Publications 2024

Amland R, Selbæk G, Brækhus A, Edwin TH, Engedal K, Knapskog AB, Olsrud ER, Persson K (2024)
Clinically feasible automated MRI volumetry of the brain as a prognostic marker in subjective and mild cognitive impairment
Front Neurol, 15, 1425502
DOI 10.3389/fneur.2024.1425502, PubMed 39011362

Sudmann TM, Torblaa A, Austeng D, Reshodko I, Rehm J, Bro T, Brækhus A, Klungsøyr O, Rowe F, Jørstad ØK (2024)
Validation of the European visual field standards for driving: A driving simulator-based study
Acta Ophthalmol (in press)
DOI 10.1111/aos.16783, PubMed 39428625

Publications 2022

Bekkhus-Wetterberg P, Brækhus A, Müller EG, Norvik MI, Winsnes IE, Wyller TB (2022)
Primary progressive aphasia
Tidsskr Nor Laegeforen, 142 (17)
DOI 10.4045/tidsskr.22.0100, PubMed 36416646

Brækhus A (2022)
Say yes to medical certificates for older drivers
Tidsskr Nor Laegeforen, 142 (6)
DOI 10.4045/tidsskr.22.0202, PubMed 35383442

Medbøen IT, Persson K, Nåvik M, Totland TH, Bergh S, Treviño CS, Ulstein I, Engedal K, Knapskog AB, Brækhus A, Øksengård AR, Horndalsveen PO, Saltvedt I, Lyngroth AL, Ranhoff AH, Skrettingland DB, Naik M, Soares JZ, Johnsen B, Selbaek G (2022)
Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection
BMJ Open, 12 (9), e058810
DOI 10.1136/bmjopen-2021-058810, PubMed 36448543

Motazedi E, Cheng W, Thomassen JQ, Frei O, Rongve A, Athanasiu L, Bahrami S, Shadrin A, Ulstein I, Stordal E, Brækhus A, Saltvedt I, Sando SB, O'Connell KS, Hindley G, van der Meer D, Bergh S, Nordestgaard BG, Tybjærg-Hansen A, Bråthen G, Pihlstrøm L, Djurovic S, Frikke-Schmidt R, Fladby T, Aarsland D et al. (2022)
Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations
J Alzheimers Dis, 88 (4), 1533-1544
DOI 10.3233/JAD-220174, PubMed 35848024

Sudmann TM, Brækhus A, Jørstad ØK (2022)
[Health requirements for driving licences – on the right path with new technology]
Tidsskr Nor Laegeforen, 142 (16)
DOI 10.4045/tidsskr.22.0607, PubMed 36345625

Vlachos G, Ihle-Hansen H, Wyller TB, Brækhus A, Mangset M, Hamre C, Fure B (2022)
Predictors of cognitive and emotional symptoms 12 months after first-ever mild stroke
Neuropsychol Rehabil, 33 (4), 662-679
DOI 10.1080/09602011.2022.2038211, PubMed 35196958

Vlachos G, Ihle-Hansen H, Wyller TB, Brækhus A, Mangset M, Hamre C, Fure B (2022)
Factors Determining Not Returning to Full-Time Work 12 Months After Mild Ischemic Stroke
Arch Rehabil Res Clin Transl, 5 (1), 100245
DOI 10.1016/j.arrct.2022.100245, PubMed 36968174

Publications 2021

Brækhus A, Kristiansen KM, Rønqvist TK (2021)
[Assessment of an older driver’s health is necessary]
Tidsskr Nor Laegeforen, 141 (6)
DOI 10.4045/tidsskr.21.0175, PubMed 33876609

GjØra L, Strand BH, Bergh S, Borza T, Brækhus A, Engedal K, Johannessen A, Kvello-Alme M, Krokstad S, Livingston G, Matthews FE, Myrstad C, Skjellegrind H, Thingstad P, Aakhus E, Aam S, Selbæk G (2021)
Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study
J Alzheimers Dis, 79 (3), 1213-1226
DOI 10.3233/JAD-201275, PubMed 33427745

Vlachos G, Ihle-Hansen H, Bruun Wyller T, Brækhus A, Mangset M, Hamre C, Fure B (2021)
Cognitive and emotional symptoms in patients with first-ever mild stroke: The syndrome of hidden impairments
J Rehabil Med, 53 (1), jrm00135
DOI 10.2340/16501977-2764, PubMed 33145603

Publications 2020

Hazen J, Vistnes M, Barca ML, Eldholm RS, Persson K, Brækhus A, Saltvedt I, Selbæk G, Engedal K, Knapskog AB (2020)
The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia
Alzheimer Dis Assoc Disord, 34 (1), 47-53
DOI 10.1097/WAD.0000000000000342, PubMed 31414991

Idland AV, Sala-Llonch R, Watne LO, Brækhus A, Hansson O, Blennow K, Zetterberg H, Sørensen Ø, Walhovd KB, Wyller TB, Fjell AM (2020)
Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Neurobiol Aging, 93, 1-15
DOI 10.1016/j.neurobiolaging.2020.04.002, PubMed 32438258

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Brækhus A, Bråthen G, de Leeuw C, Desikan RS, Djurovic S et al. (2020)
Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Nat Genet, 52 (3), 354
DOI 10.1038/s41588-019-0573-x, PubMed 32029921

Publications 2019

Creese B, Vassos E, Bergh S, Athanasiu L, Johar I, Rongve A, Medbøen IT, Vasconcelos Da Silva M, Aakhus E, Andersen F, Bettella F, Braekhus A, Djurovic S, Paroni G, Proitsi P, Saltvedt I, Seripa D, Stordal E, Fladby T, Aarsland D, Andreassen OA, Ballard C, Selbaek G, AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative (2019)
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
Transl Psychiatry, 9 (1), 273
DOI 10.1038/s41398-019-0592-5, PubMed 31641104

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Brækhus A, Bråthen G, de Leeuw C, Desikan RS, Djurovic S et al. (2019)
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Nat Genet, 51 (3), 404-413
DOI 10.1038/s41588-018-0311-9, PubMed 30617256

Knapskog AB, Braekhus A, Engedal K (2019)
The Effect of Changing the Amyloid β42 Cut-off of Cerebrospinal Fluid Biomarkers on Alzheimer Disease Diagnosis in a Memory Clinic Population in Norway
Alzheimer Dis Assoc Disord, 33 (1), 72-74
DOI 10.1097/WAD.0000000000000268, PubMed 30106756

Publications 2018

Barca ML, Eldholm RS, Persson K, Bjørkløf GH, Borza T, Telenius E, Knapskog AB, Brækhus A, Saltvedt I, Selbæk G, Engedal K (2018)
Cortisol levels among older people with and without depression and dementia
Int Psychogeriatr, 31 (4), 597-601
DOI 10.1017/S1041610218001199, PubMed 30556798

Eldholm RS, Barca ML, Persson K, Knapskog AB, Kersten H, Engedal K, Selbæk G, Brækhus A, Skovlund E, Saltvedt I (2018)
Progression of Alzheimer's Disease: A Longitudinal Study in Norwegian Memory Clinics
J Alzheimers Dis, 61 (3), 1221-1232
DOI 10.3233/JAD-170436, PubMed 29254085

Fjell AM, Idland AV, Sala-Llonch R, Watne LO, Borza T, Brækhus A, Lona T, Zetterberg H, Blennow K, Wyller TB, Walhovd KB (2018)
Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy
Cereb Cortex, 28 (8), 2775-2785
DOI 10.1093/cercor/bhx157, PubMed 28655157

Witoelar A, Rongve A, Almdahl IS, Ulstein ID, Engvig A, White LR, Selbæk G, Stordal E, Andersen F, Brækhus A, Saltvedt I, Engedal K, Hughes T, Bergh S, Bråthen G, Bogdanovic N, Bettella F, Wang Y, Athanasiu L, Bahrami S, Le Hellard S, Giddaluru S, Dale AM, Sando SB, Steinberg S et al. (2018)
Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Sci Rep, 8 (1), 18088
DOI 10.1038/s41598-018-36429-6, PubMed 30591712

Publications 2017

Córdova-Palomera A, Kaufmann T, Persson K, Alnæs D, Doan NT, Moberget T, Lund MJ, Barca ML, Engvig A, Brækhus A, Engedal K, Andreassen OA, Selbæk G, Westlye LT (2017)
Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum
Sci Rep, 7, 40268
DOI 10.1038/srep40268, PubMed 28074926

Doan NT, Engvig A, Persson K, Alnæs D, Kaufmann T, Rokicki J, Córdova-Palomera A, Moberget T, Brækhus A, Barca ML, Engedal K, Andreassen OA, Selbæk G, Westlye LT (2017)
Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum
Sci Rep, 7, 45131
DOI 10.1038/srep45131, PubMed 28338052

Doan NT, Engvig A, Zaske K, Persson K, Lund MJ, Kaufmann T, Cordova-Palomera A, Alnæs D, Moberget T, Brækhus A, Barca ML, Nordvik JE, Engedal K, Agartz I, Selbæk G, Andreassen OA, Westlye LT, Alzheimer's Disease Neuroimaging Initiative (2017)
Distinguishing early and late brain aging from the Alzheimer's disease spectrum: consistent morphological patterns across independent samples
Neuroimage, 158, 282-295
DOI 10.1016/j.neuroimage.2017.06.070, PubMed 28666881

Idland AV, Wyller TB, Støen R, Dahl GT, Frihagen F, Brækhus A, Hassel B, Watne LO (2017)
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783

Idland AV, Wyller TB, Støen R, Eri LM, Frihagen F, Ræder J, Chaudhry FA, Hansson O, Zetterberg H, Blennow K, Bogdanovic N, Brækhus A, Watne LO (2017)
Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium
J Alzheimers Dis, 55 (1), 371-379
DOI 10.3233/JAD-160461, PubMed 27662296

Knapskog AB, Eldholm RS, Braekhus A, Engedal K, Saltvedt I (2017)
Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients
BMC Geriatr, 17 (1), 210
DOI 10.1186/s12877-017-0611-4, PubMed 28893185

Persson K, Barca ML, Cavallin L, Brækhus A, Knapskog AB, Selbæk G, Engedal K (2017)
Comparison of automated volumetry of the hippocampus using NeuroQuant® and visual assessment of the medial temporal lobe in Alzheimer's disease
Acta Radiol, 59 (8), 997-1001
DOI 10.1177/0284185117743778, PubMed 29172642

Persson K, Barca ML, Eldholm RS, Cavallin L, Šaltytė Benth J, Selbæk G, Brækhus A, Saltvedt I, Engedal K (2017)
Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease
Dement Geriatr Cogn Disord, 44 (1-2), 12-24
DOI 10.1159/000477342, PubMed 28614836

Persson K, Bohbot VD, Bogdanovic N, Selbaek G, Braekhus A, Engedal K (2017)
Finding of increased caudate nucleus in patients with Alzheimer's disease
Acta Neurol Scand, 137 (2), 224-232
DOI 10.1111/ane.12800, PubMed 28741672

Persson K, Eldholm RS, Barca ML, Cavallin L, Ferreira D, Knapskog AB, Selbæk G, Brækhus A, Saltvedt I, Westman E, Engedal K (2017)
MRI-assessed atrophy subtypes in Alzheimer's disease and the cognitive reserve hypothesis
PLoS One, 12 (10), e0186595
DOI 10.1371/journal.pone.0186595, PubMed 29036183

Sala-Llonch R, Idland AV, Borza T, Watne LO, Wyller TB, Brækhus A, Zetterberg H, Blennow K, Walhovd KB, Fjell AM (2017)
Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition
J Alzheimers Dis, 58 (3), 829-840
DOI 10.3233/JAD-161146, PubMed 28505968

Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F et al. (2017)
Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Nat Genet, 49 (5), 801-805
DOI 10.1038/ng.3816, PubMed 28319091

Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F et al. (2017)
Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Nat Genet, 49 (8), 1286
DOI 10.1038/ng0817-1286b, PubMed 28747754

Publications 2016

Idland AV, Sala-Llonch R, Borza T, Watne LO, Wyller TB, Brækhus A, Zetterberg H, Blennow K, Walhovd KB, Fjell AM (2016)
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
Neurobiol Aging, 49, 138-144
DOI 10.1016/j.neurobiolaging.2016.09.012, PubMed 27794264

Knapskog AB, Engedal K, Braekhus A (2016)
Performance of Cerebrospinal Fluid Biomarkers of Alzheimer Disease in a Memory Clinic in Norway
Alzheimer Dis Assoc Disord, 30 (1), 8-14
DOI 10.1097/WAD.0000000000000126, PubMed 26629677

Persson K, Selbæk G, Brækhus A, Beyer M, Barca M, Engedal K (2016)
Fully automated structural MRI of the brain in clinical dementia workup
Acta Radiol, 58 (6), 740-747
DOI 10.1177/0284185116669874, PubMed 27687251

Publications 2015

Persson K, Brækhus A, Selbæk G, Kirkevold Ø, Engedal K (2015)
Burden of Care and Patient's Neuropsychiatric Symptoms Influence Carer's Evaluation of Cognitive Impairment
Dement Geriatr Cogn Disord, 40 (5-6), 256-67
DOI 10.1159/000437298, PubMed 26304633

Publications 2012

Engedal K, Brækhus A, Andreassen OA, Nakstad PH (2012)
Diagnosis of dementia--automatic quantification of brain structures
Tidsskr Nor Laegeforen, 132 (15), 1747-51
DOI 10.4045/tidsskr.12.0148, PubMed 22929941

Publications 2011

Brækhus A (2011)
Biomarkers of dementia
Tidsskr Nor Laegeforen, 131 (22), 2218
DOI 10.4045/tidsskr.11.1245, PubMed 22085936

Brækhus A, Ulstein I, Wyller TB, Engedal K (2011)
The Memory Clinic--outpatient assessment when dementia is suspected
Tidsskr Nor Laegeforen, 131 (22), 2254-7
DOI 10.4045/tidsskr.11.0786, PubMed 22085955

Fure B, Engebretsen EH, Thommessen B, Øksengård AR, Brækhus A (2011)
[Clinical neurological examination of the geriatric patient]
Tidsskr Nor Laegeforen, 131 (11), 1080-3
DOI 10.4045/tidsskr.10.0577, PubMed 21681235

Publications 2010

Braekhus A, Wyller TB, Engedal K (2010)
[Doctors' views on medical assessments of drivers]
Tidsskr Nor Laegeforen, 130 (13), 1343-6
DOI 10.4045/tidsskr.09.1537, PubMed 20596115

Publications 2009

Engedal K, Haugen PK, Brækhus A (2009)
Demens: fakta og utfordringer : en lærebok
Aldring og helse, Tønsberg (5. utg.), 424 s.
BIBSYS 093656084, ISBN 978-82-8061-120-8

Publications 2008

Herrman H, Braekhus A, Aaserud O, Aukrust P, Stubhaug A, Hassel B (2008)
Early treatment of tetanus-induced trismus with botulinum toxin A
Anesth Analg, 106 (5), 1591
DOI 10.1213/ANE.0b013e31816a30f0, PubMed 18420892

Skjerve A, Nordhus IH, Engedal K, Braekhus A, Nygaard HA, Pallesen S, Haugen PK (2008)
Validation of the Seven Minute Screen and Syndrom Kurztest among elderly Norwegian outpatients
Int Psychogeriatr, 20 (4), 807-14
DOI 10.1017/S1041610208007072, PubMed 18377698

Publications 2007

Skjerve A, Nordhus IH, Engedal K, Pallesen S, Braekhus A, Nygaard HA (2007)
Seven minute screen performance in a normal elderly sample
Int J Geriatr Psychiatry, 22 (8), 764-9
DOI 10.1002/gps.1736, PubMed 17152118

Publications 2005

Braekhus A (2005)
[Physicians, health and drivers licence]
Tidsskr Nor Laegeforen, 125 (19), 2609
PubMed 16215600

Engedal K, Haugen PK, Brækhus A (2005)
Demens: fakta og utfordringer : en lærebok
Aldring og helse, Tønsberg (4. utg.), 423 s.
BIBSYS 060006080, ISBN 978-82-8061-051-5

Publications 2004

Braekhus A, Engedal K (2004)
[Vascular dementia--an ill-defined concept]
Tidsskr Nor Laegeforen, 124 (8), 1097-9
PubMed 15114387

Engedal K, Braekhus A, Gjerstad L (2004)
[Effect of drugs against dementia]
Tidsskr Nor Laegeforen, 124 (12), 1641-2
PubMed 15229711

Publications 2002

Engedal K, Brækhus A (2002)
Demensutredning i primærhelsetjenesten
Nasjonalt kompetansesenter for aldersdemens, Sem, [8 s.]
BIBSYS 03184250x

Hakamies-Blomqvist L, Henriksson P, Falkmer T, Lundberg C, Braekhus A (2002)
Attitudes of primary care physicians toward older drivers: A Finnish-Swedish comparison
J. Appl. Gerontol., 21 (1), 58-69

Thommessen B, Aarsland D, Braekhus A, Oksengaard AR, Engedal K, Laake K (2002)
The psychosocial burden on spouses of the elderly with stroke, dementia and Parkinson's disease
Int J Geriatr Psychiatry, 17 (1), 78-84
DOI 10.1002/gps.524, PubMed 11802235

Publications 2000

Braekhus A (2000)
[Elderly automobile drivers]
Tidsskr Nor Laegeforen, 120 (28), 3373
PubMed 11187186

Publications 1999

Braekhus A (1999)
[Non-pharmacological treatment of mild dementia]
Tidsskr Nor Laegeforen, 119 (27), 4079-82
PubMed 10613102

Publications 1998

Braekhus A, Oksengård AR, Engedal K, Laake K (1998)
Social and depressive stress suffered by spouses of patients with mild dementia
Scand J Prim Health Care, 16 (4), 242-6
DOI 10.1080/028134398750003034, PubMed 9932319

Publications 1997

Braekhus A (1997)
[Aging, dementia and automobile driving]
Tidsskr Nor Laegeforen, 117 (25), 3688-9
PubMed 9417667

Lundberg C, Johansson K, Ball K, Bjerre B, Blomqvist C, Braekhus A, Brouwer WH, Bylsma FW, Carr DB, Englund L, Friedland RP, Hakamies-Blomqvist L, Klemetz G, O'Neill D, Odenheimer GL, Rizzo M, Schelin M, Seideman M, Tallman K, Viitanen M, Waller PF, Winblad B (1997)
Dementia and driving: an attempt at consensus
Alzheimer Dis Assoc Disord, 11 (1), 28-37
DOI 10.1097/00002093-199703000-00006, PubMed 9071442

Oksengård AR, Braekhus A, Engedal K, Laake K (1997)
[Memory clinic--ambulatory examination in suspected dementia]
Tidsskr Nor Laegeforen, 117 (25), 3678-80
PubMed 9417664

Publications 1996

Braekhus A, Engedal K (1996)
Mental impairment and driving licences for elderly people--a survey among Norwegian general practitioners
Scand J Prim Health Care, 14 (4), 223-8
DOI 10.3109/02813439608997089, PubMed 8956450

Publications 1995

Braekhus A, Laake K, Engedal K (1995)
A low, 'normal' score on the Mini-Mental State Examination predicts development of dementia after three years
J Am Geriatr Soc, 43 (6), 656-61
DOI 10.1111/j.1532-5415.1995.tb07201.x, PubMed 7775725

Oeksengaard AR, Braekhus A, Laake K, Engedal K (1995)
The set test as a diagnostic tool in elderly outpatients with suspected dementia
Aging (Milano), 7 (5), 398-401
DOI 10.1007/BF03324352, PubMed 8719608

Publications 1994

Braekhus A, Engedal K (1994)
[Delirium (acute confusion) among elderly patients after admission to a medical department]
Tidsskr Nor Laegeforen, 114 (22), 2613-5
PubMed 7985180

Publications 1993

Braekhus A, Oksengård AR (1993)
[The elderly and automobile driving]
Tidsskr Nor Laegeforen, 113 (10), 1259
PubMed 8493661

Publications 1992

Braekhus A, Laake K, Engedal K (1992)
The Mini-Mental State Examination: identifying the most efficient variables for detecting cognitive impairment in the elderly
J Am Geriatr Soc, 40 (11), 1139-45
DOI 10.1111/j.1532-5415.1992.tb01804.x, PubMed 1401700