Sebastian Imre Sarvari

  • MD, PhD
  • +47 23071395

Sebastian Sarvari, MD, PhD, Consultant Cardiologist, Department of Cardiology, Rikshospitalet, Oslo University Hospital.

He defended his PhD thesis titled "Detection of subtle myocardial alterations by echocardiographic techniques for improved prognostic information in patients with heart disease." in September 2013. Sarvari's main supervisor was Professor Thor Edvardsen, MD, PhD.

Sarvari showed that new ultrasound methods can detect cardiac function at a very early stage in different patient groups.

Sudden cardiac death due to arrhythmia is one of the most common causes of death in the Western world and in younger is often caused by hereditary heart disease. A new ultrasound method can predict which patients are going to get serious heart rhythm abnormalities. The thesis examined patients with arrhythmogenic right ventricular cardiomyopathy. The disease is one of the most common hereditary disorders that lead to sudden cardiac death. The study shows that irregular cardiac contractility measured by the new method is a risk marker of cardiovascular arrhythmia. The method improves the selection of patients with high risk of death so that these can be fitted with a defibrillator.

 

Original articles

Bjerring AW, Landgraff HE, Stokke TM, Murbræch K, Leirstein S, Aaeng A, Brun H, Haugaa KH, Hallén J, Edvardsen T, Sarvari SI (2019)
The developing athlete's heart: a cohort study in young athletes transitioning through adolescence
Eur J Prev Cardiol, 26 (18), 2001-2008
DOI 10.1177/2047487319862061, PubMed 31284749

Batlle M, Castillo N, Alcarraz A, Sarvari S, Sangüesa G, Cristóbal H, García de Frutos P, Sitges M, Mont L, Guasch E (2019)
Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload
PLoS One, 14 (6), e0217926
DOI 10.1371/journal.pone.0217926, PubMed 31181097

de Barros MVL, Macedo AVS, Sarvari SI, Faleiros MH, Felipe PT, Silva JLP, Edvardsen T (2018)
Left Ventricular Regional Wall Motion Abnormality is a Strong Predictor of Cardiotoxicity in Breast Cancer Patients Undergoing Chemotherapy
Arq Bras Cardiol, 112 (1), 50-56
DOI 10.5935/abc.20180220, PubMed 30569947

Myhre PL, Omland T, Sarvari SI, Ukkonen H, Rademakers F, Engvall JE, Hagve TA, Nagel E, Sicari R, Zamorano JL, Monaghan M, D'hooge J, Edvardsen T, Røsjø H, DOPPLER-CIP Study Group (2018)
Cardiac Troponin T Concentrations, Reversible Myocardial Ischemia, and Indices of Left Ventricular Remodeling in Patients with Suspected Stable Angina Pectoris: a DOPPLER-CIP Substudy
Clin Chem, 64 (9), 1370-1379
DOI 10.1373/clinchem.2018.288894, PubMed 29959147

Bjerring AW, Landgraff HE, Leirstein S, Aaeng A, Ansari HZ, Saberniak J, Murbræch K, Bruun H, Stokke TM, Haugaa KH, Hallén J, Edvardsen T, Sarvari SI (2018)
Morphological changes and myocardial function assessed by traditional and novel echocardiographic methods in preadolescent athlete's heart
Eur J Prev Cardiol, 25 (9), 1000-1007
DOI 10.1177/2047487318776079, PubMed 29785884

Almeida N, Papachristidis A, Pearson P, Sarvari SI, Engvall J, Edvardsen T, Monaghan M, Gérard O, Samset E, D'hooge J (2017)
Left atrial volumetric assessment using a novel automated framework for 3D echocardiography: a multi-centre analysis
Eur Heart J Cardiovasc Imaging, 18 (9), 1008-1015
DOI 10.1093/ehjci/jew166, PubMed 27550659

Stokke TM, Hasselberg NE, Smedsrud MK, Sarvari SI, Haugaa KH, Smiseth OA, Edvardsen T, Remme EW (2017)
Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain
J Am Coll Cardiol, 70 (8), 942-954
DOI 10.1016/j.jacc.2017.06.046, PubMed 28818204

Sarvari SI, Sitges M, Sanz M, Tolosana Viu JM, Edvardsen T, Stokke TM, Mont L, Bijnens B (2017)
Left ventricular dysfunction is related to the presence and extent of a septal flash in patients with right ventricular pacing
Europace, 19 (2), 289-296
DOI 10.1093/europace/euw020, PubMed 28175277

Sarvari SI, Rodriguez-Lopez M, Nuñez-Garcia M, Sitges M, Sepulveda-Martinez A, Camara O, Butakoff C, Gratacos E, Bijnens B, Crispi F (2017)
Persistence of Cardiac Remodeling in Preadolescents With Fetal Growth Restriction
Circ Cardiovasc Imaging, 10 (1)
DOI 10.1161/CIRCIMAGING.116.005270, PubMed 28093413

Bernardino G, Butakoff C, Nunez-Garcia M, Sarvari SI, Rodriguez-Lopez M, Crispi F, Ballester MAG, De Craene M, Bijnens B (2017)
Estimating 3D Ventricular Shape From 2D Echocardiography: Feasibility and Effect of Noise
LECT NOTES COMPUT SC, 10263, 450-460

Sanz-de la Garza M, Grazioli G, Bijnens BH, Sarvari SI, Guasch E, Pajuelo C, Brotons D, Subirats E, Brugada R, Roca E, Sitges M (2016)
Acute, Exercise Dose-Dependent Impairment in Atrial Performance During an Endurance Race: 2D Ultrasound Speckle-Tracking Strain Analysis
JACC Cardiovasc Imaging, 9 (12), 1380-1388
DOI 10.1016/j.jcmg.2016.03.016, PubMed 27544898

Ortigosa N, Rodriguez-Lopez M, Bailón R, Sarvari SI, Sitges M, Gratacos E, Bijnens B, Crispi F, Laguna P (2016)
Heart morphology differences induced by intrauterine growth restriction and preterm birth measured on the ECG at preadolescent age
J Electrocardiol, 49 (3), 401-9
DOI 10.1016/j.jelectrocard.2016.03.011, PubMed 27036371

Almeida N, Sarvari SI, Orderud F, Gerard O, D'hooge J, Samset E (2016)
Automatic left-atrial segmentation from cardiac 3D ultrasound: a dual-chamber model-based approach
PROC SPIE, 9790, 97900D

Almeida N, Friboulet D, Sarvari SI, Bernard O, Barbosa D, Samset E, Dhooge J (2015)
Left-Atrial Segmentation From 3-D Ultrasound Using B-Spline Explicit Active Surfaces With Scale Uncoupling
IEEE Trans Ultrason Ferroelectr Freq Control, 63 (2), 212-21
DOI 10.1109/TUFFC.2015.2507638, PubMed 26685231

Queirós S, Barbosa D, Engvall J, Ebbers T, Nagel E, Sarvari SI, Claus P, Fonseca JC, Vilaça JL, D'hooge J (2015)
Multi-centre validation of an automatic algorithm for fast 4D myocardial segmentation in cine CMR datasets
Eur Heart J Cardiovasc Imaging, 17 (10), 1118-27
DOI 10.1093/ehjci/jev247, PubMed 26494877

Sarvari SI, Haugaa KH, Stokke TM, Ansari HZ, Leren IS, Hegbom F, Smiseth OA, Edvardsen T (2015)
Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation
Eur Heart J Cardiovasc Imaging, 17 (6), 660-7
DOI 10.1093/ehjci/jev185, PubMed 26219297

Hasselberg NE, Haugaa KH, Sarvari SI, Gullestad L, Andreassen AK, Smiseth OA, Edvardsen T (2014)
Left ventricular global longitudinal strain is associated with exercise capacity in failing hearts with preserved and reduced ejection fraction
Eur Heart J Cardiovasc Imaging, 16 (2), 217-24
DOI 10.1093/ehjci/jeu277, PubMed 25552469

Saberniak J, Hasselberg NE, Borgquist R, Platonov PG, Sarvari SI, Smith HJ, Ribe M, Holst AG, Edvardsen T, Haugaa KH (2014)
Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members
Eur J Heart Fail, 16 (12), 1337-44
DOI 10.1002/ejhf.181, PubMed 25319773

Evensen K, Sarvari SI, Rønning OM, Edvardsen T, Russell D (2014)
Carotid artery intima-media thickness is closely related to impaired left ventricular function in patients with coronary artery disease: a single-centre, blinded, non-randomized study
Cardiovasc Ultrasound, 12, 39
DOI 10.1186/1476-7120-12-39, PubMed 25266446

Stokke TM, Ruddox V, Sarvari SI, Otterstad JE, Aune E, Edvardsen T (2014)
Brief group training of medical students in focused cardiac ultrasound may improve diagnostic accuracy of physical examination
J Am Soc Echocardiogr, 27 (11), 1238-46
DOI 10.1016/j.echo.2014.08.001, PubMed 25216765

Hetland M, Haugaa KH, Sarvari SI, Erikssen G, Kongsgaard E, Edvardsen T (2014)
A novel ECG-index for prediction of ventricular arrhythmias in patients after myocardial infarction
Ann Noninvasive Electrocardiol, 19 (4), 330-7
DOI 10.1111/anec.12152, PubMed 24612066

Tsadok Y, Petrank Y, Sarvari S, Edvardsen T, Adam D (2013)
Automatic segmentation of cardiac MRI cines validated for long axis views
Comput Med Imaging Graph, 37 (7-8), 500-11
DOI 10.1016/j.compmedimag.2013.09.002, PubMed 24094590

Sarvari SI, Haugaa KH, Zahid W, Bendz B, Aakhus S, Aaberge L, Edvardsen T (2013)
Layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant CAD in patients with non-ST-segment elevation acute coronary syndrome
JACC Cardiovasc Imaging, 6 (5), 535-44
DOI 10.1016/j.jcmg.2013.01.009, PubMed 23582354

Smedsrud MK, Sarvari S, Haugaa KH, Gjesdal O, Ørn S, Aaberge L, Smiseth OA, Edvardsen T (2012)
Duration of myocardial early systolic lengthening predicts the presence of significant coronary artery disease
J Am Coll Cardiol, 60 (12), 1086-93
DOI 10.1016/j.jacc.2012.06.022, PubMed 22939559

Sarvari SI, Gjesdal O, Gude E, Arora S, Andreassen AK, Gullestad L, Geiran O, Edvardsen T (2012)
Early postoperative left ventricular function by echocardiographic strain is a predictor of 1-year mortality in heart transplant recipients
J Am Soc Echocardiogr, 25 (9), 1007-14
DOI 10.1016/j.echo.2012.05.010, PubMed 22727199

Sarvari SI, Haugaa KH, Anfinsen OG, Leren TP, Smiseth OA, Kongsgaard E, Amlie JP, Edvardsen T (2011)
Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction
Eur Heart J, 32 (9), 1089-96
DOI 10.1093/eurheartj/ehr069, PubMed 21406439

Nagueh SF, Bhatt R, Vivo RP, Krim SR, Sarvari SI, Russell K, Edvardsen T, Smiseth OA, Estep JD (2011)
Echocardiographic evaluation of hemodynamics in patients with decompensated systolic heart failure
Circ Cardiovasc Imaging, 4 (3), 220-7
DOI 10.1161/CIRCIMAGING.111.963496, PubMed 21398512

Sarvari SI, Hoddevik G, Brantsaeter AB (2007)
[Acute hepatitis E]
Tidsskr Nor Laegeforen, 127 (15), 1966-8
PubMed 17700753

Review articles

Edvardsen T, Sarvari SI, Haugaa KH (2016)
Strain imaging - from Scandinavian research to global deployment
Scand Cardiovasc J, 50 (5-6), 266-275
DOI 10.1080/14017431.2016.1239836, PubMed 27650726

Other articles

Stokke TM, Hasselberg NE, Smedsrud MK, Sarvari SI, Haugaa KH, Smiseth OA, Edvardsen T, Remme EW (2018)
Reply: Interaction Between Longitudinal, Circumferential, and Radial Deformations and Their Contributions to Ejection Fraction
J Am Coll Cardiol, 71 (2), 257-258
DOI 10.1016/j.jacc.2017.10.090, PubMed 29325649

Book chapters

Sarvari S, Hahn A, Strømsøe K (2001)
Brudd i distale femur: en retrospektiv undersøkelse av 34 pasienter
In Vitenskapelige forhandlinger, Norsk kirurgisk forening., [Oslo], 2001, Abstrakt nr.197
BIBSYS 022008772

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