Publications 2024

Blom KB, Kro GB, Midtvedt K, Jenssen TG, Reisæter AV, Rollag H, Hartmann A, Sagedal S, Sjaastad I, Tylden G, Njølstad G, Nilsen E, Birkeland JA, Åsberg A (2024)
Cellular immunity against cytomegalovirus and risk of infection after kidney transplantation
Front Immunol, 15, 1414830
DOI 10.3389/fimmu.2024.1414830, PubMed 39007131

Nordén ES, Bendiksen BA, Bergo KK, Espe EKS, McGinley G, Hasic A, Hauge-Iversen IM, Ugland HK, Shen X, Frisk M, Mabotuwana NS, Louch WE, Hussain RI, Zhang L, Sjaastad I, Cataliotti A, Christensen G (2024)
Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats
ESC Heart Fail (in press)
DOI 10.1002/ehf2.15145, PubMed 39696842

Ruud M, Frisk M, Melleby AO, Norseng PA, Mohamed BA, Li J, Aronsen JM, Setterberg IE, Jakubiczka J, van Hout I, Coffey S, Shen X, Nygård S, Lunde IG, Tønnessen T, Jones PP, Sjaastad I, Gullestad L, Toischer K, Dahl CP, Christensen G, Louch WE (2024)
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
J Physiol, 602 (18), 4487-4510
DOI 10.1113/JP284566, PubMed 38686538

Publications 2023

Andreassen K, Rixon C, Hansen MH, Hauge-Iversen IM, Zhang L, Sadredini M, Erusappan PM, Sjaastad I, Christensen G, Haugaa KH, Edvardsen T, Lunde IG, Stokke MK (2023)
Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice
Am J Physiol Heart Circ Physiol, 324 (6), H881-H892
DOI 10.1152/ajpheart.00701.2022, PubMed 37115627

Berger SG, Witczak BN, Reiseter S, Schwartz T, Andersson H, Hetlevik SO, Berntsen KS, Sanner H, Lilleby V, Gunnarsson R, Molberg Ø, Sjaastad I, Stokke MK (2023)
Cardiac dysfunction in mixed connective tissue disease: a nationwide observational study
Rheumatol Int, 43 (6), 1055-1065
DOI 10.1007/s00296-023-05308-3, PubMed 36933069

Blom KB, Birkeland GK, Midtvedt K, Jenssen TG, Reisæter AV, Rollag H, Hartmann A, Sagedal S, Sjaastad I, Tylden G, Njølstad G, Nilsen E, Christensen A, Åsberg A, Birkeland JA (2023)
Cytomegalovirus High-risk Kidney Transplant Recipients Show No Difference in Long-term Outcomes Following Preemptive Versus Prophylactic Management
Transplantation, 107 (8), 1846-1853
DOI 10.1097/TP.0000000000004615, PubMed 37211633

Hou Y, Laasmaa M, Li J, Shen X, Manfra O, Norden ES, Le C, Zhang L, Sjaastad I, Jones PP, Soeller C, Louch WE (2023)
Live-cell photo-activated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Nat Cardiovasc Res, 2 (3), 251-267
DOI 10.1038/s44161-022-00199-2, PubMed 38803363

Marstein HS, Witczak BN, Godang K, Olarescu NC, Schwartz T, Flatø B, Molberg Ø, Bollerslev J, Sjaastad I, Sanner H (2023)
Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
RMD Open, 9 (1)
DOI 10.1136/rmdopen-2022-002815, PubMed 36828644

Marstein HS, Witczak BN, Godang K, Schwartz T, Flatø B, Bollerslev J, Sjaastad I, Sanner H (2023)
Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis
Rheumatology (Oxford), 62 (SI2), SI196-SI204
DOI 10.1093/rheumatology/keac293, PubMed 35575380

Nordén ES, Veras I, Yadav P, Løken K, Dishington H, Thorstensen C, Sjaastad I, Rasmussen H (2023)
Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery
Lab Anim, 58 (1), 34-43
DOI 10.1177/00236772231178417, PubMed 37669442

Sasi A, Romaine A, Erusappan PM, Melleby AO, Hasic A, Dahl CP, Broch K, Almaas VM, Puertas RD, Roderick HL, Lunde IG, Sjaastad I, Vistnes M, Christensen G (2023)
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development
Matrix Biol Plus, 19-20, 100135
DOI 10.1016/j.mbplus.2023.100135, PubMed 38076279

Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM (2023)
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
DOI 10.1161/CIRCULATIONAHA.121.054168, PubMed 36876489

Tønnessen TC, Ueland T, Ahmed MS, Attramadal H, Sjaastad I, Vinge LE (2023)
Inflammatory augmentation of the delayed type hypersensitivity arthritis mouse model
Basic Clin Pharmacol Toxicol, 132 (6), 551-555
DOI 10.1111/bcpt.13864, PubMed 36946742

Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G (2023)
Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
Cardiovasc Res, 119 (10), 1915-1927
DOI 10.1093/cvr/cvad078, PubMed 37216909

Publications 2022

Harbo MB, Stokke MK, Sjaastad I, Espe EKS (2022)
One step closer to myocardial physiology: From PV loop analysis to state-of-the-art myocardial imaging
Acta Physiol (Oxf), 234 (2), e13759
DOI 10.1111/apha.13759, PubMed 34978759

Haugsten Hansen M, Sadredini M, Hasic A, Anderson ME, Sjaastad I, Korseberg Stokke M (2022)
CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor
J Mol Cell Cardiol, 175, 49-61
DOI 10.1016/j.yjmcc.2022.12.002, PubMed 36528076

Lunde IG, Aronsen JM, Melleby AO, Strand ME, Skogestad J, Bendiksen BA, Ahmed MS, Sjaastad I, Attramadal H, Carlson CR, Christensen G (2022)
Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy
Mol Biol Rep, 49 (12), 11795-11809
DOI 10.1007/s11033-022-07985-y, PubMed 36205855

Lunde IG, Skrbic B, Sjaastad I, Christensen G, Carlson CR, Tønnessen T (2022)
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement
Front Mol Med, 2, 980717
DOI 10.3389/fmmed.2022.980717, PubMed 39086965

Lunde IG, Skrbic B, Sjaastad I, Christensen G, Carlson CR, Tønnessen T (2022)
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement
Front Mol Med, 2, 1-14
DOI 10.3389/fmmed.2022.980717, PublikaID 435

Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG (2022)
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail, 10 (2), 858-871
DOI 10.1002/ehf2.14234, PubMed 36444917

Robinson EL, Drawnel FM, Mehdi S, Archer CR, Liu W, Okkenhaug H, Alkass K, Aronsen JM, Nagaraju CK, Sjaastad I, Sipido KR, Bergmann O, Arthur JSC, Wang X, Roderick HL (2022)
MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy
Cells, 11 (4)
DOI 10.3390/cells11040604, PubMed 35203255

Romaine A, Melleby AO, Alam J, Lobert VH, Lu N, Lockwood FE, Hasic A, Lunde IG, Sjaastad I, Stenmark H, Herum KM, Gullberg D, Christensen G (2022)
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
DOI 10.1152/ajpheart.00635.2021, PubMed 35522553

Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG (2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599

Shen X, van den Brink J, Bergan-Dahl A, Kolstad TR, Norden ES, Hou Y, Laasmaa M, Aguilar-Sanchez Y, Quick AP, Espe EKS, Sjaastad I, Wehrens XHT, Edwards AG, Soeller C, Louch WE (2022)
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Elife, 11
DOI 10.7554/eLife.77725, PubMed 35913125

Smith L, Skulberg V, Zhang L, Sjaastad I, Espe E (2022)
The effects of geometry on stiffness measurements in high-field magnetic resonance elastography: A study on rodent cardiac phantoms
J Mech Behav Biomed Mater, 133, 105302
DOI 10.1016/j.jmbbm.2022.105302, PubMed 35688038

Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, Christensen G, Carlson CR (2022)
The female syndecan-4^-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
DOI 10.3389/fcell.2022.908126, PubMed 36092718

Tønnessen TC, Melleby AO, Hauge-Iversen IM, Espe EKS, Ahmed MS, Ueland T, Haavardsholm EA, Atkinson SM, Melum E, Attramadal H, Sjaastad I, Vinge LE (2022)
Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice
PLoS One, 17 (1), e0262821
DOI 10.1371/journal.pone.0262821, PubMed 35077491

Udjus C, Sjaastad I, Hjørnholm U, Tunestveit TK, Hoffmann P, Hinojosa A, Espe EKS, Christensen G, Skjønsberg OH, Larsen KO, Rostrup M (2022)
Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers
Physiol Rep, 10 (3), e15184
DOI 10.14814/phy2.15184, PubMed 35146955

Witczak BN, Bollerslev J, Godang K, Schwartz T, Flatø B, Molberg Ø, Sjaastad I, Sanner H (2022)
Body composition in long-standing juvenile dermatomyositis: associations with disease activity, muscle strength and cardiometabolic measures
Rheumatology (Oxford), 61 (7), 2959-2968
DOI 10.1093/rheumatology/keab805, PubMed 34718443

Witczak BN, Schwartz T, Barth Z, Taraldsrud E, Lund MB, Aaløkken TM, Flatø B, Sjaastad I, Sanner H (2022)
Associations between cardiac and pulmonary involvement in patients with juvenile dermatomyositis-a cross-sectional study
Rheumatol Int, 42 (7), 1213-1220
DOI 10.1007/s00296-021-05071-3, PubMed 34984516

Publications 2021

Bendiksen BA, McGinley G, Sjaastad I, Zhang L, Espe EKS (2021)
A 4D continuous representation of myocardial velocity fields from tissue phase mapping magnetic resonance imaging
PLoS One, 16 (3), e0247826
DOI 10.1371/journal.pone.0247826, PubMed 33647070

Berger SG, Sjaastad I, Stokke MK (2021)
Right ventricular involvement in hypertrophic cardiomyopathy: evidence and implications from current literature
Scand Cardiovasc J, 55 (4), 195-204
DOI 10.1080/14017431.2021.1901979, PubMed 33759664

Blom KB, Åsberg A, Sjaastad I, Kalleberg KT, Søraas A, Midtvedt K, Birkeland JA (2021)
Kidney Transplant Recipient Behavior During the Early COVID-19 Pandemic: A National Survey Study in Norway
Kidney Med, 4 (2), 100389
DOI 10.1016/j.xkme.2021.09.006, PubMed 34805967

Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703

Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca²⁺ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394

Edwards AG, Mørk H, Stokke MK, Lipsett DB, Sjaastad I, Richard S, Sejersted OM, Louch WE (2021)
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front Physiol, 12, 744730
DOI 10.3389/fphys.2021.744730, PubMed 34712150

Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397

Marstein HS, Godang K, Flatø B, Sjaastad I, Bollerslev J, Sanner H (2021)
Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study
Pediatr Rheumatol Online J, 19 (1), 56
DOI 10.1186/s12969-021-00543-z, PubMed 33902632

Nordén ES, Bendiksen BA, Andresen H, Bergo KK, Espe EK, Hasic A, Hauge-Iversen IM, Veras I, Hussain RI, Sjaastad I, Christensen G, Cataliotti A (2021)
Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
ESC Heart Fail, 8 (2), 918-927
DOI 10.1002/ehf2.13177, PubMed 33497525

Sadredini M, Haugsten Hansen M, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK (2021)
CaMKII inhibition has dual effects on spontaneous Ca²⁺ release and Ca²⁺ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
Am J Physiol Heart Circ Physiol, 321 (2), H446-H460
DOI 10.1152/ajpheart.00011.2021, PubMed 34270372

Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK (2021)
The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1
Physiol Rep, 9 (18), e15030
DOI 10.14814/phy2.15030, PubMed 34558218

Wanichawan P, Skogestad J, Lunde M, Støle TP, Stensland M, Nyman TA, Sjaastad I, Sejersted OM, Aronsen JM, Carlson CR (2021)
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
Front Pharmacol, 12, 638646
DOI 10.3389/fphar.2021.638646, PubMed 34163352

Publications 2020

Berntsen KS, Raastad T, Marstein H, Kirkhus E, Merckoll E, Cumming KT, Flatø B, Sjaastad I, Sanner H (2020)
Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis: A Controlled Cross-Sectional Study
Arthritis Rheumatol, 72 (5), 837-848
DOI 10.1002/art.41174, PubMed 31746550

Espe EKS, Bendiksen BA, Zhang L, Sjaastad I (2020)
Analysis of right ventricular mass from magnetic resonance imaging data: a simple post-processing algorithm for correction of partial-volume effects
Am J Physiol Heart Circ Physiol, 320 (2), H912-H922
DOI 10.1152/ajpheart.00494.2020, PubMed 33337965

González A, Nome CG, Bendiksen BA, Sjaastad I, Zhang L, Aleksandersen M, Taubøll E, Aurlien D, Heuser K (2020)
Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy
Epilepsy Res, 161, 106300
DOI 10.1016/j.eplepsyres.2020.106300, PubMed 32126491

Harbo MB, Nordén ES, Narula J, Sjaastad I, Espe EKS (2020)
Quantifying left ventricular function in heart failure: What makes a clinically valuable parameter?
Prog Cardiovasc Dis, 63 (5), 552-560
DOI 10.1016/j.pcad.2020.05.007, PubMed 32502560

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Longobardi S, Lewalle A, Coveney S, Sjaastad I, Espe EKS, Louch WE, Musante CJ, Sher A, Niederer SA (2020)
Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats
Philos Trans A Math Phys Eng Sci, 378 (2173), 20190334
DOI 10.1098/rsta.2019.0334, PubMed 32448071

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Marstein H, Schwartz T, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H (2020)
Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease
Rheumatology (Oxford), 59 (8), 1862-1870
DOI 10.1093/rheumatology/kez531, PubMed 31740970

Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T (2020)
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 145 (3), 187-198
DOI 10.1159/000505318, PubMed 31968347

Rønning SB, Carlson CR, Aronsen JM, Pisconti A, Høst V, Lunde M, Liland KH, Sjaastad I, Kolset SO, Christensen G, Pedersen ME (2020)
Syndecan-4^-/- Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
Front Cell Dev Biol, 8, 730
DOI 10.3389/fcell.2020.00730, PubMed 32850844

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F (2020)
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res, 116 (1), 78-90
DOI 10.1093/cvr/cvz087, PubMed 30949686

Sokolova M, Yang K, Hansen SH, Louwe MC, Kummen M, Hov JER, Sjaastad I, Berge RK, Halvorsen B, Aukrust P, Yndestad A, Ranheim T (2020)
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482

Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE (2020)
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641, PubMed 32070187

Publications 2019

Barth Z, Schwartz T, Flatø B, Aaløkken TM, Koller A, Lund MB, Sjaastad I, Sanner H (2019)
Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium to Longstanding Juvenile Dermatomyositis
Arthritis Care Res (Hoboken), 71 (4), 492-497
DOI 10.1002/acr.23687, PubMed 29953739

Berntsen KS, Edvardsen E, Hansen BH, Flatø B, Sjaastad I, Sanner H (2019)
Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease
Rheumatology (Oxford), 58 (3), 492-501
DOI 10.1093/rheumatology/key342, PubMed 30508195

Blom KB, Bergo KK, Espe EKS, Rosseland V, Grøtta OJ, Mjøen G, Åsberg A, Bergan S, Sanner H, Bergersen TK, Bjørnerheim R, Skauby M, Seljeflot I, Waldum-Grevbo B, Dahle DO, Sjaastad I, Birkeland JA (2019)
Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study
Blood Press, 29 (2), 123-134
DOI 10.1080/08037051.2019.1684817, PubMed 31718316

Espe EKS, Aronsen JM, Nordén ES, Zhang L, Sjaastad I (2019)
Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain
Am J Physiol Heart Circ Physiol, 318 (1), H143-H153
DOI 10.1152/ajpheart.00357.2019, PubMed 31774693

Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE (2019)
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J Physiol, 597 (7), 1833-1853
DOI 10.1113/JP277273, PubMed 30707448

Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR (2019)
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423, PubMed 30967474

McGinley G, Bendiksen BA, Zhang L, Aronsen JM, Nordén ES, Sjaastad I, Espe EKS (2019)
Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding
PLoS One, 14 (7), e0218874
DOI 10.1371/journal.pone.0218874, PubMed 31276508

Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T (2019)
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9 (1), 9206
DOI 10.1038/s41598-019-45651-9, PubMed 31235849

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca²⁺-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE (2019)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410

Skogestad J, Lines GT, Louch WE, Sejersted OM, Sjaastad I, Aronsen JM (2019)
Evidence for heterogeneous subsarcolemmal Na⁺ levels in rat ventricular myocytes
Am J Physiol Heart Circ Physiol, 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018, PubMed 30657726

Sokolova M, Sjaastad I, Louwe MC, Alfsnes K, Aronsen JM, Zhang L, Haugstad SB, Bendiksen BA, Øgaard J, Bliksøen M, Lien E, Berge RK, Aukrust P, Ranheim T, Yndestad A (2019)
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
Front Immunol, 10, 1621
DOI 10.3389/fimmu.2019.01621, PubMed 31379826

Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO (2019)
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, 316 (6), L999-L1012
DOI 10.1152/ajplung.00322.2018, PubMed 30908936

Witczak BN, Hetlevik SO, Sanner H, Barth Z, Schwartz T, Flatø B, Lilleby V, Sjaastad I (2019)
Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study
J Rheumatol, 46 (7), 739-747
DOI 10.3899/jrheum.180526, PubMed 30877222

Publications 2018

Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T (2018)
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422, PubMed 30052659

Barth Z, Witczak BN, Flatø B, Koller A, Sjaastad I, Sanner H (2018)
Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium- to Long-Term Followup
Arthritis Care Res (Hoboken), 70 (5), 768-776
DOI 10.1002/acr.23338, PubMed 28805016

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK (2018)
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100, PubMed 30399185

Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE (2018)
Ryanodine receptor dispersion disrupts Ca²⁺ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G (2018)
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141, PubMed 29878127

Publications 2017

Aronsen JM, Espe EKS, Skårdal K, Hasic A, Zhang L, Sjaastad I (2017)
Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography
Am J Physiol Heart Circ Physiol, 312 (5), H932-H942
DOI 10.1152/ajpheart.00668.2016, PubMed 28188213

Berntsen KS, Tollisen A, Schwartz T, Kirkhus E, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H (2017)
Submaximal Exercise Capacity in Juvenile Dermatomyositis after Longterm Disease: The Contribution of Muscle, Lung, and Heart Involvement
J Rheumatol, 44 (6), 827-834
DOI 10.3899/jrheum.160997, PubMed 28365577

Dhondup Y, Sjaastad I, Sandanger Ø, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang L, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840

Espe EKS, Aronsen JM, Eriksen M, Sejersted OM, Zhang L, Sjaastad I (2017)
Regional Dysfunction After Myocardial Infarction in Rats
Circ Cardiovasc Imaging, 10 (9)
DOI 10.1161/CIRCIMAGING.116.005997, PubMed 28838960

Gattoni S, Røe ÅT, Aronsen JM, Sjaastad I, Louch WE, Smith NP, Niederer SA (2017)
Compensatory and decompensatory alterations in cardiomyocyte Ca²⁺ dynamics in hearts with diastolic dysfunction following aortic banding
J Physiol, 595 (12), 3867-3889
DOI 10.1113/JP273879, PubMed 28542952

Johansen IB, Sandblom E, Skov PV, Gräns A, Ekström A, Lunde IG, Vindas MA, Zhang L, Höglund E, Frisk M, Sjaastad I, Nilsson GE, Øverli Ø (2017)
Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids
J Exp Biol, 220 (Pt 14), 2545-2553
DOI 10.1242/jeb.135046, PubMed 28476893

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766

Manner IW, Waldum-Grevbo B, Witczak BN, Bækken M, Øktedalen O, Os I, Schwartz T, Sjaastad I (2017)
Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients
Blood Press, 26 (6), 332-340
DOI 10.1080/08037051.2017.1346459, PubMed 28675304

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR (2017)
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014, PubMed 28697992

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Ottesen AH, Carlson CR, Louch WE, Dahl MB, Sandbu RA, Johansen RF, Jarstadmarken H, Bjørås M, Høiseth AD, Brynildsen J, Sjaastad I, Stridsberg M, Omland T, Christensen G, Røsjø H (2017)
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766

Roe AT, Sjaastad I, Louch WE (2017)
Heart failure with preserved ejection fraction
Tidsskr. Nor. Laegeforen., 137 (18), 1426-1431

Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D (2017)
Overexpression of integrin α11 induces cardiac fibrosis in mice
Acta Physiol (Oxf), 222 (2)
DOI 10.1111/apha.12932, PubMed 28771943

Røe ÅT, Aronsen JM, Skårdal K, Hamdani N, Linke WA, Danielsen HE, Sejersted OM, Sjaastad I, Louch WE (2017)
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc Res, 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087, PubMed 28472418

Røe ÅT, Sjaastad I, Louch WE (2017)
Heart failure with preserved ejection fraction
Tidsskr Nor Laegeforen, 137 (18)
DOI 10.4045/tidsskr.16.1068, PubMed 28972354

Publications 2016

Aronsen JM, Louch WE, Sjaastad I (2016)
Cardiomyocyte Ca2+ dynamics: clinical perspectives
Scand Cardiovasc J, 50 (2), 65-77
DOI 10.3109/14017431.2015.1136079, PubMed 26729487

Dhondup Y, Ueland T, Dahl CP, Askevold ET, Sandanger Ø, Fiane A, Ohm IK, Sjaastad I, Finsen AV, Wæhre A, Gullestad L, Aukrust P, Yndestad A, Vinge LE (2016)
Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure
J Card Fail, 22 (10), 823-8
DOI 10.1016/j.cardfail.2016.06.013, PubMed 27349571

Espe EKS, Skårdal K, Aronsen JM, Zhang L, Sjaastad I (2016)
A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data
Magn Reson Med, 78 (3), 1199-1207
DOI 10.1002/mrm.26486, PubMed 27699840

Frisk M, Ruud M, Espe EK, Aronsen JM, Røe ÅT, Zhang L, Norseng PA, Sejersted OM, Christensen GA, Sjaastad I, Louch WE (2016)
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc Res, 112 (1), 443-51
DOI 10.1093/cvr/cvw111, PubMed 27226008

Hortemo KH, Lunde PK, Anonsen JH, Kvaløy H, Munkvik M, Rehn TA, Sjaastad I, Lunde IG, Aronsen JM, Sejersted OM (2016)
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle
Physiol Rep, 4 (18)
DOI 10.14814/phy2.12896, PubMed 27664189

Logantha SJ, Stokke MK, Atkinson AJ, Kharche SR, Parveen S, Saeed Y, Sjaastad I, Sejersted OM, Dobrzynski H (2016)
Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Front Physiol, 7, 197
DOI 10.3389/fphys.2016.00197, PubMed 27313537

Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK (2016)
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
Cardiovasc Res, 111 (3), 295-306
DOI 10.1093/cvr/cvw095, PubMed 27161030

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG (2016)
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079, PubMed 27768722

Sadredini M, Danielsen TK, Aronsen JM, Manotheepan R, Hougen K, Sjaastad I, Stokke MK (2016)
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887, PubMed 27096943

Schwartz T, Diederichsen LP, Lundberg IE, Sjaastad I, Sanner H (2016)
Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies
RMD Open, 2 (2), e000291
DOI 10.1136/rmdopen-2016-000291, PubMed 27752355

Skårdal K, Espe EK, Zhang L, Aronsen JM, Sjaastad I (2016)
Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance
PLoS One, 11 (3), e0150536
DOI 10.1371/journal.pone.0150536, PubMed 26930073

Thienpont B, Aronsen JM, Robinson EL, Okkenhaug H, Loche E, Ferrini A, Brien P, Alkass K, Tomasso A, Agrawal A, Bergmann O, Sjaastad I, Reik W, Roderick HL (2016)
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
J Clin Invest, 127 (1), 335-348
DOI 10.1172/JCI88353, PubMed 27893464

Publications 2015

Barth Z, Nomeland Witczak B, Schwartz T, Gjesdal K, Flatø B, Koller A, Sanner H, Sjaastad I (2015)
In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years after symptom onset
Rheumatology (Oxford), 55 (3), 535-43
DOI 10.1093/rheumatology/kev376, PubMed 26500284

Bolstad I, Andreassen OA, Groote I, Server A, Sjaastad I, Kapur S, Jensen J (2015)
Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study
Eur Neuropsychopharmacol, 25 (12), 2252-61
DOI 10.1016/j.euroneuro.2015.09.016, PubMed 26476705

Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH (2015)
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
Am J Physiol Lung Cell Mol Physiol, 309 (4), L378-87
DOI 10.1152/ajplung.00342.2014, PubMed 26071556

Dhondup Y, Sjaastad I, Scott H, Sandanger Ø, Zhang L, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521

Espe EK, Aronsen JM, Eriksen GS, Zhang L, Smiseth OA, Edvardsen T, Sjaastad I, Eriksen M (2015)
Assessment of regional myocardial work in rats
Circ Cardiovasc Imaging, 8 (2), e002695
DOI 10.1161/CIRCIMAGING.114.002695, PubMed 25673647

Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR (2015)
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322

Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, Linke WA, Gomez MF, Christensen G (2015)
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Cardiovasc Res, 106 (2), 217-26
DOI 10.1093/cvr/cvv002, PubMed 25587045

Hortemo KH, Aronsen JM, Lunde IG, Sjaastad I, Lunde PK, Sejersted OM (2015)
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
Physiol Rep, 3 (2)
DOI 10.14814/phy2.12285, PubMed 25713325

Krohn-Hansen D, Zhang L, Haaskjold E, Meling TR, Nicolaissen B, Sjaastad I (2015)
Surgical anatomy of the superior orbit on ultra-high-resolution MRI at 9.4 Tesla
J Plast Surg Hand Surg, 49 (5), 284-288
DOI 10.3109/2000656X.2015.1041969, PubMed 25946966

Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793

Ottesen AH, Louch WE, Carlson CR, Landsverk OJB, Kurola J, Johansen RF, Moe MK, Aronsen JM, Høiseth AD, Jarstadmarken H, Nygård S, Bjørås M, Sjaastad I, Pettilä V, Stridsberg M, Omland T, Christensen G, Røsjø H (2015)
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832

Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bjørnstad JL, Tønnessen T (2015)
Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
Cardiovasc Res, 106 (1), 32-42
DOI 10.1093/cvr/cvv041, PubMed 25694587

Strand ME, Aronsen JM, Braathen B, Sjaastad I, Kvaløy H, Tønnessen T, Christensen G, Lunde IG (2015)
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice
J Mol Cell Cardiol, 88, 133-44
DOI 10.1016/j.yjmcc.2015.10.003, PubMed 26449522

Zoccarato A, Surdo NC, Aronsen JM, Fields LA, Mancuso L, Dodoni G, Stangherlin A, Livie C, Jiang H, Sin YY, Gesellchen F, Terrin A, Baillie GS, Nicklin SA, Graham D, Szabo-Fresnais N, Krall J, Vandeput F, Movsesian M, Furlan L, Corsetti V, Hamilton G, Lefkimmiatis K, Sjaastad I, Zaccolo M (2015)
Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2
Circ Res, 117 (8), 707-19
DOI 10.1161/CIRCRESAHA.114.305892, PubMed 26243800

Publications 2014

Aronsen JM, Skogestad J, Lewalle A, Louch WE, Hougen K, Stokke MK, Swift F, Niederer S, Smith NP, Sejersted OM, Sjaastad I (2014)
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299

Boardman NT, Aronsen JM, Louch WE, Sjaastad I, Willoch F, Christensen G, Sejersted O, Aasum E (2014)
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am J Physiol Heart Circ Physiol, 306 (7), H1018-24
DOI 10.1152/ajpheart.00741.2013, PubMed 24486508

Engebretsen KV, Skårdal K, Bjørnstad S, Marstein HS, Skrbic B, Sjaastad I, Christensen G, Bjørnstad JL, Tønnessen T (2014)
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
J Mol Cell Cardiol, 76, 148-57
DOI 10.1016/j.yjmcc.2014.08.008, PubMed 25169971

Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A (2014)
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172, PubMed 25398010

Hillestad V, Espe EK, Cero F, Larsen KO, Sjaastad I, Nygård S, Skjønsberg OH, Christensen G (2014)
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice
Acta Physiol (Oxf), 213 (2), 492-504
DOI 10.1111/apha.12376, PubMed 25182570

Manotheepan R, Saberniak J, Danielsen TK, Edvardsen T, Sjaastad I, Haugaa KH, Stokke MK (2014)
Effects of individualized exercise training in patients with catecholaminergic polymorphic ventricular tachycardia type 1
Am J Cardiol, 113 (11), 1829-33
DOI 10.1016/j.amjcard.2014.03.012, PubMed 24837260

Melsom CB, Hussain RI, Ørstavik Ø, Aronsen JM, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA (2014)
Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Naunyn Schmiedebergs Arch Pharmacol, 387 (12), 1177-86
DOI 10.1007/s00210-014-1036-7, PubMed 25216690

Moltzau LR, Aronsen JM, Meier S, Skogestad J, Ørstavik Ø, Lothe GB, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle
J Pharmacol Exp Ther, 350 (3), 681-90
DOI 10.1124/jpet.114.214882, PubMed 25022512

Moltzau LR, Meier S, Aronsen JM, Afzal F, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn Schmiedebergs Arch Pharmacol, 387 (5), 407-17
DOI 10.1007/s00210-013-0953-1, PubMed 24424715

Nordbø O, Lamata P, Land S, Niederer S, Aronsen JM, Louch WE, Sjaastad I, Martens H, Gjuvsland AB, Tøndel K, Torp H, Lohezic M, Schneider JE, Remme EW, Smith N, Omholt SW, Vik JO (2014)
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018

Sanner H, Schwartz T, Flatø B, Vistnes M, Christensen G, Sjaastad I (2014)
Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage
PLoS One, 9 (3), e92171
DOI 10.1371/journal.pone.0092171, PubMed 24647150

Sanner H, Sjaastad I, Flatø B (2014)
Disease activity and prognostic factors in juvenile dermatomyositis: a long-term follow-up study applying the Paediatric Rheumatology International Trials Organization criteria for inactive disease and the myositis disease activity assessment tool
Rheumatology (Oxford), 53 (9), 1578-85
DOI 10.1093/rheumatology/keu146, PubMed 24692575

Schwartz T, Sjaastad I, Flatø B, Vistnes M, Christensen G, Sanner H (2014)
In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction
Rheumatology (Oxford), 53 (12), 2214-22
DOI 10.1093/rheumatology/keu256, PubMed 24996906

Vistnes M, Aronsen JM, Lunde IG, Sjaastad I, Carlson CR, Christensen G (2014)
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding
PLoS One, 9 (3), e89621
DOI 10.1371/journal.pone.0089621, PubMed 24595230

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645

Publications 2013

Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T (2013)
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli
FEBS J, 280 (10), 2382-98
DOI 10.1111/febs.12235, PubMed 23480731

Engebretsen KV, Waehre A, Bjørnstad JL, Skrbic B, Sjaastad I, Behmen D, Marstein HS, Yndestad A, Aukrust P, Christensen G, Tønnessen T (2013)
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse
J Appl Physiol (1985), 114 (8), 988-97
DOI 10.1152/japplphysiol.00793.2012, PubMed 23412898

Espe EK, Aronsen JM, Skårdal K, Schneider JE, Zhang L, Sjaastad I (2013)
Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance
J Cardiovasc Magn Reson, 15 (1), 82
DOI 10.1186/1532-429X-15-82, PubMed 24034168

Espe EK, Zhang L, Sjaastad I (2013)
Unwrapping eddy current compensation: improved compensation of eddy current induced baseline shifts in high-resolution phase-contrast MRI at 9.4 Tesla
Magn Reson Med, 72 (4), 1096-102
DOI 10.1002/mrm.25023, PubMed 24264935

Land S, Louch WE, Niederer SA, Aronsen JM, Christensen G, Sjaastad I, Sejersted OM, Smith NP (2013)
Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice
Biophys J, 104 (6), 1349-56
DOI 10.1016/j.bpj.2013.01.042, PubMed 23528094

Louch WE, Hake J, Mørk HK, Hougen K, Skrbic B, Ursu D, Tønnessen T, Sjaastad I, Sejersted OM (2013)
Slow Ca²⁺ sparks de-synchronize Ca²⁺ release in failing cardiomyocytes: evidence for altered configuration of Ca²⁺ release units?
J Mol Cell Cardiol, 58, 41-52
DOI 10.1016/j.yjmcc.2013.01.014, PubMed 23376034

Moltzau LR, Aronsen JM, Meier S, Nguyen CH, Hougen K, Ørstavik Ø, Sjaastad I, Christensen G, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2013)
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br J Pharmacol, 170 (2), 366-79
DOI 10.1111/bph.12282, PubMed 23808942

Schwartz T, Sanner H, Gjesdal O, Flatø B, Sjaastad I (2013)
In juvenile dermatomyositis, cardiac systolic dysfunction is present after long-term follow-up and is predicted by sustained early skin activity
Ann Rheum Dis, 73 (10), 1805-10
DOI 10.1136/annrheumdis-2013-203279, PubMed 23881732

Slettalokken G, Rehn TA, Munkvik M, Rud B, Nymark BS, Lunde PK, Sjaastad I, Sejersted OM, Hallen J (2013)
Normal training response in skeletal muscle of post-infarction heart failure patients
Eur. J. Sport Sci., 13 (2), 231-239
DOI 10.1080/17461391.2011.624197

Solberg A, Robertson AB, Aronsen JM, Rognmo Ø, Sjaastad I, Wisløff U, Klungland A (2013)
Deletion of mouse Alkbh7 leads to obesity
J Mol Cell Biol, 5 (3), 194-203
DOI 10.1093/jmcb/mjt012, PubMed 23572141

Stokke MK, Tovsrud N, Louch WE, Øyehaug L, Hougen K, Sejersted OM, Swift F, Sjaastad I (2013)
I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation
Cardiovasc Res, 98 (2), 315-25
DOI 10.1093/cvr/cvt037, PubMed 23417043

Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG (2013)
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart
FEBS J, 280 (10), 2228-47
DOI 10.1111/febs.12161, PubMed 23374111

Øyehaug L, Loose KØ, Jølle GF, Røe ÅT, Sjaastad I, Christensen G, Sejersted OM, Louch WE (2013)
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity
Biophys J, 104 (8), 1685-97
DOI 10.1016/j.bpj.2013.03.022, PubMed 23601316

Publications 2012

Brattelid T, Qvigstad E, Moltzau LR, Bekkevold SV, Sandnes DL, Birkeland JA, Skomedal T, Osnes JB, Sjaastad I, Levy FO (2012)
The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure
PLoS One, 7 (9), e45489
DOI 10.1371/journal.pone.0045489, PubMed 23029047

Drawnel FM, Wachten D, Molkentin JD, Maillet M, Aronsen JM, Swift F, Sjaastad I, Liu N, Catalucci D, Mikoshiba K, Hisatsune C, Okkenhaug H, Andrews SR, Bootman MD, Roderick HL (2012)
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
J Cell Biol, 199 (5), 783-98
DOI 10.1083/jcb.201111095, PubMed 23166348

Espe EK, Aronsen JM, Skrbic B, Skulberg VM, Schneider JE, Sejersted OM, Zhang L, Sjaastad I (2012)
Improved MR phase-contrast velocimetry using a novel nine-point balanced motion-encoding scheme with increased robustness to eddy current effects
Magn Reson Med, 69 (1), 48-61
DOI 10.1002/mrm.24226, PubMed 22392844

Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G (2012)
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress
J Mol Cell Cardiol, 54, 73-81
DOI 10.1016/j.yjmcc.2012.11.006, PubMed 23178899

Hussain RI, Aronsen JM, Afzal F, Sjaastad I, Osnes JB, Skomedal T, Levy FO, Krobert KA (2012)
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle
J Mol Cell Cardiol, 56, 129-38
DOI 10.1016/j.yjmcc.2012.11.015, PubMed 23220156

Land S, Niederer SA, Aronsen JM, Espe EK, Zhang L, Louch WE, Sjaastad I, Sejersted OM, Smith NP (2012)
An analysis of deformation-dependent electromechanical coupling in the mouse heart
J Physiol, 590 (18), 4553-69
DOI 10.1113/jphysiol.2012.231928, PubMed 22615436

Louch WE, Stokke MK, Sjaastad I, Christensen G, Sejersted OM (2012)
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium
Physiology (Bethesda), 27 (5), 308-23
DOI 10.1152/physiol.00021.2012, PubMed 23026754

Rehn TA, Munkvik M, Lunde PK, Sjaastad I, Sejersted OM (2012)
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?
Heart Fail Rev, 17 (3), 421-36
DOI 10.1007/s10741-011-9289-4, PubMed 21996779

Røsjø H, Stridsberg M, Florholmen G, Stensløkken KO, Ottesen AH, Sjaastad I, Husberg C, Dahl MB, Øie E, Louch WE, Omland T, Christensen G (2012)
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties
PLoS One, 7 (5), e37401
DOI 10.1371/journal.pone.0037401, PubMed 22655045

Schwartz T, Magdi G, Steen TW, Sjaastad I (2012)
HIV as a risk factor for cardiac disease in Botswana: a cross-sectional study
Int Health, 4 (1), 30-7
DOI 10.1016/j.inhe.2011.12.003, PubMed 24030878

Skrbic B, Bjørnstad JL, Marstein HS, Carlson CR, Sjaastad I, Nygård S, Bjørnstad S, Christensen G, Tønnessen T (2012)
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload
Matrix Biol, 32 (2), 133-42
DOI 10.1016/j.matbio.2012.11.011, PubMed 23220517

Stokke MK, Rivelsrud F, Sjaastad I, Sejersted OM, Swift F (2012)
From global to local: a new understanding of cardiac electromechanical coupling
Tidsskr Nor Laegeforen, 132 (12-13), 1457-60
DOI 10.4045/tidsskr.11.1353, PubMed 22766818

Waehre A, Vistnes M, Sjaastad I, Nygård S, Husberg C, Lunde IG, Aukrust P, Yndestad A, Vinge LE, Behmen D, Neukamm C, Brun H, Thaulow E, Christensen G (2012)
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
J Appl Physiol (1985), 112 (8), 1372-82
DOI 10.1152/japplphysiol.01350.2011, PubMed 22345433

Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Øie E, Vinge LE, Sjaastad I, Sandanger Ø, Ranheim T, Dickstein K, Kjekshus J, Damås JK, Fiane AE, Hilfiker-Kleiner D, Lipp M, Gullestad L, Christensen G, Aukrust P (2012)
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038, PubMed 22427939

Zalvidea S, André L, Loyer X, Cassan C, Sainte-Marie Y, Thireau J, Sjaastad I, Heymes C, Pasquié JL, Cazorla O, Aimond F, Richard S (2012)
ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction
Curr Mol Med, 12 (2), 206-17
DOI 10.2174/156652412798889045, PubMed 22280358

Publications 2011

Afzal F, Aronsen JM, Moltzau LR, Sjaastad I, Levy FO, Skomedal T, Osnes JB, Qvigstad E (2011)
Differential regulation of β2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle
Br J Pharmacol, 162 (1), 54-71
DOI 10.1111/j.1476-5381.2010.00890.x, PubMed 21133887

Afzal F, Qvigstad E, Aronsen JM, Moltzau LR, Sjaastad I, Skomedal T, Osnes JB, Levy FO (2011)
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
Naunyn Schmiedebergs Arch Pharmacol, 384 (6), 543-53
DOI 10.1007/s00210-011-0670-6, PubMed 21901315

Bjørnstad JL, Skrbic B, Marstein HS, Hasic A, Sjaastad I, Louch WE, Florholmen G, Christensen G, Tønnessen T (2011)
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovasc Res, 93 (1), 100-10
DOI 10.1093/cvr/cvr294, PubMed 22049534

Bjørnstad JL, Skrbic B, Sjaastad I, Bjørnstad S, Christensen G, Tønnessen T (2011)
A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta
Acta Physiol (Oxf), 205 (1), 92-102
DOI 10.1111/j.1748-1716.2011.02369.x, PubMed 21974781

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G (2011)
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302, PubMed 22164265

Hussain RI, Afzal F, Mørk HK, Aronsen JM, Sjaastad I, Osnes JB, Skomedal T, Levy FO, Krobert KA (2011)
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle
Br J Pharmacol, 162 (4), 908-16
DOI 10.1111/j.1476-5381.2010.01097.x, PubMed 21039419

Larsen KO, Yndestad A, Sjaastad I, Løberg EM, Goverud IL, Halvorsen B, Jia J, Andreassen AK, Husberg C, Jonasson S, Lipp M, Christensen G, Aukrust P, Skjønsberg OH (2011)
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation
Am J Physiol Lung Cell Mol Physiol, 301 (1), L50-9
DOI 10.1152/ajplung.00048.2010, PubMed 21498626

Lunde IG, Aronsen JM, Kvaløy H, Qvigstad E, Sjaastad I, Tønnessen T, Christensen G, Grønning-Wang LM, Carlson CR (2011)
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure
Physiol Genomics, 44 (2), 162-72
DOI 10.1152/physiolgenomics.00016.2011, PubMed 22128088

Munkvik M, Lunde PK, Aronsen JM, Birkeland JA, Sjaastad I, Sejersted OM (2011)
Attenuated fatigue in slow twitch skeletal muscle during isotonic exercise in rats with chronic heart failure
PLoS One, 6 (7), e22695
DOI 10.1371/journal.pone.0022695, PubMed 21799933

Russell K, Smiseth OA, Gjesdal O, Qvigstad E, Norseng PA, Sjaastad I, Opdahl A, Skulstad H, Edvardsen T, Remme EW (2011)
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block
Am J Physiol Heart Circ Physiol, 301 (6), H2334-43
DOI 10.1152/ajpheart.00644.2011, PubMed 21984549

Schwartz T, Sanner H, Husebye T, Flatø B, Sjaastad I (2011)
Cardiac dysfunction in juvenile dermatomyositis: a case-control study
Ann Rheum Dis, 70 (5), 766-71
DOI 10.1136/ard.2010.137968, PubMed 21216816

Stokke MK, Briston SJ, Jølle GF, Manzoor I, Louch WE, Øyehaug L, Christensen G, Eisner DA, Trafford AW, Sejersted OM, Sjaastad I (2011)
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content
Cardiovasc Res, 90 (3), 503-12
DOI 10.1093/cvr/cvr013, PubMed 21242164

Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygård S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G (2011)
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668, PubMed 21533157

Publications 2010

Aronsen JM, Birkeland JA, Munkvik M, Sjaastad I (2010)
Repeter!: sykdomslære
Gyldendal akademisk, Oslo, 2 b.
BIBSYS 102381445

Bjørnstad JL, Sjaastad I, Nygård S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G, Tønnessen T (2010)
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur Heart J, 32 (2), 236-45
DOI 10.1093/eurheartj/ehq166, PubMed 20525982

Ericsson M, Andersson KB, Amundsen BH, Torp SH, Sjaastad I, Christensen G, Sejersted OM, Ellingsen Ø (2010)
High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2
J Appl Physiol (1985), 108 (5), 1311-20
DOI 10.1152/japplphysiol.01133.2009, PubMed 20167673

Ericsson M, Sjåland C, Andersson KB, Sjaastad I, Christensen G, Sejersted OM, Ellingsen Ø (2010)
Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice
J Appl Physiol (1985), 109 (6), 1749-55
DOI 10.1152/japplphysiol.00282.2010, PubMed 20864565

Hougen K, Aronsen JM, Stokke MK, Enger U, Nygard S, Andersson KB, Christensen G, Sejersted OM, Sjaastad I (2010)
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice
Am J Physiol Heart Circ Physiol, 299 (5), H1671-8
DOI 10.1152/ajpheart.01155.2009, PubMed 20802136

Louch WE, Hake J, Jølle GF, Mørk HK, Sjaastad I, Lines GT, Sejersted OM (2010)
Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes
Biophys J, 99 (5), 1377-86
DOI 10.1016/j.bpj.2010.06.055, PubMed 20816049

Munkvik M, Rehn TA, Slettaløkken G, Hasic A, Hallén J, Sjaastad I, Sejersted OM, Lunde PK (2010)
Training effects on skeletal muscle calcium handling in human chronic heart failure
Med Sci Sports Exerc, 42 (5), 847-55
DOI 10.1249/MSS.0b013e3181c29ec1, PubMed 19996998

Røsjø H, Husberg C, Dahl MB, Stridsberg M, Sjaastad I, Finsen AV, Carlson CR, Oie E, Omland T, Christensen G (2010)
Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium
Circ Heart Fail, 3 (4), 503-11
DOI 10.1161/CIRCHEARTFAILURE.109.867747, PubMed 20519641

Sanner H, Aaløkken TM, Gran JT, Sjaastad I, Johansen B, Flatø B (2010)
Pulmonary outcome in juvenile dermatomyositis: a case-control study
Ann Rheum Dis, 70 (1), 86-91
DOI 10.1136/ard.2010.131433, PubMed 20805295

Slettaløkken G, Rehn TA, Munkvik M, Rud B, Sökjer-Petersen M, Lunde PK, Sjaastad I, Sejersted OM, Hallén J (2010)
Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients
Scand J Med Sci Sports, 22 (2), 199-206
DOI 10.1111/j.1600-0838.2010.01226.x, PubMed 20874858

Swift F, Tovsrud N, Sjaastad I, Sejersted OM, Niggli E, Egger M (2010)
Functional coupling of alpha(2)-isoform Na(+)/K(+)-ATPase and Ca(2+) extrusion through the Na(+)/Ca(2+)-exchanger in cardiomyocytes
Cell Calcium, 48 (1), 54-60
DOI 10.1016/j.ceca.2010.06.006, PubMed 20667414

Tømte Ø, Sjaastad I, Wik L, Kuzovlev A, Eriksen M, Norseng PA, Sunde K (2010)
Discriminating the effect of accelerated compression from accelerated decompression during high-impulse CPR in a porcine model of cardiac arrest
Resuscitation, 81 (4), 488-92
DOI 10.1016/j.resuscitation.2009.12.028, PubMed 20122780

Vistnes M, Waehre A, Nygård S, Sjaastad I, Andersson KB, Husberg C, Christensen G (2010)
Circulating cytokine levels in mice with heart failure are etiology dependent
J Appl Physiol (1985), 108 (5), 1357-64
DOI 10.1152/japplphysiol.01084.2009, PubMed 20224000

Publications 2009

Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G (2009)
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
J Mol Cell Cardiol, 47 (2), 180-7
DOI 10.1016/j.yjmcc.2009.03.013, PubMed 19328205

Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G (2009)
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models
Cell Calcium, 46 (3), 219-25
DOI 10.1016/j.ceca.2009.07.004, PubMed 19692123

Hussain RI, Qvigstad E, Birkeland JA, Eikemo H, Glende A, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA (2009)
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation
Br J Pharmacol, 156 (4), 575-86
DOI 10.1111/j.1750-3639.2009.00016.x, PubMed 19159405

Iversen PO, Andersson KB, Finsen AV, Sjaastad I, von Lueder TG, Sejersted OM, Attramadal H, Christensen G (2009)
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure
Am J Physiol Regul Integr Comp Physiol, 298 (3), R808-14
DOI 10.1152/ajpregu.00250.2009, PubMed 20032264

Kjekshus JK, Torp-Pedersen C, Gullestad L, Køber L, Edvardsen T, Olsen IC, Sjaastad I, Qvigstad E, Skomedal T, Osnes JB, Levy FO (2009)
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
Eur J Heart Fail, 11 (8), 771-8
DOI 10.1093/eurjhf/hfp087, PubMed 19567409

Louch WE, Hougen K, Mørk HK, Swift F, Aronsen JM, Sjaastad I, Reims HM, Roald B, Andersson KB, Christensen G, Sejersted OM (2009)
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J Physiol, 588 (Pt 3), 465-78
DOI 10.1113/jphysiol.2009.183517, PubMed 20008467

Mørk HK, Sjaastad I, Sejersted OM, Louch WE (2009)
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice
Am J Physiol Heart Circ Physiol, 296 (4), H1069-79
DOI 10.1152/ajpheart.01009.2008, PubMed 19201998

Qvigstad E, Moltzau LR, Aronsen JM, Nguyen CH, Hougen K, Sjaastad I, Levy FO, Skomedal T, Osnes JB (2009)
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovasc Res, 85 (4), 763-72
DOI 10.1093/cvr/cvp364, PubMed 19900965

Rehn TA, Borge BA, Lunde PK, Munkvik M, Sneve ML, Grøndahl F, Aronsen JM, Sjaastad I, Prydz K, Kolset SO, Wiig H, Sejersted OM, Iversen PO (2009)
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats
Am J Physiol Regul Integr Comp Physiol, 297 (1), R26-33
DOI 10.1152/ajpregu.90617.2008, PubMed 19339678

Sanner H, Gran JT, Sjaastad I, Flatø B (2009)
Cumulative organ damage and prognostic factors in juvenile dermatomyositis: a cross-sectional study median 16.8 years after symptom onset
Rheumatology (Oxford), 48 (12), 1541-7
DOI 10.1093/rheumatology/kep302, PubMed 19776224

Sharikabad MN, Aronsen JM, Haugen E, Pedersen J, Møller AS, Mørk HK, Aass HC, Sejersted OM, Sjaastad I, Brørs O (2009)
Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance
Am J Physiol Heart Circ Physiol, 296 (3), H787-95
DOI 10.1152/ajpheart.00796.2008, PubMed 19136604

Stokke MK, Hougen K, Sjaastad I, Louch WE, Briston SJ, Enger UH, Andersson KB, Christensen G, Eisner DA, Sejersted OM, Trafford AW (2009)
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc Res, 86 (1), 63-71
DOI 10.1093/cvr/cvp401, PubMed 20019150

Yndestad A, Larsen KO, Oie E, Ueland T, Smith C, Halvorsen B, Sjaastad I, Skjønsberg OH, Pedersen TM, Anfinsen OG, Damås JK, Christensen G, Aukrust P, Andreassen AK (2009)
Elevated levels of activin A in clinical and experimental pulmonary hypertension
J Appl Physiol (1985), 106 (4), 1356-64
DOI 10.1152/japplphysiol.90719.2008, PubMed 19196915

Publications 2008

Afzal F, Andressen KW, Mørk HK, Aronsen JM, Sjaastad I, Dahl CP, Skomedal T, Levy FO, Osnes JB, Qvigstad E (2008)
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br J Pharmacol, 155 (7), 1005-14
DOI 10.1038/bjp.2008.339, PubMed 18846035

Bøkenes J, Aronsen JM, Birkeland JA, Henriksen UL, Louch WE, Sjaastad I, Sejersted OM (2008)
Slow contractions characterize failing rat hearts
Basic Res Cardiol, 103 (4), 328-44
DOI 10.1007/s00395-008-0719-y, PubMed 18347833

Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G (2008)
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc Res, 80 (1), 47-54
DOI 10.1093/cvr/cvn180, PubMed 18599478

Swift F, Birkeland JA, Tovsrud N, Enger UH, Aronsen JM, Louch WE, Sjaastad I, Sejersted OM (2008)
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha2-isoform in heart failure
Cardiovasc Res, 78 (1), 71-8
DOI 10.1093/cvr/cvn013, PubMed 18203708

Swift F, Birkeland JAK, Tovsrud N, Enger UH, Aronsen JM, Louch WE, Sjaastad I, Sejersted OM (2008)
Altered Na(+)/Ca(2+)-exchanger activity due to downregulation of Na(+)/K(+)-ATPase alpha(2)-isoform in heart failure (vol 78, pg 71, 2008)
Cardiovasc. Res., 79 (2), 352
DOI 10.1093/cvr/cvn147

Publications 2007

Birkeland JA, Swift F, Tovsrud N, Enger U, Lunde PK, Qvigstad E, Levy FO, Sejersted OM, Sjaastad I (2007)
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes
Am J Physiol Heart Circ Physiol, 293 (4), H2367-76
DOI 10.1152/ajpheart.01375.2006, PubMed 17660386

Brattelid T, Qvigstad E, Birkeland JA, Swift F, Bekkevold SV, Krobert KA, Sejersted OM, Skomedal T, Osnes JB, Levy FO, Sjaastad I (2007)
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
J Mol Cell Cardiol, 43 (6), 767-79
DOI 10.1016/j.yjmcc.2007.08.019, PubMed 17936780

Brattelid T, Tveit K, Birkeland JA, Sjaastad I, Qvigstad E, Krobert KA, Hussain RI, Skomedal T, Osnes JB, Levy FO (2007)
Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure--a quantitative RT-PCR study and the question of normalisation
Basic Res Cardiol, 102 (3), 198-208
DOI 10.1007/s00395-007-0648-1, PubMed 17370034

Mørk HK, Sjaastad I, Sande JB, Periasamy M, Sejersted OM, Louch WE (2007)
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure
J Mol Cell Cardiol, 43 (2), 177-86
DOI 10.1016/j.yjmcc.2007.05.004, PubMed 17574269

Swift F, Tovsrud N, Enger UH, Sjaastad I, Sejersted OM (2007)
The Na+/K+-ATPase alpha2-isoform regulates cardiac contractility in rat cardiomyocytes
Cardiovasc Res, 75 (1), 109-17
DOI 10.1016/j.cardiores.2007.03.017, PubMed 17442282

Publications 2006

Birkeland JA, Sjaastad I, Brattelid T, Qvigstad E, Moberg ER, Krobert KA, Bjørnerheim R, Skomedal T, Sejersted OM, Osnes JB, Levy FO (2006)
Effects of treatment with a 5-HT4 receptor antagonist in heart failure
Br J Pharmacol, 150 (2), 143-52
DOI 10.1038/sj.bjp.0706966, PubMed 17160012

Larsen KO, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G (2006)
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice
Am J Physiol Heart Circ Physiol, 291 (2), H507-16
DOI 10.1152/ajpheart.00862.2005, PubMed 16582020

Louch WE, Mørk HK, Sexton J, Strømme TA, Laake P, Sjaastad I, Sejersted OM (2006)
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction
J Physiol, 574 (Pt 2), 519-33
DOI 10.1113/jphysiol.2006.107227, PubMed 16709642

Swift F, Strømme TA, Amundsen B, Sejersted OM, Sjaastad I (2006)
Slow diffusion of K+ in the T tubules of rat cardiomyocytes
J Appl Physiol (1985), 101 (4), 1170-6
DOI 10.1152/japplphysiol.00297.2006, PubMed 16763106

Taraldsen T, Sjaastad I (2006)
Anatomi og fysiologi
In Kompendier og oppgavehefte, Medisinsk basislitteratur, Oslo, 1 (6. utg.), 279 s.
BIBSYS 061337978, ISBN 82-91562-37-7

Publications 2005

Birkeland JA, Sejersted OM, Taraldsen T, Sjaastad I (2005)
EC-coupling in normal and failing hearts
Scand Cardiovasc J, 39 (1-2), 13-23
DOI 10.1080/14017430410004632, PubMed 16097409

Bøkenes J, Sjaastad I, Sejersted OM (2005)
Artifactual contractions triggered by field stimulation of cardiomyocytes
J Appl Physiol (1985), 98 (5), 1712-9
DOI 10.1152/japplphysiol.00630.2004, PubMed 15640393

Cunderlíková B, Moan J, Sjaastad I (2005)
pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential
Cancer Lett, 222 (1), 39-47
DOI 10.1016/j.canlet.2004.09.032, PubMed 15837539

Qvigstad E, Brattelid T, Sjaastad I, Andressen KW, Krobert KA, Birkeland JA, Sejersted OM, Kaumann AJ, Skomedal T, Osnes JB, Levy FO (2005)
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure
Cardiovasc Res, 65 (4), 869-78
DOI 10.1016/j.cardiores.2004.11.017, PubMed 15721867

Qvigstad E, Brattelid T, Sjaastad I, Molenaar P, Birkeland JA, Andressen KW, Krobert KA, Sejersted OM, Skomedal T, Osnes JB, Kaumann AJ, Levy FO (2005)
Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure
PROCEEDINGS OF THE 25TH EUROPEAN SECTION MEETING INTERNATIONAL SOCIETY FOR HEART RESEARCH, 7-12

Qvigstad E, Sjaastad I, Brattelid T, Nunn C, Swift F, Birkeland JA, Krobert KA, Andersen GØ, Sejersted OM, Osnes JB, Levy FO, Skomedal T (2005)
Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart
Circ Res, 97 (3), 268-76
DOI 10.1161/01.RES.0000176970.22603.8d, PubMed 16002744

Qvigstad E, Sjaastad I, Bøkenes J, Schiander I, Solberg L, Sejersted OM, Osnes JB, Skomedal T (2005)
Carvedilol blockade of alpha1- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure
Eur J Pharmacol, 516 (1), 51-9
DOI 10.1016/j.ejphar.2005.04.027, PubMed 15916756

Schiøtz Thorud HM, Stranda A, Birkeland JA, Lunde PK, Sjaastad I, Kolset SO, Sejersted OM, Iversen PO (2005)
Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure
Am J Physiol Regul Integr Comp Physiol, 289 (2), R389-R394
DOI 10.1152/ajpregu.00067.2005, PubMed 15802562

Sjaastad I, Birkeland JA, Ferrier G, Howlett S, Skomedal T, Bjørnerheim R, Wasserstrom JA, Sejersted OM (2005)
Defective excitation-contraction coupling in hearts of rats with congestive heart failure
Acta Physiol Scand, 184 (1), 45-58
DOI 10.1111/j.1365-201X.2005.01431.x, PubMed 15847643

Thorud HM, Verburg E, Lunde PK, Strømme TA, Sjaastad I, Sejersted OM (2005)
Temperature-dependent skeletal muscle dysfunction in rats with congestive heart failure
J Appl Physiol (1985), 99 (4), 1500-7
DOI 10.1152/japplphysiol.00807.2004, PubMed 15932960

Publications 2004

Finsen AV, Christensen G, Sjaastad I (2004)
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse
J Appl Physiol (1985), 98 (2), 680-9
DOI 10.1152/japplphysiol.00924.2004, PubMed 15475595

Grund F, Tjomsland O, Sjaastad I, Ilebekk A, Kirkebøen KA (2004)
Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine
Lab Anim, 38 (1), 70-8
DOI 10.1258/00236770460734425, PubMed 14979991

Publications 2003

Qvigstad E, Osnes JB, Sandnes D, Schiander I, Bøkenes J, Sjaastad I, Skomedal T (2003)
Carvedilol blockade of rat myocardial alpha1-adrenoceptors
Eur J Pharmacol, 481 (1), 83-9
DOI 10.1016/j.ejphar.2003.09.001, PubMed 14637179

Sjaastad I, Schiander I, Sjetnan A, Qvigstad E, Bøkenes J, Sandnes D, Osnes JB, Sejersted OM, Skomedal T (2003)
Increased contribution of alpha 1- vs. beta-adrenoceptor-mediated inotropic response in rats with congestive heart failure
Acta Physiol Scand, 177 (4), 449-58
DOI 10.1046/j.1365-201X.2003.01063.x, PubMed 12648162

Sjaastad I, Wasserstrom JA, Sejersted OM (2003)
Heart failure -- a challenge to our current concepts of excitation-contraction coupling
J Physiol, 546 (Pt 1), 33-47
DOI 10.1113/jphysiol.2002.034728, PubMed 12509477

Swift F, Sjaastad I, Sejersted OM (2003)
[Does altered regulation of Na+ cause reduced myocardial contractility in heart failure?]
Tidsskr Nor Laegeforen, 123 (21), 3036-40
PubMed 14618171

Thomas MJ, Sjaastad I, Andersen K, Helm PJ, Wasserstrom JA, Sejersted OM, Ottersen OP (2003)
Localization and function of the Na+/Ca2+-exchanger in normal and detubulated rat cardiomyocytes
J Mol Cell Cardiol, 35 (11), 1325-37
DOI 10.1016/j.yjmcc.2003.08.005, PubMed 14596789

Publications 2002

Johannsson E, Sejersted OM, Lunde PK, Sjaastad I, Thomas MJ, Bergersen L, Blackstad TW, Ottersen OP, Heddle C, Halestrap AP (2002)
Cardiac energetics in congestive heart failure - Response
Circulation, 105 (6), E44-E45

Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T, Holt E, Lunde PK, Christensen G (2002)
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Cardiovasc Res, 53 (2), 382-91
DOI 10.1016/s0008-6363(01)00489-8, PubMed 11827689

Sjaastad I, Bentzen JG, Semb SO, Ilebekk A, Sejersted OM (2002)
Reduced calcium tolerance in rat cardiomyocytes after myocardial infarction
Acta Physiol Scand, 175 (4), 261-9
DOI 10.1046/j.1365-201X.2002.00999.x, PubMed 12167165

Sjaastad I, Bøkenes J, Swift F, Wasserstrom JA, Sejersted OM (2002)
Normal contractions triggered by I(Ca,L) in ventricular myocytes from rats with postinfarction CHF
Am J Physiol Heart Circ Physiol, 283 (3), H1225-36
DOI 10.1152/ajpheart.00162.2001, PubMed 12181154

Publications 2001

Borchgrevink-Lund CF, Sjaastad I (2001)
Hygiene og mikrobiologi
In Kompendier og oppgavehefte, Medisinsk basislitteratur, Oslo, 6 (10. utg.), 176 s.
BIBSYS 011669365, ISBN 82-91562-32-6

Jóhannsson E, Lunde PK, Heddle C, Sjaastad I, Thomas MJ, Bergersen L, Halestrap AP, Blackstad TW, Ottersen OP, Sejersted OM (2001)
Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure
Circulation, 104 (6), 729-34
DOI 10.1161/hc3201.092286, PubMed 11489783

Lunde PK, Sjaastad I, Schiøtz Thorud HM, Sejersted OM (2001)
Skeletal muscle disorders in heart failure
Acta Physiol Scand, 171 (3), 277-94
DOI 10.1046/j.1365-201x.2001.00830.x, PubMed 11412140

Sjaastad I (2001)
Excitation-contraction coupling in post infarction congestive heart failure
In Hjerteforum, Supplement, Norsk cardiologisk selskap, Oslo, 3, 2001, 100 s.
BIBSYS 011484217

Sjaastad I, Taraldsen T (2001)
Kompendier og oppgavehefte
Medisinsk basislitteratur, Oslo (5. utg.), b.
BIBSYS 012040908

Sjaastad I, Taraldsen T (2001)
Kompendier og oppgavehefte
Medisinsk basislitteratur, Oslo (6. utg.), b.
BIBSYS 030773776

Publications 2000

Sjaastad I, Grund F, Ilebekk A (2000)
Effects on infarct size and on arrhythmias by controlling reflow after myocardial ischaemia in pigs
Acta Physiol Scand, 169 (3), 195-201
DOI 10.1046/j.1365-201x.2000.00735.x, PubMed 10886034

Sjaastad I, Sejersted OM, Ilebekk A, Bjornerheim R (2000)
Echocardiographic criteria for detection of postinfarction congestive heart failure in rats
J Appl Physiol (1985), 89 (4), 1445-54
DOI 10.1152/jappl.2000.89.4.1445, PubMed 11007581

Sundkvist LL, Sjaastad I (2000)
Psykologi, psykiatri og kommunikasjon
Forl. Mbl, Oslo, 192 s.
BIBSYS 001223321, ISBN 82-91562-25-3

Wasserstrom JA, Holt E, Sjaastad I, Lunde PK, Odegaard A, Sejersted OM (2000)
Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI
Am J Physiol Heart Circ Physiol, 279 (2), H798-807
DOI 10.1152/ajpheart.2000.279.2.H798, PubMed 10924080

Publications 1999

Holt E, Sjaastad I, Lunde PK, Christensen G, Sejersted OM (1999)
Thyroid hormone control of contraction and the Ca(2+)-ATPase/phospholamban complex in adult rat ventricular myocytes
J Mol Cell Cardiol, 31 (3), 645-56
DOI 10.1006/jmcc.1998.0900, PubMed 10198194

Sjaastad I, Borchgrevink-Lund CF, Taraldsen T (1999)
Kompendium
Medisinsk basislitteratur, Oslo (4. utg.), b.
BIBSYS 991346661