We have discovered that inhibition of endothelial Notch signalling attenuates inflammation and we now show that selective inhibition of two Notch receptors inhibits murine arthritis. We are now generating recombinant human antibodies to these receptors with a selective ligand-neutralizing profile that will be subject to preclinical trials.
We have generated IL-33-deficient rats by means of CRISPR/Cas9 technology, mice a completely different regulation and expression pattern when compared man and most other mammals including the rat. We reveal interesting responses in a model of endotoxemian designed to resemble sepsis.
We have discovered that IL-33 modulates the differentiation of fibroblast during experimental kidney fibrosis.
We have discovered that IL-33 is induced by hypoosmosis in human keratinocytes, viewing this as an epidermal homeostatic response.
Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E(2023) Antibody blockade of Jagged1 attenuates choroidal neovascularization Nat Commun, 14(1), 3109 DOI 10.1038/s41467-023-38563-w, PubMed 37253747
Gundersen MD, Larsen KB, Johnsen KM, Goll R, Florholmen J, Haraldsen G(2022) Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis Sci Rep, 12(1), 11550 DOI 10.1038/s41598-022-15573-0, PubMed 35798804
Li G, Kolan SS, Guo S, Marciniak K, Kolan P, Malachin G, Grimolizzi F, Haraldsen G, Skålhegg BS(2021) Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice Front Immunol, 12, 689057 DOI 10.3389/fimmu.2021.689057, PubMed 34408746
Professor Guttorm Haraldsen Department of Pathology Oslo University Hospital Rikshospitalet PO Box 4950 Nydalen NO-0424 Oslo, Norway, Tel: +47 92401962 E-mail: gharalds@rr-research.no