We have discovered that inhibition of endothelial Notch signalling attenuates inflammation and we now show that selective inhibition of two Notch receptors inhibits murine arthritis. We are now generating recombinant human antibodies to these receptors with a selective ligand-neutralizing profile that will be subject to preclinical trials.
We have generated IL-33-deficient rats by means of CRISPR/Cas9 technology, mice a completely different regulation and expression pattern when compared man and most other mammals including the rat. We reveal interesting responses in a model of endotoxemian designed to resemble sepsis.
We have discovered that IL-33 modulates the differentiation of fibroblast during experimental kidney fibrosis.
We have discovered that IL-33 is induced by hypoosmosis in human keratinocytes, viewing this as an epidermal homeostatic response.
Stabell SH, Renzi A, Nilsen HR, Antonsen OH, Fosse JH, Haraldsen G, Sundnes O(2023) Detection of native, activated Notch receptors in normal human apocrine-bearing skin and in hidradenitis suppurativa Exp Dermatol, 33(1), e14977 DOI 10.1111/exd.14977, PubMed 38060347
Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E(2023) Antibody blockade of Jagged1 attenuates choroidal neovascularization Nat Commun, 14(1), 3109 DOI 10.1038/s41467-023-38563-w, PubMed 37253747
Gundersen MD, Larsen KB, Johnsen KM, Goll R, Florholmen J, Haraldsen G(2022) Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis Sci Rep, 12(1), 11550 DOI 10.1038/s41598-022-15573-0, PubMed 35798804
Professor Guttorm Haraldsen Department of Pathology Oslo University Hospital Rikshospitalet PO Box 4950 Nydalen NO-0424 Oslo, Norway, Tel: +47 92401962 E-mail: gharalds@rr-research.no
