Knut Dahl-Jørgensen
- Professor, consultant; MD, PhD
- +47 22 11 87 65
Publications 2024
Influence of sphingolipid enzymes on blood glucose levels, development of diabetes, and involvement of pericytes
Diabetes Metab Res Rev, 40 (3), e3792
DOI 10.1002/dmrr.3792, PubMed 38517704
Virus as the cause of type 1 diabetes
Trends Mol Med, 30 (11), 1020-1027
DOI 10.1016/j.molmed.2024.06.011, PubMed 39003200
Diabetes Body Project: Acute Effects of an Eating Disorder Prevention Program for Young Women With Type 1 Diabetes: A Multinational Randomized Controlled Trial
Diabetes Care (in press)
DOI 10.2337/dc24-1599, PubMed 39602474
Reduced expression of central innate defense molecules in pancreatic biopsies from subjects with Type 1 diabetes
Acta Diabetol, 61 (9), 1117-1127
DOI 10.1007/s00592-024-02286-1, PubMed 38717484
A pilot study of a virtually delivered dissonance-based eating disorder prevention program for young women with type 1 diabetes: within-subject changes over 6-month follow-up
Eat Disord, 32 (6), 686-702
DOI 10.1080/10640266.2024.2331391, PubMed 38511886
Publications 2023
Type 1 diabetes could begin with alterations in innate anti-viral immunity, which are already at this stage associated with HLA risk haplotypes
Diabetes Metab Res Rev, 39 (7), e3678
DOI 10.1002/dmrr.3678, PubMed 37395313
Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial
Nat Med, 29 (11), 2902-2908
DOI 10.1038/s41591-023-02576-1, PubMed 37789144
Sustained low-grade inflammation in young participants with childhood onset type 1 diabetes: The Norwegian atherosclerosis and childhood diabetes (ACD) study
Atherosclerosis, 379, 117151
DOI 10.1016/j.atherosclerosis.2023.05.020, PubMed 37349194
Publications 2022
Development of Type 1 Diabetes may occur through a Type 2 Diabetes mechanism
Front Endocrinol (Lausanne), 13, 1032822
DOI 10.3389/fendo.2022.1032822, PubMed 36589856
Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study
Diabetologia, 65 (12), 2108-2120
DOI 10.1007/s00125-022-05779-2, PubMed 35953727
Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study
Front Endocrinol (Lausanne), 13, 881997
DOI 10.3389/fendo.2022.881997, PubMed 35957810
PDE12 in type 1 diabetes
Sci Rep, 12 (1), 18149
DOI 10.1038/s41598-022-22890-x, PubMed 36307540
Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes
Front Endocrinol (Lausanne), 13, 861985
DOI 10.3389/fendo.2022.861985, PubMed 35498413
High Prevalence of Common Human Viruses in Thyroid Tissue
Front Endocrinol (Lausanne), 13, 938633
DOI 10.3389/fendo.2022.938633, PubMed 35909527
Publications 2021
Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study
Diabetologia, 64 (11), 2491-2501
DOI 10.1007/s00125-021-05525-0, PubMed 34390364
Genetic predisposition in the 2'-5'A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity
Diabetologia, 64 (8), 1805-1815
DOI 10.1007/s00125-021-05469-5, PubMed 33973017
Immune Transcriptome of Cells Infected with Enterovirus Strains Obtained from Cases of Autoimmune Thyroid Disease
Microorganisms, 9 (4)
DOI 10.3390/microorganisms9040876, PubMed 33921891
Expression of immunoreactive inducible nitric oxide synthase in pancreatic islet cells from newly diagnosed and long-term type 1 diabetic donors is heterogeneous and not disease-associated
Cell Tissue Res, 384 (3), 655-674
DOI 10.1007/s00441-020-03340-4, PubMed 33427953
One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24
Diabetes, 70 (3), 752-758
DOI 10.2337/db20-0908, PubMed 33414250
NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis
Cell Death Discov, 7 (1), 2
DOI 10.1038/s41420-020-00386-9, PubMed 33414444
Retinal venular oxygen saturation is associated with non-proliferative diabetic retinopathy in young patients with type 1 diabetes
Acta Ophthalmol, 100 (4), 388-394
DOI 10.1111/aos.15018, PubMed 34668632
HLA Class I Upregulation and Antiviral Immune Responses in Graves Disease
J Clin Endocrinol Metab, 106 (4), e1763-e1774
DOI 10.1210/clinem/dgaa958, PubMed 33367784
Feasibility of a virtually delivered eating disorder prevention program for young females with type 1 diabetes
Int J Eat Disord, 54 (9), 1696-1706
DOI 10.1002/eat.23578, PubMed 34245038
Publications 2020
International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between eight high-income countries but similar rise during adolescence-A quality registry study
Pediatr Diabetes, 21 (4), 621-627
DOI 10.1111/pedi.13014, PubMed 32249476
Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study
J Diabetes Res, 2020, 7216863
DOI 10.1155/2020/7216863, PubMed 32309448
Procoagulant activity in children and adolescents on intensive insulin therapy
Pediatr Diabetes, 21 (3), 496-504
DOI 10.1111/pedi.12978, PubMed 31943582
Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy
Acta Ophthalmol, 98 (8), 800-807
DOI 10.1111/aos.14462, PubMed 32410388
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Nat Commun, 11 (1), 2584
DOI 10.1038/s41467-020-16327-0, PubMed 32444635
Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes
Front Endocrinol (Lausanne), 11, 630
DOI 10.3389/fendo.2020.00630, PubMed 33042009
Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus
J Diabetes Res, 2020, 8849116
DOI 10.1155/2020/8849116, PubMed 33313325
Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis
Thyroid, 30 (3), 432-442
DOI 10.1089/thy.2019.0607, PubMed 31910110
The impact of psychological aspects, age, and BMI on eating disorder psychopathology among adult males and females with type 1 diabetes
Health Psychol Open, 7 (2), 2055102920975969
DOI 10.1177/2055102920975969, PubMed 33282331
Publications 2019
Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries
Diabetes Care, 42 (3), e37-e39
DOI 10.2337/dc18-1253, PubMed 30659071
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes
Diabetologia, 62 (5), 744-753
DOI 10.1007/s00125-019-4811-7, PubMed 30675626
Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]
Diabetologia, 62 (6), 1100-1103
DOI 10.1007/s00125-019-4873-6, PubMed 31016358
IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes
Clin Immunol, 211, 108320
DOI 10.1016/j.clim.2019.108320, PubMed 31809899
HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
Diabetes, 68 (5), 988-1001
DOI 10.2337/db18-0686, PubMed 30833470
Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced
J Pathol Clin Res, 5 (4), 248-255
DOI 10.1002/cjp2.140, PubMed 31493350
Disturbed eating, illness perceptions, and coping among adults with type 1 diabetes on intensified insulin treatment, and their associations with metabolic control
J Health Psychol, 26 (5), 688-700
DOI 10.1177/1359105319840688, PubMed 30939939
Psychometric properties and factor structure of the diabetes eating problem survey - revised (DEPS-R) among adult males and females with type 1 diabetes
J Eat Disord, 7, 2
DOI 10.1186/s40337-018-0232-0, PubMed 30675355
Publications 2018
Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes
Diabetes, 67 (9), 1858-1866
DOI 10.2337/db17-1281, PubMed 29945890
Exploring Variation in Glycemic Control Across and Within Eight High-Income Countries: A Cross-sectional Analysis of 64,666 Children and Adolescents With Type 1 Diabetes
Diabetes Care, 41 (6), 1180-1187
DOI 10.2337/dc17-2271, PubMed 29650804
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
EBioMedicine, 36, 367-375
DOI 10.1016/j.ebiom.2018.09.040, PubMed 30269996
Preserved endothelial function in young adults with type 1 diabetes
PLoS One, 13 (10), e0206523
DOI 10.1371/journal.pone.0206523, PubMed 30359432
Increased arterial stiffness in childhood onset diabetes: a cardiovascular magnetic resonance study
Eur Heart J Cardiovasc Imaging, 19 (6), 694-700
DOI 10.1093/ehjci/jex178, PubMed 28950341
Abnormal islet sphingolipid metabolism in type 1 diabetes
Diabetologia, 61 (7), 1650-1661
DOI 10.1007/s00125-018-4614-2, PubMed 29671030
β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes
Diabetes, 67 (11), 2305-2318
DOI 10.2337/db17-1006, PubMed 30150306
No Evidence for Presence of Mucosal-Associated Invariant T Cells in the Insulitic Lesions in Patients Recently Diagnosed with Type 1 Diabetes
Am J Pathol, 188 (8), 1744-1748
DOI 10.1016/j.ajpath.2018.04.009, PubMed 29803829
Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease
Diabetologia, 61 (6), 1362-1373
DOI 10.1007/s00125-018-4600-8, PubMed 29589071
Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes
JCI Insight, 3 (18)
DOI 10.1172/jci.insight.122146, PubMed 30232284
Prevalence of disturbed eating behavior and associated symptoms of anxiety and depression among adult males and females with type 1 diabetes
J Eat Disord, 6, 28
DOI 10.1186/s40337-018-0209-z, PubMed 30214804
Publications 2017
Advanced glycation end products in children with type 1 diabetes and early reduced diastolic heart function
BMC Cardiovasc Disord, 17 (1), 133
DOI 10.1186/s12872-017-0551-0, PubMed 28545398
Reduced HDL function in children and young adults with type 1 diabetes
Cardiovasc Diabetol, 16 (1), 85
DOI 10.1186/s12933-017-0570-2, PubMed 28683835
Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes
Am J Pathol, 187 (3), 581-588
DOI 10.1016/j.ajpath.2016.11.002, PubMed 28212742
The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes
PLoS One, 12 (6), e0179911
DOI 10.1371/journal.pone.0179911, PubMed 28628651
An immunohistochemical study of nitrotyrosine expression in pancreatic islets of cases with increasing duration of type 1 diabetes and without diabetes
Histochem Cell Biol, 147 (5), 605-623
DOI 10.1007/s00418-016-1533-5, PubMed 28154952
Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset
Diabetes, 66 (5), 1334-1345
DOI 10.2337/db16-1343, PubMed 28137793
HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease
HLA, 89 (5), 278-284
DOI 10.1111/tan.12986, PubMed 28247576
Islet amyloid in recent-onset type 1 diabetes-the DiViD study
Ups J Med Sci, 122 (3), 201-203
DOI 10.1080/03009734.2017.1359219, PubMed 28814132
Eating patterns in adolescents with type 1 diabetes: Associations with metabolic control, insulin omission, and eating disorder pathology
Appetite, 114, 226-231
DOI 10.1016/j.appet.2017.03.035, PubMed 28351671
Publications 2016
Early reduced myocardial diastolic function in children and adolescents with type 1 diabetes mellitus a population-based study
BMC Cardiovasc Disord, 16, 103
DOI 10.1186/s12872-016-0288-1, PubMed 27225446
Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes
BMJ Open Diabetes Res Care, 4 (1), e000219
DOI 10.1136/bmjdrc-2016-000219, PubMed 27933184
Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes
Diabetes, 65 (5), 1362-9
DOI 10.2337/db15-1615, PubMed 26858360
Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes
Diabetes, 65 (10), 3104-10
DOI 10.2337/db16-0616, PubMed 27422384
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
Diabetologia, 59 (11), 2448-2458
DOI 10.1007/s00125-016-4067-4, PubMed 27506584
Psychological barriers to optimal insulin therapy: more concerns in adolescent females than males
BMJ Open Diabetes Res Care, 4 (1), e000203
DOI 10.1136/bmjdrc-2016-000203, PubMed 27403325
Publications 2015
Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
Cardiovasc Diabetol, 14, 126
DOI 10.1186/s12933-015-0292-2, PubMed 26408307
The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes
Diab Vasc Dis Res, 12 (2), 139-45
DOI 10.1177/1479164114560910, PubMed 25616705
Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study
Diabetes, 64 (7), 2506-12
DOI 10.2337/db14-1911, PubMed 25677915
Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
Diabetologia, 59 (3), 492-501
DOI 10.1007/s00125-015-3820-4, PubMed 26602422
Expression of human leukocyte antigen class I in endocrine and exocrine pancreatic tissue at onset of type 1 diabetes
Am J Pathol, 185 (1), 129-38
DOI 10.1016/j.ajpath.2014.09.004, PubMed 25524212
Metabolic Control and Illness Perceptions in Adolescents with Type 1 Diabetes
J Diabetes Res, 2016, 3486094
DOI 10.1155/2016/3486094, PubMed 26682231
Adolescents with Type 1 Diabetes--The Impact of Gender, Age, and Health-Related Functioning on Eating Disorder Psychopathology
PLoS One, 10 (11), e0141386
DOI 10.1371/journal.pone.0141386, PubMed 26529593
Publications 2014
Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease
Thyroid, 24 (3), 537-44
DOI 10.1089/thy.2013.0287, PubMed 24032645
Inflammation in childhood type 1 diabetes; influence of glycemic control
Atherosclerosis, 238 (1), 33-7
DOI 10.1016/j.atherosclerosis.2014.11.018, PubMed 25437887
Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes
Diabetes, 64 (5), 1682-7
DOI 10.2337/db14-1370, PubMed 25422108
Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study
Diabetologia, 57 (4), 841-3
DOI 10.1007/s00125-013-3155-y, PubMed 24429579
Glucosepane and oxidative markers in skin collagen correlate with intima media thickness and arterial stiffness in long-term type 1 diabetes
J Diabetes Complications, 29 (3), 407-12
DOI 10.1016/j.jdiacomp.2014.12.011, PubMed 25600701
Impaired left ventricular function and myocardial blood flow reserve in patients with long-term type 1 diabetes and no significant coronary artery disease: associations with protein glycation
Diab Vasc Dis Res, 11 (2), 84-91
DOI 10.1177/1479164113518805, PubMed 24443481
Publications 2013
Health-related quality of life among Norwegian children and adolescents with type 1 diabetes on intensive insulin treatment: a population-based study
Acta Paediatr, 102 (9), 889-95
DOI 10.1111/apa.12312, PubMed 23738648
Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto's thyroiditis
Thyroid, 23 (3), 334-41
DOI 10.1089/thy.2012.0264, PubMed 22998463
GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation
Mol Cell Endocrinol, 382 (1), 55-65
DOI 10.1016/j.mce.2013.08.020, PubMed 24001579
Small- and large-fiber neuropathy after 40 years of type 1 diabetes: associations with glycemic control and advanced protein glycation: the Oslo Study
Diabetes Care, 36 (11), 3712-7
DOI 10.2337/dc13-0788, PubMed 24026557
Psychometric properties, norms, and factor structure of the diabetes eating problem survey-revised in a large sample of children and adolescents with type 1 diabetes
Diabetes Care, 36 (8), 2198-202
DOI 10.2337/dc12-2282, PubMed 23536586
Disturbed eating behavior and omission of insulin in adolescents receiving intensified insulin treatment: a nationwide population-based study
Diabetes Care, 36 (11), 3382-7
DOI 10.2337/dc13-0431, PubMed 23963896
Publications 2012
Reliability and validity of the Norwegian child and parent versions of the DISABKIDS Chronic Generic Module (DCGM-37) and Diabetes-Specific Module (DSM-10)
Health Qual Life Outcomes, 10, 19
DOI 10.1186/1477-7525-10-19, PubMed 22300248
Detection of enterovirus in the thyroid tissue of patients with graves' disease
J Med Virol, 85 (3), 512-8
DOI 10.1002/jmv.23476, PubMed 23280563
The associations between maternal pre-pregnancy body mass index or gestational weight change during pregnancy and body mass index of the child at 3 years of age
Int J Obes (Lond), 36 (10), 1325-31
DOI 10.1038/ijo.2012.140, PubMed 22929211
Publications 2011
[Standardized hemoglobin A1C for diagnostic use?]
Tidsskr Nor Laegeforen, 131 (6), 565-6
DOI 10.4045/tidsskr.10.1160, PubMed 21423304
Publications 2010
Early signs of atherosclerosis in diabetic children on intensive insulin treatment: a population-based study
Diabetes Care, 33 (9), 2043-8
DOI 10.2337/dc10-0505, PubMed 20530748
Publications 2009
A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma
Genes Immun, 10 (2), 181-7
DOI 10.1038/gene.2008.100, PubMed 19148143
Microvascular and macrovascular complications associated with diabetes in children and adolescents
Pediatr Diabetes, 10 Suppl 12, 195-203
DOI 10.1111/j.1399-5448.2009.00576.x, PubMed 19754630
The establishment of a new national network leads to quality improvement in childhood diabetes: implementation of the ISPAD Guidelines
Pediatr Diabetes, 11 (2), 88-95
DOI 10.1111/j.1399-5448.2009.00542.x, PubMed 19552727
Publications 2008
Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes
Diabetologia, 51 (4), 589-96
DOI 10.1007/s00125-008-0932-0, PubMed 18292987
Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families
Genes Immun, 10 (2), 141-50
DOI 10.1038/gene.2008.88, PubMed 18987644
High prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes: a population-based study
Diabetologia, 51 (4), 554-61
DOI 10.1007/s00125-007-0921-8, PubMed 18196217
Physical activity and overweight in children and adolescents using intensified insulin treatment
Pediatr Diabetes, 10 (2), 135-41
DOI 10.1111/j.1399-5448.2008.00454.x, PubMed 18721165
Sweets, snacking habits, and skipping meals in children and adolescents on intensive insulin treatment
Pediatr Diabetes, 9 (4 Pt 2), 393-400
DOI 10.1111/j.1399-5448.2008.00381.x, PubMed 18774998
Publications 2007
ISPAD Clinical Practice Consensus Guidelines 2006-2007. Microvascular and macrovascular complications
Pediatr Diabetes, 8 (3), 163-70
DOI 10.1111/j.1399-5448.2007.00250.x, PubMed 17550427
The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases
Ann Rheum Dis, 67 (9), 1287-91
DOI 10.1136/ard.2007.077826, PubMed 18065500
Intracoronary ultrasound examinations reveal significantly more advanced coronary atherosclerosis in people with type 1 diabetes than in age- and sex-matched non-diabetic controls
Diab Vasc Dis Res, 4 (1), 62-5
DOI 10.3132/dvdr.2007.009, PubMed 17469046
Strong association between time watching television and blood glucose control in children and adolescents with type 1 diabetes
Diabetes Care, 30 (6), 1567-70
DOI 10.2337/dc06-2112, PubMed 17372157
The influence of dietary intake and meal pattern on blood glucose control in children and adolescents using intensive insulin treatment
Diabetologia, 50 (10), 2044-51
DOI 10.1007/s00125-007-0775-0, PubMed 17687538
LV systolic impairment in patients with asymptomatic coronary heart disease and type 1 diabetes is related to coronary atherosclerosis, glycaemic control and advanced glycation endproducts
Eur J Heart Fail, 9 (10), 1044-50
DOI 10.1016/j.ejheart.2007.07.013, PubMed 17719271
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis
Hum Immunol, 68 (9), 748-55
DOI 10.1016/j.humimm.2007.05.009, PubMed 17869649
Publications 2006
FOXP3 polymorphisms in type 1 diabetes and coeliac disease
J Autoimmun, 27 (2), 140-4
DOI 10.1016/j.jaut.2006.06.007, PubMed 16996248
Children and adolescents with type 1 diabetes eat a more atherosclerosis-prone diet than healthy control subjects
Diabetologia, 50 (2), 307-16
DOI 10.1007/s00125-006-0540-9, PubMed 17136391
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation
Diabetes, 55 (6), 1713-22
DOI 10.2337/db05-1513, PubMed 16731834
Fibrinolytic activity is highly influenced by long-term glycemic control in Type 1 diabetic patients
J Thromb Haemost, 4 (3), 686-8
DOI 10.1111/j.1538-7836.2006.01803.x, PubMed 16460457
Publications 2005
Diabetes in childhood and adolescence
In Pediatric and adolescent medicine, Karger, Basel, v. 10, viii, 381 s.
BIBSYS 052160580, ISBN 3-8055-7766-4
Atherosclerosis in childhood and adolescent type 1 diabetes: early disease, early treatment?
Diabetologia, 48 (8), 1445-53
DOI 10.1007/s00125-005-1832-1, PubMed 15971059
Mean HbA1c over 18 years predicts carotid intima media thickness in women with type 1 diabetes
Diabetologia, 48 (4), 776-9
DOI 10.1007/s00125-005-1700-z, PubMed 15759107
Publications 2004
Eighteen years of fair glycemic control preserves cardiac autonomic function in type 1 diabetes
Diabetes Care, 27 (4), 963-6
DOI 10.2337/diacare.27.4.963, PubMed 15047656
Eighteen years of fair glycemic control preserves cardiacautonomic function in type 1 diabetes
In Diabetes care, The Association, Alexandria, VA, 27(2004)4, S. 963-6
BIBSYS 05180686x
Publications 2003
Mean HbA1c during 18 years predicts common cartoid arteryintima-media thickness in women with diabetes type 1
In Diabetes, The Association, New York, 52(2003)suppl 1, s.P687
BIBSYS 041734599
Optimal blood glucose control during 18 years preserves peripheral nerve function in patients with 30 years' duration of type 1 diabetes
Diabetes Care, 26 (8), 2400-4
DOI 10.2337/diacare.26.8.2400, PubMed 12882869
Optimal blood glucose control during 18 years preserves peripheral nerve function in patients with 30 years' duration of type 1 diabetes
In Diabetes care, The Association, Alexandria, VA, 26(2003)8, s.2400-4
BIBSYS 041719344
Publications 2002
Silent coronary atheromatosis in type 1 diabetic patients and its relation to long-term glycemic control
Diabetes, 51 (8), 2637-41
DOI 10.2337/diabetes.51.8.2637, PubMed 12145181
Publications 2001
Glycohemoglobin values over 18 years predict coronary atheromatosis in type 1 diabetics
In Diabetologia, Springer, Berlin, 44(2001)suppl 1, s.A46 Abstrakt nr 175
BIBSYS 02203546x
Publications 2000
[Genetic and immunologic risks for development of type 1 diabetes--experiences from an intervention trial]
Tidsskr Nor Laegeforen, 120 (23), 2799-803
PubMed 11107929
Genetisk og immunologisk risiko for type 1-diabetes: erfaringer fra en intervensjonsstudie
In Tidsskrift for Den norske legeforening, Foreningen, Oslo, 120(2000)nr. 23, S. 2799-2803
BIBSYS 010831932
Publications 1999
Modern insulin therapy in children and adolescents
Acta Paediatr Suppl, 88 (427), 25-30
DOI 10.1111/j.1651-2227.1999.tb14336.x, PubMed 10195850
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene
Am J Hum Genet, 64 (3), 793-800
DOI 10.1086/302283, PubMed 10053014
Publications 1998
The advanced glycation end product Nepsilon-(carboxymethyl)lysine is increased in serum from children and adolescents with type 1 diabetes
Diabetes Care, 21 (11), 1997-2002
DOI 10.2337/diacare.21.11.1997, PubMed 9802757
Diabetic microangiopathy
Acta Paediatr., 87 425, 31-34
DOI 10.1080/080352598750030582
Biochemical markers of diabetic microangiopathy. Past, present and future
Horm Res, 50 Suppl 1, 12-6
DOI 10.1159/000053096, PubMed 9676991
Diabetic microangiopathy
Acta Paediatr Suppl, 425, 31-4
DOI 10.1111/j.1651-2227.1998.tb01249.x, PubMed 9822191
Publications 1997
Increased serum levels of advanced glycation end products (AGEs) in children and adolescents with IDDM
Diabetes Care, 20 (6), 1006-8
DOI 10.2337/diacare.20.6.1006, PubMed 9167115
HLA associations in insulin-dependent diabetes mellitus: no independent association to particular DP genes
Hum Immunol, 55 (2), 170-5
DOI 10.1016/s0198-8859(97)00095-5, PubMed 9361969
No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM
Diabetes, 46 (2), 307-12
DOI 10.2337/diab.46.2.307, PubMed 9000709
HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection
Diabetes, 46 (1), 143-9
DOI 10.2337/diab.46.1.143, PubMed 8971095
Publications 1995
Urinary excretion of retinol-binding protein in healthy children and adolescents
Pediatr Nephrol, 9 (3), 299-302
DOI 10.1007/BF02254190, PubMed 7632516
No difference in the parental origin of susceptibility HLA class II haplotypes among Norwegian patients with insulin-dependent diabetes mellitus
Am J Hum Genet, 57 (6), 1511-4
PubMed 8533785
Publications 1994
The effect of 8 years of strict glycaemic control on peripheral nerve function in IDDM patients: the Oslo Study
Diabetologia, 37 (6), 579-84
DOI 10.1007/BF00403376, PubMed 7926342
Impaired contrast sensitivity in adolescents and young type 1 (insulin-dependent) diabetic patients with microalbuminuria
Acta Ophthalmol (Copenh), 72 (6), 668-73
DOI 10.1111/j.1755-3768.1994.tb04677.x, PubMed 7747572
Improvement of blood glucose control in IDDM patients retards the progression of morphological changes in early diabetic nephropathy
Diabetologia, 37 (5), 483-90
DOI 10.1007/s001250050136, PubMed 8056186
Blood glucose control and microvascular complications--what do we do now?
Diabetologia, 37 (12), 1172-7
DOI 10.1007/BF00399789, PubMed 7895945
Decreased serum insulin-like growth factor I during puberty in children with insulin dependent diabetes mellitus (IDDM)
Ups J Med Sci, 99 (2), 147-54
DOI 10.3109/03009739409179358, PubMed 7716826
Publications 1993
Urinary albumin excretion rate and puberty in non-diabetic children and adolescents
Acta Paediatr, 82 (10), 857-62
DOI 10.1111/j.1651-2227.1993.tb17628.x, PubMed 8241647
Early glomerulopathy is present in young, type 1 (insulin-dependent) diabetic patients with microalbuminuria
Diabetologia, 36 (6), 523-9
DOI 10.1007/BF02743268, PubMed 8335174
Psychophysical visual function, retinopathy, and glycemic control in insulin-dependent diabetics with normal visual acuity
Acta Ophthalmol (Copenh), 71 (2), 230-7
DOI 10.1111/j.1755-3768.1993.tb04996.x, PubMed 8333271
[Blood glucose level means everything]
Tidsskr Nor Laegeforen, 113 (23), 2890-1
PubMed 8236187
Publications 1992
Glomerular charge selectivity and the influence of improved blood glucose control in type 1 (insulin-dependent) diabetic patients with microalbuminuria
Diabetologia, 35 (12), 1165-9
DOI 10.1007/BF00401371, PubMed 1478369
Oscillatory potentials, retinopathy, and long-term glucose control in insulin-dependent diabetes
Acta Ophthalmol (Copenh), 70 (6), 705-12
DOI 10.1111/j.1755-3768.1992.tb04873.x, PubMed 1488874
Macular recovery time, diabetic retinopathy, and clinical variables after 7 years of improved glycemic control
Acta Ophthalmol (Copenh), 70 (2), 235-42
DOI 10.1111/j.1755-3768.1992.tb04130.x, PubMed 1609574
Blood glucose concentrations and progression of diabetic retinopathy: the seven year results of the Oslo study
BMJ, 304 (6818), 19-22
DOI 10.1136/bmj.304.6818.19, PubMed 1734985
Long-term glycemic control and kidney function in insulin-dependent diabetes mellitus
Kidney Int, 41 (4), 920-3
DOI 10.1038/ki.1992.140, PubMed 1513113
[Can type 1 diabetes be prevented?]
Tidsskr Nor Laegeforen, 112 (23), 2951-2
PubMed 1412340
Blood glucose control and diabetic microvascular complications: long-term effects of near-normoglycaemia
Diabet Med, 9 (8), 697-705
DOI 10.1111/j.1464-5491.1992.tb01876.x, PubMed 1395460
Publications 1991
New semiquantitative dipstick test for microalbuminuria
Diabetes Care, 14 (11), 1094-7
DOI 10.2337/diacare.14.11.1094, PubMed 1797496
Relationship between cows' milk consumption and incidence of IDDM in childhood
Diabetes Care, 14 (11), 1081-3
DOI 10.2337/diacare.14.11.1081, PubMed 1797491
Serum Lp(a) lipoprotein concentrations in insulin dependent diabetic patients with microalbuminuria
BMJ, 303 (6804), 675-8
DOI 10.1136/bmj.303.6804.675, PubMed 1833011
Height reduction in 539 tall girls treated with three different dosages of ethinyloestradiol
Arch Dis Child, 66 (11), 1275-8
DOI 10.1136/adc.66.11.1275, PubMed 1755636
Publications 1990
Glycemic control, incipient diabetic nephropathy, and diabetic retinopathy
J Diabet Complications, 4 (2), 66-7
DOI 10.1016/0891-6632(90)90035-4, PubMed 2145303
Continuous subcutaneous insulin infusion (CSII), multiple injections (MI) and conventional insulin therapy (CT) in self-selecting insulin-dependent diabetic patients. A comparison of metabolic control, acute complications and patient preferences
J Intern Med, 228 (5), 457-64
DOI 10.1111/j.1365-2796.1990.tb00263.x, PubMed 2254715
Publications 1989
Microalbuminuria is associated with long term poor glycemic control in adolescent insulin dependent diabetics
Diabetes Res, 12 (2), 71-4
PubMed 2634509
Early morning glycaemia and the metabolic consequences of delaying breakfast/morning insulin. A comparison of continuous subcutaneous insulin infusion and multiple injection therapy with human isophane or human ultralente insulin at bedtime in insulin-dependent diabetics
Scand J Clin Lab Invest, 49 (7), 653-9
DOI 10.3109/00365518909091541, PubMed 2692136
Publications 1988
[Microalbuminuria. An important marker for diabetic nephropathy and macrovascular disease]
Tidsskr Nor Laegeforen, 108 (26), 2168-70
PubMed 3206421
The response of diabetic retinopathy to 41 months of multiple insulin injections, insulin pumps, and conventional insulin therapy
Arch Ophthalmol, 106 (9), 1242-6
DOI 10.1001/archopht.1988.01060140402041, PubMed 3046587
Effects of intensified insulin treatment on retinal vessels in diabetic patients
Br J Ophthalmol, 72 (9), 666-73
DOI 10.1136/bjo.72.9.666, PubMed 3052571
Oscillatory potentials, macular recovery time, and diabetic retinopathy through 3 years of intensified insulin treatment
Ophthalmology, 95 (10), 1358-66
DOI 10.1016/s0161-6420(88)33010-1, PubMed 3067179
[Can good blood sugar regulation prevent diabetic complications?]
Nord Med, 103 (12), 343-4
PubMed 3200703
Reduction of urinary albumin excretion after 4 years of continuous subcutaneous insulin infusion in insulin-dependent diabetes mellitus. The Oslo Study
Acta Endocrinol (Copenh), 117 (1), 19-25
DOI 10.1530/acta.0.1170019, PubMed 3289293
[Effect of intensive treatment on diabetic retinopathy]
Journ Annu Diabetol Hotel Dieu, 167-73
PubMed 3050220
Transient proliferative diabetic retinopathy during intensified insulin treatment
Am J Ophthalmol, 105 (6), 618-25
DOI 10.1016/0002-9394(88)90054-2, PubMed 3287938
Publications 1987
Elevated albumin excretion rate is common among poorly controlled adolescent insulin dependent diabetics
Diabetes Res, 6 (1), 43-6
PubMed 3690956
The central light reflex of retinal arteries and veins in insulin-dependent diabetic subjects
Acta Ophthalmol (Copenh), 65 (4), 474-80
DOI 10.1111/j.1755-3768.1987.tb07026.x, PubMed 3661146
Near-normoglycemia and late diabetic complications. The Oslo Study
Acta Endocrinol Suppl (Copenh), 284, 1-38
PubMed 3300128
Increase in insulin antibodies during continuous subcutaneous insulin infusion and multiple-injection therapy in contrast to conventional treatment
Diabetes, 36 (1), 1-5
DOI 10.2337/diab.36.1.1, PubMed 3539672
Publications 1986
Near-normoglycemia and late diabetic complications: the Oslo study
In Acta endocrinologica, Supplementum, Periodica, Copenhagen, 284, 38 s.
BIBSYS 87216618x, ISBN 87-7494-318-9
Near-normoglycemia and late diabetic complications: the Oslo study : (original articles)
Aker hospital, University of Norway, Oslo, 1 b.(flere pag.)
BIBSYS 874111668
Effect of near normoglycaemia for two years on progression of early diabetic retinopathy, nephropathy, and neuropathy: the Oslo study
Br Med J (Clin Res Ed), 293 (6556), 1195-9
DOI 10.1136/bmj.293.6556.1195, PubMed 3096429
Diabetic control and microvascular complications: the near-normoglycaemic experience
Diabetologia, 29 (10), 677-84
DOI 10.1007/BF00870275, PubMed 3542669
Plasma somatostatin and plasma glucagon in long-term IDDM without residual B-cell function. No effect of different long-term metabolic control
Scand J Clin Lab Invest, 46 (7), 635-8
DOI 10.3109/00365518609083725, PubMed 2878490
Diabetic control is improved by guar gum and wheat bran supplementation
Diabet Med, 3 (3), 230-3
DOI 10.1111/j.1464-5491.1986.tb00750.x, PubMed 3030619
Publications 1985
Effects of intensified insulin treatment on various lesions of diabetic retinopathy
Am J Ophthalmol, 100 (5), 644-53
DOI 10.1016/0002-9394(85)90618-x, PubMed 3904464
Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study
Br Med J (Clin Res Ed), 290 (6471), 811-5
DOI 10.1136/bmj.290.6471.811, PubMed 3919804
The influence of strict control on diabetic complications
Acta Endocrinol Suppl (Copenh), 272, 57-60
DOI 10.1530/acta.0.110s057, PubMed 3914805
Increased peripheral venous somatostatin concentration and decreased glucagon response to arginine in patients with insulin dependent diabetes mellitus without residual B-cell function. Increased plasma SRIF in IDDM
Acta Endocrinol (Copenh), 109 (4), 517-21
DOI 10.1530/acta.0.1090517, PubMed 2863913
Publications 1984
[Determination of urinary glucose. Simple determination of urinary glucose with a new semi-quantitative reagent stick; the Diabur Test 5000]
Tidsskr Nor Laegeforen, 104 (26), 1803-6
PubMed 6495272
[New methods for subcutaneous insulin administration. A year's experience with the insulin pump and multiple insulin injection therapy]
Tidsskr Nor Laegeforen, 104 (13), 856-61
PubMed 6379982
Publications 1983
[Children and adolescents with diabetes mellitus. Understanding correlation between glycosylated hemoglobin and diabetes mellitus and its management]
Tidsskr Nor Laegeforen, 103 (5), 516-8
PubMed 6346580
Publications 1982
HbA1 determination by agar gel electrophoresis after elimination of labile HbA1: a comparison with ion-exchange chromatography
Scand J Clin Lab Invest, 42 (1), 27-33
DOI 10.1080/00365518209168046, PubMed 7134788
Diabetes mellitus and physical activity
Scand J Soc Med Suppl, 29, 209-16
PubMed 6753136
Publications 1981
[Diabetic control. Self control of urinary and blood glucose and measurement of glycosylated hemoglobin (HbA1)]
Tidsskr Nor Laegeforen, 101 (13), 780-4
PubMed 7268712
Publications 1980
The effect of exercise on diabetic control and hemoglobin A1 (HbA1) in children
Acta Paediatr Scand Suppl, 283, 53-6
DOI 10.1111/j.1651-2227.1980.tb15313.x, PubMed 6938115
[Diabetes and physical activity]
Tidsskr Nor Laegeforen, 100 (12B), 840-4
PubMed 6996213
Publications 1979
Adynamia episodica hereditaria. Treatment with salbutamol
Acta Paediatr Scand, 68 (4), 583-5
DOI 10.1111/j.1651-2227.1979.tb05059.x, PubMed 463542