Skin cancer in organ transplant recipients

The high risk of skin cancer after organ transplantation is a major clinical challenge. Taking advantage of a high-quality national cancer registry, we have studied long-term changes in the risk of cutaneous squamous cell carcinoma after organ transplantation in Norway.

PhD project: Syed Mohammad Husain Rizvi. Main supervisor: Petter Gjersvik.

Fractional laser-assisted daylight photodynamic therapy for multiple actinic keratoses of the scalp in organ transplant recipients: a randomized half-side comparative trial

Organ transplant recipients (OTRs) are at high risk of skin cancer, especially squamous cell carcinoma (SCC). SCC often develops in the area of field cancerization, areas exposed for chronical sun damage and multiple actinic keratoses (AK). It is of high clinical value to treat precancerous lesions such as AK among OTRs. In order to evaluate more effective treatment of AKs/field cancerization in OTRs we set out a randomized half-side comparative trial to investigate the effect of pre-treating the skin with ablative, fractional carbon dioxide laser before daylight PDT.

Project leader: Syed Mohammad Husain Rizvi. Others: Gro Mørk, Petter Gjersvik, Per Helsing.

Validation of staging systems for cutaneous squamous cell carcinoma: a population-based, nested case-control study

In this study, we aim to determine the rate of metastasis in cutaneous squamous cell carcinoma (cSCC) in Norway, by using high-quality population-based data.  Also, we aim to assess the impact of reported risk factors for metastasis and to externally validate three existing current cSCC staging systems for their reproducibility and practicality.

Project leader: Ingrid Roscher. Others: Petter Gjersvik, Per Helsing. Collaborators: Department of Pathology, Oslo University Hospital, Oslo, Norway; Cancer Registry of Norway; Oslo Centre for biostatistics and epidemiology, Oslo University Hospital, Oslo, Norway

Cost-benefit of a ban on sun-beds

A project to look at the costs of melanoma treatment in Norway and benefits from various measures to reduce the occurrence of melanomas. One measure is to reduce sun-bed use, other measures are more active and conscious use of shadow and sunscreen on travels to sunny areas. We will look at both saved costs and saved lives, in addition to looking at people's assessment of welfare loss associated with getting or having skin cancer

Project collaborators: Lill Tove Nilsen and Merete Hannevik (The Norwegian Radiation Protection Agency), Trude Robsahm,(Cancer Registry), Marit B. Veierød, (University of Oslo), Ingrid Roscher (Department of Dermatology,  Oslo University Hospital), Ståle Navrud, (Norwegian School of Economics at Norwegian University of Life Sciences).

Metastatic rates for cutaneous squamous cell carcinoma in organ transplant recipients and background population in Norway 1968-2016.

Cutaneous squamous cell carcinoma (cSCC) may be metastatic, and some reports indicate that cSCC in organ transplant recipients (OTRs) may have a more aggressive course and a higher risk of metastasis than cSCC in immunocompetent patients.  Studies on the metastatic rate in cSCC, however, are limited, both among OTRs and in general populations, and the results somewhat contradictory. Using data from the national cancer registry from 1968 through 2016, we will study the rate of metastasis from cSCC in OTRs and in the background population of Norway.

Project participants: Petter Gjersvik, Ingrid Roscher, Mohammad Rizvi.  Collaborators: Cancer Registry of Norway. 

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