Sjur Reppe
- Senior Scientist; PhD
Education
- 1990-1997: PhD in Biochemistry, University of Oslo (UIO), Norway.
- 1984-1987: MSc in Biochemistry, University of Oslo (UIO), Norway.
- 1980-1984: BSc in Life Sciences, University of Oslo (UIO), Norway.
Affiliation
- Department of Medical Biochemistry, Oslo University Hospital - Ullevål, Norway.
- Unger-Vetlesens Institute, Lovisenberg Diakonale Hospital, Oslo, Norway.
Links
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Publications 2024
Heritability of tear fluid cytokines in healthy twins
Ocul Surf, 32, 145-153
DOI 10.1016/j.jtos.2024.02.005, PubMed 38387783
A perspective on muscle phenotyping in musculoskeletal research
Trends Endocrinol Metab, 35 (6), 478-489
DOI 10.1016/j.tem.2024.01.004, PubMed 38553405
Tear cytokine levels are reduced in patients treated with intravitreal injections
Ocul Surf, 32, 222-226
DOI 10.1016/j.jtos.2024.03.004, PubMed 38490478
LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response
EMBO J, 43 (17), 3587-3603
DOI 10.1038/s44318-024-00143-z, PubMed 38951609
Author Correction: LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response
EMBO J, 43 (20), 4805-4806
DOI 10.1038/s44318-024-00243-w, PubMed 39304794
Network Analysis of Brain and Bone Tissue Transcripts Reveals Shared Molecular Mechanisms Underlying Alzheimer's Disease and Related Dementias and Osteoporosis
J Gerontol A Biol Sci Med Sci, 79 (11)
DOI 10.1093/gerona/glae211, PubMed 39194133
Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease
Int J Mol Sci, 25 (10)
DOI 10.3390/ijms25105554, PubMed 38791593
Publications 2023
Ocular Surface Homeostasis After Scleral Lens Usage
Eye Contact Lens, 49 (11), 459-463
DOI 10.1097/ICL.0000000000001027, PubMed 37651199
Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis
Commun Biol, 6 (1), 691
DOI 10.1038/s42003-023-04869-0, PubMed 37402774
Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization
Arthritis Rheumatol, 75 (10), 1781-1792
DOI 10.1002/art.42538, PubMed 37096546
Publications 2022
Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis
Int J Mol Sci, 23 (6)
DOI 10.3390/ijms23062957, PubMed 35328378
Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults
Eur Rev Aging Phys Act, 19 (1), 23
DOI 10.1186/s11556-022-00304-1, PubMed 36182918
In silico discovery of blood cell macromolecular associations
BMC Genom Data, 23 (1), 57
DOI 10.1186/s12863-022-01077-3, PubMed 35879676
Novel Genetic Determinants of Dental Maturation in Children
J Dent Res, 102 (3), 349-356
DOI 10.1177/00220345221132268, PubMed 36437532
Publications 2021
Lipocalin 2 serum levels correlate with age and bone turnover biomarkers in healthy subjects but not in postmenopausal osteoporotic women
Bone Rep, 14, 101059
DOI 10.1016/j.bonr.2021.101059, PubMed 34026950
Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques
Front Endocrinol (Lausanne), 12, 731217
DOI 10.3389/fendo.2021.731217, PubMed 34938269
Publications 2020
Cytokines Explored in Saliva and Tears from Radiated Cancer Patients Correlate with Clinical Manifestations, Influencing Important Immunoregulatory Cellular Pathways
Cells, 9 (9)
DOI 10.3390/cells9092050, PubMed 32911805
Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non-Weight-Bearing Human Bone
J Bone Miner Res, 35 (6), 1065-1076
DOI 10.1002/jbmr.3974, PubMed 32017184
Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins
Molecules, 25 (19)
DOI 10.3390/molecules25194395, PubMed 32987810
Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study
Ther Adv Musculoskelet Dis, 12, 1759720X20929443
DOI 10.1177/1759720X20929443, PubMed 32536985
Stem cell function is conserved during short-term storage of cultured epidermal cell sheets at 12°C
PLoS One, 15 (5), e0232270
DOI 10.1371/journal.pone.0232270, PubMed 32433698
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914, PubMed 33326470
Publications 2019
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations
Sci Rep, 9 (1), 7319
DOI 10.1038/s41598-019-43714-5, PubMed 31086200
Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry
J Bone Miner Res, 34 (7), 1284-1296
DOI 10.1002/jbmr.3698, PubMed 30888730
Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
J Bone Miner Res, 34 (10), 1824-1836
DOI 10.1002/jbmr.3803, PubMed 31170332
Publications 2018
Cultured Human Retinal Pigment Epithelial (hRPE) Sheets: A Search for Suitable Storage Conditions
Microsc Microanal, 24 (2), 147-155
DOI 10.1017/S1431927618000144, PubMed 29637873
Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women
BMC Med Genomics, 11 (1), 24
DOI 10.1186/s12920-018-0341-2, PubMed 29514638
Improvement of Storage Medium for Cultured Human Retinal Pigment Epithelial Cells Using Factorial Design
Sci Rep, 8 (1), 5688
DOI 10.1038/s41598-018-24121-8, PubMed 29632395
High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets
Stem Cells Int, 2018, 6545876
DOI 10.1155/2018/6545876, PubMed 30581473
Publications 2017
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
Ann Rheum Dis, 77 (3), 378-385
DOI 10.1136/annrheumdis-2017-212469, PubMed 29170203
Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets
Sci Rep, 7 (1), 8206
DOI 10.1038/s41598-017-08586-7, PubMed 28811665
Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD)
Int J Mol Sci, 18 (12)
DOI 10.3390/ijms18122529, PubMed 29186852
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
Nat Commun, 8 (1), 121
DOI 10.1038/s41467-017-00108-3, PubMed 28743860
Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease
Bone, 101, 88-95
DOI 10.1016/j.bone.2017.04.012, PubMed 28450214
Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women
Epigenetics, 12 (8), 674-687
DOI 10.1080/15592294.2017.1345832, PubMed 28650214
Publications 2016
The Silk-protein Sericin Induces Rapid Melanization of Cultured Primary Human Retinal Pigment Epithelial Cells by Activating the NF-κB Pathway
Sci Rep, 6, 22671
DOI 10.1038/srep22671, PubMed 26940175
Nucleus Morphometry in Cultured Epithelial Cells Correlates with Phenotype
Microsc Microanal, 22 (3), 612-20
DOI 10.1017/S1431927616000830, PubMed 27329312
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2
J Bone Miner Res, 31 (12), 2085-2097
DOI 10.1002/jbmr.2913, PubMed 27476799
Tilting the lasso by knowledge-based post-processing
BMC Bioinformatics, 17 (1), 344
DOI 10.1186/s12859-016-1210-7, PubMed 27590269
Publications 2015
Effect of Storage Temperature on the Phenotype of Cultured Epidermal Cells Stored in Xenobiotic-Free Medium
Curr Eye Res, 41 (6), 757-68
DOI 10.3109/02713683.2015.1062113, PubMed 26398483
Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors
Circ Res, 118 (1), 83-94
DOI 10.1161/CIRCRESAHA.115.306629, PubMed 26487741
The Influence of DNA Methylation on Bone Cells
Curr Genomics, 16 (6), 384-92
DOI 10.2174/1389202916666150817202913, PubMed 27019613
Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women
J Bone Miner Res, 30 (2), 249-56
DOI 10.1002/jbmr.2342, PubMed 25155887
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci
PLoS One, 10 (12), e0144531
DOI 10.1371/journal.pone.0144531, PubMed 26695485
Publications 2014
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes
Hypertension, 63 (4), 819-26
DOI 10.1161/HYPERTENSIONAHA.113.02077, PubMed 24396023
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
PLoS Genet, 10 (6), e1004423
DOI 10.1371/journal.pgen.1004423, PubMed 24945404
Enamel matrix derivative promote primary human pulp cell differentiation and mineralization
Int J Mol Sci, 15 (5), 7731-49
DOI 10.3390/ijms15057731, PubMed 24857913
Publications 2012
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Nat Genet, 44 (5), 491-501
DOI 10.1038/ng.2249, PubMed 22504420
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
PLoS Genet, 8 (7), e1002718
DOI 10.1371/journal.pgen.1002718, PubMed 22792070
Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix
Bone, 53 (1), 69-78
DOI 10.1016/j.bone.2012.11.015, PubMed 23195995
Publications 2011
Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype
J Bone Miner Res, 26 (8), 1793-801
DOI 10.1002/jbmr.396, PubMed 21452281
Publications 2010
Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone
Matrix Biol, 29 (7), 594-601
DOI 10.1016/j.matbio.2010.07.001, PubMed 20654714
Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes
FASEB J, 24 (8), 2893-903
DOI 10.1096/fj.09-148908, PubMed 20354137
Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators
Eur J Oral Sci, 118 (5), 451-9
DOI 10.1111/j.1600-0722.2010.00760.x, PubMed 20831578
Skeletal site-related variation in human trabecular bone transcriptome and signaling
PLoS One, 5 (5), e10692
DOI 10.1371/journal.pone.0010692, PubMed 20502692
Publications 2009
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women
Bone, 46 (3), 604-12
DOI 10.1016/j.bone.2009.11.007, PubMed 19922823
Abnormal adipokine levels and leptin-induced changes in gene expression profiles in multiple myeloma
Eur J Haematol, 83 (5), 460-70
DOI 10.1111/j.1600-0609.2009.01311.x, PubMed 19572994
Publications 2007
Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice
J Cell Sci, 120 (Pt 16), 2785-95
DOI 10.1242/jcs.003855, PubMed 17652162
Levetiracetam, phenytoin, and valproate act differently on rat bone mass, structure, and metabolism
Epilepsia, 48 (10), 1850-60
DOI 10.1111/j.1528-1167.2007.01176.x, PubMed 17634065
Abnormal muscle and hematopoietic gene expression may be important for clinical morbidity in primary hyperparathyroidism
Am J Physiol Endocrinol Metab, 292 (5), E1465-73
DOI 10.1152/ajpendo.00487.2006, PubMed 17227961
Publications 2006
Gene expression profiles give insight into the molecular pathology of bone in primary hyperparathyroidism
Bone, 39 (1), 189-98
DOI 10.1016/j.bone.2005.12.020, PubMed 16516570
The effect of enamel matrix derivative on gene expression in osteoblasts
Eur J Oral Sci, 114 Suppl 1, 205-11; discussion 254-6, 381-2
DOI 10.1111/j.1600-0722.2006.00333.x, PubMed 16674687
Publications 2005
Thyrotrophin-releasing hormone receptor 1 and prothyrotrophin-releasing hormone mRNA expression in the central nervous system are regulated by suckling in lactating rats
Eur J Endocrinol, 152 (5), 791-803
DOI 10.1530/eje.1.01902, PubMed 15879366
Publications 2004
Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells
Biochem Biophys Res Commun, 324 (1), 218-23
DOI 10.1016/j.bbrc.2004.09.030, PubMed 15465005
Publications 2003
Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning
Anticancer Res, 23 (3B), 2201-16
PubMed 12894494
Publications 2000
Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells
J Bone Miner Res, 15 (12), 2402-12
DOI 10.1359/jbmr.2000.15.12.2402, PubMed 11127205
Publications 1999
Difference in strength of autonomously replicating sequences among repeats in the rDNA region of Saccharomyces cerevisiae
Biochem Biophys Res Commun, 266 (1), 190-5
DOI 10.1006/bbrc.1999.1811, PubMed 10581188
Vitamin A-sensitive tissues in transgenic mice expressing high levels of human cellular retinol-binding protein type I are not altered phenotypically
J Nutr, 129 (9), 1621-7
DOI 10.1093/jn/129.9.1621, PubMed 10460195
Publications 1998
Retinol-induced secretion of human retinol-binding protein in yeast
FEBS Lett, 427 (2), 213-9
DOI 10.1016/s0014-5793(98)00428-1, PubMed 9607314
Publications 1997
Retinyl ester storage is altered in liver stellate cells and in HL60 cells transfected with cellular retinol-binding protein type I
Int J Biochem Cell Biol, 29 (2), 381-9
DOI 10.1016/s1357-2725(96)00068-4, PubMed 9147140
Binding and cyclic AMP stimulation by N-terminally deleted human PTHs (3-84 and 4-84) in a homologous ligand receptor system
J Bone Miner Res, 12 (9), 1348-57
DOI 10.1359/jbmr.1997.12.9.1348, PubMed 9286750
Publications 1996
The C-terminal RNLL sequence of the plasma retinol-binding protein is not responsible for its intracellular retention
Biochem Biophys Res Commun, 221 (2), 374-9
DOI 10.1006/bbrc.1996.0603, PubMed 8619863
Secretion of heterologous proteins from the yeast Saccharomyces cerevisiae
Institute for Nutrition Research and Department of Biochemistry, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 961419806, ISBN 82-992777-8-7
Retinyl ester storage is normal in transgenic mice with enhanced expression of cellular retinol-binding protein type I
J Nutr, 126 (11), 2709-19
DOI 10.1093/jn/126.11.2709, PubMed 8914940
Publications 1992
Isolation and characterization of two biologically active O-glycosylated forms of human parathyroid hormone produced in Saccharomyces cerevisiae. Identification of a new motif for O-glycosylation
Eur J Biochem, 205 (1), 311-9
DOI 10.1111/j.1432-1033.1992.tb16782.x, PubMed 1555591
Publications 1991
Characterization of a K26Q site-directed mutant of human parathyroid hormone expressed in yeast
J Biol Chem, 266 (22), 14198-201
PubMed 1860837
Publications 1990
Efficient secretion of human parathyroid hormone by Saccharomyces cerevisiae
Gene, 90 (2), 255-62
DOI 10.1016/0378-1119(90)90188-w, PubMed 2205532
SUCCESSFUL CLONING AND PRODUCTION OF HUMAN PARATHYROID-HORMONE (HPTH) IN YEAST AS A SECRETORY PRODUCT
5TH EUROPEAN CONGRESS ON BIOTECHNOLOGY, PROCEEDINGS, VOLS 1 AND 2, 712-714