Publications 2024
Reply: Navigating Nutritional Nuances in the Research of Heart Failure With Preserved Ejection Fraction
JACC Basic Transl Sci, 9 (3), 403
DOI 10.1016/j.jacbts.2024.01.014, PubMed 38559617
Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats
ESC Heart Fail (in press)
DOI 10.1002/ehf2.15145, PubMed 39696842
Publications 2023
Novel enhancers of guanylyl cyclase-A activity acting via allosteric modulation
Br J Pharmacol, 180 (24), 3254-3270
DOI 10.1111/bph.16203, PubMed 37522273
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction
JACC Basic Transl Sci, 9 (2), 223-240
DOI 10.1016/j.jacbts.2023.09.014, PubMed 38510717
Vibrational spectroscopy identifies myocardial chemical modifications in heart failure with preserved ejection fraction
J Transl Med, 21 (1), 617
DOI 10.1186/s12967-023-04465-0, PubMed 37697391
FTIR Analysis of Renal Tissue for the Assessment of Hypertensive Organ Damage and proANP31-67 Treatment
Int J Mol Sci, 24 (6)
DOI 10.3390/ijms24065196, PubMed 36982271
Publications 2022
Diagnostic performance of microRNAs in the detection of heart failure with reduced or preserved ejection fraction: a systematic review and meta-analysis
Eur J Heart Fail, 24 (12), 2212-2225
DOI 10.1002/ejhf.2700, PubMed 36161443
Early cardiac-chamber-specific fingerprints in heart failure with preserved ejection fraction detected by FTIR and Raman spectroscopic techniques
Sci Rep, 12 (1), 3440
DOI 10.1038/s41598-022-07390-2, PubMed 35236899
Publications 2021
Atrial Natriuretic Peptide31-67: A Novel Therapeutic Factor for Cardiovascular Diseases
Front Physiol, 12, 691407
DOI 10.3389/fphys.2021.691407, PubMed 34305645
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397
Distorted assessment of left atrial size by echocardiography in patients with increased aortic root diameter
Egypt Heart J, 73 (1), 55
DOI 10.1186/s43044-021-00177-2, PubMed 34173898
Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
ESC Heart Fail, 8 (2), 918-927
DOI 10.1002/ehf2.13177, PubMed 33497525
Publications 2020
Cardioprotective Effects of the Novel Compound Vastiras in a Preclinical Model of End-Organ Damage
Hypertension, 75 (5), 1195-1204
DOI 10.1161/HYPERTENSIONAHA.120.14704, PubMed 32200677
Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension
Blood Press, 30 (1), 31-40
DOI 10.1080/08037051.2020.1789446, PubMed 32633141
Publications 2019
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410
Publications 2018
Conflicting vascular and metabolic impact of the IL-33/sST2 axis
Cardiovasc Res, 114 (12), 1578-1594
DOI 10.1093/cvr/cvy166, PubMed 29982301
In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction
Front Cardiovasc Med, 5, 11
DOI 10.3389/fcvm.2018.00011, PubMed 29556499
IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure
Hypertension, 72 (4), 818-828
DOI 10.1161/HYPERTENSIONAHA.118.11157, PubMed 30354724
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974
Publications 2017
Targeting Obesity and Diabetes to Treat Heart Failure with Preserved Ejection Fraction
Front Endocrinol (Lausanne), 8, 160
DOI 10.3389/fendo.2017.00160, PubMed 28769873
Seasonal variations of hyponatremia in the emergency department: Age-related changes
Am J Emerg Med, 35 (5), 749-752
DOI 10.1016/j.ajem.2017.01.018, PubMed 28131601
Serum sodium correction rate and the outcome in severe hyponatremia
Am J Emerg Med, 35 (11), 1691-1694
DOI 10.1016/j.ajem.2017.05.050, PubMed 28600073
B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease
Kidney Int, 92 (3), 657-668
DOI 10.1016/j.kint.2017.02.017, PubMed 28416225
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017
BMC Pharmacol Toxicol, 18 (Suppl 1), 64
DOI 10.1186/s40360-017-0170-5, PubMed 29035170
Publications 2016
Impact of left ventricular remodeling and renal function on 24h-ECG recordings and cardiovascular outcome in elderly hypertensive patients
Eur J Intern Med, 29, 71-7
DOI 10.1016/j.ejim.2016.01.001, PubMed 26781517
Publications 2015
Long-Term Structural and Functional Myocardial Adaptations in Healthy Living Kidney Donors: A Pilot Study
PLoS One, 10 (11), e0142103
DOI 10.1371/journal.pone.0142103, PubMed 26556804
B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension
Hypertension, 66 (1), 199-210
DOI 10.1161/HYPERTENSIONAHA.115.05610, PubMed 26063669
Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study
Clin Chem, 61 (8), 1087-97
DOI 10.1373/clinchem.2015.239673, PubMed 26056354
Publications 2014
β-blockade abolishes the augmented cardiac tPA release induced by transactivation of heterodimerised bradykinin receptor-2 and β2-adrenergic receptor in vivo
Thromb Haemost, 112 (5), 951-9
DOI 10.1160/TH14-01-0059, PubMed 25078038
Circulating aldosterone and natriuretic peptides in the general community: relationship to cardiorenal and metabolic disease
Hypertension, 65 (1), 45-53
DOI 10.1161/HYPERTENSIONAHA.114.03936, PubMed 25368032
Long-term effects of moderate protein diet on renal function and low-grade inflammation in older adults with type 2 diabetes and chronic kidney disease
Nutrition, 30 (9), 1045-9
DOI 10.1016/j.nut.2014.03.007, PubMed 24993749
M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics
J Am Heart Assoc, 3 (1), e000206
DOI 10.1161/JAHA.113.000206, PubMed 24385449
Cardiac BNP gene delivery prolongs survival in aged spontaneously hypertensive rats with overt hypertensive heart disease
Aging (Albany NY), 6 (4), 311-9
DOI 10.18632/aging.100655, PubMed 24799459
Publications 2013
Abstracts of the 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications, 28-30 June 2013, Erfurt, Germany
BMC Pharmacol Toxicol, 14 Suppl 1 (Suppl 1), O1-38;P1-80
DOI 10.1186/2050-6511-14-s1-o1, PubMed 24517645
Endothelial permeability in vitro and in vivo: protective actions of ANP and omapatrilat in experimental atherosclerosis
Peptides, 48, 21-6
DOI 10.1016/j.peptides.2013.07.020, PubMed 23927843
Publications 2012
Sustained blood pressure-lowering actions of subcutaneous B-type natriuretic peptide (nesiritide) in a patient with uncontrolled hypertension
Mayo Clin Proc, 87 (4), 413-5
DOI 10.1016/j.mayocp.2012.02.003, PubMed 22469356
Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide
J Am Coll Cardiol, 60 (22), 2305-12
DOI 10.1016/j.jacc.2012.07.056, PubMed 23122795
Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP
J Am Coll Cardiol, 60 (16), 1558-65
DOI 10.1016/j.jacc.2012.05.049, PubMed 23058313
Hepatocyte growth factor and cardiomyopathy in dialysis patients
Hypertension, 60 (3), e24; author reply e25-6
DOI 10.1161/HYPERTENSIONAHA.112.198424, PubMed 22868387
Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics
Eur Heart J, 34 (12), 886-893c
DOI 10.1093/eurheartj/ehs262, PubMed 22942338
Publications 2011
A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community
J Am Coll Cardiol, 58 (6), 629-36
DOI 10.1016/j.jacc.2011.05.011, PubMed 21798427
Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive rats
Circulation, 123 (12), 1297-305
DOI 10.1161/CIRCULATIONAHA.110.981720, PubMed 21403100
Pro-B-type natriuretic peptide(1-108) circulates in the general community: plasma determinants and detection of left ventricular dysfunction
J Am Coll Cardiol, 57 (12), 1386-95
DOI 10.1016/j.jacc.2011.01.005, PubMed 21414536
Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection
Am J Physiol Regul Integr Comp Physiol, 302 (2), R292-9
DOI 10.1152/ajpregu.00194.2011, PubMed 22071162
Predictive utility of atrial, N-terminal pro-atrial, and N-terminal pro-B-type natriuretic peptides for mortality and cardiovascular events in the general community: a 9-year follow-up study
Mayo Clin Proc, 86 (12), 1154-60
DOI 10.4065/mcp.2011.0437, PubMed 22134933
Urinary C-type natriuretic peptide excretion: a potential novel biomarker for renal fibrosis during aging
Am J Physiol Renal Physiol, 301 (5), F943-52
DOI 10.1152/ajprenal.00170.2011, PubMed 21865266
Secretion of glycosylated pro-B-type natriuretic peptide from normal cardiomyocytes
Clin Chem, 57 (6), 864-73
DOI 10.1373/clinchem.2010.157438, PubMed 21482747
Publications 2010
Renal and anti-aldosterone actions of vasopressin-2 receptor antagonism and B-type natriuretic peptide in experimental heart failure
Circ Heart Fail, 3 (3), 412-9
DOI 10.1161/CIRCHEARTFAILURE.109.916114, PubMed 20176717
A novel atrial natriuretic peptide based therapeutic in experimental angiotensin II mediated acute hypertension
Hypertension, 56 (6), 1152-9
DOI 10.1161/HYPERTENSIONAHA.110.159210, PubMed 20975033
The prognostic value of N-terminal pro-B-type natriuretic peptide for death and cardiovascular events in healthy normal and stage A/B heart failure subjects
J Am Coll Cardiol, 55 (19), 2140-7
DOI 10.1016/j.jacc.2010.01.031, PubMed 20447539
Publications 2009
B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity
Am J Physiol Regul Integr Comp Physiol, 296 (6), R1744-50
DOI 10.1152/ajpregu.00059.2009, PubMed 19386989
Local renal delivery of a natriuretic peptide a renal-enhancing strategy for B-type natriuretic peptide in overt experimental heart failure
J Am Coll Cardiol, 53 (15), 1302-8
DOI 10.1016/j.jacc.2009.01.030, PubMed 19358945
A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions
J Am Coll Cardiol, 54 (11), 1024-32
DOI 10.1016/j.jacc.2009.04.080, PubMed 19729120
Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients
Nephron Clin Pract, 114 (1), c74-80
DOI 10.1159/000252806, PubMed 19851079
Publications 2008
Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension
Circulation, 118 (17), 1729-36
DOI 10.1161/CIRCULATIONAHA.107.759241, PubMed 18838565
Effect of plasma protein depletion on BNP-32 recovery
Clin Chem, 54 (5), 933-4
DOI 10.1373/clinchem.2007.098038, PubMed 18443186
Targeting the kidney in acute decompensated heart failure: conventional diuretics and renal-acting vasodilators
Rev Cardiovasc Med, 9 (1), 39-45
PubMed 18418308
B-type natriuretic peptide: beyond a diagnostic
Heart Fail Clin, 4 (4), 449-54
DOI 10.1016/j.hfc.2008.03.011, PubMed 18760756
Publications 2007
Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure
Hypertension, 49 (5), 1128-33
DOI 10.1161/HYPERTENSIONAHA.106.083832, PubMed 17325237
Oral brain natriuretic peptide: a novel strategy for chronic protein therapy for cardiovascular disease
Trends Cardiovasc Med, 17 (1), 10-4
DOI 10.1016/j.tcm.2006.10.001, PubMed 17210472
Mineralocorticoid escape by the kidney but not the heart in experimental asymptomatic left ventricular dysfunction
Hypertension, 50 (3), 481-8
DOI 10.1161/HYPERTENSIONAHA.107.088534, PubMed 17635858
Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide
Hypertension, 49 (5), 1114-9
DOI 10.1161/HYPERTENSIONAHA.106.081083, PubMed 17372040
Publications 2006
Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy
Am J Physiol Heart Circ Physiol, 291 (4), H1529-35
DOI 10.1152/ajpheart.00107.2006, PubMed 16648193
Natriuretic peptides as regulators of myocardial structure and function: pathophysiologic and therapeutic implications
Heart Fail Clin, 2 (3), 269-76
DOI 10.1016/j.hfc.2006.09.002, PubMed 17386896
Maximizing the renal cyclic 3'-5'-guanosine monophosphate system with type V phosphodiesterase inhibition and exogenous natriuretic peptide: a novel strategy to improve renal function in experimental overt heart failure
J Am Soc Nephrol, 17 (10), 2742-7
DOI 10.1681/ASN.2006020161, PubMed 16928803
Intact acute cardiorenal and humoral responsiveness following chronic subcutaneous administration of the cardiac peptide BNP in experimental heart failure
Eur J Heart Fail, 8 (7), 681-6
DOI 10.1016/j.ejheart.2005.12.005, PubMed 16459135
BNP-induced activation of cGMP in human cardiac fibroblasts: interactions with fibronectin and natriuretic peptide receptors
J Cell Physiol, 209 (3), 943-9
DOI 10.1002/jcp.20793, PubMed 16986166
Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide: biomarkers for mortality in a large community-based cohort free of heart failure
Hypertension, 47 (5), 874-80
DOI 10.1161/01.HYP.0000216794.24161.8c, PubMed 16585413
Publications 2005
Natriuretic peptides: novel therapeutic targets in heart failure
J Investig Med, 53 (7), 378-84
DOI 10.2310/6650.2005.53711, PubMed 16297366
Oral human brain natriuretic peptide activates cyclic guanosine 3',5'-monophosphate and decreases mean arterial pressure
Circulation, 112 (6), 836-40
DOI 10.1161/CIRCULATIONAHA.105.538520, PubMed 16061734
Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
Proc Natl Acad Sci U S A, 102 (48), 17442-7
DOI 10.1073/pnas.0508782102, PubMed 16293687
Congestive heart failure: pharmacological agents and the potential of B-type natriuretic Peptide
Curr Med Chem, 12 (12), 1439-47
DOI 10.2174/0929867054020909, PubMed 15974994
Natriuretic and antialdosterone actions of chronic oral NEP inhibition during progressive congestive heart failure
Kidney Int, 67 (5), 1723-30
DOI 10.1111/j.1523-1755.2005.00269.x, PubMed 15840018
Publications 2004
Brain natriuretic peptide enhances renal actions of furosemide and suppresses furosemide-induced aldosterone activation in experimental heart failure
Circulation, 109 (13), 1680-5
DOI 10.1161/01.CIR.0000124064.00494.21, PubMed 15023890
Equimolar doses of atrial and brain natriuretic peptides and urodilatin have differential renal actions in overt experimental heart failure
Am J Physiol Regul Integr Comp Physiol, 288 (5), R1093-7
DOI 10.1152/ajpregu.00682.2004, PubMed 15627648
Heart valve calcifications, survival, and cardiovascular risk in hemodialysis patients
Am J Kidney Dis, 43 (3), 479-84
DOI 10.1053/j.ajkd.2003.11.009, PubMed 14981606
Prognostic value of echocardiographic indicators of left ventricular systolic function in asymptomatic dialysis patients
J Am Soc Nephrol, 15 (4), 1029-37
DOI 10.1097/01.asn.0000117977.14912.91, PubMed 15034106
Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression
Kidney Int, 65 (4), 1492-8
DOI 10.1111/j.1523-1755.2004.00530.x, PubMed 15086493
Publications 2003
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure
Circulation, 107 (5), 686-9
DOI 10.1161/01.cir.0000055737.15443.f8, PubMed 12578869
Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure
Am J Physiol Renal Physiol, 284 (5), F1115-9
DOI 10.1152/ajprenal.00337.2002, PubMed 12676739
Leukemia inhibitory factor is augmented in the heart in experimental heart failure
Eur J Heart Fail, 5 (2), 137-45
DOI 10.1016/s1388-9842(02)00236-2, PubMed 12644003
Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure
Peptides, 24 (6), 889-92
DOI 10.1016/s0196-9781(03)00163-3, PubMed 12948841
Hepatocyte growth factor and left ventricular geometry in end-stage renal disease
Hypertension, 41 (1), 88-92
DOI 10.1161/01.hyp.0000046919.41112.4b, PubMed 12511535
Endothelin A receptor antagonism in experimental congestive heart failure results in augmentation of the renin-angiotensin system and sustained sodium retention
Circulation, 109 (2), 249-54
DOI 10.1161/01.CIR.0000109139.69775.EB, PubMed 14691038
Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart
Regul Pept, 112 (1-3), 161-6
DOI 10.1016/s0167-0115(03)00035-1, PubMed 12667638
Neuropeptide Y, left ventricular mass and function in patients with end stage renal disease
J Hypertens, 21 (7), 1355-62
DOI 10.1097/00004872-200307000-00025, PubMed 12817184
Prospective study of neuropeptide y as an adverse cardiovascular risk factor in end-stage renal disease
J Am Soc Nephrol, 14 (10), 2611-7
DOI 10.1097/01.asn.0000089026.28617.33, PubMed 14514739
Publications 2002
Changes of protein kinetics in nephrotic patients
Curr Opin Clin Nutr Metab Care, 5 (1), 51-4
DOI 10.1097/00075197-200201000-00010, PubMed 11790950
Differential actions of vasopeptidase inhibition versus angiotensin-converting enzyme inhibition on diuretic therapy in experimental congestive heart failure
Circulation, 105 (5), 639-44
DOI 10.1161/hc0502.102962, PubMed 11827932
CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome
Am J Physiol Renal Physiol, 283 (3), F464-72
DOI 10.1152/ajprenal.00372.2001, PubMed 12167597
Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells
Peptides, 23 (8), 1441-7
DOI 10.1016/s0196-9781(02)00078-5, PubMed 12182945
Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients
Kidney Int, 61 (2), 609-14
DOI 10.1046/j.1523-1755.2002.00144.x, PubMed 11849403
Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases
Circ Res, 91 (12), 1127-34
DOI 10.1161/01.res.0000046234.73401.70, PubMed 12480813
Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor
Circ Res, 90 (2), 128-34
DOI 10.1161/hh0202.103613, PubMed 11834704
Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients
Kidney Int, 62 (1), 339-45
DOI 10.1046/j.1523-1755.2002.00437.x, PubMed 12081596
Plasma norepinephrine predicts survival and incident cardiovascular events in patients with end-stage renal disease
Circulation, 105 (11), 1354-9
DOI 10.1161/hc1102.105261, PubMed 11901048
Norepinephrine and concentric hypertrophy in patients with end-stage renal disease
Hypertension, 40 (1), 41-6
DOI 10.1161/01.hyp.0000022063.50739.60, PubMed 12105136
Publications 2001
Prognostic impact of the indexation of left ventricular mass in patients undergoing dialysis
J Am Soc Nephrol, 12 (12), 2768-2774
DOI 10.1681/ASN.V12122768, PubMed 11729247
Cardiac natriuretic peptides are related to left ventricular mass and function and predict mortality in dialysis patients
J Am Soc Nephrol, 12 (7), 1508-1515
DOI 10.1681/ASN.V1271508, PubMed 11423580