Asle Wilhelm Medhus
- Head of the Department of Gastroenterology and Professor of Gastroenterology; MD, PhD
- +47 934 94 094
Education
- MD University of Oslo (1995)
- PhD University of Oslo (2001)
- Norwegian clinical specialist accreditations
- Internal medicine (2005) and gastroenterology (2006)
Current position
Head of the Department of Gastroenterology, OUS and Professor of Gastroenterology, Insititute of Clinical Medicine, University of Oslo
Publications 2024
Frailty risk and treatment strategy in elderly-onset inflammatory bowel disease. A Norwegian nationwide population-based registry study
Dig Liver Dis, 56 (9), 1503-1510
DOI 10.1016/j.dld.2024.02.002, PubMed 38433021
Low Surgery Rates in Early Crohn's Disease: Results from a Prospective Population-Based Inception Cohort-The Inflammatory Bowel Disease in South-Eastern Norway III Study
Inflamm Bowel Dis (in press)
DOI 10.1093/ibd/izae297, PubMed 39699202
Clinical course of ulcerative colitis: Frequent use of biologics and low colectomy rate first year after diagnosis-results from the IBSEN III inception cohort
Aliment Pharmacol Ther, 60 (3), 357-368
DOI 10.1111/apt.18097, PubMed 38837289
Subcutaneous Vedolizumab Treatment in a Real-World Inflammatory Bowel Disease Cohort Switched From Intravenous Vedolizumab: Eighteen-Month Prospective Follow-up Study
Crohns Colitis 360, 6 (1), otae013
DOI 10.1093/crocol/otae013, PubMed 38544907
Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study
Scand J Gastroenterol, 59 (6), 652-660
DOI 10.1080/00365521.2024.2313056, PubMed 38356408
Publications 2023
Intraoperative distensibility measurement in POEM for achalasia: impact on patient outcome and associations with other outcome variables at 1-year follow-up
Surg Endosc, 37 (12), 9283-9290
DOI 10.1007/s00464-023-10494-z, PubMed 37880446
A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation
Hepatology, 77 (3), 715-728
DOI 10.1002/hep.32773, PubMed 36056902
Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC?
Hepatology, 77 (6), E188-E189
DOI 10.1097/HEP.0000000000000340, PubMed 36815351
Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study
J Crohns Colitis, 17 (11), 1781-1790
DOI 10.1093/ecco-jcc/jjad094, PubMed 37279652
Humoral immune response to SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive medication: association to serum drug levels and disease type
Scand J Gastroenterol, 58 (8), 874-882
DOI 10.1080/00365521.2023.2177884, PubMed 36788656
ERCP for the initial management of malignant biliary obstruction - real world data on 596 procedures
Scand J Gastroenterol, 59 (3), 369-377
DOI 10.1080/00365521.2023.2282375, PubMed 37994406
Patient-reported outcomes, weight loss, and remission of type 2 diabetes 3 years after gastric bypass and sleeve gastrectomy (Oseberg); a single-centre, randomised controlled trial
Lancet Diabetes Endocrinol, 11 (8), 555-566
DOI 10.1016/S2213-8587(23)00127-4, PubMed 37414071
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 8 (1), 4
DOI 10.1038/s41541-023-00600-6, PubMed 36697432
Switching from intravenous to subcutaneous vedolizumab maintenance treatment in patients with inflammatory bowel disease followed by therapeutic drug monitoring
Scand J Gastroenterol, 58 (8), 863-873
DOI 10.1080/00365521.2023.2176252, PubMed 36799155
Publications 2022
Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy
Endosc Int Open, 10 (12), E1570-E1576
DOI 10.1055/a-1968-7682, PubMed 36531682
Plasma α-Glutathione S-Transferase in Patients with Chronic Mesenteric Ischemia and Median Arcuate Ligament Syndrome
Vasc Health Risk Manag, 18, 567-574
DOI 10.2147/VHRM.S365625, PubMed 35903288
Letter to the Editor regarding the article «Gerd symptoms after laparoscopic Roux-en-Y gastric bypass: an emerging scenario» by Antonella Santonicola, Luigi Ruggiero, Rossella Palma, Luigi Angrisani and Paola Iovino. International Journal of Obesity (2022) 46:1076-1078
Int J Obes (Lond), 46 (10), 1936-1937
DOI 10.1038/s41366-022-01200-5, PubMed 35933446
Human Immunodeficiency Virus-Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction
J Infect Dis, 225 (4), 661-674
DOI 10.1093/infdis/jiaa714, PubMed 33216130
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
J Acquir Immune Defic Syndr, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817, PubMed 34878437
Early Identification of Chronic Mesenteric Ischemia with Endoscopic Duplex Ultrasound
Vasc Health Risk Manag, 18, 233-243
DOI 10.2147/VHRM.S358570, PubMed 35431549
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 7 (1), 174
DOI 10.1038/s41541-022-00586-7, PubMed 36585405
Publications 2021
First-line biologic treatment of inflammatory bowel disease during the first 12 months after diagnosis from 2010 to 2016: a Norwegian nationwide registry study
Scand J Gastroenterol, 56 (10), 1163-1168
DOI 10.1080/00365521.2021.1955147, PubMed 34320885
One year comprehensive prospective follow-up of achalasia patients after peroral endoscopic myotomy
Ann Med, 53 (1), 2225-2233
DOI 10.1080/07853890.2021.2005253, PubMed 34806501
The effect of train-the-colonoscopy-trainer course on colonoscopy quality indicators
Endoscopy, 53 (12), 1229-1234
DOI 10.1055/a-1352-4583, PubMed 33622001
Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway
Scand J Gastroenterol, 56 (8), 899-905
DOI 10.1080/00365521.2021.1922746, PubMed 34154494
Sleeve Gastrectomy Confers Higher Risk of Gastroesophageal Reflux Disease Than Gastric Bypass: A Randomized Controlled Trial From the Oseberg Reflux Working Group
Gastroenterology, 161 (6), 2044-2046.e4
DOI 10.1053/j.gastro.2021.08.021, PubMed 34419459
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047
A novel intragastric balloon for treatment of obesity and type 2 diabetes. A two-center pilot trial
Scand J Gastroenterol, 57 (2), 232-238
DOI 10.1080/00365521.2021.1994641, PubMed 34714203
Publications 2020
Perioperative Microcirculatory Changes Detected with Gastroscopy Assisted Laser Doppler Flowmetry and Visible Light Spectroscopy in Patients with Median Arcuate Ligament Syndrome
Vasc Health Risk Manag, 16, 331-341
DOI 10.2147/VHRM.S252192, PubMed 32982262
A Short Series of Laparoscopic Mesenteric Bypasses for Chronic Mesenteric Ischemia
Vasc Health Risk Manag, 16, 87-97
DOI 10.2147/VHRM.S243264, PubMed 32256075
Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study
Obes Surg, 30 (7), 2667-2675
DOI 10.1007/s11695-020-04545-w, PubMed 32193740
Laser Doppler Flowmetry and Visible Light Spectroscopy of the Gastric Tube During Minimally Invasive Esophagectomy
Vasc Health Risk Manag, 16, 497-505
DOI 10.2147/VHRM.S269138, PubMed 33273819
Publications 2019
Gastroscopy assisted laser Doppler flowmetry and visible light spectroscopy in patients with chronic mesenteric ischemia
Scand J Clin Lab Invest, 79 (7), 541-549
DOI 10.1080/00365513.2019.1672084, PubMed 31560225
Plasma cytokine levels in patients with chronic alcohol overconsumption: Relations to gut microbiota markers and clinical correlates
Alcohol, 85, 35-40
DOI 10.1016/j.alcohol.2019.10.002, PubMed 31610228
Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption
Gut Microbes, 10 (6), 663-675
DOI 10.1080/19490976.2019.1580097, PubMed 30894059
Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort
Scand J Gastroenterol, 54 (1), 41-48
DOI 10.1080/00365521.2018.1548646, PubMed 30650312
Outcome of peroral endoscopic myotomy (POEM) in treatment-naive patients. A systematic review
Scand J Gastroenterol, 54 (1), 1-7
DOI 10.1080/00365521.2018.1549271, PubMed 30650313
Response to letter to the editor: 'Outcome of peroral endoscopic myotomy (POEM) in treatment-naive patients. A systematic review'
Scand J Gastroenterol, 54 (4), 520
DOI 10.1080/00365521.2019.1599416, PubMed 30978123
Publications 2018
Combining Anti-TNF-α and Vedolizumab in the Treatment of Inflammatory Bowel Disease: A Case Series
Inflamm Bowel Dis, 24 (5), 997-1004
DOI 10.1093/ibd/izx110, PubMed 29668901
Endoscopy assistants influence the quality of colonoscopy
Endoscopy, 50 (9), 871-877
DOI 10.1055/s-0044-101706, PubMed 29444529
Switching from originator to biosimilar infliximab - real world data of a prospective 18 months follow-up of a single-centre IBD population
Scand J Gastroenterol, 53 (6), 692-699
DOI 10.1080/00365521.2018.1463391, PubMed 29852793
Publications 2017
Chronic alcohol overconsumption may alter gut microbial metabolism: a retrospective study of 719 13C-D-xylose breath test results
Microb Ecol Health Dis, 28 (1), 1301725
DOI 10.1080/16512235.2017.1301725, PubMed 28572752
Does the Introduction of Biosimilars Change Our Understanding about Treatment Modalities for Inflammatory Bowel Disease?
Dig Dis, 35 (1-2), 74-82
DOI 10.1159/000449087, PubMed 28147370
Switching from Remicade® to Remsima® is well Tolerated and Feasible: A Prospective, Open-label Study
J Crohns Colitis, 11 (3), 297-304
DOI 10.1093/ecco-jcc/jjw166, PubMed 27660339
Publications 2016
Preoperative liquid gastric emptying rate does not predict outcome after fundoplication
J Pediatr Surg, 52 (4), 540-543
DOI 10.1016/j.jpedsurg.2016.09.068, PubMed 28277299
Publications 2013
Secular reduction of excess mortality in hip fracture patients >85 years
BMC Geriatr, 13, 25
DOI 10.1186/1471-2318-13-25, PubMed 23496953
Correction to: Small intestinal malabsorption in chronic alcoholism: a retrospective study of alcoholic patients by the 14C-D-xylose breath test
Scand J Gastroenterol, 48 (10), 1231-1232
DOI 10.3109/00365521.2013.825316, PubMed 28078905
Gastric emptying in children with gastroesophageal reflux and in healthy children
J Pediatr Surg, 48 (9), 1856-61
DOI 10.1016/j.jpedsurg.2013.03.076, PubMed 24074657
Publications 2012
Nissen fundoplication in children with cerebral palsy: influence on rate of gastric emptying and postprandial symptoms in relation to protein source in caloric liquid meals
Clin Nutr, 32 (4), 619-23
DOI 10.1016/j.clnu.2012.11.010, PubMed 23196118
Small intestinal malabsorption in chronic alcoholism: a retrospective study of alcoholic patients by the ¹⁴C-D-xylose breath test
Scand J Gastroenterol, 47 (4), 428-34
DOI 10.3109/00365521.2011.648951, PubMed 22229732
Stent treatment of malignant gastric outlet obstruction: the effect on rate of gastric emptying, symptoms, and survival
Surg Endosc, 26 (10), 2955-60
DOI 10.1007/s00464-012-2291-7, PubMed 22538695
Long-term outcome of palliative treatment with self-expanding metal stents for malignant obstructions of the GI tract
Scand J Gastroenterol, 47 (12), 1505-14
DOI 10.3109/00365521.2012.711854, PubMed 23046494
Publications 2011
The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy
Clin Nutr, 31 (1), 108-12
DOI 10.1016/j.clnu.2011.07.009, PubMed 21835514
Reduced ¹³C-D-xylose absorption in alcoholics is more likely caused by alterations in small intestinal mucosa than delayed gastric emptying
Scand J Gastroenterol, 46 (4), 414-9
DOI 10.3109/00365521.2010.536252, PubMed 21275757
Patient-reported outcomes in palliative gastrointestinal stenting: a Norwegian multicenter study
Surg Endosc, 25 (10), 3162-9
DOI 10.1007/s00464-011-1680-7, PubMed 21487867
Publications 2010
Database validity in assessing population trends in hip fracture rates in Canada
JAMA, 303 (2), 134-5; author reply 135
DOI 10.1001/jama.2009.1973, PubMed 20068206
Publications 2009
Treatment of malignant gastric outlet obstruction with stents: an evaluation of the reported variables for clinical outcome
BMC Gastroenterol, 9, 45
DOI 10.1186/1471-230X-9-45, PubMed 19534803
Motility of the oesophagus and small bowel in adults treated for Hirschsprung's disease during early childhood
Neurogastroenterol Motil, 22 (2), 154-60, e49
DOI 10.1111/j.1365-2982.2009.01397.x, PubMed 19735477
Publications 2007
Liquid and solid gastric emptying in adults treated for Hirschsprung's disease during early childhood
Scand J Gastroenterol, 42 (1), 34-40
DOI 10.1080/00365520600842211, PubMed 17190760
Publications 2005
Local and national electronic databases in Norway demonstrate a varying degree of validity
J Clin Epidemiol, 58 (3), 280-5
DOI 10.1016/j.jclinepi.2004.07.003, PubMed 15718117
Publications 2001
Are patients with Hirschsprung's disease prediabetic?
Metabolism, 50 (12), 1389-90
DOI 10.1053/meta.2001.28139, PubMed 11735080
Are patients with Hirschsprung's disease prediabetic?
In Metabolism, Grune & Stratton, New York, 50(2001)nr 12, s.1389-1390
BIBSYS 022058494
Gastric emptying: the validity of the paracetamol absorption test adjusted for individual pharmacokinetics
Neurogastroenterol Motil, 13 (3), 179-85
DOI 10.1046/j.1365-2982.2001.00249.x, PubMed 11437980
Publications 2000
Low-dose intravenous erythromycin: effects on postprandial and fasting motility of the small bowel
Aliment Pharmacol Ther, 14 (2), 233-40
DOI 10.1046/j.1365-2036.2000.00693.x, PubMed 10651665
Stimulation of the small intestine by nutrients in relation to phase of the migrating motor complex
Scand J Gastroenterol, 35 (5), 494-500
DOI 10.1080/003655200750023750, PubMed 10868452
Publications 1999
Delay of gastric emptying by duodenal intubation: sensitive measurement of gastric emptying by the paracetamol absorption test
Aliment Pharmacol Ther, 13 (5), 609-20
DOI 10.1046/j.1365-2036.1999.00519.x, PubMed 10233184
The influence of the migrating motor complex on the postprandial endocrine response
Scand J Gastroenterol, 34 (10), 1012-8
DOI 10.1080/003655299750025129, PubMed 10563672