Inge Christoffer Olsen
- Researcher CTU (Statistician); PhD
Publications 2024
Clinical trial: An open-label, randomised trial of different re-start strategies after treatment withdrawal in HBeAg negative chronic hepatitis B
Aliment Pharmacol Ther, 60 (4), 434-445
DOI 10.1111/apt.18147, PubMed 38970293
Effects of tapering conventional synthetic disease-modifying antirheumatic drugs to drug-free remission versus stable treatment in rheumatoid arthritis (ARCTIC REWIND): 3-year results from an open-label, randomised controlled, non-inferiority trial
Lancet Rheumatol, 6 (5), e268-e278
DOI 10.1016/S2665-9913(24)00021-3, PubMed 38583450
Opportunistic Treatment of Hepatitis C Infection Among Hospitalized People Who Inject Drugs (OPPORTUNI-C): A Stepped Wedge Cluster Randomized Trial
Clin Infect Dis, 78 (3), 582-590
DOI 10.1093/cid/ciad711, PubMed 37992203
Experiences and challenges with the new European Clinical Trials Regulation
Trials, 25 (1), 3
DOI 10.1186/s13063-023-07869-x, PubMed 38167484
Publications 2023
Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials
Lancet Respir Med, 11 (5), 453-464
DOI 10.1016/S2213-2600(22)00528-8, PubMed 36828006
Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH-mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden
BMJ Open, 13 (3), e070071
DOI 10.1136/bmjopen-2022-070071, PubMed 36940951
Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial
Ann Rheum Dis, 82 (11), 1394-1403
DOI 10.1136/ard-2023-224476, PubMed 37607809
The international Unity study for antivirals against mpox is a blueprint for future epidemics
Nat Med, 29 (8), 1894-1895
DOI 10.1038/s41591-023-02393-6, PubMed 37391664
Implementation of a centralized pharmacovigilance system in academic pan-European clinical trials: Experience from EU-Response and conect4children consortia
Br J Clin Pharmacol, 89 (4), 1318-1328
DOI 10.1111/bcp.15669, PubMed 36680782
Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial
Crit Care, 27 (1), 9
DOI 10.1186/s13054-022-04205-8, PubMed 36627655
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
Ann Rheum Dis, 82 (10), 1286-1295
DOI 10.1136/ard-2023-224116, PubMed 37423647
Publications 2022
Risk factors for anti-drug antibody formation to infliximab: Secondary analyses of a randomised controlled trial
J Intern Med, 292 (3), 477-491
DOI 10.1111/joim.13495, PubMed 35411981
Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial
Lancet, 399 (10344), 2398-2411
DOI 10.1016/S0140-6736(22)00687-0, PubMed 35753340
Immunocompromised patients have been neglected in COVID-19 trials: a call for action
Clin Microbiol Infect, 28 (9), 1182-1183
DOI 10.1016/j.cmi.2022.05.005, PubMed 35623577
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations
J Intern Med, 291 (6), 801-812
DOI 10.1111/joim.13458, PubMed 35212063
Publications 2021
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial
Ann Intern Med, 174 (9), 1261-1269
DOI 10.7326/M21-0653, PubMed 34251903
Accelerating clinical trial implementation in the context of the COVID-19 pandemic: challenges, lessons learned and recommendations from DisCoVeRy and the EU-SolidAct EU response group
Clin Microbiol Infect, 28 (1), 1-5
DOI 10.1016/j.cmi.2021.10.011, PubMed 34763056
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
Nat Commun, 12 (1), 6774
DOI 10.1038/s41467-021-27029-6, PubMed 34811370
Neutrophil count predicts clinical outcome in hospitalized COVID-19 patients: Results from the NOR-Solidarity trial
J Intern Med, 291 (2), 241-243
DOI 10.1111/joim.13377, PubMed 34411368
Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9
Sci Rep, 11 (1), 23205
DOI 10.1038/s41598-021-02547-x, PubMed 34853380
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial
JAMA, 325 (17), 1755-1764
DOI 10.1001/jama.2021.4542, PubMed 33944875
Joint tenderness and ultrasound inflammation in DMARD-naïve patients with early rheumatoid arthritis
Ann Rheum Dis, 80 (11), 1493-1494
DOI 10.1136/annrheumdis-2021-220265, PubMed 34083205
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
JAMA, 325 (17), 1744-1754
DOI 10.1001/jama.2021.4172, PubMed 33944876
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
JAMA, 326 (23), 2375-2384
DOI 10.1001/jama.2021.21316, PubMed 34932077
Publications 2020
Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial
BMJ, 371, m4328
DOI 10.1136/bmj.m4328, PubMed 33268527
Efficacy and Safety of CT-P13 in Inflammatory Bowel Disease after Switching from Originator Infliximab: Exploratory Analyses from the NOR-SWITCH Main and Extension Trials
BioDrugs, 34 (5), 681-694
DOI 10.1007/s40259-020-00438-7, PubMed 32965617
Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trial
Trials, 21 (1), 485
DOI 10.1186/s13063-020-04420-0, PubMed 32503662
A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics
Nat Commun, 11 (1), 5284
DOI 10.1038/s41467-020-19056-6, PubMed 33082342
Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial
Lancet, 395 (10228), 951-961
DOI 10.1016/S0140-6736(19)32983-6, PubMed 32087121
Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)
Trials, 21 (1), 13
DOI 10.1186/s13063-019-3734-4, PubMed 31907007
Publications 2019
Zhang's guidelines vs WHO guidelines for diagnosing labour dystocia - Authors' reply
Lancet, 394 (10198), e11
DOI 10.1016/S0140-6736(19)31110-9, PubMed 31253363
The Labor Progression Study: The use of oxytocin augmentation during labor following Zhang's guideline and the WHO partograph in a cluster randomized trial
Acta Obstet Gynecol Scand, 98 (9), 1187-1194
DOI 10.1111/aogs.13629, PubMed 31017306
The Labour Progression Study (LaPS): Duration of labour following Zhang's guideline and the WHO partograph - A cluster randomised trial
Midwifery, 81, 102578
DOI 10.1016/j.midw.2019.102578, PubMed 31783231
Comment on: Assessments of the unmet need in the management of patients with rheumatoid arthritis: analyses from the NOR-DMARD registry: reply
Rheumatology (Oxford), 58 (10), 1885-1886
DOI 10.1093/rheumatology/kez211, PubMed 31170288
Assessments of the unmet need in the management of patients with rheumatoid arthritis: analyses from the NOR-DMARD registry
Rheumatology (Oxford), 58 (3), 481-491
DOI 10.1093/rheumatology/key338, PubMed 30508189
Publications 2018
The frequency of intrapartum caesarean section use with the WHO partograph versus Zhang's guideline in the Labour Progression Study (LaPS): a multicentre, cluster-randomised controlled trial
Lancet, 393 (10169), 340-348
DOI 10.1016/S0140-6736(18)31991-3, PubMed 30581039
Feasibility of cardiovascular disease risk assessments in rheumatology outpatient clinics: experiences from the nationwide NOCAR project
RMD Open, 4 (2), e000737
DOI 10.1136/rmdopen-2018-000737, PubMed 30305931
Guideline recommended treatment to targets of cardiovascular risk is inadequate in patients with inflammatory joint diseases
Int J Cardiol, 274, 311-318
DOI 10.1016/j.ijcard.2018.06.111, PubMed 30007486
The Impact of Ultrasound on the Use and Efficacy of Intraarticular Glucocorticoid Injections in Early Rheumatoid Arthritis: Secondary Analyses From a Randomized Trial Examining the Benefit of Ultrasound in a Clinical Tight Control Regimen
Arthritis Rheumatol, 70 (8), 1192-1199
DOI 10.1002/art.40494, PubMed 29575737
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial
RMD Open, 4 (2), e000752
DOI 10.1136/rmdopen-2018-000752, PubMed 30564452
Predicting achievement of the treatment targets at 6 months from 3-month response levels in rheumatoid arthritis: data from real-life follow-up in the NOR-DMARD study
RMD Open, 4 (2), e000773
DOI 10.1136/rmdopen-2018-000773, PubMed 30488000
Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: associations to future good radiographic and physical outcomes
Ann Rheum Dis, 77 (10), 1421-1425
DOI 10.1136/annrheumdis-2017-212830, PubMed 29934373
Predictors of sustained remission in patients with early rheumatoid arthritis treated according to an aggressive treat-to-target protocol
Rheumatology (Oxford), 57 (11), 2022-2031
DOI 10.1093/rheumatology/key202, PubMed 30053199
Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial
PLoS Med, 15 (5), e1002569
DOI 10.1371/journal.pmed.1002569, PubMed 29763434
Discrepancies in risk age and relative risk estimations of cardiovascular disease in patients with inflammatory joint diseases
Int J Cardiol, 252, 201-206
DOI 10.1016/j.ijcard.2017.10.038, PubMed 29249429
Publications 2017
Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis
Ann Rheum Dis, 76 (12), 2031-2037
DOI 10.1136/annrheumdis-2017-211695, PubMed 28814431
Efficacy of infliximab biosimilars in patients with Crohn's disease - Authors' reply
Lancet, 390 (10111), 2436
DOI 10.1016/S0140-6736(17)32463-7, PubMed 29208304
Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial
Lancet, 389 (10086), 2304-2316
DOI 10.1016/S0140-6736(17)30068-5, PubMed 28502609
Tumour necrosis factor inhibitor treatment and occurrence of anterior uveitis in ankylosing spondylitis: results from the Swedish biologics register
Ann Rheum Dis, 76 (9), 1515-1521
DOI 10.1136/annrheumdis-2016-210931, PubMed 28254789
Cardiovascular disease risk profiles in inflammatory joint disease entities
Arthritis Res Ther, 19 (1), 153
DOI 10.1186/s13075-017-1358-1, PubMed 28673314
Publications 2016
Ultrasound in management of rheumatoid arthritis: ARCTIC randomised controlled strategy trial
BMJ, 354, i4205
DOI 10.1136/bmj.i4205, PubMed 27530741
Sustained Improvement of Arterial Stiffness and Blood Pressure after Long-Term Rosuvastatin Treatment in Patients with Inflammatory Joint Diseases: Results from the RORA-AS Study
PLoS One, 11 (4), e0153440
DOI 10.1371/journal.pone.0153440, PubMed 27093159
Predictive Value of Arterial Stiffness and Subclinical Carotid Atherosclerosis for Cardiovascular Disease in Patients with Rheumatoid Arthritis
J Rheumatol, 43 (9), 1622-30
DOI 10.3899/jrheum.160053, PubMed 27307523
The association of hypertension with asymptomatic cardiovascular organ damage in rheumatoid arthritis
Blood Press, 25 (5), 298-304
DOI 10.3109/08037051.2016.1172867, PubMed 27123584
Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria
Ann Rheum Dis, 76 (2), 341-345
DOI 10.1136/annrheumdis-2015-208873, PubMed 27094444
Calcium supplementation and inflammation increase mortality in rheumatoid arthritis: A 15-year cohort study in 609 patients from the Oslo Rheumatoid Arthritis Register
Semin Arthritis Rheum, 46 (4), 411-417
DOI 10.1016/j.semarthrit.2016.07.011, PubMed 27522465
Involvement of the multidisciplinary team and outcomes in inpatient rehabilitation among patients with inflammatory rheumatic disease
BMC Musculoskelet Disord, 17, 18
DOI 10.1186/s12891-016-0870-9, PubMed 26762160
Achievement of Remission and Low Disease Activity Definitions in Patients with Rheumatoid Arthritis in Clinical Practice: Results from the NOR-DMARD Study
J Rheumatol, 43 (4), 716-23
DOI 10.3899/jrheum.151132, PubMed 26879358
Publications 2015
First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach
Ann Rheum Dis, 75 (8), 1444-51
DOI 10.1136/annrheumdis-2015-207572, PubMed 26085490
CRP and ASDAS are associated with future elevated arterial stiffness, a risk marker of cardiovascular disease, in patients with ankylosing spondylitis: results after 5-year follow-up
Ann Rheum Dis, 74 (8), 1562-6
DOI 10.1136/annrheumdis-2014-206773, PubMed 25795906
Disease activity in ankylosing spondylitis and associations to markers of vascular pathology and traditional cardiovascular disease risk factors: a cross-sectional study
J Rheumatol, 42 (4), 645-53
DOI 10.3899/jrheum.141018, PubMed 25641897
Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: results from the RORA-AS statin intervention study
Arthritis Res Ther, 17, 279
DOI 10.1186/s13075-015-0795-y, PubMed 26445924
EULAR task force recommendations on annual cardiovascular risk assessment for patients with rheumatoid arthritis: an audit of the success of implementation in a rheumatology outpatient clinic
Biomed Res Int, 2015, 515280
DOI 10.1155/2015/515280, PubMed 25815322
Effectiveness of an Integrated Multidisciplinary Osteoarthritis Outpatient Program versus Outpatient Clinic as Usual: A Randomized Controlled Trial
J Rheumatol, 43 (2), 411-8
DOI 10.3899/jrheum.150157, PubMed 26669917
Performance development in adolescent track and field athletes according to age, sex and sport discipline
PLoS One, 10 (6), e0129014
DOI 10.1371/journal.pone.0129014, PubMed 26043192
Publications 2014
Uveitis is associated with hypertension and atherosclerosis in patients with ankylosing spondylitis: a cross-sectional study
Semin Arthritis Rheum, 44 (3), 309-13
DOI 10.1016/j.semarthrit.2014.05.017, PubMed 24968705
Disease activity and left ventricular structure in patients with rheumatoid arthritis
Rheumatology (Oxford), 54 (3), 511-9
DOI 10.1093/rheumatology/keu368, PubMed 25224414
Efficacy of high intensity exercise on disease activity and cardiovascular risk in active axial spondyloarthritis: a randomized controlled pilot study
PLoS One, 9 (9), e108688
DOI 10.1371/journal.pone.0108688, PubMed 25268365
Publications 2013
Time trends in disease activity, response and remission rates in rheumatoid arthritis during the past decade: results from the NOR-DMARD study 2000-2010
Ann Rheum Dis, 74 (2), 381-8
DOI 10.1136/annrheumdis-2013-204020, PubMed 24285493
Determining a magnetic resonance imaging inflammatory activity acceptable state without subsequent radiographic progression in rheumatoid arthritis: results from a followup MRI study of 254 patients in clinical remission or low disease activity
J Rheumatol, 41 (2), 398-406
DOI 10.3899/jrheum.131088, PubMed 24334647
Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis
Ann Rheum Dis, 74 (4), 762-8
DOI 10.1136/annrheumdis-2013-204173, PubMed 24336335
Associations between APOE genotypes and disease susceptibility, joint damage and lipid levels in patients with rheumatoid arthritis
PLoS One, 8 (4), e60970
DOI 10.1371/journal.pone.0060970, PubMed 23613766
Carotid plaque characteristics and disease activity in rheumatoid arthritis
J Rheumatol, 40 (4), 359-68
DOI 10.3899/jrheum.120621, PubMed 23322468
Publications 2012
ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial
Arch Neurol, 69 (8), 1044-51
DOI 10.1001/archneurol.2012.283, PubMed 22507886
An approach to combining parallel and cross-over trials with and without run-in periods using individual patient data
Clin Trials, 9 (2), 164-75
DOI 10.1177/1740774511430714, PubMed 22297620
Publications 2011
Bioavailability of EPA and DHA delivered by gelled emulsions and soft gel capsules
Eur. J. Lipid Sci. Technol., 113 (2), 137-145
DOI 10.1002/ejlt.201000450
Publications 2009
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
Eur J Heart Fail, 11 (8), 771-8
DOI 10.1093/eurjhf/hfp087, PubMed 19567409
Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia
Dement Geriatr Cogn Disord, 27 (2), 155-63
DOI 10.1159/000199236, PubMed 19182483
NORdic trial of oral Methylprednisolone as add-on therapy to Interferon beta-1a for treatment of relapsing-remitting Multiple Sclerosis (NORMIMS study): a randomised, placebo-controlled trial
Lancet Neurol, 8 (6), 519-29
DOI 10.1016/S1474-4422(09)70085-7, PubMed 19409854