Publications 2024
Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine
J Pharmacol Exp Ther, 390 (1), 146-158
DOI 10.1124/jpet.123.002084, PubMed 38772719
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
J Physiol, 602 (18), 4487-4510
DOI 10.1113/JP284566, PubMed 38686538
Electrophysiological tolerance: a new concept for understanding the electrical stability of the heart
Europace, 26 (11)
DOI 10.1093/europace/euae282, PubMed 39487808
Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells
Cells, 13 (11)
DOI 10.3390/cells13110947, PubMed 38891079
Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling
bioRxiv
DOI 10.1101/2024.03.04.583217, PubMed 38496584
Enhanced Ca2+-Driven Arrhythmogenic Events in Female Patients With Atrial Fibrillation: Insights From Computational Modeling
JACC Clin Electrophysiol, 10 (11), 2371-2391
DOI 10.1016/j.jacep.2024.07.020, PubMed 39340505
Publications 2023
A single amino acid deletion in the ER Ca2+ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation
Sci Signal, 16 (771), eadd0509
DOI 10.1126/scisignal.add0509, PubMed 36749824
Live-cell photo-activated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Nat Cardiovasc Res, 2 (3), 251-267
DOI 10.1038/s44161-022-00199-2, PubMed 38803363
Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
Circ Res, 133 (3), 255-270
DOI 10.1161/CIRCRESAHA.123.322588, PubMed 37401464
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
DOI 10.3390/cells12192358, PubMed 37830576
Cardiomyocytes from female compared to male mice have larger ryanodine receptor clusters and higher calcium spark frequency
J Physiol, 601 (18), 4033-4052
DOI 10.1113/JP284515, PubMed 37561554
Augmenting workload drives T-tubule assembly in developing cardiomyocytes
J Physiol, 602 (18), 4461-4486
DOI 10.1113/JP284538, PubMed 37128962
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Circ Res, 132 (11), e188-e205
DOI 10.1161/CIRCRESAHA.122.321732, PubMed 37139790
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
DOI 10.1161/CIRCULATIONAHA.121.054168, PubMed 36876489
Publications 2022
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Nat Commun, 13 (1), 3018
DOI 10.1038/s41467-022-29703-9, PubMed 35641497
Tubulator: an automated approach to analysis of t-tubule and dyadic organization in cardiomyocytes
Philos Trans R Soc Lond B Biol Sci, 377 (1864), 20210468
DOI 10.1098/rstb.2021.0468, PubMed 36189810
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks
PLoS Comput Biol, 18 (6), e1010126
DOI 10.1371/journal.pcbi.1010126, PubMed 35666763
A TRP to the emergency room: Understanding arrhythmia in the ageing heart
Cardiovasc Res, 118 (4), 932-933
DOI 10.1093/cvr/cvac017, PubMed 35225325
Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?
Front Physiol, 13, 834211
DOI 10.3389/fphys.2022.834211, PubMed 35356084
Editorial: Nanodomain regulation of muscle physiology and alterations in disease
Front Physiol, 13, 1092304
DOI 10.3389/fphys.2022.1092304, PubMed 36523550
Europhysiology 2022: Let's meet for real
Acta Physiol (Oxf), 235 (2), e13825
DOI 10.1111/apha.13825, PubMed 35466542
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail, 10 (2), 858-871
DOI 10.1002/ehf2.14234, PubMed 36444917
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Elife, 11
DOI 10.7554/eLife.77725, PubMed 35913125
Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation
Pflugers Arch, 474 (6), 625-636
DOI 10.1007/s00424-022-02678-8, PubMed 35235009
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
DOI 10.3389/fcell.2022.908126, PubMed 36092718
Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation
J Physiol, 601 (13), 2655-2683
DOI 10.1113/JP283363, PubMed 36094888
Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+ -handling protein variation
J Physiol, 601 (13), 2685-2710
DOI 10.1113/JP283602, PubMed 36114707
Publications 2021
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394
Cardiac Transverse Tubules in Physiology and Heart Failure
Annu Rev Physiol, 84, 229-255
DOI 10.1146/annurev-physiol-061121-040148, PubMed 34780259
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front Physiol, 12, 744730
DOI 10.3389/fphys.2021.744730, PubMed 34712150
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Nat Commun, 12 (1), 5180
DOI 10.1038/s41467-021-25439-0, PubMed 34462437
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart
J Gen Physiol, 153 (11)
DOI 10.1085/jgp.202012860, PubMed 34605861
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
Mol Med, 27 (1), 102
DOI 10.1186/s10020-021-00362-8, PubMed 34496741
CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
Am J Physiol Heart Circ Physiol, 321 (2), H446-H460
DOI 10.1152/ajpheart.00011.2021, PubMed 34270372
The Physiology and Pathophysiology of T-Tubules in the Heart
Front Physiol, 12, 718404
DOI 10.3389/fphys.2021.718404, PubMed 34566684
Corrigendum: The Physiology and Pathophysiology of T-Tubules in the Heart
Front Physiol, 12, 790227
DOI 10.3389/fphys.2021.790227, PubMed 34764889
Role of t-tubule remodeling on mechanisms of abnormal calcium release during heart failure development in canine ventricle
Am J Physiol Heart Circ Physiol, 320 (4), H1658-H1669
DOI 10.1152/ajpheart.00946.2020, PubMed 33635163
Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure
Front Physiol, 12, 782767
DOI 10.3389/fphys.2021.782767, PubMed 35002765
Publications 2020
Cardioprotective Effects of the Novel Compound Vastiras in a Preclinical Model of End-Organ Damage
Hypertension, 75 (5), 1195-1204
DOI 10.1161/HYPERTENSIONAHA.120.14704, PubMed 32200677
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Mol Ther, 29 (1), 409
DOI 10.1016/j.ymthe.2020.11.015, PubMed 33296664
Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs
Nanomaterials (Basel), 10 (3)
DOI 10.3390/nano10030532, PubMed 32188039
Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats
Philos Trans A Math Phys Eng Sci, 378 (2173), 20190334
DOI 10.1098/rsta.2019.0334, PubMed 32448071
A horse of a different colour: distinct mechanisms of HFpEF and HFrEF
J Physiol, 598 (22), 5005-5006
DOI 10.1113/JP280691, PubMed 32985684
Chronic cardiac structural damage, diastolic and systolic dysfunction following acute myocardial injury due to bromine exposure in rats
Arch Toxicol, 95 (1), 179-193
DOI 10.1007/s00204-020-02919-8, PubMed 32979061
Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis
Pediatr Cardiol, 41 (8), 1675-1688
DOI 10.1007/s00246-020-02427-7, PubMed 32770262
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641, PubMed 32070187
Publications 2019
A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues
Biophys J, 116 (8), 1386-1393
DOI 10.1016/j.bpj.2019.03.010, PubMed 30979553
Reply from M. Frisk, D. B. Lipsett and W. E. Louch
J Physiol, 597 (11), 2967-2968
DOI 10.1113/JP278067, PubMed 31021407
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J Physiol, 597 (7), 1833-1853
DOI 10.1113/JP277273, PubMed 30707448
Channel surfing: new insights into plasticity of excitation-contraction coupling
J Physiol, 597 (8), 2119-2120
DOI 10.1113/JP277783, PubMed 30854650
Multi-nodal nano-actuator pacemaker for energy-efficient stimulation of cardiomyocytes
Nano Commun.Netw., 22, 100270
DOI 10.1016/j.nancom.2019.100270
Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses
Sci Rep, 9 (1), 13307
DOI 10.1038/s41598-019-49791-w, PubMed 31527628
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410
Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes
Biophys J, 118 (2), 476-491
DOI 10.1016/j.bpj.2019.12.012, PubMed 31889516
Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes
Am J Physiol Heart Circ Physiol, 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018, PubMed 30657726
Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation-A single-blinded, randomized clinical trial
Am Heart J, 221, 114-124
DOI 10.1016/j.ahj.2019.12.014, PubMed 31986288
Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study
PLoS One, 14 (4), e0215673
DOI 10.1371/journal.pone.0215673, PubMed 31022222
Publications 2018
Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats
Am J Physiol Heart Circ Physiol, 316 (1), H212-H223
DOI 10.1152/ajpheart.00652.2017, PubMed 30379573
Bringing European physiologists together
Acta Physiol (Oxf), 222 (4), e13043
DOI 10.1111/apha.13043, PubMed 29377580
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Mol Ther, 26 (7), 1644-1659
DOI 10.1016/j.ymthe.2018.02.012, PubMed 29606507
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422
IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure
Hypertension, 72 (4), 818-828
DOI 10.1161/HYPERTENSIONAHA.118.11157, PubMed 30354724
Dyadic Plasticity in Cardiomyocytes
Front Physiol, 9, 1773
DOI 10.3389/fphys.2018.01773, PubMed 30618792
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974
3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes
J Physiol, 597 (2), 399-418
DOI 10.1113/JP277360, PubMed 30412283
Publications 2017
Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus
Clin Med Insights Cardiol, 11, 1179546816686061
DOI 10.1177/1179546816686061, PubMed 28469490
Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding
J Physiol, 595 (12), 3867-3889
DOI 10.1113/JP273879, PubMed 28542952
Gene Transfer in Isolated Adult Cardiomyocytes
Methods Mol Biol, 1521, 169-182
DOI 10.1007/978-1-4939-6588-5_11, PubMed 27910048
T-tubular collagen: a new player in mechanosensing and disease?
Cardiovasc Res, 113 (8), 839-840
DOI 10.1093/cvr/cvx091, PubMed 28481973
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
DOI 10.1002/pmic.201600417, PubMed 28755400
Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling
Clin Med Insights Cardiol, 11, 1179546817698602
DOI 10.1177/1179546817698602, PubMed 28469494
Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy
Curr Heart Fail Rep, 14 (3), 167-178
DOI 10.1007/s11897-017-0329-9, PubMed 28447290
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circ Res, 121 (12), 1323-1330
DOI 10.1161/CIRCRESAHA.117.311920, PubMed 28974554
Heart failure with preserved ejection fraction
Tidsskr. Nor. Laegeforen., 137 (18), 1426-1431
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc Res, 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087, PubMed 28472418
Heart failure with preserved ejection fraction
Tidsskr Nor Laegeforen, 137 (18)
DOI 10.4045/tidsskr.16.1068, PubMed 28972354
Publications 2016
Cardiomyocyte Ca2+ dynamics: clinical perspectives
Scand Cardiovasc J, 50 (2), 65-77
DOI 10.3109/14017431.2015.1136079, PubMed 26729487
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc Res, 112 (1), 443-51
DOI 10.1093/cvr/cvw111, PubMed 27226008
The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study
J Physiol, 594 (15), 4193-224
DOI 10.1113/JP272011, PubMed 26916026
Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
Biochem J, 473 (15), 2413-23
DOI 10.1042/BCJ20160465, PubMed 27247424
Publications 2015
Deranged sodium to sudden death
J Physiol, 593 (6), 1331-45
DOI 10.1113/jphysiol.2014.281204, PubMed 25772289
Linking ryanodine receptor Ca(2+) leak and Na(+) current in heart: a day in the life of flecainide
Acta Physiol (Oxf), 214 (3), 300-2
DOI 10.1111/apha.12526, PubMed 25976700
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Cardiovasc Res, 106 (2), 217-26
DOI 10.1093/cvr/cvv002, PubMed 25587045
Calcium-activated potassium current: parallels in cardiac development and disease
Acta Physiol (Oxf), 216 (1), 7-9
DOI 10.1111/apha.12556, PubMed 26189640
Calcium signalling in developing cardiomyocytes: implications for model systems and disease
J Physiol, 593 (5), 1047-63
DOI 10.1113/jphysiol.2014.274712, PubMed 25641733
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832
Contemporary treatment of amyloid heart disease
Curr Pharm Des, 21 (4), 491-506
DOI 10.2174/138161282104141204143657, PubMed 25483951
Targeting cardiomyocyte Ca2+ homeostasis in heart failure
Curr Pharm Des, 21 (4), 431-48
DOI 10.2174/138161282104141204124129, PubMed 25483944
Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells
PLoS One, 10 (1), e0117404
DOI 10.1371/journal.pone.0117404, PubMed 25617766
Publications 2014
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am J Physiol Heart Circ Physiol, 306 (7), H1018-24
DOI 10.1152/ajpheart.00741.2013, PubMed 24486508
Variable t-tubule organization and Ca2+ homeostasis across the atria
Am J Physiol Heart Circ Physiol, 307 (4), H609-20
DOI 10.1152/ajpheart.00295.2014, PubMed 24951751
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle
Am J Physiol Heart Circ Physiol, 307 (10), H1487-96
DOI 10.1152/ajpheart.00443.2014, PubMed 25239804
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645
Publications 2013
Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice
Biophys J, 104 (6), 1349-56
DOI 10.1016/j.bpj.2013.01.042, PubMed 23528094
Integrating multi-scale data to create a virtual physiological mouse heart
Interface Focus, 3 (2), 20120076
DOI 10.1098/rsfs.2012.0076, PubMed 24427525
Slow Ca²⁺ sparks de-synchronize Ca²⁺ release in failing cardiomyocytes: evidence for altered configuration of Ca²⁺ release units?
J Mol Cell Cardiol, 58, 41-52
DOI 10.1016/j.yjmcc.2013.01.014, PubMed 23376034
Mind the store: modulating Ca(2+) reuptake with a leaky sarcoplasmic reticulum
Cardiovasc Res, 98 (2), 165-8
DOI 10.1093/cvr/cvt069, PubMed 23524302
I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation
Cardiovasc Res, 98 (2), 315-25
DOI 10.1093/cvr/cvt037, PubMed 23417043
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity
Biophys J, 104 (8), 1685-97
DOI 10.1016/j.bpj.2013.03.022, PubMed 23601316
Publications 2012
An analysis of deformation-dependent electromechanical coupling in the mouse heart
J Physiol, 590 (18), 4553-69
DOI 10.1113/jphysiol.2012.231928, PubMed 22615436
Sodium accumulation in SERCA knockout-induced heart failure
Biophys J, 102 (9), 2039-48
DOI 10.1016/j.bpj.2012.03.045, PubMed 22824267
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium
Physiology (Bethesda), 27 (5), 308-23
DOI 10.1152/physiol.00021.2012, PubMed 23026754
Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signaling
Am J Physiol Heart Circ Physiol, 302 (12), H2574-82
DOI 10.1152/ajpheart.01166.2011, PubMed 22505640
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties
PLoS One, 7 (5), e37401
DOI 10.1371/journal.pone.0037401, PubMed 22655045
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout
Proc Natl Acad Sci U S A, 109 (10), 3997-4001
DOI 10.1073/pnas.1120172109, PubMed 22355118
Special Interest Group on Cardiac Physiology established within the Scandinavian Physiological Society
Acta Physiol (Oxf), 204 (4), 464
DOI 10.1111/j.1748-1716.2011.02374.x, PubMed 22364639
Publications 2011
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovasc Res, 93 (1), 100-10
DOI 10.1093/cvr/cvr294, PubMed 22049534
Effects of serum-free storage on morphology, phenotype, and viability of ex vivo cultured human conjunctival epithelium
Exp Eye Res, 94 (1), 109-16
DOI 10.1016/j.exer.2011.11.015, PubMed 22154551
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302, PubMed 22164265
Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study
Biophys J, 100 (2), 322-31
DOI 10.1016/j.bpj.2010.11.048, PubMed 21244828
Methods in cardiomyocyte isolation, culture, and gene transfer
J Mol Cell Cardiol, 51 (3), 288-98
DOI 10.1016/j.yjmcc.2011.06.012, PubMed 21723873
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content
Cardiovasc Res, 90 (3), 503-12
DOI 10.1093/cvr/cvr013, PubMed 21242164
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668, PubMed 21533157
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A
Am J Physiol Cell Physiol, 300 (5), C989-97
DOI 10.1152/ajpcell.00196.2010, PubMed 21289289
Publications 2010
Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir
Wien Klin Wochenschr, 122 (19-20), 592-5
DOI 10.1007/s00508-010-1456-4, PubMed 20865454
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis
Cell Calcium, 49 (4), 201-7
DOI 10.1016/j.ceca.2010.09.009, PubMed 20965565
Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes
Biophys J, 99 (5), 1377-86
DOI 10.1016/j.bpj.2010.06.055, PubMed 20816049
There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling
J Biomed Biotechnol, 2010, 503906
DOI 10.1155/2010/503906, PubMed 20396394
Presence of Borrelia burgdorferi in endomyocardial biopsies in patients with new-onset unexplained dilated cardiomyopathy
Med Microbiol Immunol, 199 (2), 139-43
DOI 10.1007/s00430-009-0141-6, PubMed 20052487
Publications 2009
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
J Mol Cell Cardiol, 47 (2), 180-7
DOI 10.1016/j.yjmcc.2009.03.013, PubMed 19328205
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models
Cell Calcium, 46 (3), 219-25
DOI 10.1016/j.ceca.2009.07.004, PubMed 19692123
Cardiac structural and functional changes in competitive amateur cyclists
Echocardiography, 27 (1), 11-6
DOI 10.1111/j.1540-8175.2009.00965.x, PubMed 19765071
DYADIC GEOMETRY IN NORMAL AND FAILING CARDIOMYOCYTES
J. Appl. Physiol., 107 (6), 1985
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J Physiol, 588 (Pt 3), 465-78
DOI 10.1113/jphysiol.2009.183517, PubMed 20008467
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice
Am J Physiol Heart Circ Physiol, 296 (4), H1069-79
DOI 10.1152/ajpheart.01009.2008, PubMed 19201998
Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint
J Appl Physiol (1985), 107 (6), 1985-7; author reply 1988
DOI 10.1152/japplphysiol.01028.2009, PubMed 19952386
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc Res, 86 (1), 63-71
DOI 10.1093/cvr/cvp401, PubMed 20019150
Publications 2008
Slow contractions characterize failing rat hearts
Basic Res Cardiol, 103 (4), 328-44
DOI 10.1007/s00395-008-0719-y, PubMed 18347833
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha2-isoform in heart failure
Cardiovasc Res, 78 (1), 71-8
DOI 10.1093/cvr/cvn013, PubMed 18203708
Altered Na(+)/Ca(2+)-exchanger activity due to downregulation of Na(+)/K(+)-ATPase alpha(2)-isoform in heart failure (vol 78, pg 71, 2008)
Cardiovasc. Res., 79 (2), 352
DOI 10.1093/cvr/cvn147
Publications 2007
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure
J Mol Cell Cardiol, 43 (2), 177-86
DOI 10.1016/j.yjmcc.2007.05.004, PubMed 17574269
Publications 2006
Contribution of the Na+/Ca2+ exchanger to rapid Ca2+ release in cardiomyocytes
Biophys J, 91 (3), 779-92
DOI 10.1529/biophysj.105.072447, PubMed 16679359
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction
J Physiol, 574 (Pt 2), 519-33
DOI 10.1113/jphysiol.2006.107227, PubMed 16709642
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span
J Mol Cell Cardiol, 41 (2), 308-17
DOI 10.1016/j.yjmcc.2006.05.014, PubMed 16814319
Publications 2004
Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes
Cardiovasc Res, 62 (1), 63-73
DOI 10.1016/j.cardiores.2003.12.031, PubMed 15023553
Attentuation of cardiac stunning by losartan in a cellular model of ischemia and reperfusion is accompanied by increased sarcoplasmic reticulum Ca2+ stores and prevention of cytosolic Ca2+ elevation
J Pharmacol Exp Ther, 312 (1), 238-47
DOI 10.1124/jpet.104.072769, PubMed 15316090
Publications 2003
L-Arginine ameliorates effects of ischemia and reperfusion in isolated cardiac myocytes
Eur J Pharmacol, 476 (1-2), 45-54
DOI 10.1016/s0014-2999(03)02175-7, PubMed 12969748
Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart
Cell Calcium, 34 (6), 457-64
DOI 10.1016/s0143-4160(03)00126-x, PubMed 14572804
Publications 2002
Changes in excitation-contraction coupling in an isolated ventricular myocyte model of cardiac stunning
Am J Physiol Heart Circ Physiol, 283 (2), H800-10
DOI 10.1152/ajpheart.00020.2002, PubMed 12124230
Publications 2000
Losartan improves recovery of contraction and inhibits transient inward current in a cellular model of cardiac ischemia and reperfusion
J Pharmacol Exp Ther, 295 (2), 697-704
PubMed 11046108