Reidar Fossmark

  • Consultant; MD, PhD

Mini CV

Education:

  • MD University of Oslo (1998)
  • PhD Norwegian University of Science and Technology (2004)
  • Norwegian clinical specialist accreditations:
    Gastroenterology and Internal Medicine (2010)

Current positions:
Consultant, Department of Gastroenterology, Oslo University Hospital.

Professor, Department of Clinical and Molecular Medicine, NTNU, Trondheim. https://www.ntnu.edu/employees/reidar.fossmark

 

Publications 2024

Berg S, Amini N, Solberg S, Ødegård RA, Kulseng BE, Fossmark R, Muller S, Dankel SN, Berge RK, Rønne E, Mjønes P, Hansen R (2024)
Ex Vivo Demonstration of a Novel Dual-Frequency Ultrasound Method for Quantitative Measurements of Liver Fat Content
Ultrasound Med Biol, 51 (1), 159-168
DOI 10.1016/j.ultrasmedbio.2024.09.019, PubMed 39424495

Bringeland EA, Våge C, Ubøe AAS, Sandø AD, Mjønes P, Fossmark R (2024)
Epstein-Barr Virus and Clinico-Endoscopic Characteristics of Gastric Remnant Cancers Compared to Proximal Non-Remnant Cancers: A Population-Based Study
Cancers (Basel), 16 (11)
DOI 10.3390/cancers16112000, PubMed 38893119

Fossmark R, Olaisen M (2024)
Changes in the Gastrointestinal Microbiota Induced by Proton Pump Inhibitors-A Review of Findings from Experimental Trials
Microorganisms, 12 (6)
DOI 10.3390/microorganisms12061110, PubMed 38930492

Kvamme CJ, Stillingen TL, Sandø AD, Mjønes P, Bringeland EA, Fossmark R (2024)
Early Gastric Cancers in Central Norway 2001 to 2016-A Population-Based Study
Cancers (Basel), 16 (6)
DOI 10.3390/cancers16061222, PubMed 38539555

Straum S, Wollan K, Rekstad LC, Fossmark R (2024)
Esophageal cancers missed at upper endoscopy in Central Norway 2004 to 2021 - A population-based study
BMC Gastroenterol, 24 (1), 279
DOI 10.1186/s12876-024-03371-z, PubMed 39169296

Waldum H, Fossmark R (2024)
Eradication of Helicobacter pylori by a potassium-competitive acid blocker alone?
Scand J Gastroenterol, 1-3 (in press)
DOI 10.1080/00365521.2024.2444477, PubMed 39722595

Publications 2023

Folkestad O, Hauso Ø, Mjønes P, Fougner R, Wasmuth HH, Fossmark R (2023)
Survival Trends in Patients with Small Intestinal Neuroendocrine Tumours-A Cohort Study in Central Norway
Cancers (Basel), 15 (13)
DOI 10.3390/cancers15133272, PubMed 37444383

Fossmark R, Dalsbø PL, Rokseth KM, Hauso Ø (2023)
Laser lithotripsy for the treatment of a giant fecalith obstructing a colorectal anastomosis
Endoscopy, 55 (S 01), E568-E569
DOI 10.1055/a-2040-3868, PubMed 36958354

Fossmark R, Lirhus SS, Høivik ML (2023)
The impact of proton pump inhibitors on the course of ulcerative colitis: a cohort study of over 10,000 newly diagnosed patients in Norway
Scand J Gastroenterol, 59 (1), 46-51
DOI 10.1080/00365521.2023.2255710, PubMed 37681998

Fossmark R, Ness-Jensen E, Sørdal Ø (2023)
Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified?
BMC Gastroenterol, 23 (1), 303
DOI 10.1186/s12876-023-02945-7, PubMed 37674110

Ubøe AAS, Våge C, Mjønes P, Bringeland EA, Fossmark R (2023)
Gastric remnant cancer and long-term survival in Central Norway 2001 to 2016 - A population-based study
Surg Oncol, 51, 102008
DOI 10.1016/j.suronc.2023.102008, PubMed 37866308

Waldum H, Fossmark R (2023)
Inflammation and Digestive Cancer
Int J Mol Sci, 24 (17)
DOI 10.3390/ijms241713503, PubMed 37686307

Publications 2022

Ausen K, Fossmark R, Spigset O, Pleym H (2022)
Safety and Efficacy of Local Tranexamic Acid for the Prevention of Surgical Bleeding in Soft-Tissue Surgery: A Review of the Literature and Recommendations for Plastic Surgery
Plast Reconstr Surg, 149 (3), 774-787
DOI 10.1097/PRS.0000000000008884, PubMed 35196701

Fossmark R, Johannessen R, Qvigstad G, Mjønes P (2022)
Do Gastric Signet Ring Cell Carcinomas and ECL-Cell Neuroendocrine Tumours Have a Common Origin?
Medicina (Kaunas), 58 (4)
DOI 10.3390/medicina58040470, PubMed 35454309

Ness-Jensen E, Bringeland EA, Mjønes P, Lagergren J, Grønbech JE, Waldum H, Fossmark R (2022)
Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study
Scand J Gastroenterol, 57 (5), 558-565
DOI 10.1080/00365521.2022.2026462, PubMed 35068320

Olaisen M, Fossmark R (2022)
Reply to "Too Soon to Dismiss Inflammation-Related Differences in the Mucosa-Associated Microbiota in Crohn's Disease Patients"
Inflamm Bowel Dis, 28 (8), e121
DOI 10.1093/ibd/izac047, PubMed 35460413

Olaisen M, Richard ML, Beisvåg V, Granlund AVB, Røyset ES, Rué O, Martinsen TC, Sandvik AK, Sokol H, Fossmark R (2022)
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course
Front Med (Lausanne), 9, 868812
DOI 10.3389/fmed.2022.868812, PubMed 36237548

Sandvik ECS, Aasarød KM, Johnsen G, Hoff DAL, Kulseng B, Hyldmo ÅA, Græslie H, Nymo S, Sandvik J, Fossmark R (2022)
The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores-An 11.6-Year Follow-Up Study
J Clin Med, 11 (16)
DOI 10.3390/jcm11164910, PubMed 36013149

Waldum HL, Fossmark R (2022)
Proton Pump Inhibitors and Mortality
Gastroenterology, 164 (6), 1021
DOI 10.1053/j.gastro.2022.10.006, PubMed 36216162

Publications 2021

Beck M, Bringeland EA, Qvigstad G, Fossmark R (2021)
Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016-A Population-Based Study
Cancers (Basel), 13 (22)
DOI 10.3390/cancers13225628, PubMed 34830783

Folkestad O, Wasmuth HH, Mjønes P, Fougner R, Hauso Ø, Fossmark R (2021)
Survival and Disease Recurrence in Patients with Duodenal Neuroendocrine Tumours-A Single Centre Cohort
Cancers (Basel), 13 (16)
DOI 10.3390/cancers13163985, PubMed 34439140

Fossmark R, Olaisen M, Martinsen TC, Melberg HO (2021)
Factors associated with the persistence of oral 5-aminosalicylic acid monotherapy in ulcerative colitis: a nationwide Norwegian cohort study
Therap Adv Gastroenterol, 14, 17562848211021760
DOI 10.1177/17562848211021760, PubMed 34262610

Olaisen M, Flatberg A, Granlund AVB, Røyset ES, Martinsen TC, Sandvik AK, Fossmark R (2021)
Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease
Inflamm Bowel Dis, 27 (1), 12-24
DOI 10.1093/ibd/izaa107, PubMed 32448900

Waldum H, Fossmark R (2021)
Gastritis, Gastric Polyps and Gastric Cancer
Int J Mol Sci, 22 (12)
DOI 10.3390/ijms22126548, PubMed 34207192

Aasarød KM, Mosti MP, Finstad MT, Stunes AK, Fossmark R, Syversen U (2021)
Do patients with gastroesophageal reflux disease exhibit compromised bone quality prior to proton pump inhibitor therapy?
Bone Rep, 14, 101095
DOI 10.1016/j.bonr.2021.101095, PubMed 34095362

Publications 2020

Folkestad O, Wasmuth HH, Mjønes P, Fougner R, Hauso Ø, Fossmark R (2020)
Survival and disease recurrence in patients operated for small intestinal neuroendocrine tumors at a referral hospital
Surg Oncol, 35, 336-343
DOI 10.1016/j.suronc.2020.09.015, PubMed 32979699

Ness-Jensen E, Bringeland EA, Mattsson F, Mjønes P, Lagergren J, Grønbech JE, Waldum HL, Fossmark R (2020)
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Int J Cancer, 148 (8), 1879-1886
DOI 10.1002/ijc.33354, PubMed 33091962

Aasarød KM, Waldum HL, Stunes AK, Sandvik AK, Flatberg A, Mjønes P, Syversen U, Bakke I, Fossmark R (2020)
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Int J Mol Sci, 21 (3)
DOI 10.3390/ijms21030927, PubMed 32023822

Publications 2019

Fossmark R, Balto TM, Martinsen TC, Grønbech JE, Munkvold B, Mjønes PG, Waldum HL (2019)
Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection
Scand J Gastroenterol, 54 (8), 1003-1007
DOI 10.1080/00365521.2019.1647281, PubMed 31368380

Fossmark R, Martinsen TC, Waldum HL (2019)
Adverse Effects of Proton Pump Inhibitors-Evidence and Plausibility
Int J Mol Sci, 20 (20)
DOI 10.3390/ijms20205203, PubMed 31640115

Martinsen TC, Fossmark R, Waldum HL (2019)
The Phylogeny and Biological Function of Gastric Juice-Microbiological Consequences of Removing Gastric Acid
Int J Mol Sci, 20 (23)
DOI 10.3390/ijms20236031, PubMed 31795477

Olaisen M, Fossmark R (2019)
Editorial: mesalamine and mucosal microbiome in quiescent ulcerative colitis-what can we learn? Authors' reply
Aliment Pharmacol Ther, 49 (12), 1532
DOI 10.1111/apt.15285, PubMed 31134653

Olaisen M, Spigset O, Flatberg A, Granlund AVB, Brede WR, Albrektsen G, Røyset ES, Gilde B, Sandvik AK, Martinsen TC, Fossmark R (2019)
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Aliment Pharmacol Ther, 49 (10), 1301-1313
DOI 10.1111/apt.15227, PubMed 30895635

Waldum HL, Fossmark R (2019)
Role of Autoimmune Gastritis in Gastric Cancer
Clin Transl Gastroenterol, 10 (9), e00080
DOI 10.14309/ctg.0000000000000080, PubMed 31517647

Publications 2018

Waldum HL, Fossmark R (2018)
Types of Gastric Carcinomas
Int J Mol Sci, 19 (12)
DOI 10.3390/ijms19124109, PubMed 30567376

Waldum HL, Sørdal Ø, Fossmark R (2018)
Proton pump inhibitors (PPIs) may cause gastric cancer - clinical consequences
Scand J Gastroenterol, 53 (6), 639-642
DOI 10.1080/00365521.2018.1450442, PubMed 29852782

Waldum HL, Öberg K, Sørdal ØF, Sandvik AK, Gustafsson BI, Mjønes P, Fossmark R (2018)
Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift
Therap Adv Gastroenterol, 11, 1756284818775054
DOI 10.1177/1756284818775054, PubMed 29872453

Publications 2017

Mjønes P, Nordrum IS, Sørdal Ø, Sagatun L, Fossmark R, Sandvik A, Waldum HL (2017)
Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells
Horm Cancer, 9 (1), 40-54
DOI 10.1007/s12672-017-0311-8, PubMed 28980157

Vange P, Bruland T, Doseth B, Fossmark R, Sousa MML, Beisvag V, Sørdal Ø, Qvigstad G, Waldum HL, Sandvik AK, Bakke I (2017)
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
PLoS One, 12 (9), e0184514
DOI 10.1371/journal.pone.0184514, PubMed 28902909

Waldum HL, Fossmark R (2017)
Proton pump inhibitors and gastric cancer: a long expected side effect finally reported also in man
Gut, 67 (1), 199-200
DOI 10.1136/gutjnl-2017-315629, PubMed 29158236

Publications 2016

Boyce M, Moore AR, Sagatun L, Parsons BN, Varro A, Campbell F, Fossmark R, Waldum HL, Pritchard DM (2016)
Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis
Br J Clin Pharmacol, 83 (3), 466-475
DOI 10.1111/bcp.13146, PubMed 27704617

Fossmark R, Calvete O, Mjønes P, Benitez J, Waldum HL (2016)
ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit
APMIS, 124 (7), 561-6
DOI 10.1111/apm.12546, PubMed 27150581

Fossmark R, Rao S, Mjønes P, Munkvold B, Flatberg A, Varro A, Thommesen L, Nørsett KG (2016)
PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa
Peptides, 79, 83-94
DOI 10.1016/j.peptides.2016.03.016, PubMed 27038741

Ness-Jensen E, Fossmark R (2016)
Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease
JAMA Intern Med, 176 (6), 868
DOI 10.1001/jamainternmed.2016.1857, PubMed 27273497

Sagatun L, Fossmark R, Jianu CS, Qvigstad G, Nordrum IS, Mjønes P, Waldum HL (2016)
Follow-up of patients with ECL cell-derived tumours
Scand J Gastroenterol, 51 (11), 1398-405
DOI 10.3109/00365521.2016.1169588, PubMed 27309188

Sagatun L, Mjønes P, Jianu CS, Boyce M, Waldum HL, Fossmark R (2016)
The gastrin receptor antagonist netazepide (YF476) in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours: review of long-term treatment
Eur J Gastroenterol Hepatol, 28 (11), 1345-1352
DOI 10.1097/MEG.0000000000000713, PubMed 27682220

Waldum HL, Hauso Ø, Brenna E, Qvigstad G, Fossmark R (2016)
Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?
Scand J Gastroenterol, 51 (7), 767-73
DOI 10.3109/00365521.2016.1143527, PubMed 26872579

Aasarød KM, Mosti MP, Stunes AK, Reseland JE, Basso T, Syversen U, Fossmark R (2016)
Impaired skeletal health in patients with chronic atrophic gastritis
Scand J Gastroenterol, 51 (7), 774-81
DOI 10.3109/00365521.2016.1141317, PubMed 26854332

Aasarød KM, Ramezanzadehkoldeh M, Shabestari M, Mosti MP, Stunes AK, Reseland JE, Beisvag V, Eriksen EF, Sandvik AK, Erben RG, Schüler C, Boyce M, Skallerud BH, Syversen U, Fossmark R (2016)
Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice
J Endocrinol, 230 (2), 251-62
DOI 10.1530/JOE-16-0017, PubMed 27325243

Aasarød KM, Stunes AK, Mosti MP, Ramezanzadehkoldeh M, Viggaklev BI, Reseland JE, Skallerud BH, Fossmark R, Syversen U (2016)
Effects of the Histamine 1 Receptor Antagonist Cetirizine on the Osteoporotic Phenotype in H(+) /K(+) ATPase Beta Subunit KO Mice
J Cell Biochem, 117 (9), 2089-96
DOI 10.1002/jcb.25514, PubMed 26869358

Publications 2015

Ausen K, Fossmark R, Spigset O, Pleym H (2015)
Randomized clinical trial of topical tranexamic acid after reduction mammoplasty
Br J Surg, 102 (11), 1348-53
DOI 10.1002/bjs.9878, PubMed 26349843

Fossmark R, Sagatun L, Nordrum IS, Sandvik AK, Waldum HL (2015)
Hypergastrinemia is associated with adenocarcinomas in the gastric corpus and shorter patient survival
APMIS, 123 (6), 509-14
DOI 10.1111/apm.12380, PubMed 25939315

Olsen PA, Fossmark R, Qvigstad G (2015)
Fecal calprotectin in patients with suspected small bowel disease--a selection tool for small bowel capsule endoscopy?
Scand J Gastroenterol, 50 (3), 272-7
DOI 10.3109/00365521.2014.1003395, PubMed 25591948

Waldum HL, Hauso Ø, Fossmark R (2015)
Letter: proton pump inhibitors, hypergastrinaemia and the risk of gastric neoplasia
Aliment Pharmacol Ther, 42 (3), 389
DOI 10.1111/apt.13282, PubMed 26147114

Waldum HL, Kleveland PM, Fossmark R (2015)
Upper gastrointestinal physiology and diseases
Scand J Gastroenterol, 50 (6), 649-56
DOI 10.3109/00365521.2015.1009157, PubMed 25857514

Publications 2014

Olaisen M, Rydning A, Martinsen TC, Nordrum IS, Mjønes P, Fossmark R (2014)
Cytomegalovirus infection and postoperative complications in patients with ulcerative colitis undergoing colectomy
Scand J Gastroenterol, 49 (7), 845-52
DOI 10.3109/00365521.2014.929172, PubMed 24947587

Sagatun L, Jianu CS, Fossmark R, Mårvik R, Nordrum IS, Waldum HL (2014)
The gastric mucosa 25 years after proximal gastric vagotomy
Scand J Gastroenterol, 49 (10), 1173-80
DOI 10.3109/00365521.2014.950979, PubMed 25157752

Waldum HL, Hauso Ø, Sørdal ØF, Fossmark R (2014)
Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach
Dig Dis Sci, 60 (6), 1522-7
DOI 10.1007/s10620-014-3468-9, PubMed 25480404

Walenkamp A, Crespo G, Fierro Maya F, Fossmark R, Igaz P, Rinke A, Tamagno G, Vitale G, Öberg K, Meyer T (2014)
Hallmarks of gastrointestinal neuroendocrine tumours: implications for treatment
Endocr Relat Cancer, 21 (6), R445-60
DOI 10.1530/ERC-14-0106, PubMed 25296914

Publications 2013

Fossmark R, Bretthauer M, Gustafsson BI (2013)
[Who should perform endoscopies?]
Tidsskr Nor Laegeforen, 133 (11), 1171
DOI 10.4045/tidsskr.13.0625, PubMed 23759774

Fossmark R, Skarsvåg E, Aarset H, Hjorth-Hansen H, Waldum HL (2013)
Symptomatic primary (Al) amyloidosis of the stomach and duodenum
Case Rep Gastrointest Med, 2013, 525439
DOI 10.1155/2013/525439, PubMed 23533841

Fossmark R, Sørdal ØF, Bakkelund KE, Nordrum IS, Waldum H (2013)
The effects of unilateral truncal vagotomy on gastric carcinogenesis in hypergastrinemic Japanese female cotton rats
Regul Pept, 184, 62-7
DOI 10.1016/j.regpep.2013.03.006, PubMed 23499800

Fossmark R, Waldum H (2013)
The distressing overuse of gastric acid inhibitors
Dig Dis Sci, 58 (3), 600-1
DOI 10.1007/s10620-012-2532-6, PubMed 23306853

Fossmark R, Waldum H (2013)
Development of diffuse carcinomas in the gastric corpus in patients with rugal hyperplastic gastritis
Int J Cancer, 133 (9), 2260
DOI 10.1002/ijc.28227, PubMed 23613381

Vigen RA, Kodama Y, Viset T, Fossmark R, Waldum H, Kidd M, Wang TC, Modlin IM, Chen D, Zhao CM (2013)
Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patients
Histol Histopathol, 28 (4), 531-42
DOI 10.14670/HH-28.531, PubMed 23389729

Waldum HL, Hauso Ø, Fossmark R (2013)
The regulation of gastric acid secretion - clinical perspectives
Acta Physiol (Oxf), 210 (2), 239-56
DOI 10.1111/apha.12208, PubMed 24279703

Zeinali F, Fossmark R, Hauso Ø, Wiseth R, Hjertner Ø, Waldum HL (2013)
Serotonin in blood: assessment of its origin by concomitant determination of β-thromboglobulin (platelets) and chromogranin A (enterochromaffin cells)
Scand J Clin Lab Invest, 73 (2), 148-53
DOI 10.3109/00365513.2012.756121, PubMed 23327100

Publications 2012

Bakkelund KE, Nordrum IS, Fossmark R, Waldum HL (2012)
Gastric carcinomas localized to the cardia
Gastroenterol Res Pract, 2012, 457831
DOI 10.1155/2012/457831, PubMed 22474435

Erlandsen SE, Qvigstad G, Fossmark R, Bakke I, Chen D, Sandvik AK (2012)
Regulated endocrine-specific protein 18 (RESP18) is localized to and regulated in A-like cells and G-cells in rat stomach
Regul Pept, 177 (1-3), 53-9
DOI 10.1016/j.regpep.2012.04.008, PubMed 22561140

Fossmark R, Stunes AK, Petzold C, Waldum HL, Rubert M, Lian AM, Reseland JE, Syversen U (2012)
Decreased bone mineral density and reduced bone quality in H(+) /K(+) ATPase beta-subunit deficient mice
J Cell Biochem, 113 (1), 141-7
DOI 10.1002/jcb.23337, PubMed 21882222

Fossmark R, Sørdal Ø, Jianu CS, Qvigstad G, Nordrum IS, Boyce M, Waldum HL (2012)
Treatment of gastric carcinoids type 1 with the gastrin receptor antagonist netazepide (YF476) results in regression of tumours and normalisation of serum chromogranin A
Aliment Pharmacol Ther, 36 (11-12), 1067-75
DOI 10.1111/apt.12090, PubMed 23072686

Jianu CS, Fossmark R, Viset T, Qvigstad G, Sørdal O, Mårvik R, Waldum HL (2012)
Gastric carcinoids after long-term use of a proton pump inhibitor
Aliment Pharmacol Ther, 36 (7), 644-9
DOI 10.1111/apt.12012, PubMed 22861200

Riis A, Martinsen TC, Waldum HL, Fossmark R (2012)
Clinical experience with infliximab and adalimumab in a single-center cohort of patients with Crohn's disease
Scand J Gastroenterol, 47 (6), 649-57
DOI 10.3109/00365521.2012.672591, PubMed 22472026

Waldum HL, Sandvik AK, Hauso O, Qvigstad G, Fossmark R (2012)
Withdrawing PPI therapy: response to Metz et al
Am J Gastroenterol, 107 (2), 325-6; author reply 326
DOI 10.1038/ajg.2011.391, PubMed 22306953

Publications 2011

Gustafsson BI, Bakke I, Hauso Ø, Kidd M, Modlin IM, Fossmark R, Brenna E, Waldum HL (2011)
Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism for histamine induced secretion of hydrochloric acid
Scand J Gastroenterol, 46 (5), 531-7
DOI 10.3109/00365521.2011.558113, PubMed 21342027

Jianu CS, Lange OJ, Viset T, Qvigstad G, Martinsen TC, Fougner R, Kleveland PM, Fossmark R, Hauso Ø, Waldum HL (2011)
Gastric neuroendocrine carcinoma after long-term use of proton pump inhibitor
Scand J Gastroenterol, 47 (1), 64-7
DOI 10.3109/00365521.2011.627444, PubMed 22087794

Stunes AK, Westbroek I, Fossmark R, Berge RK, Reseland JE, Syversen U (2011)
Skeletal effects of the saturated 3-thia Fatty Acid tetradecylthioacetic Acid in rats
PPAR Res, 2011, 436358
DOI 10.1155/2011/436358, PubMed 22190907

Stunes AK, Westbroek I, Gustafsson BI, Fossmark R, Waarsing JH, Eriksen EF, Petzold C, Reseland JE, Syversen U (2011)
The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
BMC Endocr Disord, 11, 11
DOI 10.1186/1472-6823-11-11, PubMed 21615901

Publications 2010

Bakkelund KE, Waldum HL, Nordrum IS, Hauso Ø, Fossmark R (2010)
Long-term gastric changes in achlorhydric H(+)/K(+)-ATPase beta subunit deficient mice
Scand J Gastroenterol, 45 (9), 1042-7
DOI 10.3109/00365521.2010.490952, PubMed 20476858

Fossmark R, Qvigstad G, Martinsen TC, Hauso Ø, Waldum HL (2010)
Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis
J Biomed Biotechnol, 2011, 975479
DOI 10.1155/2011/975479, PubMed 21127707

Jianu CS, Fossmark R, Syversen U, Hauso Ø, Fykse V, Waldum HL (2010)
Five-year follow-up of patients treated for 1 year with octreotide long-acting release for enterochromaffin-like cell carcinoids
Scand J Gastroenterol, 46 (4), 456-63
DOI 10.3109/00365521.2010.539255, PubMed 21133821

Jianu CS, Fossmark R, Syversen U, Hauso Ø, Waldum HL (2010)
A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia
Tumour Biol, 31 (5), 373-80
DOI 10.1007/s13277-010-0045-5, PubMed 20480408

Martinsen TC, Skogaker NE, Fossmark R, Nordrum IS, Sandvik AK, Bendheim MØ, Bakkelund KE, Waldum HL (2010)
Neuroendocrine cells in diffuse gastric carcinomas: an ultrastructural study with immunogold labeling of chromogranin A
Appl Immunohistochem Mol Morphol, 18 (1), 62-8
DOI 10.1097/PAI.0b013e3181b70594, PubMed 19713831

Waldum HL, Qvigstad G, Fossmark R, Kleveland PM, Sandvik AK (2010)
Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint
Scand J Gastroenterol, 45 (4), 389-94
DOI 10.3109/00365520903477348, PubMed 20001749

Publications 2009

Bakkelund K, Fossmark R, Nordrum IS, Waldum HL (2009)
Effect of antrectomy in hypergastrinaemic female Japanese cotton rats
Scand J Gastroenterol, 44 (1), 32-9
DOI 10.1080/00365520802308011, PubMed 19037819

Waldum HL, Kleveland PM, Brenna E, Bakke I, Qvigstad G, Martinsen TC, Fossmark R, Gustafsson BI, Sandvik AK (2009)
Interactions between gastric acid secretagogues and the localization of the gastrin receptor
Scand J Gastroenterol, 44 (4), 390-3
DOI 10.1080/00365520802624219, PubMed 19089789

Publications 2008

Fossmark R, Jianu CS, Martinsen TC, Qvigstad G, Syversen U, Waldum HL (2008)
Serum gastrin and chromogranin A levels in patients with fundic gland polyps caused by long-term proton-pump inhibition
Scand J Gastroenterol, 43 (1), 20-4
DOI 10.1080/00365520701561959, PubMed 18938772

Fossmark R, Qvigstad G, Waldum HL (2008)
Gastric cancer: animal studies on the risk of hypoacidity and hypergastrinemia
World J Gastroenterol, 14 (11), 1646-51
DOI 10.3748/wjg.14.1646, PubMed 18350594

Nørsett KG, Laegreid A, Kusnierczyk W, Langaas M, Ylving S, Fossmark R, Myhre S, Falkmer S, Waldum HL, Sandvik AK (2008)
Changes in gene expression of gastric mucosa during therapeutic acid inhibition
Eur J Gastroenterol Hepatol, 20 (7), 613-23
DOI 10.1097/MEG.0b013e3282f5dc19, PubMed 18679062

Waldum HL, Sandvik AK, Brenna E, Fossmark R, Qvigstad G, Soga J (2008)
Classification of tumours
J Exp Clin Cancer Res, 27 (1), 70
DOI 10.1186/1756-9966-27-70, PubMed 19014574

Publications 2007

Bendheim MO, Fossmark R, Waldum HL, Martinsen TC (2007)
Morphology of g cells in hypergastrinemic cotton rats
Scand. J. Lab. Anim. Sci., 34 (3), 173-183

Fossmark R, Brenna E, Waldum HL (2007)
pH 4.0
Scand J Gastroenterol, 42 (3), 297-8
DOI 10.1080/00365520600887828, PubMed 17354107

Fossmark R, Waldum H (2007)
Rebound acid hypersecretion
Aliment Pharmacol Ther, 25 (8), 999-1000; author reply 1000
DOI 10.1111/j.1365-2036.2007.03263.x, PubMed 17403004

Publications 2005

Bakkelund K, Fossmark R, Nordrum I, Waldum H (2005)
Signet ring cells in gastric carcinomas are derived from neuroendocrine cells
J Histochem Cytochem, 54 (6), 615-21
DOI 10.1369/jhc.5A6806.2005, PubMed 16344325

Fossmark R, Johnsen G, Johanessen E, Waldum HL (2005)
Rebound acid hypersecretion after long-term inhibition of gastric acid secretion
Aliment Pharmacol Ther, 21 (2), 149-54
DOI 10.1111/j.1365-2036.2004.02271.x, PubMed 15679764

Fossmark R, Martinsen TC, Qvigstad G, Bendheim MØ, Kopstad G, Kashima K, Waldum HL (2005)
Ultrastructure and chromogranin A immunogold labelling of ECL cell carcinoids
APMIS, 113 (7-8), 506-12
DOI 10.1111/j.1600-0463.2005.apm_147.x, PubMed 16086820

Fossmark R, Zhao CM, Martinsen TC, Kawase S, Chen D, Waldum HL (2005)
Dedifferentiation of enterochromaffin-like cells in gastric cancer of hypergastrinemic cotton rats
APMIS, 113 (6), 436-49
DOI 10.1111/j.1600-0463.2005.apm_134.x, PubMed 15996161

Gustafsson BI, Tømmerås K, Nordrum I, Loennechen JP, Brunsvik A, Solligård E, Fossmark R, Bakke I, Syversen U, Waldum H (2005)
Long-term serotonin administration induces heart valve disease in rats
Circulation, 111 (12), 1517-22
DOI 10.1161/01.CIR.0000159356.42064.48, PubMed 15781732

Mähler M, Heidtmann W, Niewiesk S, Gruber A, Fossmark R, Beil W, Hedrich H, Wagner S (2005)
Experimental Helicobacter pylori infection induces antral-predominant, chronic active gastritis in hispid cotton rats (Sigmodon hispidus)
Helicobacter, 10 (4), 332-44
DOI 10.1111/j.1523-5378.2005.00320.x, PubMed 16104950

Nørsett KG, Laegreid A, Langaas M, Wörlund S, Fossmark R, Waldum HL, Sandvik AK (2005)
Molecular characterization of rat gastric mucosal response to potent acid inhibition
Physiol Genomics, 22 (1), 24-32
DOI 10.1152/physiolgenomics.00245.2004, PubMed 15827235

Waldum HL, Fossmark R (2005)
Idiopathic gastric acid hypersecretion
Eur J Gastroenterol Hepatol, 17 (12), 1433
DOI 10.1097/00042737-200512000-00028, PubMed 16292103

Waldum HL, Fossmark R, Martinsen TC, Qvigstad G, Bakkelund KE, Kawase S (2005)
The Japanese cotton rat develops spontaneously an ECL cell derived gastric carcinoma
PROCEEDINGS OF THE 6TH INTERNATIONAL GASTRIC CANCER CONGRESS, 317-322

Waldum HL, Gustafsson B, Fossmark R, Qvigstad G (2005)
Antiulcer drugs and gastric cancer
Dig Dis Sci, 50 Suppl 1, S39-44
DOI 10.1007/s10620-005-2805-4, PubMed 16184420

Publications 2004

Fossmark R, Martinsen TC, Bakkelund KE, Kawase S, Torp SH, Waldum HL (2004)
Hypergastrinaemia induced by partial corpectomy results in development of enterochromaffin-like cell carcinoma in male Japanese cotton rats
Scand J Gastroenterol, 39 (10), 919-26
DOI 10.1080/00365520410003281, PubMed 15513328

Fossmark R, Martinsen TC, Bakkelund KE, Kawase S, Waldum HL (2004)
ECL-cell derived gastric cancer in male cotton rats dosed with the H2-blocker loxtidine
Cancer Res, 64 (10), 3687-93
DOI 10.1158/0008-5472.CAN-03-3647, PubMed 15150129

Fossmark R, Martinsen TC, Torp SH, Kawase S, Sandvik AK, Waldum HL (2004)
Spontaneous enterochromaffin-like cell carcinomas in cotton rats (Sigmodon hispidus) are prevented by a somatostatin analogue
Endocr Relat Cancer, 11 (1), 149-60
DOI 10.1677/erc.0.0110149, PubMed 15027892

Waldum HL, Fossmark R, Bakke I, Martinsen TC, Qvigstad G (2004)
Hypergastrinemia in animals and man: causes and consequences
Scand J Gastroenterol, 39 (6), 505-9
DOI 10.1080/00365520410005072, PubMed 15223671

Publications 2003

Martinsen TC, Kawase S, Håkanson R, Torp SH, Fossmark R, Qvigstad G, Sandvik AK, Waldum HL (2003)
Spontaneous ECL cell carcinomas in cotton rats: natural course and prevention by a gastrin receptor antagonist
Carcinogenesis, 24 (12), 1887-96
DOI 10.1093/carcin/bgg156, PubMed 12949047

Publications 1994

Fossmark R, Bergström S (1994)
[Malaria in Norway--a tropical disease off the track?]
Tidsskr Nor Laegeforen, 114 (30), 3643-5
PubMed 7825149