We have discovered that inhibition of endothelial Notch signalling attenuates inflammation and we now show that selective inhibition of two Notch receptors inhibits murine arthritis. We are now generating recombinant human antibodies to these receptors with a selective ligand-neutralizing profile that will be subject to preclinical trials.
We have generated IL-33-deficient rats by means of CRISPR/Cas9 technology, mice a completely different regulation and expression pattern when compared man and most other mammals including the rat. We reveal interesting responses in a model of endotoxemian designed to resemble sepsis.
We have discovered that IL-33 modulates the differentiation of fibroblast during experimental kidney fibrosis.
We have discovered that IL-33 is induced by hypoosmosis in human keratinocytes, viewing this as an epidermal homeostatic response.
Gundersen MD, Larsen KB, Johnsen KM, Goll R, Florholmen J, Haraldsen G(2022) Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis Sci Rep, 12(1), 11550 DOI 10.1038/s41598-022-15573-0, PubMed 35798804
Li G, Kolan SS, Guo S, Marciniak K, Kolan P, Malachin G, Grimolizzi F, Haraldsen G, Skålhegg BS(2021) Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice Front Immunol, 12, 689057 DOI 10.3389/fimmu.2021.689057, PubMed 34408746
Fjær R, Marciniak K, Sundnes O, Hjorthaug H, Sheng Y, Hammarström C, Sitek JC, Vigeland MD, Backe PH, Øye AM, Fosse JH, Stav-Noraas TE, Uchiyama Y, Matsumoto N, Comi A, Pevsner J, Haraldsen G, Selmer KK(2021) A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome Hum Mol Genet, 30(21), 1919-1931 DOI 10.1093/hmg/ddab144, PubMed 34124757