Publications - Delirium Research Group
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Persistent delirium is associated with cerebrospinal fluid markers of neuronal injury
Brain Commun, 6 (5), fcae319
DOI 10.1093/braincomms/fcae319, PubMed 39355007 -
Delirium and frailty in older adults: Clinical overlap and biological underpinnings
J Intern Med, 296 (5), 382-398
DOI 10.1111/joim.20014, PubMed 39352688 -
International Delirium Pathophysiology & Electrophysiology Network for Data sharing (iDEPEND)
BJA Open, 11, 100304
DOI 10.1016/j.bjao.2024.100304, PubMed 39176303 -
Sex-specific associations of kynurenic acid with neopterin in Alzheimer's disease
Alzheimers Res Ther, 16 (1), 167
DOI 10.1186/s13195-024-01531-7, PubMed 39068471 -
Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium
Commun Med (Lond), 4 (1), 124
DOI 10.1038/s43856-024-00558-z, PubMed 38937571 -
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers
bioRxiv
DOI 10.1101/2024.03.04.583291, PubMed 38496633 -
Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records
Age Ageing, 53 (2)
DOI 10.1093/ageing/afae006, PubMed 38342753 -
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
J Gerontol A Biol Sci Med Sci, 79 (4)
DOI 10.1093/gerona/glae029, PubMed 38289789 -
Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery: An Individual Patient Data Meta-Analysis
JAMA Netw Open, 6 (10), e2337239
DOI 10.1001/jamanetworkopen.2023.37239, PubMed 37819663 -
No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
Nat Hum Behav, 7 (11), 2008-2022
DOI 10.1038/s41562-023-01707-5, PubMed 37798367 -
Impaired glucose utilization in the brain of patients with delirium following hip fracture
Brain, 147 (1), 215-223
DOI 10.1093/brain/awad296, PubMed 37658825 -
Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals
Neurobiol Aging, 131, 11-23
DOI 10.1016/j.neurobiolaging.2023.05.012, PubMed 37549446 -
Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort
Lancet Healthy Longev, 4 (8), e399-e408
DOI 10.1016/S2666-7568(23)00098-3, PubMed 37459878 -
Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers - in cognitively unimpaired older adults
Brain Behav Immun, 113, 56-65
DOI 10.1016/j.bbi.2023.06.027, PubMed 37400002 -
Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers
J Neurosci, 43 (28), 5241-5250
DOI 10.1523/JNEUROSCI.2330-22.2023, PubMed 37365003 -
Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease
Alzheimers Dement, 19 (12), 5573-5582
DOI 10.1002/alz.13162, PubMed 37264981 -
Sex-specific associations of matrix metalloproteinases in Alzheimer's disease
Biol Sex Differ, 14 (1), 35
DOI 10.1186/s13293-023-00514-x, PubMed 37221606 -
What we know about the possible link between delirium and dementia with Lewy bodies, and why we need to learn more
Acta Psychiatr Scand, 147 (5), 401-402
DOI 10.1111/acps.13526, PubMed 37102380 -
Longitudinal trajectories of functional recovery after hip fracture
PLoS One, 18 (3), e0283551
DOI 10.1371/journal.pone.0283551, PubMed 36989248 -
[We need to pay attention to delirium]
Tidsskr Nor Laegeforen, 143 (5)
DOI 10.4045/tidsskr.23.0037, PubMed 36987895 -
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients
J Clin Invest, 133 (2)
DOI 10.1172/JCI163472, PubMed 36409557 -
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Oxid Med Cell Longev, 2022, 5019752
DOI 10.1155/2022/5019752, PubMed 36312896 -
Cognitive decline and dementia: does delirium matter?
Lancet Healthy Longev, 3 (4), e217-e218
DOI 10.1016/S2666-7568(22)00056-3, PubMed 36098293 -
Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial
BMJ Open, 12 (6), e057460
DOI 10.1136/bmjopen-2021-057460, PubMed 35725264 -
Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis
Brain Sci, 12 (5)
DOI 10.3390/brainsci12050568, PubMed 35624955 -
Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults
Neurobiol Aging, 116, 80-91
DOI 10.1016/j.neurobiolaging.2022.04.010, PubMed 35584575 -
Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients
EBioMedicine, 80, 104043
DOI 10.1016/j.ebiom.2022.104043, PubMed 35533500 -
Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease
Transl Psychiatry, 12 (1), 151
DOI 10.1038/s41398-022-01901-5, PubMed 35397615 -
Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan
Brain Behav Immun, 100, 243-253
DOI 10.1016/j.bbi.2021.12.008, PubMed 34920091 -
Delirium screening in an acute geriatric ward by nurses using 4AT: results from a quality improvement project
Eur Geriatr Med, 10 (4), 667-671
DOI 10.1007/s41999-019-00215-y, PubMed 34652742 -
Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study
Eur Geriatr Med, 13 (1), 155-162
DOI 10.1007/s41999-021-00558-5, PubMed 34625920 -
Cerebrospinal fluid catecholamines in delirium and dementia
Brain Commun, 3 (3), fcab121
DOI 10.1093/braincomms/fcab121, PubMed 34423298 -
Association between clinical frailty, illness severity and post-discharge survival: a prospective cohort study of older medical inpatients in Norway
Eur Geriatr Med, 13 (2), 453-461
DOI 10.1007/s41999-021-00555-8, PubMed 34417977 -
Association between psychotropic drug use and handgrip strength in older hospitalized patients
Eur Geriatr Med, 12 (6), 1213-1220
DOI 10.1007/s41999-021-00511-6, PubMed 34033072 -
Orthogeriatric co-management reduces incidence of delirium in hip fracture patients
Osteoporos Int, 32 (11), 2225-2233
DOI 10.1007/s00198-021-05974-8, PubMed 33963884 -
Delirium is common in patients hospitalized with COVID-19
Intern Emerg Med, 16 (7), 1997-2000
DOI 10.1007/s11739-021-02715-x, PubMed 33830418 -
Low Heart Rate Variability Predicts Stroke and Other Complications in the First Six Postoperative Months After a Hip Fracture Operation
Front Cardiovasc Med, 8, 640970
DOI 10.3389/fcvm.2021.640970, PubMed 33829048 -
Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium
J Alzheimers Dis, 81 (2), 667-677
DOI 10.3233/JAD-201341, PubMed 33814433 -
Orthogeriatrics prevents functional decline in hip fracture patients: report from two randomized controlled trials
BMC Geriatr, 21 (1), 208
DOI 10.1186/s12877-021-02152-7, PubMed 33765935 -
[Corticosteroids for nursing home patients with COVID-19]
Tidsskr Nor Laegeforen, 140 (1)
DOI 10.4045/tidsskr.20.0975, PubMed 33433109 -
A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
Alzheimers Dement (Amst), 12 (1), e12128
DOI 10.1002/dad2.12128, PubMed 33313376 -
Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium
Cereb Cortex, 31 (4), 1953-1969
DOI 10.1093/cercor/bhaa332, PubMed 33236064 -
Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan
Neurol Genet, 6 (5), e506
DOI 10.1212/NXG.0000000000000506, PubMed 33134508 -
Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers
Alzheimers Dement (Amst), 12 (1), e12110
DOI 10.1002/dad2.12110, PubMed 33015312 -
Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
Sci Rep, 10 (1), 15886
DOI 10.1038/s41598-020-72878-8, PubMed 32985583 -
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Int Rev Neurobiol, 155, 169-202
DOI 10.1016/bs.irn.2020.02.008, PubMed 32854854 -
The pandemic of the vulnerable
Tidsskr Nor Laegeforen, 140 (11)
DOI 10.4045/tidsskr.20.0583, PubMed 32815339 -
Fatty Acid-Binding Protein 3 in Cerebrospinal Fluid of Hip Fracture Patients with Delirium
J Alzheimers Dis, 77 (1), 183-190
DOI 10.3233/JAD-200364, PubMed 32804136 -
Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis
Cells, 9 (7)
DOI 10.3390/cells9071686, PubMed 32668809 -
Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
J Neurosci, 40 (29), 5681-5696
DOI 10.1523/JNEUROSCI.2876-19.2020, PubMed 32513828 -
Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Neurobiol Aging, 93, 1-15
DOI 10.1016/j.neurobiolaging.2020.04.002, PubMed 32438258 -
COVID-19 in an elderly woman with acute functional decline
Tidsskr Nor Laegeforen, 140 (7)
DOI 10.4045/tidsskr.20.0307, PubMed 32378845 -
[Not Available]
Tidsskr Nor Laegeforen, 140
DOI 10.4045/tidsskr.20.0264, PubMed 32323958 -
Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression
Cereb Cortex, 30 (4), 2144-2156
DOI 10.1093/cercor/bhz228, PubMed 32142100 -
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
J Alzheimers Dis, 73 (4), 1363-1372
DOI 10.3233/JAD-190941, PubMed 31929159 -
Results after introduction of a hip fracture care pathway: comparison with usual care
Acta Orthop, 91 (2), 139-145
DOI 10.1080/17453674.2019.1710804, PubMed 31928088 -
Delirium in patients with hip fracture is associated with increased heart rate variability
Aging Clin Exp Res, 32 (11), 2311-2318
DOI 10.1007/s40520-019-01447-5, PubMed 31916197 -
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
Cereb Cortex, 30 (4), 2295-2306
DOI 10.1093/cercor/bhz240, PubMed 31812991 -
Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium
Sleep, 43 (5)
DOI 10.1093/sleep/zsz280, PubMed 31738420 -
Pharmacological Management of Delirium
JAMA Psychiatry, 76 (9), 983
DOI 10.1001/jamapsychiatry.2019.1513, PubMed 31268505 -
The study protocol for a randomized, controlled trial of acupuncture versus a sham procedure versus standard care alone for the treatment of delirium in acutely hospitalized older adults with a medical illness
Maturitas, 124, 72-80
DOI 10.1016/j.maturitas.2019.03.001, PubMed 31097183 -
Delirium and cognitive impairment among older patients in Norwegian emergency departments
Tidsskr Nor Laegeforen, 139 (6)
DOI 10.4045/tidsskr.18.0578, PubMed 30917648 -
The Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial
Int J Geriatr Psychiatry, 34 (7), 974-981
DOI 10.1002/gps.5098, PubMed 30901487 -
Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses
BMC Geriatr, 19 (1), 23
DOI 10.1186/s12877-019-1035-0, PubMed 30683068 -
Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial
Clin Nutr ESPEN, 29, 52-58
DOI 10.1016/j.clnesp.2017.11.012, PubMed 30661701 -
Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium
Dement Geriatr Cogn Disord, 46 (5-6), 346-357
DOI 10.1159/000494754, PubMed 30522125 -
CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
J Neuroinflammation, 15 (1), 304
DOI 10.1186/s12974-018-1331-1, PubMed 30390679 -
CSF sodium at toxic levels precedes delirium in hip fracture patients
Neurotoxicology, 69, 11-16
DOI 10.1016/j.neuro.2018.08.010, PubMed 30149051 -
The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses
BMC Pharmacol Toxicol, 19 (1), 29
DOI 10.1186/s40360-018-0218-1, PubMed 29884231 -
[How to describe delirium?]
Tidsskr Nor Laegeforen, 138 (5)
DOI 10.4045/tidsskr.18.0087, PubMed 29513451 -
[Delirium – still underdiagnosed]
Tidsskr Nor Laegeforen, 138 (5)
DOI 10.4045/tidsskr.18.0118, PubMed 29513435 -
Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium
Dement Geriatr Cogn Dis Extra, 7 (3), 374-385
DOI 10.1159/000481853, PubMed 29282410 -
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783 -
Decreases in heart rate variability are associated with postoperative complications in hip fracture patients
PLoS One, 12 (7), e0180423
DOI 10.1371/journal.pone.0180423, PubMed 28742855 -
Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study
PLoS One, 12 (7), e0180641
DOI 10.1371/journal.pone.0180641, PubMed 28700610 -
[Assessment of mental status in acutely ill elderly]
Tidsskr Nor Laegeforen, 137 (12-13), 859
DOI 10.4045/tidsskr.17.0480, PubMed 28655228 -
Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy
Cereb Cortex, 28 (8), 2775-2785
DOI 10.1093/cercor/bhx157, PubMed 28655157 -
CSF biomarkers in delirium: a systematic review
Int J Geriatr Psychiatry, 33 (11), 1479-1500
DOI 10.1002/gps.4720, PubMed 28585290 -
Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition
J Alzheimers Dis, 58 (3), 829-840
DOI 10.3233/JAD-161146, PubMed 28505968 -
Prosthetic joint infection-a devastating complication of hemiarthroplasty for hip fracture
Acta Orthop, 88 (4), 383-389
DOI 10.1080/17453674.2017.1301009, PubMed 28271919 -
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
Neurobiol Aging, 49, 138-144
DOI 10.1016/j.neurobiolaging.2016.09.012, PubMed 27794264 -
Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium
J Alzheimers Dis, 55 (1), 371-379
DOI 10.3233/JAD-160461, PubMed 27662296 -
[Not Available]
Tidsskr Nor Laegeforen, 136 (16), 1325-6
DOI 10.4045/tidsskr.16.0686, PubMed 27637035 -
Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity
BMC Geriatr, 16, 149
DOI 10.1186/s12877-016-0324-0, PubMed 27484129 -
Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture
J Neuroinflammation, 13 (1), 170
DOI 10.1186/s12974-016-0636-1, PubMed 27357281 -
Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture
J Am Geriatr Soc, 64 (7), 1456-63
DOI 10.1111/jgs.14238, PubMed 27341529 -
Blood-Cerebrospinal Fluid Barrier Integrity in Delirium Determined by Q-Albumin
Dement Geriatr Cogn Disord, 41 (3-4), 192-8
DOI 10.1159/000443789, PubMed 27058253 -
Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients
Arch Gerontol Geriatr, 64, 38-44
DOI 10.1016/j.archger.2015.12.004, PubMed 26952375 -
Micronutrients and the risk of hip fracture: Case-control study
Clin Nutr, 36 (2), 438-443
DOI 10.1016/j.clnu.2015.12.014, PubMed 26795217 -
Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients
BMC Res Notes, 8, 186
DOI 10.1186/s13104-015-1129-5, PubMed 25943983 -
The protocol of the Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial
BMC Geriatr, 15, 7
DOI 10.1186/s12877-015-0006-3, PubMed 25887557 -
[Why orthogeriatrics?]
Tidsskr Nor Laegeforen, 135 (6), 523-4
DOI 10.4045/tidsskr.15.0188, PubMed 25806757 -
Response to Paul Regal
J Am Geriatr Soc, 62 (7), 1415
DOI 10.1111/jgs.12875, PubMed 25039530 -
A comparison of the revised Delirium Rating Scale (DRS-R98) and the Memorial Delirium Assessment Scale (MDAS) in a palliative care cohort with DSM-IV delirium
Palliat Support Care, 13 (4), 937-44
DOI 10.1017/S1478951514000613, PubMed 24991706 -
The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: randomized controlled trial (Oslo Orthogeriatric Trial)
BMC Med, 12, 63
DOI 10.1186/1741-7015-12-63, PubMed 24735588 -
Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: a case control study
Clin Nutr, 34 (1), 101-6
DOI 10.1016/j.clnu.2014.01.016, PubMed 24559841 -
New consciousness scale for delirium
Tidsskr Nor Laegeforen, 134 (2), 150
DOI 10.4045/tidsskr.13.1603, PubMed 24477145 -
Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium
J Am Geriatr Soc, 62 (1), 94-102
DOI 10.1111/jgs.12612, PubMed 24383557 -
[Delirium in elderly patients]
Tidsskr Nor Laegeforen, 133 (15), 1596-600
DOI 10.4045/tidsskr.12.1327, PubMed 23970274 -
The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial
BMC Geriatr, 12, 36
DOI 10.1186/1471-2318-12-36, PubMed 22817102 -
Delirium and cognitive impairment among older patients in Norwegian emergency departments
Tidsskr. Nor. Laegeforen., 139 (6), 517-520 -
Delirium- still under diagnosed
Tidsskr. Nor. Laegeforen., 138 (5), 418 -
The pandemic of the vulnerable people
Tidsskr. Nor. Laegeforen., 140 (11), 1086 -
Geriatrics
Tidsskr. Nor. Laegeforen., 136 (14-15), 1255
DOI 10.4045/tidsskr.16.0443 -
Corticosteroids for nursing home patients with covid-19?
Tidsskr. Nor. Laegeforen., 141 (1), 13-14 -
How to describe delirium?
Tidsskr. Nor. Laegeforen., 138 (5), 479 -
Vitamin deficiency as a risk factor for delirium
Eur. Geriatr. Med., 6 (4), 314-318
DOI 10.1016/j.eurger.2014.09.002