Epilepsiforskningsgruppen ERGO (med forfattere overlege Line Bedos Ulvin, overlege Kjell Heuser og prof. Erik Taubøll) har vært delaktig i en 3-nasjonal studie for å bedre prognostisering av langtidsoverlevelse etter status epilepticus.
Nyslått Oslo-ambassadør og professor Erik Taubøll, Nevrologisk avdeling, Institutt for klinisk medisin (Klinmed) ble hedret for sin innsats med å få European Academy of Neurology - EAN til byen i 2019 under en seremoni på Grand Hotel i Oslo.
Lege og phd stipendiat Toni Berger ved Nevrologisk avdeling, Oslo Universitetssykehus – Rikshospitalet og Institutt for klinisk medisin ved Universitetet i Oslo skal forsvare sin avhandling: "A translational view on epileptogenesis" for graden phd fredag 4 februar.
Arbeidet utgår fra epilepsiforskningsgruppen i Nevrologisk avdeling, ERGO (Epilepsy Research Group of Oslo) og hovedveileder er overlege, phd Kjell Heuser. Prosjektet har vært finansiert fra EU gjennom Horizon2020, Marie Sklodowska Curie programmet.
Prøveforelesning fredag 4 februar kl 10.15. Tittel: The role of microglia in neurodegenerative diseases. Therapeutic implications” (digital, Se Digital Trial Lecture)
Brain glial cells - a new target for future epilepsy treatment?
Senior consultant and Head of translational epilepsy research within the Epilepsy Research Group of Oslo (ERGO), Kjell Heuser, recently pointed to the glial cells as a possible new target for epilepsy treatment in a reader's letter to the Journal of the Norwegian Medical Association. This was also commented on by the Norwegian Brain Council. The authors behind the post are besides Kjell Heuser (pictured), Rune Enger, Toni Berger and Erik Taubøll.
The Epilepsy Research Group in Department of Neurology (ERGO - Epilepsy Research Group of Oslo) and the Department of Neurosurgery at Ullevål are now starting clinical studies of possible biomarkers for the development of epilepsy after head injuries. In the next round, it may be relevant to try out intervention treatment with medication. The main study will be part of an international multi-center study we are now participating in and where Oslo could become one of the largest contributors. The project has received support from the CURE Epilepsy Foundation in the USA, which in turn has received USD 10 million from the US Department of Defense to study the mechanisms behind the development of post-traumatic epilepsy.
Glias rolle ved epilepsi har blitt stadig tydeligere og stadig flere tenker seg at glia kan representere et nytt angrepspunkt ikke bare for anfallsbehandling, men også for å stanse selve utviklingen av epilepsi – «kurere epilepsi». Dette var da også temaet på en av sesjonene under EAN kongressen i Oslo i 2019. Kjell Heuser er deretter bedt om å være guest editor for en e-bok i serien Frontiers in Neurology – epilepsy section, med tittelen «Glial Dysfunction in Epileptogenesis». Her har han fått med seg professorene Marco De Curtis (Italia) og Christian Steinhauser (Tyskland).
ERGO - Epilepsy Research Group of Oslo - presented their research at an open public meeting in September during the "Forskningsdagene 2020". Title of the meeting was: "Epilepsy - from basic research to modern clinical treatment". Senior consultant, MD, PhD Kjell Heuser, discussed the role of glial cells in epilepsy. Thereafter, the PhD candidates Toni Berger, Cecilie Bugge Bakketun and Monika Mochol talked about epigentics in epilepsy (TB), how to use brain slices in the study of epilepsy (CBB) and the use of zebrafish in epilepsy research (MM) to understand basic mechanisms of epileptogenesis.
Scientitsts from the Epilepsy Research Group at the Nevrological Department, ERGO (Epilepsy Research Group of Oslo) have recently, in collaboration with the Letten Center at the University of Oslo, studied how the glia cells contribute actively and are crucial in epilepsy. They have demonstrate that the glial cells are activated prior to the neurons by seizures, which is completely new knowledge. The findings have been achieved through the combination of several completely new techniques that include high-resolution microscopy, the use of biosensors and advanced neurophysiology, and have recently been published in the journal "Cerebral Cortex".
The groundbreaking research on the role of glial cells in epilepsy has been thorougly presented in a popular science form in a feature article (in Norwegian) entitled "The forgotten cells of the brain - a new path into treatment of epilepsy" on the OUS blog "Ekspertsykehuset".
Bojarskaite L, Vallet A, Bjørnstad DM, Gullestad Binder KM, Cunen C, Heuser K, Kuchta M, Mardal KA, Enger R(2023) Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport Nat Commun, 14(1), 953 DOI 10.1038/s41467-023-36643-5, PubMed 36806170