Specific projects focus on the epigenetic reprogramming of early embryo development and its significance for human reproduction. An overarching theme is the understanding of mechanisms and epigenetic information in the passing of life from one generation to the next. Aging related projects have a focus on stem cell aging and rejuvenation after hematopoietic stem cell transplantation. We have a particular interest in the mechanisms of aging and rejuvenation. In addition, the Dahl lab works on Neuroepigenetics and Cancer epimutations.
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection
PLoS Pathog, 17 (3), e1009476
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Sci Adv, 6 (37)
Analysis of epigenetic aging in vivo and in vitro: Factors controlling the speed and direction
Exp Biol Med (Maywood), 245 (17), 1543-1551