Publications - Delirium Research Group

  1. Tsui A, Johnstone B, Heslegrave A, Zetterberg H, Watne LO, Neerland BE, Krogseth M, Cunningham C, MacLullich A, Muniz Terrera G, Davis D, Caplan G (2024)
    Persistent delirium is associated with cerebrospinal fluid markers of neuronal injury
    Brain Commun, 6 (5), fcae319
    DOI 10.1093/braincomms/fcae319, PubMed 39355007
  2. Bellelli G, Triolo F, Ferrara MC, Deiner SG, Morandi A, Cesari M, Davis D, Marengoni A, Inzitari M, Watne LO, Rockwood K, Vetrano DL (2024)
    Delirium and frailty in older adults: Clinical overlap and biological underpinnings
    J Intern Med, 296 (5), 382-398
    DOI 10.1111/joim.20014, PubMed 39352688
  3. Sanders RD, Watne L, Roberson SW, Kimchi EY, Slooter AJC, Cunningham C, Nourski KV, Palanca BJA, Lennertz R, Banks MI (2024)
    International Delirium Pathophysiology & Electrophysiology Network for Data sharing (iDEPEND)
    BJA Open, 11, 100304
    DOI 10.1016/j.bjao.2024.100304, PubMed 39176303
  4. Knapskog AB, Edwin TH, Ueland PM, Ulvik A, Fang EF, Eldholm RS, Halaas NB, Giil LM, Saltvedt I, Watne LO, Aksnes M (2024)
    Sex-specific associations of kynurenic acid with neopterin in Alzheimer's disease
    Alzheimers Res Ther, 16 (1), 167
    DOI 10.1186/s13195-024-01531-7, PubMed 39068471
  5. Aksnes M, Schibstad MH, Chaudhry FA, Neerland BE, Caplan G, Saltvedt I, Eldholm RS, Myrstad M, Edwin TH, Persson K, Idland AV, Pollmann CT, Olsen RB, Wyller TB, Zetterberg H, Cunningham E, Watne LO (2024)
    Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium
    Commun Med (Lond), 4 (1), 124
    DOI 10.1038/s43856-024-00558-z, PubMed 38937571
  6. Capogna E, Sørensen Ø, Watne LO, Roe J, Strømstad M, Idland AV, Halaas NB, Blennow K, Zetterberg H, Walhovd KB, Fjell AM, Vidal-Piñeiro D (2024)
    Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers
    bioRxiv
    DOI 10.1101/2024.03.04.583291, PubMed 38496633
  7. Titlestad I, Haugarvoll K, Solvang SH, Norekvål TM, Skogseth RE, Andreassen OA, Årsland D, Neerland BE, Nordrehaug JE, Tell GS, Giil LM (2024)
    Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records
    Age Ageing, 53 (2)
    DOI 10.1093/ageing/afae006, PubMed 38342753
  8. Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, De Zeeuw CI, Watne LO, Vyhnalek M, Veverova K, Liang KX, Tavernarakis N, Bohr VA, Yokote K, Saarela J, Nilsen H et al. (2024)
    Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
    J Gerontol A Biol Sci Med Sci, 79 (4)
    DOI 10.1093/gerona/glae029, PubMed 38289789
  9. Sadeghirad B, Dodsworth BT, Schmutz Gelsomino N, Goettel N, Spence J, Buchan TA, Crandon HN, Baneshi MR, Pol RA, Brattinga B, Park UJ, Terashima M, Banning LBD, Van Leeuwen BL, Neerland BE, Chuan A, Martinez FT, Van Vugt JLA, Rampersaud YR, Hatakeyama S, Di Stasio E, Milisen K, Van Grootven B, van der Laan L, Thomson Mangnall L et al. (2023)
    Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery: An Individual Patient Data Meta-Analysis
    JAMA Netw Open, 6 (10), e2337239
    DOI 10.1001/jamanetworkopen.2023.37239, PubMed 37819663
  10. Fjell AM, Sørensen Ø, Wang Y, Amlien IK, Baaré WFC, Bartrés-Faz D, Bertram L, Boraxbekk CJ, Brandmaier AM, Demuth I, Drevon CA, Ebmeier KP, Ghisletta P, Kievit R, Kühn S, Madsen KS, Mowinckel AM, Nyberg L, Sexton CE, Solé-Padullés C, Vidal-Piñeiro D, Wagner G, Watne LO, Walhovd KB (2023)
    No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
    Nat Hum Behav, 7 (11), 2008-2022
    DOI 10.1038/s41562-023-01707-5, PubMed 37798367
  11. Titlestad I, Watne LO, Caplan GA, McCann A, Ueland PM, Neerland BE, Myrstad M, Halaas NB, Pollmann CT, Henjum K, Ranhoff AH, Solberg LB, Figved W, Cunningham C, Giil LM (2024)
    Impaired glucose utilization in the brain of patients with delirium following hip fracture
    Brain, 147 (1), 215-223
    DOI 10.1093/brain/awad296, PubMed 37658825
  12. Aksnes M, Capogna E, Vidal-Piñeiro D, Chaudhry FA, Myrstad M, Idland AV, Halaas NB, Dakhil S, Blennow K, Zetterberg H, Walhovd KB, Watne LO, Fjell AM (2023)
    Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals
    Neurobiol Aging, 131, 11-23
    DOI 10.1016/j.neurobiolaging.2023.05.012, PubMed 37549446
  13. Krogseth M, Davis D, Jackson TA, Zetterberg H, Watne LO, Lindberg M, Chitalu P, Tsui A, Selbæk G, Wyller TB (2023)
    Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort
    Lancet Healthy Longev, 4 (8), e399-e408
    DOI 10.1016/S2666-7568(23)00098-3, PubMed 37459878
  14. Capogna E, Watne LO, Sørensen Ø, Guichelaar CJ, Idland AV, Halaas NB, Blennow K, Zetterberg H, Walhovd KB, Fjell AM, Vidal-Piñeiro D (2023)
    Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers - in cognitively unimpaired older adults
    Brain Behav Immun, 113, 56-65
    DOI 10.1016/j.bbi.2023.06.027, PubMed 37400002
  15. Fjell AM, Sørensen Ø, Wang Y, Amlien IK, Baaré WFC, Bartrés-Faz D, Boraxbekk CJ, Brandmaier AM, Demuth I, Drevon CA, Ebmeier KP, Ghisletta P, Kievit R, Kühn S, Madsen KS, Nyberg L, Solé-Padullés C, Vidal-Piñeiro D, Wagner G, Watne LO, Walhovd KB (2023)
    Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers
    J Neurosci, 43 (28), 5241-5250
    DOI 10.1523/JNEUROSCI.2330-22.2023, PubMed 37365003
  16. Knapskog AB, Aksnes M, Edwin TH, Ueland PM, Ulvik A, Fang EF, Eldholm RS, Halaas NB, Saltvedt I, Giil LM, Watne LO (2023)
    Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease
    Alzheimers Dement, 19 (12), 5573-5582
    DOI 10.1002/alz.13162, PubMed 37264981
  17. Aksnes M, Edwin TH, Saltvedt I, Eldholm RS, Chaudhry FA, Halaas NB, Myrstad M, Watne LO, Knapskog AB (2023)
    Sex-specific associations of matrix metalloproteinases in Alzheimer's disease
    Biol Sex Differ, 14 (1), 35
    DOI 10.1186/s13293-023-00514-x, PubMed 37221606
  18. Petersen Hella MN, Bergland AK, Soennesyn H, Halaas NB, Watne LO, Bonanni L, Aarsland D (2023)
    What we know about the possible link between delirium and dementia with Lewy bodies, and why we need to learn more
    Acta Psychiatr Scand, 147 (5), 401-402
    DOI 10.1111/acps.13526, PubMed 37102380
  19. Dakhil S, Saltvedt I, Benth JŠ, Thingstad P, Watne LO, Bruun Wyller T, Helbostad JL, Frihagen F, Johnsen LG, Taraldsen K (2023)
    Longitudinal trajectories of functional recovery after hip fracture
    PLoS One, 18 (3), e0283551
    DOI 10.1371/journal.pone.0283551, PubMed 36989248
  20. Hella MNP, Sønnesyn H, Bergland AK, Årsland D, Djuv A, Vik-Mo AO, Holen E, Naalsund P, Neerland BE, Watne LO (2023)
    [We need to pay attention to delirium]
    Tidsskr Nor Laegeforen, 143 (5)
    DOI 10.4045/tidsskr.23.0037, PubMed 36987895
  21. Watne LO, Pollmann CT, Neerland BE, Quist-Paulsen E, Halaas NB, Idland AV, Hassel B, Henjum K, Knapskog AB, Frihagen F, Raeder J, Godø A, Ueland PM, McCann A, Figved W, Selbæk G, Zetterberg H, Fang EF, Myrstad M, Giil LM (2023)
    Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients
    J Clin Invest, 133 (2)
    DOI 10.1172/JCI163472, PubMed 36409557
  22. Solvang SH, Hodge A, Watne LO, Cabral-Marques O, Nordrehaug JE, Giles GG, Dugué PA, Nygård O, Ueland PM, McCann A, Idland AV, Midttun Ø, Ulvik A, Halaas NB, Tell GS, Giil LM (2022)
    Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
    Oxid Med Cell Longev, 2022, 5019752
    DOI 10.1155/2022/5019752, PubMed 36312896
  23. Selbæk G, Neerland BE (2022)
    Cognitive decline and dementia: does delirium matter?
    Lancet Healthy Longev, 3 (4), e217-e218
    DOI 10.1016/S2666-7568(22)00056-3, PubMed 36098293
  24. Neerland BE, Busund R, Haaverstad R, Helbostad JL, Landsverk SA, Martinaityte I, Norum HM, Ræder J, Selbaek G, Simpson MR, Skaar E, Skjærvold NK, Skovlund E, Slooter AJ, Svendsen ØS, Tønnessen T, Wahba A, Zetterberg H, Wyller TB (2022)
    Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial
    BMJ Open, 12 (6), e057460
    DOI 10.1136/bmjopen-2021-057460, PubMed 35725264
  25. Golubovic J, Neerland BE, Aune D, Baker FA (2022)
    Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis
    Brain Sci, 12 (5)
    DOI 10.3390/brainsci12050568, PubMed 35624955
  26. Vidal-Piñeiro D, Sørensen Ø, Blennow K, Capogna E, Halaas NB, Idland AV, Mowinckel AM, Pereira JB, Watne LO, Zetterberg H, Walhovd KB, Fjell AM, Alzheimer's Disease Neuroimaging Initiative (2022)
    Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults
    Neurobiol Aging, 116, 80-91
    DOI 10.1016/j.neurobiolaging.2022.04.010, PubMed 35584575
  27. Page VJ, Watne LO, Heslegrave A, Clark A, McAuley DF, Sanders RD, Zetterberg H (2022)
    Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients
    EBioMedicine, 80, 104043
    DOI 10.1016/j.ebiom.2022.104043, PubMed 35533500
  28. Henjum K, Watne LO, Godang K, Halaas NB, Eldholm RS, Blennow K, Zetterberg H, Saltvedt I, Bollerslev J, Knapskog AB (2022)
    Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease
    Transl Psychiatry, 12 (1), 151
    DOI 10.1038/s41398-022-01901-5, PubMed 35397615
  29. Wang Y, Grydeland H, Roe JM, Pan M, Magnussen F, Amlien IK, Watne LO, Idland AV, Bertram L, Gundersen TE, Pascual-Leone A, Cabello-Toscano M, Tormos JM, Bartres-Faz D, Drevon CA, Fjell AM, Walhovd KW (2021)
    Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan
    Brain Behav Immun, 100, 243-253
    DOI 10.1016/j.bbi.2021.12.008, PubMed 34920091
  30. Myrstad M, Watne LO, Johnsen NT, Børs-Lind E, Neerland BE (2019)
    Delirium screening in an acute geriatric ward by nurses using 4AT: results from a quality improvement project
    Eur Geriatr Med, 10 (4), 667-671
    DOI 10.1007/s41999-019-00215-y, PubMed 34652742
  31. Myrstad M, Kuwelker K, Haakonsen S, Valebjørg T, Langeland N, Kittang BR, Hagberg G, Neerland BE, Bakken MS (2021)
    Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study
    Eur Geriatr Med, 13 (1), 155-162
    DOI 10.1007/s41999-021-00558-5, PubMed 34625920
  32. Henjum K, Godang K, Quist-Paulsen E, Idland AV, Neerland BE, Sandvig H, Brugård A, Raeder J, Frihagen F, Wyller TB, Hassel B, Bollerslev J, Watne LO (2021)
    Cerebrospinal fluid catecholamines in delirium and dementia
    Brain Commun, 3 (3), fcab121
    DOI 10.1093/braincomms/fcab121, PubMed 34423298
  33. Engvig A, Wyller TB, Skovlund E, Ahmed MV, Hall TS, Rockwood K, Njaastad AM, Neerland BE (2021)
    Association between clinical frailty, illness severity and post-discharge survival: a prospective cohort study of older medical inpatients in Norway
    Eur Geriatr Med, 13 (2), 453-461
    DOI 10.1007/s41999-021-00555-8, PubMed 34417977
  34. Sandvik MK, Watne LO, Brugård A, Wang-Hansen MS, Kersten H (2021)
    Association between psychotropic drug use and handgrip strength in older hospitalized patients
    Eur Geriatr Med, 12 (6), 1213-1220
    DOI 10.1007/s41999-021-00511-6, PubMed 34033072
  35. Pollmann CT, Mellingsæter MR, Neerland BE, Straume-Næsheim T, Årøen A, Watne LO (2021)
    Orthogeriatric co-management reduces incidence of delirium in hip fracture patients
    Osteoporos Int, 32 (11), 2225-2233
    DOI 10.1007/s00198-021-05974-8, PubMed 33963884
  36. Watne LO, Tonby K, Holten AR, Olasveengen TM, Romundstad LG, Neerland BE (2021)
    Delirium is common in patients hospitalized with COVID-19
    Intern Emerg Med, 16 (7), 1997-2000
    DOI 10.1007/s11739-021-02715-x, PubMed 33830418
  37. Ernst G, Watne LO, Frihagen F, Wyller TB, Dominik A, Rostrup M (2021)
    Low Heart Rate Variability Predicts Stroke and Other Complications in the First Six Postoperative Months After a Hip Fracture Operation
    Front Cardiovasc Med, 8, 640970
    DOI 10.3389/fcvm.2021.640970, PubMed 33829048
  38. Halaas NB, Zetterberg H, Idland AV, Knapskog AB, Watne LO, Blennow K (2021)
    Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium
    J Alzheimers Dis, 81 (2), 667-677
    DOI 10.3233/JAD-201341, PubMed 33814433
  39. Dakhil S, Thingstad P, Frihagen F, Johnsen LG, Lydersen S, Skovlund E, Wyller TB, Sletvold O, Saltvedt I, Watne LO (2021)
    Orthogeriatrics prevents functional decline in hip fracture patients: report from two randomized controlled trials
    BMC Geriatr, 21 (1), 208
    DOI 10.1186/s12877-021-02152-7, PubMed 33765935
  40. Myrstad M, Kittang BR, Ranhoff AH, Neerland BE, Wyller TB (2020)
    [Corticosteroids for nursing home patients with COVID-19]
    Tidsskr Nor Laegeforen, 140 (1)
    DOI 10.4045/tidsskr.20.0975, PubMed 33433109
  41. Edwin TH, Henjum K, Nilsson LNG, Watne LO, Persson K, Eldholm RS, Saltvedt I, Halaas NB, Selbæk G, Engedal K, Strand BH, Knapskog AB (2020)
    A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
    Alzheimers Dement (Amst), 12 (1), e12128
    DOI 10.1002/dad2.12128, PubMed 33313376
  42. Fjell AM, Sørensen Ø, Amlien IK, Bartrés-Faz D, Brandmaier AM, Buchmann N, Demuth I, Drevon CA, Düzel S, Ebmeier KP, Ghisletta P, Idland AV, Kietzmann TC, Kievit RA, Kühn S, Lindenberger U, Magnussen F, Macià D, Mowinckel AM, Nyberg L, Sexton CE, Solé-Padullés C, Pudas S, Roe JM, Sederevicius D et al. (2021)
    Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium
    Cereb Cortex, 31 (4), 1953-1969
    DOI 10.1093/cercor/bhaa332, PubMed 33236064
  43. Walhovd KB, Fjell AM, Sørensen Ø, Mowinckel AM, Reinbold CS, Idland AV, Watne LO, Franke A, Dobricic V, Kilpert F, Bertram L, Wang Y (2020)
    Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan
    Neurol Genet, 6 (5), e506
    DOI 10.1212/NXG.0000000000000506, PubMed 33134508
  44. Gorbach T, Pudas S, Bartrés-Faz D, Brandmaier AM, Düzel S, Henson RN, Idland AV, Lindenberger U, Macià Bros D, Mowinckel AM, Solé-Padullés C, Sørensen Ø, Walhovd KB, Watne LO, Westerhausen R, Fjell AM, Nyberg L (2020)
    Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers
    Alzheimers Dement (Amst), 12 (1), e12110
    DOI 10.1002/dad2.12110, PubMed 33015312
  45. Knapskog AB, Henjum K, Idland AV, Eldholm RS, Persson K, Saltvedt I, Watne LO, Engedal K, Nilsson LNG (2020)
    Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
    Sci Rep, 10 (1), 15886
    DOI 10.1038/s41598-020-72878-8, PubMed 32985583
  46. Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF (2020)
    Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
    Int Rev Neurobiol, 155, 169-202
    DOI 10.1016/bs.irn.2020.02.008, PubMed 32854854
  47. Neerland BE (2020)
    The pandemic of the vulnerable
    Tidsskr Nor Laegeforen, 140 (11)
    DOI 10.4045/tidsskr.20.0583, PubMed 32815339
  48. Neerland BE, Halaas NB, Idland AV, Henjum K, Blennow K, Zetterberg H, Watne LO (2020)
    Fatty Acid-Binding Protein 3 in Cerebrospinal Fluid of Hip Fracture Patients with Delirium
    J Alzheimers Dis, 77 (1), 183-190
    DOI 10.3233/JAD-200364, PubMed 32804136
  49. Qureshi T, Bjørkmo M, Nordengen K, Gundersen V, Utheim TP, Watne LO, Storm-Mathisen J, Hassel B, Chaudhry FA (2020)
    Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis
    Cells, 9 (7)
    DOI 10.3390/cells9071686, PubMed 32668809
  50. Kealy J, Murray C, Griffin EW, Lopez-Rodriguez AB, Healy D, Tortorelli LS, Lowry JP, Watne LO, Cunningham C (2020)
    Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
    J Neurosci, 40 (29), 5681-5696
    DOI 10.1523/JNEUROSCI.2876-19.2020, PubMed 32513828
  51. Idland AV, Sala-Llonch R, Watne LO, Brækhus A, Hansson O, Blennow K, Zetterberg H, Sørensen Ø, Walhovd KB, Wyller TB, Fjell AM (2020)
    Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
    Neurobiol Aging, 93, 1-15
    DOI 10.1016/j.neurobiolaging.2020.04.002, PubMed 32438258
  52. Neerland BE, Dobloug A, Nore KG, Mikaelsen EE, Halsen A, Ahmed MV (2020)
    COVID-19 in an elderly woman with acute functional decline
    Tidsskr Nor Laegeforen, 140 (7)
    DOI 10.4045/tidsskr.20.0307, PubMed 32378845
  53. Neerland BE, Watne LO, Krogseth M (2020)
    [Not Available]
    Tidsskr Nor Laegeforen, 140
    DOI 10.4045/tidsskr.20.0264, PubMed 32323958
  54. Fjell AM, Sederevicius D, Sneve MH, de Lange AG, Bråthen AC, Idland AV, Watne LO, Wang Y, Reinbold C, Dobricic V, Kilpert F, Blennow K, Zetterbergj H, Hong S, Bertram L, Walhovd KB, Alzheimer’s Disease Neuroimaging Initiative (2020)
    Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression
    Cereb Cortex, 30 (4), 2144-2156
    DOI 10.1093/cercor/bhz228, PubMed 32142100
  55. Sajjad MU, Blennow K, Knapskog AB, Idland AV, Chaudhry FA, Wyller TB, Zetterberg H, Watne LO (2020)
    Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
    J Alzheimers Dis, 73 (4), 1363-1372
    DOI 10.3233/JAD-190941, PubMed 31929159
  56. Svenøy S, Watne LO, Hestnes I, Westberg M, Madsen JE, Frihagen F (2020)
    Results after introduction of a hip fracture care pathway: comparison with usual care
    Acta Orthop, 91 (2), 139-145
    DOI 10.1080/17453674.2019.1710804, PubMed 31928088
  57. Ernst G, Watne LO, Rostrup M, Neerland BE (2020)
    Delirium in patients with hip fracture is associated with increased heart rate variability
    Aging Clin Exp Res, 32 (11), 2311-2318
    DOI 10.1007/s40520-019-01447-5, PubMed 31916197
  58. Halaas NB, Henjum K, Blennow K, Dakhil S, Idland AV, Nilsson LN, Sederevicius D, Vidal-Piñeiro D, Walhovd KB, Wyller TB, Zetterberg H, Watne LO, Fjell AM (2020)
    CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
    Cereb Cortex, 30 (4), 2295-2306
    DOI 10.1093/cercor/bhz240, PubMed 31812991
  59. Fjell AM, Sørensen Ø, Amlien IK, Bartrés-Faz D, Bros DM, Buchmann N, Demuth I, Drevon CA, Düzel S, Ebmeier KP, Idland AV, Kietzmann TC, Kievit R, Kühn S, Lindenberger U, Mowinckel AM, Nyberg L, Price D, Sexton CE, Solé-Padullés C, Pudas S, Sederevicius D, Suri S, Wagner G, Watne LO et al. (2020)
    Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium
    Sleep, 43 (5)
    DOI 10.1093/sleep/zsz280, PubMed 31738420
  60. Neerland BE, Neufeld KJ, Slooter AJC (2019)
    Pharmacological Management of Delirium
    JAMA Psychiatry, 76 (9), 983
    DOI 10.1001/jamapsychiatry.2019.1513, PubMed 31268505
  61. Levy I, Attias S, Gavrieli S, Oliven R, Neerland BE, Devlin JW, Ben-Arye E, Greenberg D, Schiff E (2019)
    The study protocol for a randomized, controlled trial of acupuncture versus a sham procedure versus standard care alone for the treatment of delirium in acutely hospitalized older adults with a medical illness
    Maturitas, 124, 72-80
    DOI 10.1016/j.maturitas.2019.03.001, PubMed 31097183
  62. Evensen S, Saltvedt I, Ranhoff AH, Myrstad M, Myrstad C, Mellingsæter M, Wang-Hansen MS, Neerland BE (2019)
    Delirium and cognitive impairment among older patients in Norwegian emergency departments
    Tidsskr Nor Laegeforen, 139 (6)
    DOI 10.4045/tidsskr.18.0578, PubMed 30917648
  63. Hov KR, Neerland BE, Undseth Ø, Wyller VBB, MacLullich AMJ, Qvigstad E, Skovlund E, Wyller TB (2019)
    The Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial
    Int J Geriatr Psychiatry, 34 (7), 974-981
    DOI 10.1002/gps.5098, PubMed 30901487
  64. Neerland BE, Wyller TB, Wyller VBB (2019)
    Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses
    BMC Geriatr, 19 (1), 23
    DOI 10.1186/s12877-019-1035-0, PubMed 30683068
  65. Torbergsen AC, Watne LO, Frihagen F, Wyller TB, Mowè M (2018)
    Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial
    Clin Nutr ESPEN, 29, 52-58
    DOI 10.1016/j.clnesp.2017.11.012, PubMed 30661701
  66. Halaas NB, Blennow K, Idland AV, Wyller TB, Ræder J, Frihagen F, Staff AC, Zetterberg H, Watne LO (2018)
    Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium
    Dement Geriatr Cogn Disord, 46 (5-6), 346-357
    DOI 10.1159/000494754, PubMed 30522125
  67. Henjum K, Quist-Paulsen E, Zetterberg H, Blennow K, Nilsson LNG, Watne LO (2018)
    CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
    J Neuroinflammation, 15 (1), 304
    DOI 10.1186/s12974-018-1331-1, PubMed 30390679
  68. Hassel B, Mariussen E, Idland AV, Dahl GT, Ræder J, Frihagen F, Berg JP, Chaudhry FA, Wyller TB, Watne LO (2018)
    CSF sodium at toxic levels precedes delirium in hip fracture patients
    Neurotoxicology, 69, 11-16
    DOI 10.1016/j.neuro.2018.08.010, PubMed 30149051
  69. Hov KR, Neerland BE, Andersen AM, Undseth Ø, Wyller VB, MacLullich AMJ, Skovlund E, Qvigstad E, Wyller TB (2018)
    The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses
    BMC Pharmacol Toxicol, 19 (1), 29
    DOI 10.1186/s40360-018-0218-1, PubMed 29884231
  70. Neerland BE, Krogseth M, Wyller TB (2018)
    [How to describe delirium?]
    Tidsskr Nor Laegeforen, 138 (5)
    DOI 10.4045/tidsskr.18.0087, PubMed 29513451
  71. Watne LO, Wyller TB (2018)
    [Delirium – still underdiagnosed]
    Tidsskr Nor Laegeforen, 138 (5)
    DOI 10.4045/tidsskr.18.0118, PubMed 29513435
  72. Hov KR, Bolstad N, Idland AV, Zetterberg H, Blennow K, Chaudhry FA, Frihagen F, Ræder J, Wyller TB, Watne LO (2017)
    Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium
    Dement Geriatr Cogn Dis Extra, 7 (3), 374-385
    DOI 10.1159/000481853, PubMed 29282410
  73. Idland AV, Wyller TB, Støen R, Dahl GT, Frihagen F, Brækhus A, Hassel B, Watne LO (2017)
    Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
    Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
    DOI 10.1159/000478723, PubMed 29118783
  74. Ernst G, Watne LO, Frihagen F, Wyller TB, Dominik A, Rostrup M (2017)
    Decreases in heart rate variability are associated with postoperative complications in hip fracture patients
    PLoS One, 12 (7), e0180423
    DOI 10.1371/journal.pone.0180423, PubMed 28742855
  75. Neerland BE, Krogseth M, Juliebø V, Hylen Ranhoff A, Engedal K, Frihagen F, Ræder J, Bruun Wyller T, Watne LO (2017)
    Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study
    PLoS One, 12 (7), e0180641
    DOI 10.1371/journal.pone.0180641, PubMed 28700610
  76. Myrstad M, Neerland BE, Hagberg G, Watne LO (2017)
    [Assessment of mental status in acutely ill elderly]
    Tidsskr Nor Laegeforen, 137 (12-13), 859
    DOI 10.4045/tidsskr.17.0480, PubMed 28655228
  77. Fjell AM, Idland AV, Sala-Llonch R, Watne LO, Borza T, Brækhus A, Lona T, Zetterberg H, Blennow K, Wyller TB, Walhovd KB (2018)
    Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy
    Cereb Cortex, 28 (8), 2775-2785
    DOI 10.1093/cercor/bhx157, PubMed 28655157
  78. Hall RJ, Watne LO, Cunningham E, Zetterberg H, Shenkin SD, Wyller TB, MacLullich AMJ (2017)
    CSF biomarkers in delirium: a systematic review
    Int J Geriatr Psychiatry, 33 (11), 1479-1500
    DOI 10.1002/gps.4720, PubMed 28585290
  79. Sala-Llonch R, Idland AV, Borza T, Watne LO, Wyller TB, Brækhus A, Zetterberg H, Blennow K, Walhovd KB, Fjell AM (2017)
    Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition
    J Alzheimers Dis, 58 (3), 829-840
    DOI 10.3233/JAD-161146, PubMed 28505968
  80. Guren E, Figved W, Frihagen F, Watne LO, Westberg M (2017)
    Prosthetic joint infection-a devastating complication of hemiarthroplasty for hip fracture
    Acta Orthop, 88 (4), 383-389
    DOI 10.1080/17453674.2017.1301009, PubMed 28271919
  81. Idland AV, Sala-Llonch R, Borza T, Watne LO, Wyller TB, Brækhus A, Zetterberg H, Blennow K, Walhovd KB, Fjell AM (2016)
    CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
    Neurobiol Aging, 49, 138-144
    DOI 10.1016/j.neurobiolaging.2016.09.012, PubMed 27794264
  82. Idland AV, Wyller TB, Støen R, Eri LM, Frihagen F, Ræder J, Chaudhry FA, Hansson O, Zetterberg H, Blennow K, Bogdanovic N, Brækhus A, Watne LO (2017)
    Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium
    J Alzheimers Dis, 55 (1), 371-379
    DOI 10.3233/JAD-160461, PubMed 27662296
  83. Wyller TB, Watne LO (2016)
    [Not Available]
    Tidsskr Nor Laegeforen, 136 (16), 1325-6
    DOI 10.4045/tidsskr.16.0686, PubMed 27637035
  84. Watne LO, Idland AV, Fekkes D, Raeder J, Frihagen F, Ranhoff AH, Chaudhry FA, Engedal K, Wyller TB, Hassel B (2016)
    Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity
    BMC Geriatr, 16, 149
    DOI 10.1186/s12877-016-0324-0, PubMed 27484129
  85. Hall RJ, Watne LO, Idland AV, Raeder J, Frihagen F, MacLullich AM, Staff AC, Wyller TB, Fekkes D (2016)
    Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture
    J Neuroinflammation, 13 (1), 170
    DOI 10.1186/s12974-016-0636-1, PubMed 27357281
  86. Neerland BE, Hall RJ, Seljeflot I, Frihagen F, MacLullich AM, Raeder J, Wyller TB, Watne LO (2016)
    Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture
    J Am Geriatr Soc, 64 (7), 1456-63
    DOI 10.1111/jgs.14238, PubMed 27341529
  87. Hov KR, Berg JP, Frihagen F, Ræder J, Hall R, Wyller TB, Watne LO (2016)
    Blood-Cerebrospinal Fluid Barrier Integrity in Delirium Determined by Q-Albumin
    Dement Geriatr Cogn Disord, 41 (3-4), 192-8
    DOI 10.1159/000443789, PubMed 27058253
  88. Krogseth M, Watne LO, Juliebø V, Skovlund E, Engedal K, Frihagen F, Wyller TB (2015)
    Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients
    Arch Gerontol Geriatr, 64, 38-44
    DOI 10.1016/j.archger.2015.12.004, PubMed 26952375
  89. Torbergsen AC, Watne LO, Wyller TB, Frihagen F, Strømsøe K, Bøhmer T, Mowe M (2015)
    Micronutrients and the risk of hip fracture: Case-control study
    Clin Nutr, 36 (2), 438-443
    DOI 10.1016/j.clnu.2015.12.014, PubMed 26795217
  90. Skrede K, Wyller TB, Watne LO, Seljeflot I, Juliebø V (2015)
    Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients
    BMC Res Notes, 8, 186
    DOI 10.1186/s13104-015-1129-5, PubMed 25943983
  91. Neerland BE, Hov KR, Bruun Wyller V, Qvigstad E, Skovlund E, MacLullich AM, Bruun Wyller T (2015)
    The protocol of the Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial
    BMC Geriatr, 15, 7
    DOI 10.1186/s12877-015-0006-3, PubMed 25887557
  92. Johnsen LG, Watne LO, Frihagen F, Helbostad JL, Prestmo A, Saltvedt I, Sletvold O, Wyller TB (2015)
    [Why orthogeriatrics?]
    Tidsskr Nor Laegeforen, 135 (6), 523-4
    DOI 10.4045/tidsskr.15.0188, PubMed 25806757
  93. Watne LO, Wyller T, Hall R, MacLullich A (2014)
    Response to Paul Regal
    J Am Geriatr Soc, 62 (7), 1415
    DOI 10.1111/jgs.12875, PubMed 25039530
  94. O'Sullivan R, Meagher D, Leonard M, Watne LO, Hall RJ, Maclullich AM, Trzepacz P, Adamis D (2014)
    A comparison of the revised Delirium Rating Scale (DRS-R98) and the Memorial Delirium Assessment Scale (MDAS) in a palliative care cohort with DSM-IV delirium
    Palliat Support Care, 13 (4), 937-44
    DOI 10.1017/S1478951514000613, PubMed 24991706
  95. Watne LO, Torbergsen AC, Conroy S, Engedal K, Frihagen F, Hjorthaug GA, Juliebo V, Raeder J, Saltvedt I, Skovlund E, Wyller TB (2014)
    The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: randomized controlled trial (Oslo Orthogeriatric Trial)
    BMC Med, 12, 63
    DOI 10.1186/1741-7015-12-63, PubMed 24735588
  96. Torbergsen AC, Watne LO, Wyller TB, Frihagen F, Strømsøe K, Bøhmer T, Mowe M (2014)
    Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: a case control study
    Clin Nutr, 34 (1), 101-6
    DOI 10.1016/j.clnu.2014.01.016, PubMed 24559841
  97. Neerland BE, Ahmed M, Watne LO, Hov KR, Wyller TB (2014)
    New consciousness scale for delirium
    Tidsskr Nor Laegeforen, 134 (2), 150
    DOI 10.4045/tidsskr.13.1603, PubMed 24477145
  98. Watne LO, Hall RJ, Molden E, Raeder J, Frihagen F, MacLullich AM, Juliebø V, Nyman A, Meagher D, Wyller TB (2014)
    Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium
    J Am Geriatr Soc, 62 (1), 94-102
    DOI 10.1111/jgs.12612, PubMed 24383557
  99. Neerland BE, Watne LO, Wyller TB (2013)
    [Delirium in elderly patients]
    Tidsskr Nor Laegeforen, 133 (15), 1596-600
    DOI 10.4045/tidsskr.12.1327, PubMed 23970274
  100. Wyller TB, Watne LO, Torbergsen A, Engedal K, Frihagen F, Juliebø V, Saltvedt I, Skovlund E, Ræder J, Conroy S (2012)
    The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial
    BMC Geriatr, 12, 36
    DOI 10.1186/1471-2318-12-36, PubMed 22817102
  101. Neerland BE, Krogseth M, Wyller TB (2018)
    How to describe delirium?
    Tidsskr. Nor. Laegeforen., 138 (5), 479
  102. Torbergsen AC, Watne LO, Frihagen F, Wyller TB, Brugaard A, Mowe M (2015)
    Vitamin deficiency as a risk factor for delirium
    Eur. Geriatr. Med., 6 (4), 314-318
    DOI 10.1016/j.eurger.2014.09.002
  103. Evensen S, Saltvedt I, Ranhoff AH, Myrstad M, Myrstad C, Mellingsaeter M, Wang-Hansen MS, Neerland BE (2019)
    Delirium and cognitive impairment among older patients in Norwegian emergency departments
    Tidsskr. Nor. Laegeforen., 139 (6), 517-520
  104. Watne LO, Wyller TB (2018)
    Delirium- still under diagnosed
    Tidsskr. Nor. Laegeforen., 138 (5), 418
  105. Neerland BE (2020)
    The pandemic of the vulnerable people
    Tidsskr. Nor. Laegeforen., 140 (11), 1086
  106. Neerland BE (2016)
    Geriatrics
    Tidsskr. Nor. Laegeforen., 136 (14-15), 1255
    DOI 10.4045/tidsskr.16.0443
  107. Myrstad M, Kittang BR, Neerland BE, Ranhoff AH, Wyller TB (2021)
    Corticosteroids for nursing home patients with covid-19?
    Tidsskr. Nor. Laegeforen., 141 (1), 13-14

 
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