Publications 2023

Watne LO, Pollmann CT, Neerland BE, Quist-Paulsen E, Halaas NB, Idland AV, Hassel B, Henjum K, Knapskog AB, Frihagen F, Raeder J, Godø A, Ueland PM, McCann A, Figved W, Selbæk G, Zetterberg H, Fang EF, Myrstad M, Giil LM (2023)
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients
J Clin Invest, 133 (2)
DOI 10.1172/JCI163472, PubMed 36409557

Publications 2022

Aksnes M, Aass HCD, Tiiman A, Terenius L, Bogdanović N, Vukojević V, Knapskog AB (2022)
Serum Amyloidogenic Nanoplaques and Cytokines in Alzheimer's Disease: Pilot Study in a Small Naturalistic Memory Clinic Cohort
J Alzheimers Dis, 86 (3), 1459-1470
DOI 10.3233/JAD-215504, PubMed 35213378

Henjum K, Watne LO, Godang K, Halaas NB, Eldholm RS, Blennow K, Zetterberg H, Saltvedt I, Bollerslev J, Knapskog AB (2022)
Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease
Transl Psychiatry, 12 (1), 151
DOI 10.1038/s41398-022-01901-5, PubMed 35397615

Jansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, Zettergren A, Mishra A, Ali M, Andrade V, Bellenguez C, Kleineidam L, Küçükali F, Sung YJ, Tesí N, Vromen EM, Wightman DP, Alcolea D, Alegret M, Alvarez I, Amouyel P, Athanasiu L, Bahrami S, Bailly H, Belbin O et al. (2022)
Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers
Acta Neuropathol, 144 (5), 821-842
DOI 10.1007/s00401-022-02454-z, PubMed 36066633

Medbøen IT, Persson K, Nåvik M, Totland TH, Bergh S, Treviño CS, Ulstein I, Engedal K, Knapskog AB, Brækhus A, Øksengård AR, Horndalsveen PO, Saltvedt I, Lyngroth AL, Ranhoff AH, Skrettingland DB, Naik M, Soares JZ, Johnsen B, Selbaek G (2022)
Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection
BMJ Open, 12 (9), e058810
DOI 10.1136/bmjopen-2021-058810, PubMed 36448543

Müller EG, Edwin TH, Strand BH, Stokke C, Revheim ME, Knapskog AB (2022)
Is Amyloid Burden Measured by 18F-Flutemetamol PET Associated with Progression in Clinical Alzheimer's Disease?
J Alzheimers Dis, 85 (1), 197-205
DOI 10.3233/JAD-215046, PubMed 34776444

Müller EG, Stokke C, Stokmo HL, Edwin TH, Knapskog AB, Revheim ME (2022)
Evaluation of semi-quantitative measures of ¹⁸F-flutemetamol PET for the clinical diagnosis of Alzheimer's disease
Quant Imaging Med Surg, 12 (1), 493-509
DOI 10.21037/qims-21-188, PubMed 34993096

Persson K, Edwin TH, Knapskog AB, Tangen GG, Selbæk G, Engedal K (2022)
Hippocampal Atrophy Subtypes of Alzheimer's Disease Using Automatic MRI in a Memory Clinic Cohort: Clinical Implications
Dement Geriatr Cogn Disord, 51 (1), 80-89
DOI 10.1159/000522382, PubMed 35344967

Soares JZ, Valeur J, Šaltytė Benth J, Knapskog AB, Selbæk G, Arefi G, Gilfillan GD, Tollisen A, Bogdanovic N, Pettersen R (2022)
Vitamin D in Alzheimer's Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum
J Alzheimers Dis, 86 (3), 1301-1314
DOI 10.3233/JAD-215536, PubMed 35180126

Soares JZ, Valeur J, Šaltytė Benth J, Knapskog AB, Selbæk G, Bogdanovic N, Pettersen R (2022)
Associations Between Intrathecal Levels of Vitamin D, Cytokines, and Core Biomarkers of Alzheimer's Disease: A Cross-Sectional Study
J Alzheimers Dis, 89 (3), 825-834
DOI 10.3233/JAD-220407, PubMed 35938253

Publications 2021

Aksnes M, Tiiman A, Edwin TH, Terenius L, Bogdanović N, Vukojević V, Knapskog AB (2021)
Comparison of Cerebrospinal Fluid Amyloidogenic Nanoplaques With Core Biomarkers of Alzheimer's Disease
Front Aging Neurosci, 12, 608628
DOI 10.3389/fnagi.2020.608628, PubMed 33488383

Aksnes M, Aass HCD, Tiiman A, Edwin TH, Terenius L, Bogdanović N, Vukojević V, Knapskog AB (2021)
Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer's disease
Transl Neurodegener, 10 (1), 18
DOI 10.1186/s40035-021-00244-3, PubMed 34099032

Alme KN, Askim T, Assmus J, Mollnes TE, Naik M, Næss H, Saltvedt I, Ueland PM, Ulvik A, Knapskog AB (2021)
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
BMC Neurol, 21 (1), 318
DOI 10.1186/s12883-021-02343-0, PubMed 34399717

Alme KN, Ulvik A, Askim T, Assmus J, Mollnes TE, Naik M, Næss H, Saltvedt I, Ueland PM, Knapskog AB (2021)
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke
BMC Neurol, 21 (1), 476
DOI 10.1186/s12883-021-02498-w, PubMed 34879833

Edwin TH, Strand BH, Persson K, Engedal K, Selbaek G, Knapskog AB (2021)
Neuropsychiatric symptoms and comorbidity: Associations with dementia progression rate in a memory clinic cohort
Int J Geriatr Psychiatry, 36 (6), 960-969
DOI 10.1002/gps.5500, PubMed 33462872

Einstad MS, Saltvedt I, Lydersen S, Ursin MH, Munthe-Kaas R, Ihle-Hansen H, Knapskog AB, Askim T, Beyer MK, Næss H, Seljeseth YM, Ellekjær H, Thingstad P (2021)
Associations between post-stroke motor and cognitive function: a cross-sectional study
BMC Geriatr, 21 (1), 103
DOI 10.1186/s12877-021-02055-7, PubMed 33546620

Halaas NB, Zetterberg H, Idland AV, Knapskog AB, Watne LO, Blennow K (2021)
Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium
J Alzheimers Dis, 81 (2), 667-677
DOI 10.3233/JAD-201341, PubMed 33814433

Hernes SS, Flak MM, Løhaugen GCC, Skranes J, Hol HR, Madsen BO, Knapskog AB, Engvig A, Pripp A, Ulstein I, Lona T, Zhang X, Chang L (2021)
Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects
Front Aging Neurosci, 13, 624253
DOI 10.3389/fnagi.2021.624253, PubMed 33658917

Knapskog AB, Engedal K, Selbæk G, Øksengård AR (2021)
[Alzheimer’s disease – diagnosis and treatment]
Tidsskr Nor Laegeforen, 141 (7)
DOI 10.4045/tidsskr.20.0919, PubMed 33950641

Schellhorn T, Zucknick M, Askim T, Munthe-Kaas R, Ihle-Hansen H, Seljeseth YM, Knapskog AB, Næss H, Ellekjær H, Thingstad P, Wyller TB, Saltvedt I, Beyer MK (2021)
Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study
BMC Geriatr, 21 (1), 362
DOI 10.1186/s12877-021-02327-2, PubMed 34126944

Aam S, Gynnild MN, Munthe-Kaas R, Saltvedt I, Lydersen S, Knapskog AB, Ihle-Hansen H, Ellekjær H, Eldholm RS, Fure B (2021)
The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study
Front Neurol, 12, 678794
DOI 10.3389/fneur.2021.678794, PubMed 34421786

Publications 2020

Aksnes M, Müller EG, Tiiman A, Edwin TH, Terenius L, Revheim ME, Vukojević V, Bogdanović N, Knapskog AB (2020)
Amyloidogenic Nanoplaques in Cerebrospinal Fluid: Relationship to Amyloid Brain Uptake and Clinical Alzheimer's Disease in a Memory Clinic Cohort
J Alzheimers Dis, 77 (2), 831-842
DOI 10.3233/JAD-200237, PubMed 32741818

Alme KN, Knapskog AB, Næss H, Naik M, Beyer M, Ellekjaer H, English C, Hansen HI, Kummeneje CS, Munthe-Kaas R, Saltvedt I, Seljeseth Y, Tan X, Thingstad P, Askim T (2020)
Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study
BMJ Open, 10 (11), e037475
DOI 10.1136/bmjopen-2020-037475, PubMed 33243789

Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF (2020)
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Int Rev Neurobiol, 155, 169-202
DOI 10.1016/bs.irn.2020.02.008, PubMed 32854854

Edwin TH, Henjum K, Nilsson LNG, Watne LO, Persson K, Eldholm RS, Saltvedt I, Halaas NB, Selbæk G, Engedal K, Strand BH, Knapskog AB (2020)
A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
Alzheimers Dement (Amst), 12 (1), e12128
DOI 10.1002/dad2.12128, PubMed 33313376

Edwin TH, Strand BH, Persson K, Engedal K, Selbæk G, Knapskog AB (2020)
Trajectories and risk factors of dementia progression: a memory clinic cohort followed up to 3 years from diagnosis
Int Psychogeriatr, 33 (8), 779-789
DOI 10.1017/S1041610220003270, PubMed 33213607

Gynnild MN, Aakerøy R, Spigset O, Askim T, Beyer MK, Ihle-Hansen H, Munthe-Kaas R, Knapskog AB, Lydersen S, Naess H, Røsstad TG, Seljeseth YM, Thingstad P, Saltvedt I, Ellekjaer H (2020)
Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke
J Intern Med, 289 (3), 355-368
DOI 10.1111/joim.13161, PubMed 32743852

Hazen J, Vistnes M, Barca ML, Eldholm RS, Persson K, Brækhus A, Saltvedt I, Selbæk G, Engedal K, Knapskog AB (2020)
The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia
Alzheimer Dis Assoc Disord, 34 (1), 47-53
DOI 10.1097/WAD.0000000000000342, PubMed 31414991

Knapskog AB, Henjum K, Idland AV, Eldholm RS, Persson K, Saltvedt I, Watne LO, Engedal K, Nilsson LNG (2020)
Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
Sci Rep, 10 (1), 15886
DOI 10.1038/s41598-020-72878-8, PubMed 32985583

Mjørud M, Selbæk G, Bjertness E, Edwin TH, Engedal K, Knapskog AB, Strand BH (2020)
Time from dementia diagnosis to nursing-home admission and death among persons with dementia: A multistate survival analysis
PLoS One, 15 (12), e0243513
DOI 10.1371/journal.pone.0243513, PubMed 33275638

Munthe-Kaas R, Aam S, Ihle-Hansen H, Lydersen S, Knapskog AB, Wyller TB, Fure B, Thingstad P, Askim T, Beyer MK, Næss H, Seljeseth YM, Ellekjær H, Pendlebury ST, Saltvedt I (2020)
Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study
Alzheimers Dement (N Y), 6 (1), e12000
DOI 10.1002/trc2.12000, PubMed 32211505

Sajjad MU, Blennow K, Knapskog AB, Idland AV, Chaudhry FA, Wyller TB, Zetterberg H, Watne LO (2020)
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
J Alzheimers Dis, 73 (4), 1363-1372
DOI 10.3233/JAD-190941, PubMed 31929159

Aam S, Einstad MS, Munthe-Kaas R, Lydersen S, Ihle-Hansen H, Knapskog AB, Ellekjær H, Seljeseth Y, Saltvedt I (2020)
Post-stroke Cognitive Impairment-Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study
Front Neurol, 11, 699
DOI 10.3389/fneur.2020.00699, PubMed 32765406

Publications 2019

Flak MM, Hol HR, Hernes SS, Chang L, Engvig A, Bjuland KJ, Pripp A, Madsen BO, Knapskog AB, Ulstein I, Lona T, Skranes J, Løhaugen GCC (2019)
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial
Front Psychol, 10, 807
DOI 10.3389/fpsyg.2019.00807, PubMed 31031677

Flak MM, Hol HR, Hernes SS, Chang L, Ernst T, Engvig A, Bjuland KJ, Madsen BO, Lindland EMS, Knapskog AB, Ulstein ID, Lona TEE, Skranes J, Løhaugen GCC (2019)
Corrigendum: Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment
Front Aging Neurosci, 11, 37
DOI 10.3389/fnagi.2019.00037, PubMed 30863303

Knapskog AB, Braekhus A, Engedal K (2019)
The Effect of Changing the Amyloid β42 Cut-off of Cerebrospinal Fluid Biomarkers on Alzheimer Disease Diagnosis in a Memory Clinic Population in Norway
Alzheimer Dis Assoc Disord, 33 (1), 72-74
DOI 10.1097/WAD.0000000000000268, PubMed 30106756

Leavey N, Hammond SP, Shepstone L, Cross J, Zetterberg H, Cunningham C, MacLullich A, Leiv Otto Watne, Minihane AM, Ballard C, Knapskog AB, Hall R, Howard G, Hammond M, Fox C (2019)
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients
BMC Neurol, 19 (1), 223
DOI 10.1186/s12883-019-1447-7, PubMed 31493787

Müller EG, Edwin TH, Stokke C, Navelsaker SS, Babovic A, Bogdanovic N, Knapskog AB, Revheim ME (2019)
Amyloid-β PET-Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic
PLoS One, 14 (8), e0221365
DOI 10.1371/journal.pone.0221365, PubMed 31430334

Strand BH, Knapskog AB, Persson K, Holt Edwin T, Bjertness E, Engedal K, Selbaek G (2019)
The Loss in Expectation of Life due to Early-Onset Mild Cognitive Impairment and Early-Onset Dementia in Norway
Dement Geriatr Cogn Disord, 47 (4-6), 355-365
DOI 10.1159/000501269, PubMed 31319412

Zugic Soares J, Pettersen R, Saltyte Benth J, Knapskog AB, Selbæk G, Bogdanovic N (2019)
Higher Vitamin D Levels Are Associated with Better Attentional Functions: Data from the NorCog Register
J Nutr Health Aging, 23 (8), 725-731
DOI 10.1007/s12603-019-1220-z, PubMed 31560030

Publications 2018

Barca ML, Eldholm RS, Persson K, Bjørkløf GH, Borza T, Telenius E, Knapskog AB, Brækhus A, Saltvedt I, Selbæk G, Engedal K (2018)
Cortisol levels among older people with and without depression and dementia
Int Psychogeriatr, 31 (4), 597-601
DOI 10.1017/S1041610218001199, PubMed 30556798

Eldholm RS, Barca ML, Persson K, Knapskog AB, Kersten H, Engedal K, Selbæk G, Brækhus A, Skovlund E, Saltvedt I (2018)
Progression of Alzheimer's Disease: A Longitudinal Study in Norwegian Memory Clinics
J Alzheimers Dis, 61 (3), 1221-1232
DOI 10.3233/JAD-170436, PubMed 29254085

Eldholm RS, Persson K, Barca ML, Knapskog AB, Cavallin L, Engedal K, Selbaek G, Skovlund E, Saltvedt I (2018)
Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics
BMC Geriatr, 18 (1), 120
DOI 10.1186/s12877-018-0813-4, PubMed 29788900

Flak MM, Hol HR, Hernes SS, Chang L, Ernst T, Engvig A, Bjuland KJ, Madsen BO, Lindland EMS, Knapskog AB, Ulstein ID, Lona TEE, Skranes J, Løhaugen GCC (2018)
Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment
Front Aging Neurosci, 10, 384
DOI 10.3389/fnagi.2018.00384, PubMed 30519185

Strand BH, Knapskog AB, Persson K, Edwin TH, Amland R, Mjørud M, Bjertness E, Engedal K, Selbæk G (2018)
Survival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norway
PLoS One, 13 (9), e0204436
DOI 10.1371/journal.pone.0204436, PubMed 30240425

Thingstad P, Askim T, Beyer MK, Bråthen G, Ellekjær H, Ihle-Hansen H, Knapskog AB, Lydersen S, Munthe-Kaas R, Næss H, Pendlebury ST, Seljeseth YM, Saltvedt I (2018)
The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study
BMC Neurol, 18 (1), 193
DOI 10.1186/s12883-018-1198-x, PubMed 30477436

Publications 2017

Barca ML, Persson K, Eldholm R, Benth JŠ, Kersten H, Knapskog AB, Saltvedt I, Selbaek G, Engedal K (2017)
Trajectories of depressive symptoms and their relationship to the progression of dementia
J Affect Disord, 222, 146-152
DOI 10.1016/j.jad.2017.07.008, PubMed 28704802

Knapskog AB, Bogdanovic N (2017)
[Not Available]
Tidsskr Nor Laegeforen, 137 (10), 685
DOI 10.4045/tidsskr.17.0388, PubMed 28551955

Knapskog AB, Eldholm RS, Braekhus A, Engedal K, Saltvedt I (2017)
Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients
BMC Geriatr, 17 (1), 210
DOI 10.1186/s12877-017-0611-4, PubMed 28893185

Persson K, Barca ML, Cavallin L, Brækhus A, Knapskog AB, Selbæk G, Engedal K (2017)
Comparison of automated volumetry of the hippocampus using NeuroQuant® and visual assessment of the medial temporal lobe in Alzheimer's disease
Acta Radiol, 59 (8), 997-1001
DOI 10.1177/0284185117743778, PubMed 29172642

Persson K, Eldholm RS, Barca ML, Cavallin L, Ferreira D, Knapskog AB, Selbæk G, Brækhus A, Saltvedt I, Westman E, Engedal K (2017)
MRI-assessed atrophy subtypes in Alzheimer's disease and the cognitive reserve hypothesis
PLoS One, 12 (10), e0186595
DOI 10.1371/journal.pone.0186595, PubMed 29036183

Publications 2016

Knapskog AB, Engedal K, Braekhus A (2016)
Performance of Cerebrospinal Fluid Biomarkers of Alzheimer Disease in a Memory Clinic in Norway
Alzheimer Dis Assoc Disord, 30 (1), 8-14
DOI 10.1097/WAD.0000000000000126, PubMed 26629677

Publications 2015

Barca ML, Engedal K, Selbaek G, Knapskog AB, Laks J, Coutinho E, Benth JŠ (2015)
Confirmatory factor analysis of the Cornell scale for depression in dementia among patient with dementia of various degrees
J Affect Disord, 188, 173-8
DOI 10.1016/j.jad.2015.08.062, PubMed 26363614

Publications 2014

Araujo NB, Moraes HS, Silveira H, Arcoverde C, Vasques PE, Barca ML, Knapskog AB, Engedal K, Coutinho ES, Deslandes AC, Laks J (2014)
Impaired cognition in depression and Alzheimer (AD): a gradient from depression to depression in AD
Arq Neuropsiquiatr, 72 (9), 671-9
DOI 10.1590/0004-282x20140108, PubMed 25252230

Publications 2013

Knapskog AB, Barca ML, Engedal K (2013)
A comparison of the cornell scale for depression in dementia and the Montgomery-Aasberg depression rating scale in a memory clinic population
Dement Geriatr Cogn Disord, 35 (5-6), 256-65
DOI 10.1159/000348345, PubMed 23594823

Knapskog AB, Barca ML, Engedal K (2013)
Prevalence of depression among memory clinic patients as measured by the Cornell Scale of Depression in Dementia
Aging Ment Health, 18 (5), 579-87
DOI 10.1080/13607863.2013.827630, PubMed 23998196

Publications 2012

Knapskog AB, Portugal Mda G, Barca ML, Coutinho ES, Laks J, Engedal K (2012)
A cross-cultural comparison of the phenotype of depression as measured by the Cornell Scale and the MADRS in two elderly outpatient populations
J Affect Disord, 144 (1-2), 34-41
DOI 10.1016/j.jad.2012.06.003, PubMed 22858259

Publications 2011

Knapskog AB, Barca ML, Engedal K (2011)
A comparison of the validity of the Cornell Scale and the MADRS in detecting depression among memory clinic patients
Dement Geriatr Cogn Disord, 32 (4), 287-94
DOI 10.1159/000334983, PubMed 22262043

Portugal Mda G, Coutinho ES, Almeida C, Barca ML, Knapskog AB, Engedal K, Laks J (2011)
Validation of Montgomery-Åsberg Rating Scale and Cornell Scale for Depression in Dementia in Brazilian elderly patients
Int Psychogeriatr, 24 (8), 1291-8
DOI 10.1017/S1041610211002250, PubMed 22185723