Specific projects focus on the epigenetic reprogramming of early embryo development and its significance for human reproduction. An overarching theme is the understanding of mechanisms and epigenetic information in the passing of life from one generation to the next. Aging related projects have a focus on stem cell aging and rejuvenation after hematopoietic stem cell transplantation. We have a particular interest in the mechanisms of aging and rejuvenation. In addition, the Dahl lab works on Neuroepigenetics and Cancer epimutations.
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
Nat Cell Biol, 22 (4), 380-388
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
Going low to reach high: Small-scale ChIP-seq maps new terrain
Wiley Interdiscip Rev Syst Biol Med, 12 (1), e1465