Publications 2025

Kjørholt KE, Sundlisæter NP, Aga AB, Sexton J, Olsen IC, Lexberg ÅS, Madland TM, Fremstad H, Høili CA, Bakland G, Spada C, Haukeland H, Hansen IM, Moholt E, Holten K, Uhlig T, Kvien TK, Solomon DH, van der Heijde D, Haavardsholm EA, Lillegraven S (2025)
3-year Results of Tapering TNFi to Withdrawal Compared to Stable TNFi Among Patients with Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial
Arthritis Rheumatol (in press)
DOI 10.1002/art.43199, PubMed 40289847

Rampinelli V, Ferrari M, Dohin I, Vinciguerra A, Mattavelli D, Saccardo T, Testa G, Conti C, Frigerio C, Verillaud B, Ajasllari G, Gaudioso P, Cazzador D, Aga A, Taboni S, Daniele Arioso A, Neri L, Borsetto D, Wolf A, Rodriguez-Van Strahlen C, Turri-Zanoni M, Emanuelli E, Schreiber A, Battaglia P, Pagella F et al. (2025)
Advanced paranasal sinuses osteomas: a retrospective multicentric analysis on surgical management outcomes and intra- and postsurgical complications
Rhinology, 63 (2), 209-220
DOI 10.4193/Rhin24.165, PubMed 39831842

Publications 2024

Holten K, Paulshus Sundlisæter N, Sexton J, Kjørholt KE, Nordberg LB, Moholt E, Uhlig T, van der Heijde D, Solomon DH, Haavardsholm EA, Lillegraven S, Aga AB, ARCTIC REWIND study group (2024)
Agreement between patient-reported flares and clinically significant flare status in patients with rheumatoid arthritis in sustained remission: data from the ARCTIC REWIND trials
RMD Open, 10 (3)
DOI 10.1136/rmdopen-2024-004444, PubMed 39237295

Holten K, Paulshus Sundlisæter N, Sexton J, Nordberg LB, Uhlig T, Kvien TK, Solomon DH, Haavardsholm EA, Lillegraven S, Aga AB, ARCTIC REWIND study group (2024)
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity
RMD Open, 10 (1)
DOI 10.1136/rmdopen-2023-003486, PubMed 38216290

Kjørholt KE, Sundlisæter NP, Aga AB, Sexton J, Olsen IC, Fremstad H, Spada C, Madland TM, Høili CA, Bakland G, Lexberg Å, Hansen IJW, Hansen IM, Haukeland H, Ljoså MA, Moholt E, Uhlig T, Kvien TK, Solomon DH, van der Heijde D, Haavardsholm EA, Lillegraven S (2024)
Effects of tapering conventional synthetic disease-modifying antirheumatic drugs to drug-free remission versus stable treatment in rheumatoid arthritis (ARCTIC REWIND): 3-year results from an open-label, randomised controlled, non-inferiority trial
Lancet Rheumatol, 6 (5), e268-e278
DOI 10.1016/S2665-9913(24)00021-3, PubMed 38583450

Melokhina V, Paulshus Sundlisæter N, Sexton J, Sundin U, Aga AB, Kjørholt KE, Nordberg LB, van der Heijde D, Haavardsholm E, Lillegraven S (2024)
Subclinical inflammation and joint damage progression in patients with early RA fulfilling 2011 vs 2022 ACR/EULAR Boolean remission criteria: data from the ARCTIC study
Ann Rheum Dis, 83 (4), 540-541
DOI 10.1136/ard-2023-224950, PubMed 38049997

Sande NK, Kirkhus E, Lilleby V, Tomterstad AH, Aga AB, Flatø B, Bøyesen P (2024)
Validity of an ultrasonographic joint-specific scoring system in juvenile idiopathic arthritis: a cross-sectional study comparing ultrasound findings of synovitis with whole-body magnetic resonance imaging and clinical assessment
RMD Open, 10 (1)
DOI 10.1136/rmdopen-2023-003965, PubMed 38428979

Publications 2023

Lillegraven S, Paulshus Sundlisæter N, Aga AB, Sexton J, Olsen IC, Lexberg ÅS, Madland TM, Fremstad H, Høili CA, Bakland G, Spada C, Haukeland H, Hansen IM, Moholt E, Uhlig T, Solomon DH, van der Heijde D, Kvien TK, Haavardsholm EA (2023)
Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial
Ann Rheum Dis, 82 (11), 1394-1403
DOI 10.1136/ard-2023-224476, PubMed 37607809

Lillegraven S, Paulshus Sundlisæter N, Aga AB, Sexton J, Solomon DH, van der Heijde D, Haavardsholm EA (2023)
Discontinuation of Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis and Excellent Disease Control
JAMA, 329 (12), 1024-1026
DOI 10.1001/jama.2023.0492, PubMed 36976288

Sande NK, Lilleby V, Aga AB, Kirkhus E, Flatø B, Bøyesen P (2023)
Associations between power Doppler ultrasound findings and B-mode synovitis and clinical arthritis in juvenile idiopathic arthritis using a standardised scanning approach and scoring system
RMD Open, 9 (1)
DOI 10.1136/rmdopen-2022-002937, PubMed 36963783

Østergaard M, van Vollenhoven RF, Rudin A, Hetland ML, Heiberg MS, Nordström DC, Nurmohamed MT, Gudbjornsson B, Ørnbjerg LM, Bøyesen P, Lend K, Hørslev-Petersen K, Uhlig T, Sokka T, Grondal G, Krabbe S, Lindqvist J, Gjertsson I, Glinatsi D, Kapetanovic MC, Aga AB, Faustini F, Parmanne P, Lorenzen T, Giovanni C et al. (2023)
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
Ann Rheum Dis, 82 (10), 1286-1295
DOI 10.1136/ard-2023-224116, PubMed 37423647

Publications 2022

Bardan I, Fagerli KM, Sexton J, Kvien TK, Bakland G, Mielnik P, Hu Y, Lien G, Flatø B, Molberg Ø, Kristianslund EK, Aga AB (2022)
Treatment Response to Tumor Necrosis Factor Inhibitors and Methotrexate Monotherapy in Adults With Juvenile Idiopathic Arthritis: Data From NOR-DMARD
J Rheumatol, 50 (4), 538-547
DOI 10.3899/jrheum.220645, PubMed 36379571

Paulshus Sundlisæter N, Sundin U, Aga AB, Sexton J, Hammer HB, Uhlig T, Kvien TK, Haavardsholm EA, Lillegraven S (2022)
Inflammation and biologic therapy in patients with rheumatoid arthritis achieving versus not achieving ACR/EULAR Boolean remission in a treat-to-target study
RMD Open, 8 (1)
DOI 10.1136/rmdopen-2021-002013, PubMed 35091463

Podewski AF, Glimm AM, Fischer I, Bruyn GAW, Hanova P, Hammer HB, Aga AB, Haavardsholm EA, Ramiro S, Burmester GR, Backhaus M, Ohrndorf S (2022)
The MCP2 and the wrist plus two extensor compartments are the most affected and responsive joints/tendons out of the US7 score in patients with rheumatoid arthritis-an observational study
Arthritis Res Ther, 24 (1), 183
DOI 10.1186/s13075-022-02874-y, PubMed 35932087

Publications 2021

Heinicke F, Zhong X, Flåm ST, Breidenbach J, Leithaug M, Mæhlen MT, Lillegraven S, Aga AB, Norli ES, Mjaavatten MD, Haavardsholm EA, Zucknick M, Rayner S, Lie BA (2021)
MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients
Front Immunol, 12, 663736
DOI 10.3389/fimmu.2021.663736, PubMed 33897713

Holten K, Paulshus Sundlisater N, Lillegraven S, Sexton J, Nordberg LB, Moholt E, Hammer HB, Uhlig T, Kvien TK, Haavardsholm EA, Aga AB (2021)
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment
Ann Rheum Dis, 81 (3), 344-350
DOI 10.1136/annrheumdis-2021-220750, PubMed 34389605

Lillegraven S, Paulshus Sundlisæter N, Aga AB, Sexton J, Olsen IC, Fremstad H, Spada C, Madland TM, Høili CA, Bakland G, Lexberg Å, Hansen IJW, Hansen IM, Haukeland H, Ljoså MA, Moholt E, Uhlig T, Solomon DH, van der Heijde D, Kvien TK, Haavardsholm EA (2021)
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial
JAMA, 325 (17), 1755-1764
DOI 10.1001/jama.2021.4542, PubMed 33944875

Paulshus Sundlisater N, Aga AB, Olsen IC, Hammer HB, Uhlig T, van der Heijde D, Kvien TK, Haavardsholm EA, Lillegraven S (2021)
Joint tenderness and ultrasound inflammation in DMARD-naïve patients with early rheumatoid arthritis
Ann Rheum Dis, 80 (11), 1493-1494
DOI 10.1136/annrheumdis-2021-220265, PubMed 34083205

Sande NK, Bøyesen P, Aga AB, Hammer HB, Flatø B, Roth J, Lilleby V (2021)
Development and reliability of a novel ultrasonographic joint-specific scoring system for synovitis with reference atlas for patients with juvenile idiopathic arthritis
RMD Open, 7 (2)
DOI 10.1136/rmdopen-2021-001581, PubMed 33883255

Sundin U, Sundlisater NP, Aga AB, Sexton J, Nordberg LB, Hammer HB, van der Heijde D, Kvien TK, Haavardsholm EA, Lillegraven S, the ARCTIC Study Group (2021)
Value of MRI and ultrasound for prediction of therapeutic response and erosive progression in patients with early rheumatoid arthritis managed by an aggressive treat-to-target strategy
RMD Open, 7 (1)
DOI 10.1136/rmdopen-2020-001525, PubMed 33547228

Publications 2020

Guderud K, Sunde LH, Flåm ST, Mæhlen MT, Mjaavatten MD, Lillegraven S, Aga AB, Evenrød IM, Norli ES, Andreassen BK, Franzenburg S, Franke A, Haavardsholm EA, Rayner S, Gervin K, Lie BA (2020)
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4⁺ Memory Than in CD4⁺ Naïve T Cells
Front Immunol, 11, 194
DOI 10.3389/fimmu.2020.00194, PubMed 32117312

Norvang V, Brinkmann GH, Yoshida K, Lillegraven S, Aga AB, Sexton J, Tedeschi SK, Lyu H, Norli ES, Uhlig T, Kvien TK, Mjaavatten MD, Solomon DH, Haavardsholm EA, ARCTIC study group, NOR-VEAC study group (2020)
Achievement of remission in two early rheumatoid arthritis cohorts implementing different treat-to-target strategies
Arthritis Rheumatol, 72 (7), 1072-1081
DOI 10.1002/art.41232, PubMed 32090491

Sundin U, Aga AB, Skare Ø, Nordberg LB, Uhlig T, Hammer HB, van der Heijde D, Kvien TK, Lillegraven S, Haavardsholm EA, ARCTIC study group (2020)
Conventional versus ultrasound treat to target: no difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis
Rheumatology (Oxford), 59 (9), 2550-2555
DOI 10.1093/rheumatology/kez674, PubMed 31999341

Publications 2019

Jonsson MK, Kantyka T, Falkowski K, Aliko A, Aga AB, Lillegraven S, Sexton J, Fevang BT, Mydel P, Haavardsholm EA (2019)
Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis
Scand J Rheumatol, 49 (2), 87-95
DOI 10.1080/03009742.2019.1641216, PubMed 31544586

Sundin U, Østergaard M, Glinatsi D, Aga AB, Hørslev-Petersen K, Hetland ML, Stengard-Pedersen K, Junker P, Ejbjerg BJ, Bird P, Conaghan PG, Lillegraven S, Haavardsholm EA (2019)
Validity and Responsiveness of Combined Inflammation and Combined Joint Damage Scores Based on the OMERACT Rheumatoid Arthritis MRI Scoring System (RAMRIS)
J Rheumatol, 46 (9), 1222-1227
DOI 10.3899/jrheum.181064, PubMed 30770509

Terslev L, Christensen R, Aga AB, Sexton J, Haavardsholm EA, Hammer HB (2019)
Assessing synovitis in the hands in patients with rheumatoid arthritis by ultrasound: an agreement study exploring the most inflammatory active side from two Norwegian trials
Arthritis Res Ther, 21 (1), 166
DOI 10.1186/s13075-019-1930-y, PubMed 31277679

Publications 2018

Holten K, Sexton J, Kvien TK, Aga AB, Haavardsholm EA (2018)
Comparative analyses of responsiveness between the Rheumatoid Arthritis Impact of Disease score, other patient-reported outcomes and disease activity measures: secondary analyses from the ARCTIC study
RMD Open, 4 (2), e000754
DOI 10.1136/rmdopen-2018-000754, PubMed 30487996

Jonsson MK, Hensvold AH, Hansson M, Aga AB, Sexton J, Mathsson-Alm L, Cornillet M, Serre G, Lillegraven S, Fevang BS, Catrina AI, Haavardsholm EA (2018)
The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy
Arthritis Res Ther, 20 (1), 146
DOI 10.1186/s13075-018-1635-7, PubMed 30001740

Jonsson MK, Sundlisæter NP, Nordal HH, Hammer HB, Aga AB, van der Heijde D, Kvien TK, Fevang BS, Lillegraven S, Haavardsholm EA (2018)
Response to: 'Calprotectin is not independent from baseline erosion in predicting radiological progression in early rheumatoid arthritis' by Chevreau et al
Ann Rheum Dis, 77 (12), e85
DOI 10.1136/annrheumdis-2017-212869, PubMed 29321158

Nordberg LB, Lillegraven S, Aga AB, Sexton J, Lie E, Hammer HB, Olsen IC, Uhlig T, van der Heijde D, Kvien TK, Haavardsholm EA (2018)
The Impact of Ultrasound on the Use and Efficacy of Intraarticular Glucocorticoid Injections in Early Rheumatoid Arthritis: Secondary Analyses From a Randomized Trial Examining the Benefit of Ultrasound in a Clinical Tight Control Regimen
Arthritis Rheumatol, 70 (8), 1192-1199
DOI 10.1002/art.40494, PubMed 29575737

Nordberg LB, Lillegraven S, Aga AB, Sexton J, Olsen IC, Lie E, Berner Hammer H, Uhlig T, van der Heijde D, Kvien TK, Haavardsholm EA (2018)
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial
RMD Open, 4 (2), e000752
DOI 10.1136/rmdopen-2018-000752, PubMed 30564452

Paulshus Sundlisæter N, Aga AB, Olsen IC, Hammer HB, Uhlig T, van der Heijde D, Kvien TK, Lillegraven S, Haavardsholm EA, ARCTIC study group (2018)
Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: associations to future good radiographic and physical outcomes
Ann Rheum Dis, 77 (10), 1421-1425
DOI 10.1136/annrheumdis-2017-212830, PubMed 29934373

Paulshus Sundlisæter N, Olsen IC, Aga AB, Hammer HB, Uhlig T, van der Heijde D, Kvien TK, Lillegraven S, Haavardsholm EA, ARCTIC study group (2018)
Predictors of sustained remission in patients with early rheumatoid arthritis treated according to an aggressive treat-to-target protocol
Rheumatology (Oxford), 57 (11), 2022-2031
DOI 10.1093/rheumatology/key202, PubMed 30053199

Publications 2017

Aga AB (2017)
[Not Available]
Tidsskr Nor Laegeforen, 137 (6), 471
DOI 10.4045/tidsskr.16.1120, PubMed 28332809

Jonsson MK, Sundlisæter NP, Nordal HH, Hammer HB, Aga AB, Olsen IC, Brokstad KA, van der Heijde D, Kvien TK, Fevang BS, Lillegraven S, Haavardsholm EA (2017)
Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis
Ann Rheum Dis, 76 (12), 2031-2037
DOI 10.1136/annrheumdis-2017-211695, PubMed 28814431

Publications 2016

Aga AB, Berner Hammer H, Christoffer Olsen I, Uhlig T, Kvien TK, van der Heijde D, Fremstad H, Madland TM, Lexberg ÅS, Haukeland H, Rødevand E, Høili C, Stray H, Noraas AL, Widding Hansen IJ, Bakland G, Lillegraven S, Lie E, Haavardsholm EA (2016)
Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach
RMD Open, 2 (2), e000325
DOI 10.1136/rmdopen-2016-000325, PubMed 28074154

Haavardsholm EA, Aga AB, Olsen IC, Lillegraven S, Hammer HB, Uhlig T, Fremstad H, Madland TM, Lexberg ÅS, Haukeland H, Rødevand E, Høili C, Stray H, Noraas A, Hansen IJ, Bakland G, Nordberg LB, van der Heijde D, Kvien TK (2016)
Ultrasound in management of rheumatoid arthritis: ARCTIC randomised controlled strategy trial
BMJ, 354, i4205
DOI 10.1136/bmj.i4205, PubMed 27530741

Nordberg LB, Lillegraven S, Lie E, Aga AB, Olsen IC, Hammer HB, Uhlig T, Jonsson MK, van der Heijde D, Kvien TK, Haavardsholm EA, and the ARCTIC working group (2016)
Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria
Ann Rheum Dis, 76 (2), 341-345
DOI 10.1136/annrheumdis-2015-208873, PubMed 27094444

Publications 2015

Aga AB, Hammer HB, Olsen IC, Uhlig T, Kvien TK, van der Heijde D, Fremstad H, Madland TM, Lexberg ÅS, Haukeland H, Rødevand E, Høili C, Stray H, Bendvold AN, Soldal DM, Bakland G, Lie E, Haavardsholm EA (2015)
First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach
Ann Rheum Dis, 75 (8), 1444-51
DOI 10.1136/annrheumdis-2015-207572, PubMed 26085490

Publications 2013

Aga AB, Lie E, Uhlig T, Olsen IC, Wierød A, Kalstad S, Rødevand E, Mikkelsen K, Kvien TK, Haavardsholm EA (2013)
Time trends in disease activity, response and remission rates in rheumatoid arthritis during the past decade: results from the NOR-DMARD study 2000-2010
Ann Rheum Dis, 74 (2), 381-8
DOI 10.1136/annrheumdis-2013-204020, PubMed 24285493

Publications 2001

Aga A (2001)
Juvenile nasopharyngeal angiofibroma presenting as Foster Kennedy Syndrome
Ethiop Med J, 39 (3), 251-60
PubMed 11921556

Publications 1989

Tomescu P, Rădescu A, Aga A, Marin M (1989)
[Cases of serous otitis admitted to the ENT Department of the V. Babeş Hospital over the last 7 years]
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Otorinolaringol, 34 (1), 57-62
PubMed 2528792

Publications 1946

AGA AB (1946)
[Improved dropper for ether anesthesia]
Khirurgiia (Mosk) (7), 87-9
PubMed 20283318