Håvard Takle Lindholm

  • Researcher; PhD

Mini CV:

Education

  • PhD - Norwegian University of Science and Technology (2021)
  • Molecular Biology
  • Bioinformatics


Current position

Researcher, Department of Pathology, Oslo University Hospital

 

Publications 2024

Hosseini A, Lindholm HT, Chen R, Mehdipour P, Marhon SA, Ishak CA, Moore PC, Classon M, Di Gioacchino A, Greenbaum B, De Carvalho DD (2024)
Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
Cell Rep, 43 (2), 113684
DOI 10.1016/j.celrep.2024.113684, PubMed 38261511

Publications 2023

Heck KA, Lindholm HT, Niederdorfer B, Tsirvouli E, Kuiper M, Flobak Å, Lægreid A, Thommesen L (2023)
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles
Proteomes, 11 (1)
DOI 10.3390/proteomes11010003, PubMed 36648961

Vornewald PM, Forman R, Yao R, Parmar N, Lindholm HT, Lee LSK, Martín-Alonso M, Else KJ, Oudhoff MJ (2023)
Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection
Front Immunol, 14, 1243528
DOI 10.3389/fimmu.2023.1243528, PubMed 37869014

Publications 2022

Lindholm HT, Chen R, De Carvalho DD (2022)
Endogenous retroelements as alarms for disruptions to cellular homeostasis
Trends Cancer, 9 (1), 55-68
DOI 10.1016/j.trecan.2022.09.001, PubMed 36216729

Lindholm HT, Parmar N, Drurey C, Campillo Poveda M, Vornewald PM, Ostrop J, Díez-Sanchez A, Maizels RM, Oudhoff MJ (2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Sci Immunol, 7 (71), eabl6543
DOI 10.1126/sciimmunol.abl6543, PubMed 35559665

Publications 2021

Drurey C, Lindholm HT, Coakley G, Poveda MC, Löser S, Doolan R, Gerbe F, Jay P, Harris N, Oudhoff MJ, Maizels RM (2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products
J Exp Med, 219 (1)
DOI 10.1084/jem.20211140, PubMed 34779829

Martín-Alonso M, Iqbal S, Vornewald PM, Lindholm HT, Damen MJ, Martínez F, Hoel S, Díez-Sánchez A, Altelaar M, Katajisto P, Arroyo AG, Oudhoff MJ (2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
Nat Commun, 12 (1), 6741
DOI 10.1038/s41467-021-26904-6, PubMed 34795242

Ostrop J, Zwiggelaar RT, Terndrup Pedersen M, Gerbe F, Bösl K, Lindholm HT, Díez-Sánchez A, Parmar N, Radetzki S, von Kries JP, Jay P, Jensen KB, Arrowsmith C, Oudhoff MJ (2021)
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation
Front Cell Dev Biol, 8, 618552
DOI 10.3389/fcell.2020.618552, PubMed 33575256

Parmar N, Burrows K, Vornewald PM, Lindholm HT, Zwiggelaar RT, Díez-Sánchez A, Martín-Alonso M, Fosslie M, Vallance BA, Dahl JA, Zaph C, Oudhoff MJ (2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection
PLoS Pathog, 17 (3), e1009476
DOI 10.1371/journal.ppat.1009476, PubMed 33788902

Strømme O, Heck KA, Brede G, Lindholm HT, Otterlei M, Arum CJ (2021)
Differentially Expressed Extracellular Vesicle-Contained microRNAs before and after Transurethral Resection of Bladder Tumors
Curr Issues Mol Biol, 43 (1), 286-300
DOI 10.3390/cimb43010024, PubMed 34199766

Publications 2020

Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ (2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Sci Adv, 6 (37)
DOI 10.1126/sciadv.abc0367, PubMed 32917713

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