Static Breath-Hold MRI Based Measurement of Change in Pulmonary Function Following a Course of Radiation Therapy
Med Phys, 39 (6Part9), 3697
DOI 10.1118/1.4735033, PubMed 28519030

Ding K, Deng J, Du K, Cao K, Christensen G, Reinhardt J, Sheng K, Libby B, Benedict S, Lamer J, Chen Q (2012)
SU-D-BRB-05: Small Animal Lung Compliance Imaging: Assessment System for Tissue Sensitivity to Radiation Induced Lung Injury
Med Phys, 39 (6Part3), 3615
DOI 10.1118/1.4734677, PubMed 28517399

Du K, Reinhardt J, Christensen G, Ding K, Cao K, Bayouth J (2012)
SU-E-J-82: Improvement in Reproducibility of Lung Expansion Measures with Respiratory Effort Correction
Med Phys, 39 (6Part7), 3671
DOI 10.1118/1.4734917, PubMed 28519786

Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G (2012)
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress
J Mol Cell Cardiol, 54, 73-81
DOI 10.1016/j.yjmcc.2012.11.006, PubMed 23178899

Husberg C, Agnetti G, Holewinski RJ, Christensen G, Van Eyk JE (2012)
Dephosphorylation of cardiac proteins in vitro - a matter of phosphatase specificity
Proteomics, 12 (7), 973-8
DOI 10.1002/pmic.201100116, PubMed 22522803

Li L, Louch WE, Niederer SA, Aronsen JM, Christensen G, Sejersted OM, Smith NP (2012)
Sodium accumulation in SERCA knockout-induced heart failure
Biophys J, 102 (9), 2039-48
DOI 10.1016/j.bpj.2012.03.045, PubMed 22824267

Louch WE, Stokke MK, Sjaastad I, Christensen G, Sejersted OM (2012)
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium
Physiology (Bethesda), 27 (5), 308-23
DOI 10.1152/physiol.00021.2012, PubMed 23026754

Majak P, Bjørnstad JL, Braathen B, Lunde IG, Husebye T, Christensen G, Tønnessen T (2012)
Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement
Cardiology, 123 (1), 1-10
DOI 10.1159/000339756, PubMed 22907118

Røsjø H, Stridsberg M, Florholmen G, Stensløkken KO, Ottesen AH, Sjaastad I, Husberg C, Dahl MB, Øie E, Louch WE, Omland T, Christensen G (2012)
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties
PLoS One, 7 (5), e37401
DOI 10.1371/journal.pone.0037401, PubMed 22655045

Skrbic B, Bjørnstad JL, Marstein HS, Carlson CR, Sjaastad I, Nygård S, Bjørnstad S, Christensen G, Tønnessen T (2012)
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload
Matrix Biol, 32 (2), 133-42
DOI 10.1016/j.matbio.2012.11.011, PubMed 23220517

Swift F, Christensen G (2012)
Calcium release units in heart failure: that's about the size of it
Cardiovasc Res, 95 (4), 397-8
DOI 10.1093/cvr/cvs241, PubMed 22832099

Swift F, Franzini-Armstrong C, Øyehaug L, Enger UH, Andersson KB, Christensen G, Sejersted OM, Louch WE (2012)
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout
Proc Natl Acad Sci U S A, 109 (10), 3997-4001
DOI 10.1073/pnas.1120172109, PubMed 22355118

Waehre A, Vistnes M, Sjaastad I, Nygård S, Husberg C, Lunde IG, Aukrust P, Yndestad A, Vinge LE, Behmen D, Neukamm C, Brun H, Thaulow E, Christensen G (2012)
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
J Appl Physiol (1985), 112 (8), 1372-82
DOI 10.1152/japplphysiol.01350.2011, PubMed 22345433

Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Øie E, Vinge LE, Sjaastad I, Sandanger Ø, Ranheim T, Dickstein K, Kjekshus J, Damås JK, Fiane AE, Hilfiker-Kleiner D, Lipp M, Gullestad L, Christensen G, Aukrust P (2012)
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038, PubMed 22427939

Publications 2011

Bjørnstad JL, Skrbic B, Marstein HS, Hasic A, Sjaastad I, Louch WE, Florholmen G, Christensen G, Tønnessen T (2011)
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovasc Res, 93 (1), 100-10
DOI 10.1093/cvr/cvr294, PubMed 22049534

Bjørnstad JL, Skrbic B, Sjaastad I, Bjørnstad S, Christensen G, Tønnessen T (2011)
A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta
Acta Physiol (Oxf), 205 (1), 92-102
DOI 10.1111/j.1748-1716.2011.02369.x, PubMed 21974781

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G (2011)
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302, PubMed 22164265

Johansen IB, Lunde IG, Røsjø H, Christensen G, Nilsson GE, Bakken M, Overli O (2011)
Cortisol response to stress is associated with myocardial remodeling in salmonid fishes
J Exp Biol, 214 (Pt 8), 1313-21
DOI 10.1242/jeb.053058, PubMed 21430209

Larsen KO, Yndestad A, Sjaastad I, Løberg EM, Goverud IL, Halvorsen B, Jia J, Andreassen AK, Husberg C, Jonasson S, Lipp M, Christensen G, Aukrust P, Skjønsberg OH (2011)
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation
Am J Physiol Lung Cell Mol Physiol, 301 (1), L50-9
DOI 10.1152/ajplung.00048.2010, PubMed 21498626

Li L, Louch WE, Niederer SA, Andersson KB, Christensen G, Sejersted OM, Smith NP (2011)
Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study
Biophys J, 100 (2), 322-31
DOI 10.1016/j.bpj.2010.11.048, PubMed 21244828

Lunde IG, Aronsen JM, Kvaløy H, Qvigstad E, Sjaastad I, Tønnessen T, Christensen G, Grønning-Wang LM, Carlson CR (2011)
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure
Physiol Genomics, 44 (2), 162-72
DOI 10.1152/physiolgenomics.00016.2011, PubMed 22128088

Lunde IG, Kvaløy H, Austbø B, Christensen G, Carlson CR (2011)
Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes
J Appl Physiol (1985), 111 (5), 1278-89
DOI 10.1152/japplphysiol.01383.2010, PubMed 21474694

Sjåland C, Lunde PK, Swift F, Munkvik M, Ericsson M, Lunde M, Boye S, Christensen G, Ellingsen Ø, Sejersted OM, Andersson KB (2011)
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle
J Physiol, 589 (Pt 24), 6139-55
DOI 10.1113/jphysiol.2011.211987, PubMed 21946846

Stokke MK, Briston SJ, Jølle GF, Manzoor I, Louch WE, Øyehaug L, Christensen G, Eisner DA, Trafford AW, Sejersted OM, Sjaastad I (2011)
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content
Cardiovasc Res, 90 (3), 503-12
DOI 10.1093/cvr/cvr013, PubMed 21242164

Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygård S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G (2011)
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668, PubMed 21533157

Publications 2010

Bjørnstad JL, Sjaastad I, Nygård S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G, Tønnessen T (2010)
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur Heart J, 32 (2), 236-45
DOI 10.1093/eurheartj/ehq166, PubMed 20525982

Ericsson M, Andersson KB, Amundsen BH, Torp SH, Sjaastad I, Christensen G, Sejersted OM, Ellingsen Ø (2010)
High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2
J Appl Physiol (1985), 108 (5), 1311-20
DOI 10.1152/japplphysiol.01133.2009, PubMed 20167673

Ericsson M, Sjåland C, Andersson KB, Sjaastad I, Christensen G, Sejersted OM, Ellingsen Ø (2010)
Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice
J Appl Physiol (1985), 109 (6), 1749-55
DOI 10.1152/japplphysiol.00282.2010, PubMed 20864565

Hougen K, Aronsen JM, Stokke MK, Enger U, Nygard S, Andersson KB, Christensen G, Sejersted OM, Sjaastad I (2010)
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice
Am J Physiol Heart Circ Physiol, 299 (5), H1671-8
DOI 10.1152/ajpheart.01155.2009, PubMed 20802136

Liu XH, Zhang ZY, Andersson KB, Husberg C, Enger UH, Ræder MG, Christensen G, Louch WE (2010)
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis
Cell Calcium, 49 (4), 201-7
DOI 10.1016/j.ceca.2010.09.009, PubMed 20965565

Majak P, Bjørnstad J, Vengen OA, Neverdal NO, Husebye T, Woldbaek P, Pepper J, Lie M, Christensen G, Tønnessen T (2010)
Plasma IL-18 and IL-18BP are altered differently in reverse remodeling following aortic valve replacement
Scand Cardiovasc J, 44 (2), 113-8
DOI 10.3109/14017430903426902, PubMed 19961286

Røsjø H, Husberg C, Dahl MB, Stridsberg M, Sjaastad I, Finsen AV, Carlson CR, Oie E, Omland T, Christensen G (2010)
Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium
Circ Heart Fail, 3 (4), 503-11
DOI 10.1161/CIRCHEARTFAILURE.109.867747, PubMed 20519641

Vistnes M, Christensen G, Omland T (2010)
Multiple cytokine biomarkers in heart failure
Expert Rev Mol Diagn, 10 (2), 147-57
DOI 10.1586/erm.10.3, PubMed 20214534

Vistnes M, Waehre A, Nygård S, Sjaastad I, Andersson KB, Husberg C, Christensen G (2010)
Circulating cytokine levels in mice with heart failure are etiology dependent
J Appl Physiol (1985), 108 (5), 1357-64
DOI 10.1152/japplphysiol.01084.2009, PubMed 20224000

Publications 2009

Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G (2009)
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
J Mol Cell Cardiol, 47 (2), 180-7
DOI 10.1016/j.yjmcc.2009.03.013, PubMed 19328205

Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G (2009)
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models
Cell Calcium, 46 (3), 219-25
DOI 10.1016/j.ceca.2009.07.004, PubMed 19692123

Dahl CP, Husberg C, Gullestad L, Waehre A, Damås JK, Vinge LE, Finsen AV, Ueland T, Florholmen G, Aakhus S, Halvorsen B, Aukrust P, Oie E, Yndestad A, Christensen G (2009)
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling
Circ Heart Fail, 2 (6), 624-32
DOI 10.1161/CIRCHEARTFAILURE.108.821074, PubMed 19919988

Iversen PO, Andersson KB, Finsen AV, Sjaastad I, von Lueder TG, Sejersted OM, Attramadal H, Christensen G (2009)
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure
Am J Physiol Regul Integr Comp Physiol, 298 (3), R808-14
DOI 10.1152/ajpregu.00250.2009, PubMed 20032264

Louch WE, Hougen K, Mørk HK, Swift F, Aronsen JM, Sjaastad I, Reims HM, Roald B, Andersson KB, Christensen G, Sejersted OM (2009)
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J Physiol, 588 (Pt 3), 465-78
DOI 10.1113/jphysiol.2009.183517, PubMed 20008467

Madsen LH, Lund T, Grieg Z, Nygaard S, Holmvang L, Jurlander B, Grande P, Christensen G, Atar D (2009)
Cardiac troponin I degradation in serum of patients with hypertrophic obstructive cardiomyopathy undergoing percutaneous septal ablation
Cardiology, 114 (3), 167-73
DOI 10.1159/000226596, PubMed 19571537

Stokke MK, Hougen K, Sjaastad I, Louch WE, Briston SJ, Enger UH, Andersson KB, Christensen G, Eisner DA, Sejersted OM, Trafford AW (2009)
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc Res, 86 (1), 63-71
DOI 10.1093/cvr/cvp401, PubMed 20019150

Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE, Espevik T, Frøland SS, Husberg C, Christensen G, Dickstein K, Kjekshus J, Øie E, Gullestad L, Aukrust P (2009)
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur Heart J, 30 (10), 1229-36
DOI 10.1093/eurheartj/ehp088, PubMed 19329498

Yndestad A, Larsen KO, Oie E, Ueland T, Smith C, Halvorsen B, Sjaastad I, Skjønsberg OH, Pedersen TM, Anfinsen OG, Damås JK, Christensen G, Aukrust P, Andreassen AK (2009)
Elevated levels of activin A in clinical and experimental pulmonary hypertension
J Appl Physiol (1985), 106 (4), 1356-64
DOI 10.1152/japplphysiol.90719.2008, PubMed 19196915

Publications 2008

Bjørnstad JL, Neverdal NO, Vengen OA, Knudsen CW, Husebye T, Pepper J, Lie M, Christensen G, Tønnessen T (2008)
Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis
Eur J Heart Fail, 10 (12), 1201-7
DOI 10.1016/j.ejheart.2008.09.010, PubMed 18996047

Husberg C, Nygård S, Finsen AV, Damås JK, Frigessi A, Oie E, Waehre A, Gullestad L, Aukrust P, Yndestad A, Christensen G (2008)
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
J Mol Cell Cardiol, 45 (2), 261-9
DOI 10.1016/j.yjmcc.2008.05.009, PubMed 18585734

Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G (2008)
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc Res, 80 (1), 47-54
DOI 10.1093/cvr/cvn180, PubMed 18599478

Publications 2006

Andersson KB, Florholmen G, Winer LH, Tønnessen T, Christensen G (2006)
Regulation of neuronal type genes in congestive heart failure rats
Acta Physiol (Oxf), 186 (1), 17-27
DOI 10.1111/j.1748-1716.2005.01503.x, PubMed 16497176

Florholmen G, Halvorsen B, Beraki K, Lyberg T, Sagen EL, Aukrust P, Christensen G, Yndestad A (2006)
Activin A inhibits organization of sarcomeric proteins in cardiomyocytes induced by leukemia inhibitory factor
J Mol Cell Cardiol, 41 (4), 689-97
DOI 10.1016/j.yjmcc.2006.07.009, PubMed 16926021

Florholmen G, Thoresen GH, Rustan AC, Jensen J, Christensen G, Aas V (2006)
Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure
Diabetologia, 49 (4), 724-31
DOI 10.1007/s00125-006-0150-6, PubMed 16489447

Larsen KO, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G (2006)
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice
Am J Physiol Heart Circ Physiol, 291 (2), H507-16
DOI 10.1152/ajpheart.00862.2005, PubMed 16582020

Lunde PK, Sejersted OM, Thorud HM, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J (2006)
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue
Circ Res, 98 (12), 1514-9
DOI 10.1161/01.RES.0000226529.66545.e5, PubMed 16690878

Madsen LH, Christensen G, Lund T, Serebruany VL, Granger CB, Hoen I, Grieg Z, Alexander JH, Jaffe AS, Van Eyk JE, Atar D (2006)
Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy
Circ Res, 99 (10), 1141-7
DOI 10.1161/01.RES.0000249531.23654.e1, PubMed 17038641

Publications 2005

Iversen PO, Woldbaek PR, Christensen G (2005)
Reduced immune responses to an aseptic inflammation in mice with congestive heart failure
Eur J Haematol, 75 (2), 156-63
DOI 10.1111/j.1600-0609.2005.00440.x, PubMed 16000132

Ueland T, Yndestad A, Øie E, Florholmen G, Halvorsen B, Frøland SS, Simonsen S, Christensen G, Gullestad L, Aukrust P (2005)
Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure
Circulation, 111 (19), 2461-8
DOI 10.1161/01.CIR.0000165119.62099.14, PubMed 15883214

Woldbaek PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T (2005)
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice
Am J Physiol Heart Circ Physiol, 289 (2), H708-14
DOI 10.1152/ajpheart.01179.2004, PubMed 15821032

Publications 2004

Djurovic S, Iversen N, Jeansson S, Hoover F, Christensen G (2004)
Comparison of nonviral transfection and adeno-associated viral transduction on cardiomyocytes
Mol Biotechnol, 28 (1), 21-32
DOI 10.1385/MB:28:1:21, PubMed 15456960

Finsen AV, Christensen G, Sjaastad I (2004)
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse
J Appl Physiol (1985), 98 (2), 680-9
DOI 10.1152/japplphysiol.00924.2004, PubMed 15475595

Finsen AV, Woldbaek PR, Li J, Wu J, Lyberg T, Tønnessen T, Christensen G (2004)
Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling
Physiol Genomics, 16 (3), 301-8
DOI 10.1152/physiolgenomics.00144.2002, PubMed 14625378

Florholmen G, Andersson KB, Yndestad A, Austbø B, Henriksen UL, Christensen G (2004)
Leukaemia inhibitory factor alters expression of genes involved in rat cardiomyocyte energy metabolism
Acta Physiol Scand, 180 (2), 133-42
DOI 10.1046/j.0001-6772.2003.01245.x, PubMed 14738472

Florholmen G, Aas V, Rustan AC, Lunde PK, Straumann N, Eid H, Odegaard A, Dishington H, Andersson KB, Christensen G (2004)
Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes
J Mol Cell Cardiol, 37 (6), 1183-93
DOI 10.1016/j.yjmcc.2004.09.008, PubMed 15572048

Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, Simonsen S, Frøland SS, Gullestad L, Christensen G, Damås JK, Aukrust P (2004)
Elevated levels of activin A in heart failure: potential role in myocardial remodeling
Circulation, 109 (11), 1379-85
DOI 10.1161/01.CIR.0000120704.97934.41, PubMed 14993131

Publications 2003

Christensen G, Gruber PJ, Wang Y, Chien KR (2003)
Embryonic and neonatal cardiac gene transfer in vivo
Methods Mol Biol, 219, 169-78
DOI 10.1385/1-59259-350-x:169, PubMed 12597007

Tønnessen T, Florholmen G, Henriksen UL, Christensen G (2003)
Cardiopulmonary alterations in mRNA expression for interleukin-1beta, the interleukin-6 superfamily and CXC-chemokines during development of postischaemic heart failure in the rat
Clin Physiol Funct Imaging, 23 (5), 263-8
DOI 10.1046/j.1475-097x.2003.00503.x, PubMed 12950323

Woldbaek PR, Stromme TA, Sande JB, Christensen G, Tønnessen T, Ilebekk A (2003)
Evaluation of a new fiber-optic pressure recording system for cardiovascular measurements in mice
Am J Physiol Heart Circ Physiol, 285 (5), H2233-9
DOI 10.1152/ajpheart.01123.2002, PubMed 12829434

Woldbaek PR, Tønnessen T, Henriksen UL, Florholmen G, Lunde PK, Lyberg T, Christensen G (2003)
Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction
Cardiovasc Res, 59 (1), 122-31
DOI 10.1016/s0008-6363(03)00339-0, PubMed 12829183

Publications 2002

Finsnes F, Lyberg T, Christensen G, Skjønsberg OH (2002)
Leukotriene antagonism reduces the generation of endothelin-1 and interferon-gamma and inhibits eosinophilic airway inflammation
Respir Med, 96 (11), 901-6
DOI 10.1053/rmed.2002.1375, PubMed 12418588

Iversen PO, Woldbaek PR, Tønnessen T, Christensen G (2002)
Decreased hematopoiesis in bone marrow of mice with congestive heart failure
Am J Physiol Regul Integr Comp Physiol, 282 (1), R166-72
DOI 10.1152/ajpregu.2002.282.1.R166, PubMed 11742835

Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T, Holt E, Lunde PK, Christensen G (2002)
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Cardiovasc Res, 53 (2), 382-91
DOI 10.1016/s0008-6363(01)00489-8, PubMed 11827689

Schiøtz Thorud HM, Wisløff U, Lunde PK, Christensen G, Ellingsen Ø, Sejersted OM (2002)
Surgical manipulation, but not moderate exercise, is associated with increased cytokine mRNA expression in the rat soleus muscle
Acta Physiol Scand, 175 (3), 219-26
DOI 10.1046/j.1365-201X.2002.00990.x, PubMed 12100361

Woldbaek PR, Hoen IB, Christensen G, Tønnessen T (2002)
Gene expression of colony-stimulating factors and stem cell factor after myocardial infarction in the mouse
Acta Physiol Scand, 175 (3), 173-81
DOI 10.1046/j.1365-201X.2002.00989.x, PubMed 12100356

Publications 2001

Damås JK, Aukrust P, Ueland T, Odegaard A, Eiken HG, Gullestad L, Sejersted OM, Christensen G (2001)
Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes
Basic Res Cardiol, 96 (4), 345-52
DOI 10.1007/s003950170042, PubMed 11518190

Eiken HG, Øie E, Damås JK, Yndestad A, Bjerkeli V, Aass H, Simonsen S, Geiran OR, Tønnessen T, Christensen G, Frøland SS, Gullestad L, Attramadal H, Aukrust P (2001)
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Eur J Clin Invest, 31 (5), 389-97
DOI 10.1046/j.1365-2362.2001.00795.x, PubMed 11380590

Finsnes F, Lyberg T, Christensen G, Skjønsberg OH (2001)
Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation
Am J Physiol Lung Cell Mol Physiol, 280 (4), L659-65
DOI 10.1152/ajplung.2001.280.4.L659, PubMed 11238005

Leistad E, Ohmori K, Peterson TA, Christensen G, DeMaria AN (2001)
Quantitative assessment of myocardial perfusion during graded coronary artery stenoses by intravenous myocardial contrast echocardiography
J Am Coll Cardiol, 37 (2), 624-31
DOI 10.1016/s0735-1097(00)01127-x, PubMed 11216989

Publications 2000

Christensen G, Minamisawa S, Gruber PJ, Wang Y, Chien KR (2000)
High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates
Circulation, 101 (2), 178-84
DOI 10.1161/01.cir.101.2.178, PubMed 10637206

Damås JK, Eiken HG, Oie E, Bjerkeli V, Yndestad A, Ueland T, Tonnessen T, Geiran OR, Aass H, Simonsen S, Christensen G, Froland SS, Attramadal H, Gullestad L, Aukrust P (2000)
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Cardiovasc Res, 47 (4), 778-87
DOI 10.1016/s0008-6363(00)00142-5, PubMed 10974226

Finsnes F, Skjønsberg OH, Lyberg T, Christensen G (2000)
Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation
Eur Respir J, 15 (4), 743-50
DOI 10.1034/j.1399-3003.2000.15d19.x, PubMed 10780768

Tønnessen T, Lyberg T, Geiran O, Christensen G (2000)
Cardiac endothelin-like immunoreactivity and preproendothelin-1 mRNA expression in human heart failure
Scand Cardiovasc J, 34 (1), 21-7
DOI 10.1080/14017430050142350, PubMed 10816056

Publications 1999

Holt E, Sjaastad I, Lunde PK, Christensen G, Sejersted OM (1999)
Thyroid hormone control of contraction and the Ca(2+)-ATPase/phospholamban complex in adult rat ventricular myocytes
J Mol Cell Cardiol, 31 (3), 645-56
DOI 10.1006/jmcc.1998.0900, PubMed 10198194

Publications 1998

Finsnes F, Christensen G, Lyberg T, Sejersted OM, Skjønsberg OH (1998)
Increased synthesis and release of endothelin-1 during the initial phase of airway inflammation
Am J Respir Crit Care Med, 158 (5 Pt 1), 1600-6
DOI 10.1164/ajrccm.158.5.9707082, PubMed 9817714

Holt E, Tønnessen T, Lunde PK, Semb SO, Wasserstrom JA, Sejersted OM, Christensen G (1998)
Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats
J Mol Cell Cardiol, 30 (8), 1581-93
DOI 10.1006/jmcc.1998.0724, PubMed 9737944

Semb SO, Lunde PK, Holt E, Tønnessen T, Christensen G, Sejersted OM (1998)
Reduced myocardial Na+, K(+)-pump capacity in congestive heart failure following myocardial infarction in rats
J Mol Cell Cardiol, 30 (7), 1311-28
DOI 10.1006/jmcc.1998.0696, PubMed 9710800

Tønnessen T, Lunde PK, Giaid A, Sejersted OM, Christensen G (1998)
Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats. Localization of preproendothelin-1 mRNA and endothelin peptide
Cardiovasc Res, 39 (3), 633-43
DOI 10.1016/s0008-6363(98)00156-4, PubMed 9861306

Publications 1997

Christensen G, Leistad E (1997)
Atrial systolic pressure, as well as stretch, is a principal stimulus for release of ANF
Am J Physiol, 272 (2 Pt 2), H820-6
DOI 10.1152/ajpheart.1997.272.2.H820, PubMed 9124444

Christensen G, Wang Y, Chien KR (1997)
Physiological assessment of complex cardiac phenotypes in genetically engineered mice
Am J Physiol, 272 (6 Pt 2), H2513-24
DOI 10.1152/ajpheart.1997.272.6.H2513, PubMed 9227526

Finsnes F, Skjønsberg OH, Tønnessen T, Naess O, Lyberg T, Christensen G (1997)
Endothelin production and effects of endothelin antagonism during experimental airway inflammation
Am J Respir Crit Care Med, 155 (4), 1404-12
DOI 10.1164/ajrccm.155.4.9105086, PubMed 9105086

Holt E, Christensen G (1997)
Transient Ca2+ overload alters Ca2+ handling in rat cardiomyocytes: effects on shortening and relaxation
Am J Physiol, 273 (2 Pt 2), H573-82
DOI 10.1152/ajpheart.1997.273.2.H573, PubMed 9277471

Holt E, Lunde PK, Sejersted OM, Christensen G (1997)
Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling
Basic Res Cardiol, 92 (5), 289-98
DOI 10.1007/BF00788941, PubMed 9486350

Oie E, Vinge LE, Tønnessen T, Grøgaard HK, Kjekshus H, Christensen G, Smiseth OA, Attramadal H (1997)
Transient, isopeptide-specific induction of myocardial endothelin-1 mRNA in congestive heart failure in rats
Am J Physiol, 273 (4), H1727-36
DOI 10.1152/ajpheart.1997.273.4.H1727, PubMed 9362237

Tønnessen T, Christensen G, Oie E, Holt E, Kjekshus H, Smiseth OA, Sejersted OM, Attramadal H (1997)
Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats
Cardiovasc Res, 33 (3), 601-10
DOI 10.1016/s0008-6363(96)00266-0, PubMed 9093530

Publications 1996

Leistad E, Aksnes G, Verburg E, Christensen G (1996)
Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644
Circulation, 93 (9), 1747-54
DOI 10.1161/01.cir.93.9.1747, PubMed 8653882

Naess PA, Bugge JF, Christensen G (1996)
Lack of inhibitory effect of atrial natriuretic factor on renin release induced by renal hypotension
Scand J Clin Lab Invest, 56 (7), 665-70
DOI 10.1080/00365519609090603, PubMed 8981664

Tønnessen T, Ilebekk A, Naess PA, Christensen G (1996)
Inhibition of granulocyte-derived proteases reduces the increase in plasma endothelin associated with myocardial ischemia in the pig
Basic Res Cardiol, 91 (4), 289-95
DOI 10.1007/BF00789301, PubMed 8874778

Publications 1995

Tønnessen T, Giaid A, Saleh D, Naess PA, Yanagisawa M, Christensen G (1995)
Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia
Circ Res, 76 (5), 767-72
DOI 10.1161/01.res.76.5.767, PubMed 7728993

Tønnessen T, Schlichting E, Lyberg T, Christensen G (1995)
Endothelin release associated with splanchnic ischemia is abolished by inhibition of leukocyte-derived proteases
Endothelium, 3, 225-234
DOI 10.3109/10623329509024668, PublikaID 318

Publications 1994

Christensen G (1994)
[Endothelin--an important factor in coronary heart disease]
Tidsskr Nor Laegeforen, 114 (29), 3450-3
PubMed 7998052

Christensen G (1994)
PACSUS - PACS for Ullevål sykehus
Trondheim
BIBSYS 952210738

Christensen G, Lunde GH (1994)
Internprising for bedre økonomisk styring: internprisingspraksis i fire bilfirma sammenlignet med teorien på området
[Forfatterne], Bergen, 53 bl.
BIBSYS 942419294

Kirkebøen KA, Ilebekk A, Tønnessen T, Leistad E, Naess PA, Christensen G, Aksnes G (1994)
Cardiac contractile function following repetitive brief ischemia: effects of nucleoside transport inhibition
Am J Physiol, 267 (1 Pt 2), H57-65
DOI 10.1152/ajpheart.1994.267.1.H57, PubMed 8048608

STRAND P, NIKITIN A, RUDJORD AL, SALBU B, CHRISTENSEN G, FOYN L, KRYSHEV II, CHUMICHEV VB, DAHLGAARD H, HOLM E (1994)
SURVEY OF ARTIFICIAL RADIONUCLIDES IN THE BARENTS SEA AND THE KARA SEA
J. Environ. Radioact., 25 (1-2), 99-112
DOI 10.1016/0265-931X(94)90010-8

TONNESSEN T, NAESS PA, KIRKEBOEN KA, ILEBEKK A, CHRISTENSEN G (1994)
ENDOTHELIN SECRETION BY ENDOCARDIAL ENDOTHELIAL-CELLS - RESPONSE
Cardiovasc. Res., 28 (5), 722
DOI 10.1093/cvr/28.5.722a

Publications 1993

Christensen G (1993)
Cardiovascular and renal effects of atrial natriuretic factor
Scand J Clin Lab Invest, 53 (3), 203-9
DOI 10.1080/00365519309088410, PubMed 8316748

Christensen G (1993)
Release of atrial natriuretic factor
Scand J Clin Lab Invest, 53 (2), 91-100
DOI 10.3109/00365519309088395, PubMed 8469920

Grotmol T, Rødnes JT, Buanes T, Christensen G, Landsverk T (1993)
Atrial natriuretic factor (ANF) does not affect ion transport in human intestine but does in porcine intestine
Acta Physiol Scand, 147 (4), 417-29
DOI 10.1111/j.1748-1716.1993.tb09517.x, PubMed 7684181

Ilebekk A, Christensen G, Leistad E, Rutlen DL (1993)
Atrial natriuretic factor increases peritoneal fluid formation in the pig
Acta Physiol Scand, 149 (1), 121-2
DOI 10.1111/j.1748-1716.1993.tb09601.x, PubMed 8237417

Leistad E, Christensen G, Ilebekk A (1993)
Significance of increased atrial pressure on stroke volume during atrial fibrillation in anaesthetized pigs
Acta Physiol Scand, 149 (2), 157-61
DOI 10.1111/j.1748-1716.1993.tb09608.x, PubMed 8266805

Leistad E, Christensen G, Ilebekk A (1993)
Atrial contractile performance after cessation of atrial fibrillation
Am J Physiol, 264 (1 Pt 2), H104-9
DOI 10.1152/ajpheart.1993.264.1.H104, PubMed 8430837

Leistad E, Christensen G, Ilebekk A (1993)
Effects of atrial fibrillation on left and right atrial dimensions, pressures, and compliances
Am J Physiol, 264 (4 Pt 2), H1093-7
DOI 10.1152/ajpheart.1993.264.4.H1093, PubMed 8476085

Naess PA, Christensen G, Kiil F (1993)
Inhibitory effect of endothelin on renin release in dog kidneys
Acta Physiol Scand, 148 (2), 131-6
DOI 10.1111/j.1748-1716.1993.tb09542.x, PubMed 8102503

Naess PA, Christensen G, Kirkebøen KA, Kiil F (1993)
Effect on renin release of inhibiting renal nitric oxide synthesis in anaesthetized dogs
Acta Physiol Scand, 148 (2), 137-42
DOI 10.1111/j.1748-1716.1993.tb09543.x, PubMed 8352025

Tønnessen T, Naess PA, Kirkebøen KA, Ilebekk A, Christensen G (1993)
Alterations in plasma endothelin during passage through the left heart chambers before and after brief myocardial ischaemia
Cardiovasc Res, 27 (12), 2160-3
DOI 10.1093/cvr/27.12.2160, PubMed 8313423

Tønnessen T, Naess PA, Kirkebøen KA, Offstad J, Ilebekk A, Christensen G (1993)
Endothelin is released from the porcine coronary circulation after short-term ischemia
J Cardiovasc Pharmacol, 22 Suppl 8, S313-6
DOI 10.1097/00005344-199322008-00082, PubMed 7509974

Tønnessen T, Naess PA, Kirkebøen KA, Offstad J, Ilebekk A, Christensen G (1993)
Release of endothelin from the porcine heart after short term coronary artery occlusion
Cardiovasc Res, 27 (8), 1482-5
DOI 10.1093/cvr/27.8.1482, PubMed 8221801

Publications 1992

Aksnes G, Kirkebøen KA, Christensen G, Ilebekk A (1992)
Characteristics and development of myocardial stunning in the pig
Am J Physiol, 263 (2 Pt 2), H544-51
DOI 10.1152/ajpheart.1992.263.2.H544, PubMed 1354942

Christensen G (1992)
Atrial natriuretic factor: an experimental study on release mechanisms and on cardiovascular and renal effects
[Universitetet i Oslo, Institutt for eksperiementell medisinsk forskning], Oslo, 1 b. (flere pag.)
BIBSYS 930211189, ISBN 82-90246-39-0

Christensen G, Bugge JF, Ostensen J, Kiil F (1992)
Atrial natriuretic factor and renal sodium excretion during ventilation with PEEP in hypervolemic dogs
J Appl Physiol (1985), 72 (3), 993-7
DOI 10.1152/jappl.1992.72.3.993, PubMed 1533215

Kirkebøen KA, Naess PA, Christensen G, Kiil F (1992)
Importance of nitric oxide in canine femoral circulation: comparison of two NO inhibitors
Cardiovasc Res, 26 (4), 357-61
DOI 10.1093/cvr/26.4.357, PubMed 1638567

Naess PA, Christensen G, Kirkebøen KA, Kiil F (1992)
Effect of atrial natriuretic factor on renal prostaglandin E2 release in the anaesthetized dog
Acta Physiol Scand, 145 (4), 369-75
DOI 10.1111/j.1748-1716.1992.tb09377.x, PubMed 1356292

Naess PA, Kirkebøen KA, Christensen G, Kiil F (1992)
Inhibition of renal nitric oxide synthesis with NG-monomethyl-L-arginine and NG-nitro-L-arginine
Am J Physiol, 262 (6 Pt 2), F939-42
DOI 10.1152/ajprenal.1992.262.6.F939, PubMed 1535755

Publications 1991

Christensen G, Aksnes G, Ilebekk A, Kiil F (1991)
Release of atrial natriuretic factor during selective cardiac alpha- and beta-adrenergic stimulation, intracoronary Ca2+ infusion, and aortic constriction in pigs
Circ Res, 68 (3), 638-44
DOI 10.1161/01.res.68.3.638, PubMed 1835907

Hysing J, Gordeladze JO, Christensen G, Tolleshaug H (1991)
Renal uptake and degradation of trapped-label calcitonin
Biochem Pharmacol, 41 (8), 1119-26
DOI 10.1016/0006-2952(91)90649-p, PubMed 1848983

Leistad E, Christensen G, Ilebekk A (1991)
Right and left atrial diameters during incremental atrial pacing in pigs
Am J Physiol, 260 (3 Pt 2), H973-8
DOI 10.1152/ajpheart.1991.260.3.H973, PubMed 2000990

Naess PA, Christensen G, Kiil F (1991)
Atrial natriuretic factor reduces renin release by opposing alpha-adrenoceptor activity
Am J Physiol, 261 (2 Pt 1), E240-5
DOI 10.1152/ajpendo.1991.261.2.E240, PubMed 1678582

Publications 1990

Rutlen DL, Christensen G, Helgesen KG, Ilebekk A (1990)
Influence of atrial natriuretic factor on intravascular volume displacement in pigs
Am J Physiol, 259 (5 Pt 2), H1595-600
DOI 10.1152/ajpheart.1990.259.5.H1595, PubMed 2146890

Rutlen DL, Helgesen KG, Christensen G, Vengen OA, Ilebekk A (1990)
Influence of angiotensin on total intravascular capacity in the anaesthetized pig
Acta Physiol Scand, 139 (4), 569-73
DOI 10.1111/j.1748-1716.1990.tb08960.x, PubMed 2248036

Publications 1989

Christensen G, Bugge JF, Ilebekk A, Kiil F (1989)
Atrial natriuretic factor induces natriuresis during pacing tachycardia in dogs
Am J Physiol, 256 (6 Pt 2), R1245-9
DOI 10.1152/ajpregu.1989.256.6.R1245, PubMed 2525348

Christensen G, Ilebekk A, Kiil F (1989)
Release of atrial natriuretic factor during infusion of isoproterenol and angiotensin II
Am J Physiol, 257 (4 Pt 2), R896-900
DOI 10.1152/ajpregu.1989.257.4.R896, PubMed 2529784

Publications 1988

Christensen G, Ilebekk A, Aakeson I, Kiil F (1988)
The release mechanism for atrial natriuretic factor during blood volume expansion and tachycardia in dogs
Acta Physiol Scand, 134 (2), 263-70
DOI 10.1111/j.1748-1716.1988.tb08487.x, PubMed 2976238