Publications 2024

Masjoan Juncos JX, Nadeem F, Shakil S, El-Husari M, Zafar I, Louch WE, Halade GV, Zaky A, Ahmad A, Ahmad S (2024)
Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine
J Pharmacol Exp Ther, 390 (1), 146-158
DOI 10.1124/jpet.123.002084, PubMed 38772719

Nordén ES, Bendiksen BA, Bergo KK, Espe EKS, McGinley G, Hasic A, Hauge-Iversen IM, Ugland HK, Shen X, Frisk M, Mabotuwana NS, Louch WE, Hussain RI, Zhang L, Sjaastad I, Cataliotti A, Christensen G (2024)
Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats
ESC Heart Fail (in press)
DOI 10.1002/ehf2.15145, PubMed 39696842

Ruud M, Frisk M, Melleby AO, Norseng PA, Mohamed BA, Li J, Aronsen JM, Setterberg IE, Jakubiczka J, van Hout I, Coffey S, Shen X, Nygård S, Lunde IG, Tønnessen T, Jones PP, Sjaastad I, Gullestad L, Toischer K, Dahl CP, Christensen G, Louch WE (2024)
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
J Physiol, 602 (18), 4487-4510
DOI 10.1113/JP284566, PubMed 38686538

Stokke MK, Louch WE, Smith GL (2024)
Electrophysiological tolerance: a new concept for understanding the electrical stability of the heart
Europace, 26 (11)
DOI 10.1093/europace/euae282, PubMed 39487808

Støle TP, Lunde M, Gehmlich K, Christensen G, Louch WE, Carlson CR (2024)
Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells
Cells, 13 (11)
DOI 10.3390/cells13110947, PubMed 38891079

Zhang X, Wu Y, Smith C, Louch WE, Morotti S, Dobrev D, Grandi E, Ni H (2024)
Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling
bioRxiv
DOI 10.1101/2024.03.04.583217, PubMed 38496584

Zhang X, Wu Y, Smith CER, Louch WE, Morotti S, Dobrev D, Grandi E, Ni H (2024)
Enhanced Ca²⁺-Driven Arrhythmogenic Events in Female Patients With Atrial Fibrillation: Insights From Computational Modeling
JACC Clin Electrophysiol, 10 (11), 2371-2391
DOI 10.1016/j.jacep.2024.07.020, PubMed 39340505

Publications 2023

Gamage TH, Grabmayr H, Horvath F, Fahrner M, Misceo D, Louch WE, Gunnes G, Pullisaar H, Reseland JE, Lyngstadaas SP, Holmgren A, Amundsen SS, Rathner P, Cerofolini L, Ravera E, Krobath H, Luchinat C, Renger T, Müller N, Romanin C, Frengen E (2023)
A single amino acid deletion in the ER Ca²⁺ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation
Sci Signal, 16 (771), eadd0509
DOI 10.1126/scisignal.add0509, PubMed 36749824

Hou Y, Laasmaa M, Li J, Shen X, Manfra O, Norden ES, Le C, Zhang L, Sjaastad I, Jones PP, Soeller C, Louch WE (2023)
Live-cell photo-activated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Nat Cardiovasc Res, 2 (3), 251-267
DOI 10.1038/s44161-022-00199-2, PubMed 38803363

Li J, Sundnes J, Hou Y, Laasmaa M, Ruud M, Unger A, Kolstad TR, Frisk M, Norseng PA, Yang L, Setterberg IE, Alves ES, Kalakoutis M, Sejersted OM, Lanner JT, Linke WA, Lunde IG, de Tombe PP, Louch WE (2023)
Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
Circ Res, 133 (3), 255-270
DOI 10.1161/CIRCRESAHA.123.322588, PubMed 37401464

Lunde PK, Manfra O, Støle TP, Lunde M, Martinsen M, Carlson CR, Louch WE (2023)
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
DOI 10.3390/cells12192358, PubMed 37830576

Laasmaa M, Branovets J, Stolova J, Shen X, Rätsepso T, Balodis MJ, Grahv C, Hendrikson E, Louch WE, Birkedal R, Vendelin M (2023)
Cardiomyocytes from female compared to male mice have larger ryanodine receptor clusters and higher calcium spark frequency
J Physiol, 601 (18), 4033-4052
DOI 10.1113/JP284515, PubMed 37561554

Manfra O, Louey S, Jonker SS, Perdreau-Dahl H, Frisk M, Giraud GD, Thornburg KL, Louch WE (2023)
Augmenting workload drives T-tubule assembly in developing cardiomyocytes
J Physiol, 602 (18), 4461-4486
DOI 10.1113/JP284538, PubMed 37128962

Perdreau-Dahl H, Lipsett DB, Frisk M, Kermani F, Carlson CR, Brech A, Shen X, Bergan-Dahl A, Hou Y, Tuomainen T, Tavi P, Jones PP, Lunde M, Wasserstrom JA, Laporte J, Ullrich ND, Christensen G, Morth JP, Louch WE (2023)
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Circ Res, 132 (11), e188-e205
DOI 10.1161/CIRCRESAHA.122.321732, PubMed 37139790

Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM (2023)
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
DOI 10.1161/CIRCULATIONAHA.121.054168, PubMed 36876489

Publications 2022

De Genst E, Foo KS, Xiao Y, Rohner E, de Vries E, Sohlmér J, Witman N, Hidalgo A, Kolstad TRS, Louch WE, Pehrsson S, Park A, Ikeda Y, Li X, Mayr LM, Wickson K, Jennbacken K, Hansson K, Fritsche-Danielson R, Hunt J, Chien KR (2022)
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Nat Commun, 13 (1), 3018
DOI 10.1038/s41467-022-29703-9, PubMed 35641497

Frisk M, Norseng PA, Stenersen Espe EK, Louch WE (2022)
Tubulator: an automated approach to analysis of t-tubule and dyadic organization in cardiomyocytes
Philos Trans R Soc Lond B Biol Sci, 377 (1864), 20210468
DOI 10.1098/rstb.2021.0468, PubMed 36189810

Hernández Mesa M, van den Brink J, Louch WE, McCabe KJ, Rangamani P (2022)
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks
PLoS Comput Biol, 18 (6), e1010126
DOI 10.1371/journal.pcbi.1010126, PubMed 35666763

Louch WE (2022)
A TRP to the emergency room: Understanding arrhythmia in the ageing heart
Cardiovasc Res, 118 (4), 932-933
DOI 10.1093/cvr/cvac017, PubMed 35225325

Louch WE, Perdreau-Dahl H, Edwards AG (2022)
Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?
Front Physiol, 13, 834211
DOI 10.3389/fphys.2022.834211, PubMed 35356084

Louch WE, Ullrich ND, Navedo MF, Macquaide N (2022)
Editorial: Nanodomain regulation of muscle physiology and alterations in disease
Front Physiol, 13, 1092304
DOI 10.3389/fphys.2022.1092304, PubMed 36523550

Praetorius H, Louch WE (2022)
Europhysiology 2022: Let's meet for real
Acta Physiol (Oxf), 235 (2), e13825
DOI 10.1111/apha.13825, PubMed 35466542

Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG (2022)
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail, 10 (2), 858-871
DOI 10.1002/ehf2.14234, PubMed 36444917

Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG (2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599

Shen X, van den Brink J, Bergan-Dahl A, Kolstad TR, Norden ES, Hou Y, Laasmaa M, Aguilar-Sanchez Y, Quick AP, Espe EKS, Sjaastad I, Wehrens XHT, Edwards AG, Soeller C, Louch WE (2022)
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Elife, 11
DOI 10.7554/eLife.77725, PubMed 35913125

Sommese LM, Racioppi MF, Shen X, Orlowski A, Valverde CA, Louch WE, Vila Petroff M, Gonano LA (2022)
Discordant Ca²⁺ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation
Pflugers Arch, 474 (6), 625-636
DOI 10.1007/s00424-022-02678-8, PubMed 35235009

Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)
The female syndecan-4^-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
DOI 10.3389/fcell.2022.908126, PubMed 36092718

Zhang X, Ni H, Morotti S, Smith CER, Sato D, Louch WE, Edwards AG, Grandi E (2022)
Mechanisms of spontaneous Ca²⁺ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation
J Physiol, 601 (13), 2655-2683
DOI 10.1113/JP283363, PubMed 36094888

Zhang X, Smith CER, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E (2022)
Mechanisms of spontaneous Ca²⁺ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca²⁺ -handling protein variation
J Physiol, 601 (13), 2685-2710
DOI 10.1113/JP283602, PubMed 36114707

Publications 2021

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703

Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca²⁺ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394

Dibb KM, Louch WE, Trafford AW (2021)
Cardiac Transverse Tubules in Physiology and Heart Failure
Annu Rev Physiol, 84, 229-255
DOI 10.1146/annurev-physiol-061121-040148, PubMed 34780259

Edwards AG, Mørk H, Stokke MK, Lipsett DB, Sjaastad I, Richard S, Sejersted OM, Louch WE (2021)
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front Physiol, 12, 744730
DOI 10.3389/fphys.2021.744730, PubMed 34712150

Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397

Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, Boogerd CJ, Frisk M, van Rooij E, Damle S, Louch WE, Wang QD, Fritsche-Danielson R, Chien KR, Hansson KM, Mullick AE et al. (2021)
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Nat Commun, 12 (1), 5180
DOI 10.1038/s41467-021-25439-0, PubMed 34462437

Kobirumaki-Shimozawa F, Shimozawa T, Oyama K, Baba S, Li J, Nakanishi T, Terui T, Louch WE, Ishiwata S, Fukuda N (2021)
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart
J Gen Physiol, 153 (11)
DOI 10.1085/jgp.202012860, PubMed 34605861

Rohner E, Witman N, Sohlmer J, De Genst E, Louch WE, Sahara M, Chien KR (2021)
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
Mol Med, 27 (1), 102
DOI 10.1186/s10020-021-00362-8, PubMed 34496741

Sadredini M, Haugsten Hansen M, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK (2021)
CaMKII inhibition has dual effects on spontaneous Ca²⁺ release and Ca²⁺ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
Am J Physiol Heart Circ Physiol, 321 (2), H446-H460
DOI 10.1152/ajpheart.00011.2021, PubMed 34270372

Setterberg IE, Le C, Frisk M, Li J, Louch WE (2021)
The Physiology and Pathophysiology of T-Tubules in the Heart
Front Physiol, 12, 718404
DOI 10.3389/fphys.2021.718404, PubMed 34566684

Setterberg IE, Le C, Frisk M, Perdreau-Dahl H, Li J, Louch WE (2021)
Corrigendum: The Physiology and Pathophysiology of T-Tubules in the Heart
Front Physiol, 12, 790227
DOI 10.3389/fphys.2021.790227, PubMed 34764889

Yamakawa S, Wu D, Dasgupta M, Pedamallu H, Gupta B, Modi R, Mufti M, O'Callaghan C, Frisk M, Louch WE, Arora R, Shiferaw Y, Burrell A, Ryan J, Nelson L, Chow M, Shah SJ, Aistrup G, Zhou J, Marszalec W, Wasserstrom JA (2021)
Role of t-tubule remodeling on mechanisms of abnormal calcium release during heart failure development in canine ventricle
Am J Physiol Heart Circ Physiol, 320 (4), H1658-H1669
DOI 10.1152/ajpheart.00946.2020, PubMed 33635163

Zhou J, Singh N, Monnier C, Marszalec W, Gao L, Jin J, Frisk M, Louch WE, Verma S, Krishnamurthy P, Nico E, Mulla M, Aistrup GL, Kishore R, Wasserstrom JA (2021)
Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure
Front Physiol, 12, 782767
DOI 10.3389/fphys.2021.782767, PubMed 35002765

Publications 2020

Altara R, da Silva GJJ, Frisk M, Spelta F, Zouein FA, Louch WE, Booz GW, Cataliotti A (2020)
Cardioprotective Effects of the Novel Compound Vastiras in a Preclinical Model of End-Organ Damage
Hypertension, 75 (5), 1195-1204
DOI 10.1161/HYPERTENSIONAHA.120.14704, PubMed 32200677

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR (2020)
Human ISL1⁺ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Mol Ther, 29 (1), 409
DOI 10.1016/j.ymthe.2020.11.015, PubMed 33296664

Kobirumaki-Shimozawa F, Nakanishi T, Shimozawa T, Terui T, Oyama K, Li J, Louch WE, Ishiwata S, Fukuda N (2020)
Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs
Nanomaterials (Basel), 10 (3)
DOI 10.3390/nano10030532, PubMed 32188039

Longobardi S, Lewalle A, Coveney S, Sjaastad I, Espe EKS, Louch WE, Musante CJ, Sher A, Niederer SA (2020)
Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats
Philos Trans A Math Phys Eng Sci, 378 (2173), 20190334
DOI 10.1098/rsta.2019.0334, PubMed 32448071

Louch WE (2020)
A horse of a different colour: distinct mechanisms of HFpEF and HFrEF
J Physiol, 598 (22), 5005-5006
DOI 10.1113/JP280691, PubMed 32985684

Masjoan Juncos JX, Shakil S, Bradley WE, Wei CC, Zafar I, Powell P, Mariappan N, Louch WE, Ford DA, Ahmad A, Dell'Italia LJ, Ahmad S (2020)
Chronic cardiac structural damage, diastolic and systolic dysfunction following acute myocardial injury due to bromine exposure in rats
Arch Toxicol, 95 (1), 179-193
DOI 10.1007/s00204-020-02919-8, PubMed 32979061

Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR (2020)
Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis
Pediatr Cardiol, 41 (8), 1675-1688
DOI 10.1007/s00246-020-02427-7, PubMed 32770262

Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE (2020)
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641, PubMed 32070187

Publications 2019

Colli DF, Blood SR, Sankarankutty AC, Sachse FB, Frisk M, Louch WE, Kekenes-Huskey PM (2019)
A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues
Biophys J, 116 (8), 1386-1393
DOI 10.1016/j.bpj.2019.03.010, PubMed 30979553

Frisk M, Lipsett DB, Louch WE (2019)
Reply from M. Frisk, D. B. Lipsett and W. E. Louch
J Physiol, 597 (11), 2967-2968
DOI 10.1113/JP278067, PubMed 31021407

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279

Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE (2019)
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J Physiol, 597 (7), 1833-1853
DOI 10.1113/JP277273, PubMed 30707448

Louch WE (2019)
Channel surfing: new insights into plasticity of excitation-contraction coupling
J Physiol, 597 (8), 2119-2120
DOI 10.1113/JP277783, PubMed 30854650

Lu PF, Veletic M, Laasmaa M, Vendelin M, Louch WE, Halvorsen PS, Bergsland J, Balasingham I (2019)
Multi-nodal nano-actuator pacemaker for energy-efficient stimulation of cardiomyocytes
Nano Commun.Netw., 22, 100270
DOI 10.1016/j.nancom.2019.100270

Laasmaa M, Lu P, Veletić M, Louch WE, Bergsland J, Balasingham I, Vendelin M (2019)
Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses
Sci Rep, 9 (1), 13307
DOI 10.1038/s41598-019-49791-w, PubMed 31527628

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca²⁺-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE (2019)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410

Shiferaw Y, Aistrup GL, Louch WE, Wasserstrom JA (2019)
Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes
Biophys J, 118 (2), 476-491
DOI 10.1016/j.bpj.2019.12.012, PubMed 31889516

Skogestad J, Lines GT, Louch WE, Sejersted OM, Sjaastad I, Aronsen JM (2019)
Evidence for heterogeneous subsarcolemmal Na⁺ levels in rat ventricular myocytes
Am J Physiol Heart Circ Physiol, 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018, PubMed 30657726

Tazmini K, Fraz MSA, Nymo SH, Stokke MK, Louch WE, Øie E (2019)
Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation-A single-blinded, randomized clinical trial
Am Heart J, 221, 114-124
DOI 10.1016/j.ahj.2019.12.014, PubMed 31986288

Tazmini K, Nymo SH, Louch WE, Ranhoff AH, Øie E (2019)
Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study
PLoS One, 14 (4), e0215673
DOI 10.1371/journal.pone.0215673, PubMed 31022222

Publications 2018

Ahmad S, Masjoan Juncos JX, Ahmad A, Zaky A, Wei CC, Bradley WE, Zafar I, Powell P, Mariappan N, Vetal N, Louch WE, Ford DA, Doran SF, Matalon S, Dell'Italia LJ (2018)
Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats
Am J Physiol Heart Circ Physiol, 316 (1), H212-H223
DOI 10.1152/ajpheart.00652.2017, PubMed 30379573

Bie P, Brandes RP, Deuchars SA, Eisner DA, Fandrey J, Hecker M, Louch WE, Taira T, Yilmaz B, Europhysiology Organizing Committee (2018)
Bringing European physiologists together
Acta Physiol (Oxf), 222 (4), e13043
DOI 10.1111/apha.13043, PubMed 29377580

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR (2018)
Human ISL1⁺ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Mol Ther, 26 (7), 1644-1659
DOI 10.1016/j.ymthe.2018.02.012, PubMed 29606507

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422

Ghali R, Altara R, Louch WE, Cataliotti A, Mallat Z, Kaplan A, Zouein FA, Booz GW (2018)
IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure
Hypertension, 72 (4), 818-828
DOI 10.1161/HYPERTENSIONAHA.118.11157, PubMed 30354724

Jones PP, MacQuaide N, Louch WE (2018)
Dyadic Plasticity in Cardiomyocytes
Front Physiol, 9, 1773
DOI 10.3389/fphys.2018.01773, PubMed 30618792

Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE (2018)
Ryanodine receptor dispersion disrupts Ca²⁺ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974

Shen X, van den Brink J, Hou Y, Colli D, Le C, Kolstad TR, MacQuaide N, Carlson CR, Kekenes-Huskey PM, Edwards AG, Soeller C, Louch WE (2018)
3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes
J Physiol, 597 (2), 399-418
DOI 10.1113/JP277360, PubMed 30412283

Publications 2017

Edwards AG, Louch WE (2017)
Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus
Clin Med Insights Cardiol, 11, 1179546816686061
DOI 10.1177/1179546816686061, PubMed 28469490

Gattoni S, Røe ÅT, Aronsen JM, Sjaastad I, Louch WE, Smith NP, Niederer SA (2017)
Compensatory and decompensatory alterations in cardiomyocyte Ca²⁺ dynamics in hearts with diastolic dysfunction following aortic banding
J Physiol, 595 (12), 3867-3889
DOI 10.1113/JP273879, PubMed 28542952

Hodne K, Lipsett DB, Louch WE (2017)
Gene Transfer in Isolated Adult Cardiomyocytes
Methods Mol Biol, 1521, 169-182
DOI 10.1007/978-1-4939-6588-5_11, PubMed 27910048

Louch WE, Nattel S (2017)
T-tubular collagen: a new player in mechanosensing and disease?
Cardiovasc Res, 113 (8), 839-840
DOI 10.1093/cvr/cvx091, PubMed 28481973

Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza GA, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2017)
Mapping the in vitro interactome of cardiac sodium (Na⁺ )-calcium (Ca²⁺ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
DOI 10.1002/pmic.201600417, PubMed 28755400

Maleckar MM, Edwards AG, Louch WE, Lines GT (2017)
Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca²⁺ (mis)handling
Clin Med Insights Cardiol, 11, 1179546817698602
DOI 10.1177/1179546817698602, PubMed 28469494

Manfra O, Frisk M, Louch WE (2017)
Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy
Curr Heart Fail Rep, 14 (3), 167-178
DOI 10.1007/s11897-017-0329-9, PubMed 28447290

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Ottesen AH, Carlson CR, Louch WE, Dahl MB, Sandbu RA, Johansen RF, Jarstadmarken H, Bjørås M, Høiseth AD, Brynildsen J, Sjaastad I, Stridsberg M, Omland T, Christensen G, Røsjø H (2017)
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane A, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC (2017)
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circ Res, 121 (12), 1323-1330
DOI 10.1161/CIRCRESAHA.117.311920, PubMed 28974554

Roe AT, Sjaastad I, Louch WE (2017)
Heart failure with preserved ejection fraction
Tidsskr. Nor. Laegeforen., 137 (18), 1426-1431

Røe ÅT, Aronsen JM, Skårdal K, Hamdani N, Linke WA, Danielsen HE, Sejersted OM, Sjaastad I, Louch WE (2017)
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc Res, 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087, PubMed 28472418

Røe ÅT, Sjaastad I, Louch WE (2017)
Heart failure with preserved ejection fraction
Tidsskr Nor Laegeforen, 137 (18)
DOI 10.4045/tidsskr.16.1068, PubMed 28972354

Publications 2016

Aronsen JM, Louch WE, Sjaastad I (2016)
Cardiomyocyte Ca2+ dynamics: clinical perspectives
Scand Cardiovasc J, 50 (2), 65-77
DOI 10.3109/14017431.2015.1136079, PubMed 26729487

Frisk M, Ruud M, Espe EK, Aronsen JM, Røe ÅT, Zhang L, Norseng PA, Sejersted OM, Christensen GA, Sjaastad I, Louch WE (2016)
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc Res, 112 (1), 443-51
DOI 10.1093/cvr/cvw111, PubMed 27226008

Gattoni S, Røe ÅT, Frisk M, Louch WE, Niederer SA, Smith NP (2016)
The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study
J Physiol, 594 (15), 4193-224
DOI 10.1113/JP272011, PubMed 26916026

Wanichawan P, Hodne K, Hafver TL, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2016)
Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
Biochem J, 473 (15), 2413-23
DOI 10.1042/BCJ20160465, PubMed 27247424

Publications 2015

Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A (2015)
Deranged sodium to sudden death
J Physiol, 593 (6), 1331-45
DOI 10.1113/jphysiol.2014.281204, PubMed 25772289

Curran J, Louch WE (2015)
Linking ryanodine receptor Ca(2+) leak and Na(+) current in heart: a day in the life of flecainide
Acta Physiol (Oxf), 214 (3), 300-2
DOI 10.1111/apha.12526, PubMed 25976700

Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR (2015)
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322

Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, Linke WA, Gomez MF, Christensen G (2015)
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Cardiovasc Res, 106 (2), 217-26
DOI 10.1093/cvr/cvv002, PubMed 25587045

Liebau S, Louch WE (2015)
Calcium-activated potassium current: parallels in cardiac development and disease
Acta Physiol (Oxf), 216 (1), 7-9
DOI 10.1111/apha.12556, PubMed 26189640

Louch WE, Koivumäki JT, Tavi P (2015)
Calcium signalling in developing cardiomyocytes: implications for model systems and disease
J Physiol, 593 (5), 1047-63
DOI 10.1113/jphysiol.2014.274712, PubMed 25641733

Ottesen AH, Louch WE, Carlson CR, Landsverk OJB, Kurola J, Johansen RF, Moe MK, Aronsen JM, Høiseth AD, Jarstadmarken H, Nygård S, Bjørås M, Sjaastad I, Pettilä V, Stridsberg M, Omland T, Christensen G, Røsjø H (2015)
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832

Palecek T, Fikrle M, Nemecek E, Bauerova L, Kuchynka P, Louch WE, Spicka I, Rysava R (2015)
Contemporary treatment of amyloid heart disease
Curr Pharm Des, 21 (4), 491-506
DOI 10.2174/138161282104141204143657, PubMed 25483951

Roe AT, Frisk M, Louch WE (2015)
Targeting cardiomyocyte Ca2+ homeostasis in heart failure
Curr Pharm Des, 21 (4), 431-48
DOI 10.2174/138161282104141204124129, PubMed 25483944

Tinholt M, Stavik B, Louch W, Carlson CR, Sletten M, Ruf W, Skretting G, Sandset PM, Iversen N (2015)
Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells
PLoS One, 10 (1), e0117404
DOI 10.1371/journal.pone.0117404, PubMed 25617766

Publications 2014

Aronsen JM, Skogestad J, Lewalle A, Louch WE, Hougen K, Stokke MK, Swift F, Niederer S, Smith NP, Sejersted OM, Sjaastad I (2014)
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299

Boardman NT, Aronsen JM, Louch WE, Sjaastad I, Willoch F, Christensen G, Sejersted O, Aasum E (2014)
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am J Physiol Heart Circ Physiol, 306 (7), H1018-24
DOI 10.1152/ajpheart.00741.2013, PubMed 24486508

Frisk M, Koivumäki JT, Norseng PA, Maleckar MM, Sejersted OM, Louch WE (2014)
Variable t-tubule organization and Ca2+ homeostasis across the atria
Am J Physiol Heart Circ Physiol, 307 (4), H609-20
DOI 10.1152/ajpheart.00295.2014, PubMed 24951751

Land S, Niederer SA, Louch WE, Røe ÅT, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon AR, Harding SE, Smith NP (2014)
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle
Am J Physiol Heart Circ Physiol, 307 (10), H1487-96
DOI 10.1152/ajpheart.00443.2014, PubMed 25239804

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930

Nordbø O, Lamata P, Land S, Niederer S, Aronsen JM, Louch WE, Sjaastad I, Martens H, Gjuvsland AB, Tøndel K, Torp H, Lohezic M, Schneider JE, Remme EW, Smith N, Omholt SW, Vik JO (2014)
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645

Publications 2013

Land S, Louch WE, Niederer SA, Aronsen JM, Christensen G, Sjaastad I, Sejersted OM, Smith NP (2013)
Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice
Biophys J, 104 (6), 1349-56
DOI 10.1016/j.bpj.2013.01.042, PubMed 23528094

Land S, Niederer SA, Louch WE, Sejersted OM, Smith NP (2013)
Integrating multi-scale data to create a virtual physiological mouse heart
Interface Focus, 3 (2), 20120076
DOI 10.1098/rsfs.2012.0076, PubMed 24427525

Louch WE, Hake J, Mørk HK, Hougen K, Skrbic B, Ursu D, Tønnessen T, Sjaastad I, Sejersted OM (2013)
Slow Ca²⁺ sparks de-synchronize Ca²⁺ release in failing cardiomyocytes: evidence for altered configuration of Ca²⁺ release units?
J Mol Cell Cardiol, 58, 41-52
DOI 10.1016/j.yjmcc.2013.01.014, PubMed 23376034

Louch WE, Lyon AR (2013)
Mind the store: modulating Ca(2+) reuptake with a leaky sarcoplasmic reticulum
Cardiovasc Res, 98 (2), 165-8
DOI 10.1093/cvr/cvt069, PubMed 23524302

Stokke MK, Tovsrud N, Louch WE, Øyehaug L, Hougen K, Sejersted OM, Swift F, Sjaastad I (2013)
I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation
Cardiovasc Res, 98 (2), 315-25
DOI 10.1093/cvr/cvt037, PubMed 23417043

Øyehaug L, Loose KØ, Jølle GF, Røe ÅT, Sjaastad I, Christensen G, Sejersted OM, Louch WE (2013)
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity
Biophys J, 104 (8), 1685-97
DOI 10.1016/j.bpj.2013.03.022, PubMed 23601316

Publications 2012

Land S, Niederer SA, Aronsen JM, Espe EK, Zhang L, Louch WE, Sjaastad I, Sejersted OM, Smith NP (2012)
An analysis of deformation-dependent electromechanical coupling in the mouse heart
J Physiol, 590 (18), 4553-69
DOI 10.1113/jphysiol.2012.231928, PubMed 22615436

Li L, Louch WE, Niederer SA, Aronsen JM, Christensen G, Sejersted OM, Smith NP (2012)
Sodium accumulation in SERCA knockout-induced heart failure
Biophys J, 102 (9), 2039-48
DOI 10.1016/j.bpj.2012.03.045, PubMed 22824267

Louch WE, Stokke MK, Sjaastad I, Christensen G, Sejersted OM (2012)
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium
Physiology (Bethesda), 27 (5), 308-23
DOI 10.1152/physiol.00021.2012, PubMed 23026754

Louch WE, Vangheluwe P, Bito V, Raeymaekers L, Wuytack F, Sipido KR (2012)
Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signaling
Am J Physiol Heart Circ Physiol, 302 (12), H2574-82
DOI 10.1152/ajpheart.01166.2011, PubMed 22505640

Røsjø H, Stridsberg M, Florholmen G, Stensløkken KO, Ottesen AH, Sjaastad I, Husberg C, Dahl MB, Øie E, Louch WE, Omland T, Christensen G (2012)
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties
PLoS One, 7 (5), e37401
DOI 10.1371/journal.pone.0037401, PubMed 22655045

Swift F, Franzini-Armstrong C, Øyehaug L, Enger UH, Andersson KB, Christensen G, Sejersted OM, Louch WE (2012)
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout
Proc Natl Acad Sci U S A, 109 (10), 3997-4001
DOI 10.1073/pnas.1120172109, PubMed 22355118

Thomsen MB, Louch WE (2012)
Special Interest Group on Cardiac Physiology established within the Scandinavian Physiological Society
Acta Physiol (Oxf), 204 (4), 464
DOI 10.1111/j.1748-1716.2011.02374.x, PubMed 22364639

Publications 2011

Bjørnstad JL, Skrbic B, Marstein HS, Hasic A, Sjaastad I, Louch WE, Florholmen G, Christensen G, Tønnessen T (2011)
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovasc Res, 93 (1), 100-10
DOI 10.1093/cvr/cvr294, PubMed 22049534

Eidet JR, Utheim OA, Raeder S, Dartt DA, Lyberg T, Carreras E, Huynh TT, Messelt EB, Louch WE, Roald B, Utheim TP (2011)
Effects of serum-free storage on morphology, phenotype, and viability of ex vivo cultured human conjunctival epithelium
Exp Eye Res, 94 (1), 109-16
DOI 10.1016/j.exer.2011.11.015, PubMed 22154551

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G (2011)
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302, PubMed 22164265

Li L, Louch WE, Niederer SA, Andersson KB, Christensen G, Sejersted OM, Smith NP (2011)
Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study
Biophys J, 100 (2), 322-31
DOI 10.1016/j.bpj.2010.11.048, PubMed 21244828

Louch WE, Sheehan KA, Wolska BM (2011)
Methods in cardiomyocyte isolation, culture, and gene transfer
J Mol Cell Cardiol, 51 (3), 288-98
DOI 10.1016/j.yjmcc.2011.06.012, PubMed 21723873

Stokke MK, Briston SJ, Jølle GF, Manzoor I, Louch WE, Øyehaug L, Christensen G, Eisner DA, Trafford AW, Sejersted OM, Sjaastad I (2011)
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content
Cardiovasc Res, 90 (3), 503-12
DOI 10.1093/cvr/cvr013, PubMed 21242164

Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygård S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G (2011)
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668, PubMed 21533157

Wanichawan P, Louch WE, Hortemo KH, Austbø B, Lunde PK, Scott JD, Sejersted OM, Carlson CR (2011)
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A
Am J Physiol Cell Physiol, 300 (5), C989-97
DOI 10.1152/ajpcell.00196.2010, PubMed 21289289

Publications 2010

Kuchynka P, Palecek T, Hrbackova H, Vitkova I, Simek S, Nemecek E, Aster V, Louch WE, Aschermann M, Linhart A (2010)
Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir
Wien Klin Wochenschr, 122 (19-20), 592-5
DOI 10.1007/s00508-010-1456-4, PubMed 20865454

Liu XH, Zhang ZY, Andersson KB, Husberg C, Enger UH, Ræder MG, Christensen G, Louch WE (2010)
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis
Cell Calcium, 49 (4), 201-7
DOI 10.1016/j.ceca.2010.09.009, PubMed 20965565

Louch WE, Hake J, Jølle GF, Mørk HK, Sjaastad I, Lines GT, Sejersted OM (2010)
Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes
Biophys J, 99 (5), 1377-86
DOI 10.1016/j.bpj.2010.06.055, PubMed 20816049

Louch WE, Sejersted OM, Swift F (2010)
There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling
J Biomed Biotechnol, 2010, 503906
DOI 10.1155/2010/503906, PubMed 20396394

Palecek T, Kuchynka P, Hulinska D, Schramlova J, Hrbackova H, Vitkova I, Simek S, Horak J, Louch WE, Linhart A (2010)
Presence of Borrelia burgdorferi in endomyocardial biopsies in patients with new-onset unexplained dilated cardiomyopathy
Med Microbiol Immunol, 199 (2), 139-43
DOI 10.1007/s00430-009-0141-6, PubMed 20052487

Publications 2009

Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G (2009)
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
J Mol Cell Cardiol, 47 (2), 180-7
DOI 10.1016/j.yjmcc.2009.03.013, PubMed 19328205

Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G (2009)
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models
Cell Calcium, 46 (3), 219-25
DOI 10.1016/j.ceca.2009.07.004, PubMed 19692123

Kuchynka P, Palecek T, Vilikus Z, Havranek S, Taborska K, Louch WE, Linhart A (2009)
Cardiac structural and functional changes in competitive amateur cyclists
Echocardiography, 27 (1), 11-6
DOI 10.1111/j.1540-8175.2009.00965.x, PubMed 19765071

Louch WE (2009)
DYADIC GEOMETRY IN NORMAL AND FAILING CARDIOMYOCYTES
J. Appl. Physiol., 107 (6), 1985

Louch WE, Hougen K, Mørk HK, Swift F, Aronsen JM, Sjaastad I, Reims HM, Roald B, Andersson KB, Christensen G, Sejersted OM (2009)
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J Physiol, 588 (Pt 3), 465-78
DOI 10.1113/jphysiol.2009.183517, PubMed 20008467

Mørk HK, Sjaastad I, Sejersted OM, Louch WE (2009)
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice
Am J Physiol Heart Circ Physiol, 296 (4), H1069-79
DOI 10.1152/ajpheart.01009.2008, PubMed 19201998

Reuter H, Louch WE, Brette F, Sham JS, Sun H, Yang XR, Soeller C, Lakatta EG, Balijepalli RC (2009)
Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint
J Appl Physiol (1985), 107 (6), 1985-7; author reply 1988
DOI 10.1152/japplphysiol.01028.2009, PubMed 19952386

Stokke MK, Hougen K, Sjaastad I, Louch WE, Briston SJ, Enger UH, Andersson KB, Christensen G, Eisner DA, Sejersted OM, Trafford AW (2009)
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc Res, 86 (1), 63-71
DOI 10.1093/cvr/cvp401, PubMed 20019150

Publications 2008

Bøkenes J, Aronsen JM, Birkeland JA, Henriksen UL, Louch WE, Sjaastad I, Sejersted OM (2008)
Slow contractions characterize failing rat hearts
Basic Res Cardiol, 103 (4), 328-44
DOI 10.1007/s00395-008-0719-y, PubMed 18347833

Swift F, Birkeland JA, Tovsrud N, Enger UH, Aronsen JM, Louch WE, Sjaastad I, Sejersted OM (2008)
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha2-isoform in heart failure
Cardiovasc Res, 78 (1), 71-8
DOI 10.1093/cvr/cvn013, PubMed 18203708

Swift F, Birkeland JAK, Tovsrud N, Enger UH, Aronsen JM, Louch WE, Sjaastad I, Sejersted OM (2008)
Altered Na(+)/Ca(2+)-exchanger activity due to downregulation of Na(+)/K(+)-ATPase alpha(2)-isoform in heart failure (vol 78, pg 71, 2008)
Cardiovasc. Res., 79 (2), 352
DOI 10.1093/cvr/cvn147

Publications 2007

Mørk HK, Sjaastad I, Sande JB, Periasamy M, Sejersted OM, Louch WE (2007)
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure
J Mol Cell Cardiol, 43 (2), 177-86
DOI 10.1016/j.yjmcc.2007.05.004, PubMed 17574269

Publications 2006

Lines GT, Sande JB, Louch WE, Mørk HK, Grøttum P, Sejersted OM (2006)
Contribution of the Na+/Ca2+ exchanger to rapid Ca2+ release in cardiomyocytes
Biophys J, 91 (3), 779-92
DOI 10.1529/biophysj.105.072447, PubMed 16679359

Louch WE, Mørk HK, Sexton J, Strømme TA, Laake P, Sjaastad I, Sejersted OM (2006)
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction
J Physiol, 574 (Pt 2), 519-33
DOI 10.1113/jphysiol.2006.107227, PubMed 16709642

Vangheluwe P, Tjwa M, Van Den Bergh A, Louch WE, Beullens M, Dode L, Carmeliet P, Kranias E, Herijgers P, Sipido KR, Raeymaekers L, Wuytack F (2006)
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span
J Mol Cell Cardiol, 41 (2), 308-17
DOI 10.1016/j.yjmcc.2006.05.014, PubMed 16814319

Publications 2004

Louch WE, Bito V, Heinzel FR, Macianskiene R, Vanhaecke J, Flameng W, Mubagwa K, Sipido KR (2004)
Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes
Cardiovasc Res, 62 (1), 63-73
DOI 10.1016/j.cardiores.2003.12.031, PubMed 15023553

Louch WE, Ferrier GR, Howlett SE (2004)
Attentuation of cardiac stunning by losartan in a cellular model of ischemia and reperfusion is accompanied by increased sarcoplasmic reticulum Ca2+ stores and prevention of cytosolic Ca2+ elevation
J Pharmacol Exp Ther, 312 (1), 238-47
DOI 10.1124/jpet.104.072769, PubMed 15316090

Publications 2003

Au A, Louch WE, Ferrier GR, Howlett SE (2003)
L-Arginine ameliorates effects of ischemia and reperfusion in isolated cardiac myocytes
Eur J Pharmacol, 476 (1-2), 45-54
DOI 10.1016/s0014-2999(03)02175-7, PubMed 12969748

Vangheluwe P, Louch WE, Ver Heyen M, Sipido K, Raeymaekers L, Wuytack F (2003)
Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart
Cell Calcium, 34 (6), 457-64
DOI 10.1016/s0143-4160(03)00126-x, PubMed 14572804

Publications 2002

Louch WE, Ferrier GR, Howlett SE (2002)
Changes in excitation-contraction coupling in an isolated ventricular myocyte model of cardiac stunning
Am J Physiol Heart Circ Physiol, 283 (2), H800-10
DOI 10.1152/ajpheart.00020.2002, PubMed 12124230

Publications 2000

Louch WE, Ferrier GR, Howlett SE (2000)
Losartan improves recovery of contraction and inhibits transient inward current in a cellular model of cardiac ischemia and reperfusion
J Pharmacol Exp Ther, 295 (2), 697-704
PubMed 11046108