Mette Kalager

  • Researcher; MD, PhD

Main home page at UiO


Publications 2023

Adami HO, Kalager M, Bretthauer M (2023)
The Future of Cancer Screening-Guided Without Conflicts of Interest
JAMA Intern Med, 183 (10), 1047-1048
DOI 10.1001/jamainternmed.2023.4064, PubMed 37639267

Bretthauer M, Kalager M (2023)
What is my risk, doctor? How to convey disease risk and treatment effects
BMJ, 381, e075289
DOI 10.1136/bmj-2022-075289, PubMed 37328165

Bretthauer M, Wieszczy P, Løberg M, Kaminski MF, Werner TF, Helsingen LM, Mori Y, Holme Ø, Adami HO, Kalager M (2023)
Estimated Lifetime Gained With Cancer Screening Tests: A Meta-Analysis of Randomized Clinical Trials
JAMA Intern Med, 183 (11), 1196-1203
DOI 10.1001/jamainternmed.2023.3798, PubMed 37639247

Jodal HC, Akwiwu EU, Lemmens M, Delis-van Diemen PM, Klotz D, Leon LG, Lakbir S, de Wit M, Fijneman RJA, van Leerdam ME, Dekker E, Spaander MCW, Meijer GA, Løberg M, Coupé VMH, Kalager M, Carvalho B (2023)
Risk Prediction of Metachronous Colorectal Cancer from Molecular Features of Adenomas: A Nested Case-Control Study
Cancer Res Commun, 3 (11), 2292-2301
DOI 10.1158/2767-9764.CRC-23-0186, PubMed 37921412

Jodal HC, Wieszczy-Szczepanik P, Klotz D, Herfindal M, Barua I, Tag P, Helsingen LM, Refsum E, Holme Ø, Adami HO, Bretthauer M, Kalager M, Løberg M (2023)
A Comparison of Risk Classification Systems of Colorectal Adenomas: A Case-Cohort Study
Gastroenterology, 165 (2), 483-491.e7
DOI 10.1053/j.gastro.2023.04.028, PubMed 37146913

Langeland EA, Pisani SER, Kalager M, Bretthauer M, Helsingen LM (2023)
[Not Available]
Tidsskr Nor Laegeforen, 143 (14)
DOI 10.4045/tidsskr.23.0110, PubMed 37830968

Skaare D, Hannisdal A, Kalager M, Berild D (2023)
Measuring broad-spectrum antibiotic use in hospitals with established versus new indicators
Tidsskr Nor Laegeforen, 143 (6)
DOI 10.4045/tidsskr.22.0427, PubMed 37097231

Skaare D, Hannisdal A, Kalager M, Berild D (2023)
[Correction: Measuring broad-spectrum antibiotic use in hospitals with established versus new indicators]
Tidsskr Nor Laegeforen, 143 (7)
DOI 10.4045/tidsskr.23.0301, PubMed 37158510

Tønnesen CJ, Hjelmesæth J, Aabakken L, Lund RS, Johnson LK, Hertel JK, Kalager M, Løberg M, Bretthauer M (2023)
A pilot study of implementation of endoscopic sleeve gastroplasty (ESG) in Norway
Scand J Gastroenterol, 58 (10), 1180-1184
DOI 10.1080/00365521.2023.2204389, PubMed 37128713

Yu J, Refsum E, Wieszczy P, Helsingen LM, Perrin V, Högdén A, Løberg M, Blom J, Bretthauer M, Adami HO, Ye W, Kalager M (2023)
Risk of malignant lymphomas in patients with inflammatory bowel disease: a population-based cohort study
BMJ Open Gastroenterol, 10 (1)
DOI 10.1136/bmjgast-2022-001037, PubMed 37142293

Publications 2022

Ainechi D, Misawa M, Barua I, Larsen SLV, Paulsen V, Garborg KK, Aabakken L, Tønnesen CJ, Løberg M, Kalager M, Kudo SE, Hotta K, Ohtsuka K, Saito S, Ikematsu H, Saito Y, Matsuda T, Itoh H, Mori K, Bretthauer M, Mori Y (2022)
Impact of artificial intelligence on colorectal polyp detection for early-career endoscopists: an international comparative study
Scand J Gastroenterol, 57 (10), 1272-1277
DOI 10.1080/00365521.2022.2070436, PubMed 35605150

Akwiwu EU, Klausch T, Jodal HC, Carvalho B, Løberg M, Kalager M, Berkhof J, Coupé VMH (2022)
A progressive three-state model to estimate time to cancer: a likelihood-based approach
BMC Med Res Methodol, 22 (1), 179
DOI 10.1186/s12874-022-01645-2, PubMed 35761181

Anda EE, Braaten T, Borch KB, Nøst TH, Chen SLF, Lukic M, Lund E, Forland F, Leon DA, Winje BA, Kran AB, Kalager M, Johansen FL, Sandanger TM (2022)
Seroprevalence of antibodies against SARS-CoV-2 in the adult population during the pre-vaccination period, Norway, winter 2020/21
Euro Surveill, 27 (13)
DOI 10.2807/1560-7917.ES.2022.27.13.2100376, PubMed 35362405

Barua I, Misawa M, Glissen Brown JR, Walradt T, Kudo SE, Sheth SG, Nee J, Iturrino J, Mukherjee R, Cheney CP, Sawhney MS, Pleskow DK, Mori K, Løberg M, Kalager M, Wieszczy P, Bretthauer M, Berzin TM, Mori Y (2022)
Speedometer for withdrawal time monitoring during colonoscopy: a clinical implementation trial
Scand J Gastroenterol, 58 (6), 664-670
DOI 10.1080/00365521.2022.2154616, PubMed 36519564

Bretthauer M, Løberg M, Wieszczy P, Kalager M, Emilsson L, Garborg K, Rupinski M, Dekker E, Spaander M, Bugajski M, Holme Ø, Zauber AG, Pilonis ND, Mroz A, Kuipers EJ, Shi J, Hernán MA, Adami HO, Regula J, Hoff G, Kaminski MF, NordICC Study Group (2022)
Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death
N Engl J Med, 387 (17), 1547-1556
DOI 10.1056/NEJMoa2208375, PubMed 36214590

Helsingen LM, Løberg M, Bretthauer M, Kalager M (2022)
Reply to: Letter to the Editor regarding "Covid-19 transmission in fitness centers in Norway-a randomized trial"
BMC Public Health, 22 (1), 2437
DOI 10.1186/s12889-022-14799-x, PubMed 36575428

Jodal HC, Bretthauer M, Kalager M, Løberg M (2022)
Letter: long-term colorectal cancer incidence and mortality after adenoma removal associated with heritable factors, colonoscopic surveillance and aspirin-authors' reply
Aliment Pharmacol Ther, 55 (10), 1363-1364
DOI 10.1111/apt.16929, PubMed 35472187

Jodal HC, Juul FE, Barua I, Bretthauer M, Kalager M, Løberg M, Emilsson L (2022)
Emergency hospital admissions, prognosis, and population mortality in Norway during the first wave of the Covid-19 epidemic
Scand J Public Health, 50 (6), 795-802
DOI 10.1177/14034948221082959, PubMed 35546560

Juul FE, Cross AJ, Schoen RE, Senore C, Pinsky P, Miller E, Segnan N, Wooldrage K, Wieszczy-Szczepanik P, Armaroli P, Garborg KK, Adami HO, Hoff G, Kalager M, Bretthauer M, Løberg M, Holme Ø (2022)
15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality : A Pooled Analysis of Randomized Trials
Ann Intern Med, 175 (11), 1525-1533
DOI 10.7326/M22-0835, PubMed 36215714

Juul FE, Garborg K, Nesbakken E, Løberg M, Wieszczy P, Cubiella J, Kalager M, Kaminski MF, Erichsen R, Adami HO, Ferlitsch M, Furholm SKB, Zauber AG, Quintero E, Bugajski M, Holme Ø, Dekker E, Jover R, Bretthauer M (2022)
Rates of repeated colonoscopies to clean the colon from low-risk and high-risk adenomas: results from the EPoS trials
Gut, 72 (5), 951-957
DOI 10.1136/gutjnl-2022-327696, PubMed 36307178

Kalager M, Adami HO, Dickman PW, Lagergren P, Steindorf K (2022)
Cancer outcome research - a European challenge Part II: Opportunities and priorities
Mol Oncol, 16 (12), 2300-2311
DOI 10.1002/1878-0261.13169, PubMed 34939327

Mori Y, Wang P, Løberg M, Misawa M, Repici A, Spadaccini M, Correale L, Antonelli G, Yu H, Gong D, Ishiyama M, Kudo SE, Kamba S, Sumiyama K, Saito Y, Nishino H, Liu P, Glissen Brown JR, Mansour NM, Gross SA, Kalager M, Bretthauer M, Rex DK, Sharma P, Berzin TM et al. (2022)
Impact of Artificial Intelligence on Colonoscopy Surveillance After Polyp Removal: A Pooled Analysis of Randomized Trials
Clin Gastroenterol Hepatol, 21 (4), 949-959.e2
DOI 10.1016/j.cgh.2022.08.022, PubMed 36038128

Pedersen IB, Rawa-Golebiewska A, Calderwood AH, Brix LD, Grode LB, Botteri E, Bugajski M, Kaminski MF, Januszewicz W, Ødegaard H, Kleist B, Kalager M, Løberg M, Bretthauer M, Hoff G, Medhus A, Holme Ø (2022)
Complete polyp resection with cold snare versus hot snare polypectomy for polyps of 4-9 mm: a randomized controlled trial
Endoscopy, 54 (10), 961-969
DOI 10.1055/a-1734-7952, PubMed 35008112

Ribe SG, Botteri E, Løberg M, Randel KR, Kalager M, Nilsen JA, Gulichsen EH, Holme Ø (2022)
Impact of time between faecal immunochemical tests in colorectal cancer screening on screening results: A natural experiment
Int J Cancer, 152 (7), 1414-1424
DOI 10.1002/ijc.34351, PubMed 36346118

Yu J, Refsum E, Helsingen LM, Folseraas T, Ploner A, Wieszczy P, Barua I, Jodal HC, Melum E, Løberg M, Blom J, Bretthauer M, Adami HO, Kalager M, Ye W (2022)
Risk of hepato-pancreato-biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population-based cohort study
United European Gastroenterol J, 10 (2), 212-224
DOI 10.1002/ueg2.12204, PubMed 35107865

Yu J, Refsum E, Perrin V, Helsingen LM, Wieszczy P, Løberg M, Bretthauer M, Adami HO, Ye W, Blom J, Kalager M (2022)
Inflammatory bowel disease and risk of adenocarcinoma and neuroendocrine tumors in the small bowel
Ann Oncol, 33 (6), 649-656
DOI 10.1016/j.annonc.2022.02.226, PubMed 35276334

Publications 2021

Bretthauer M, Helsingen LM, Løberg M, Kalager M, Guyatt G (2021)
Evidence and Precaution for Legal Health Interventions: Learning From the COVID-19 Pandemic
Ann Intern Med, 174 (10), 1456-1457
DOI 10.7326/M21-2839, PubMed 34370512

Bretthauer M, Løberg M, Holme Ø, Adami HO, Kalager M (2021)
Deep learning and cancer biomarkers: recognising lead-time bias
Lancet, 397 (10270), 194
DOI 10.1016/S0140-6736(20)32402-8, PubMed 33453776

Helsingen LM, Løberg M, Refsum E, Gjøstein DK, Wieszczy P, Olsvik Ø, Juul FE, Barua I, Jodal HC, Herfindal M, Mori Y, Jore S, Lund-Johansen F, Fretheim A, Bretthauer M, Kalager M, TRAiN study group (2021)
Covid-19 transmission in fitness centers in Norway - a randomized trial
BMC Public Health, 21 (1), 2103
DOI 10.1186/s12889-021-12073-0, PubMed 34789188

Jodal HC, Klotz D, Herfindal M, Barua I, Tag P, Helsingen LM, Refsum E, Holme Ø, Adami HO, Bretthauer M, Kalager M, Løberg M (2021)
Long-term colorectal cancer incidence and mortality after adenoma removal in women and men
Aliment Pharmacol Ther, 55 (4), 412-421
DOI 10.1111/apt.16686, PubMed 34716941

Juul FE, Jodal HC, Barua I, Refsum E, Olsvik Ø, Helsingen LM, Løberg M, Bretthauer M, Kalager M, Emilsson L (2021)
Mortality in Norway and Sweden during the COVID-19 pandemic
Scand J Public Health, 50 (1), 38-45
DOI 10.1177/14034948211047137, PubMed 34609261

Kalager M, Adami HO, Lagergren P, Steindorf K, Dickman PW (2021)
Cancer outcomes research-a European challenge: measures of the cancer burden
Mol Oncol, 15 (12), 3225-3241
DOI 10.1002/1878-0261.13012, PubMed 34003576

Mori Y, Bretthauer M, Kalager M (2021)
Hopes and Hypes for Artificial Intelligence in Colorectal Cancer Screening
Gastroenterology, 161 (3), 774-777
DOI 10.1053/j.gastro.2021.04.078, PubMed 33989659

Tønnesen CJ, Hjelmesæth J, Hofsø D, Tonstad S, Hertel JK, Heggen E, Johnson LK, Mathisen TE, Kalager M, Wieszczy P, Medhus AW, Løberg M, Aabakken L, Bretthauer M (2021)
A novel intragastric balloon for treatment of obesity and type 2 diabetes. A two-center pilot trial
Scand J Gastroenterol, 57 (2), 232-238
DOI 10.1080/00365521.2021.1994641, PubMed 34714203

Wieszczy P, Kaminski MF, Løberg M, Bugajski M, Bretthauer M, Kalager M (2021)
Estimation of overdiagnosis in colorectal cancer screening with sigmoidoscopy and faecal occult blood testing: comparison of simulation models
BMJ Open, 11 (4), e042158
DOI 10.1136/bmjopen-2020-042158, PubMed 33853794

Publications 2020

Adami HO, Bretthauer M, Kalager M (2020)
Assessment of cancer screening effectiveness in the era of screening programs
Eur J Epidemiol, 35 (10), 891-897
DOI 10.1007/s10654-020-00684-7, PubMed 32929645

Barua I, Vinsard DG, Jodal HC, Løberg M, Kalager M, Holme Ø, Misawa M, Bretthauer M, Mori Y (2020)
Artificial intelligence for polyp detection during colonoscopy: a systematic review and meta-analysis
Endoscopy, 53 (3), 277-284
DOI 10.1055/a-1201-7165, PubMed 32557490

Berns A, Ringborg U, Celis JE, Heitor M, Aaronson NK, Abou-Zeid N, Adami HO, Apostolidis K, Baumann M, Bardelli A, Bernards R, Brandberg Y, Caldas C, Calvo F, Dive C, Eggert A, Eggermont A, Espina C, Falkenburg F, Foucaud J, Hanahan D, Helbig U, Jönsson B, Kalager M, Karjalainen S et al. (2020)
Towards a cancer mission in Horizon Europe: recommendations
Mol Oncol, 14 (8), 1589-1615
DOI 10.1002/1878-0261.12763, PubMed 32749074

Bretthauer M, Helsingen LM, Kalager M, Vandvik PO, Agoritsas T, Guyatt G (2020)
The future of colorectal cancer screening: Parentalism or shared decision-making?
CMAJ, 192 (18), E484
DOI 10.1503/cmaj.74839, PubMed 32366471

Bretthauer M, Kalager M (2020)
Disparities in Preventive Health Services: Targeting Minorities and Majorities
Ann Intern Med, 172 (4), 287-288
DOI 10.7326/M19-3899, PubMed 31931529

Bretthauer M, Kalager M, Weinberg DS (2020)
Colorectal Cancer Screening in Young Adults: About Carcinoid Tumors and Cancer
Ann Intern Med, 174 (2), 263-264
DOI 10.7326/M20-7244, PubMed 33315472

Hassan C, Antonelli G, Dumonceau JM, Regula J, Bretthauer M, Chaussade S, Dekker E, Ferlitsch M, Gimeno-Garcia A, Jover R, Kalager M, Pellisé M, Pox C, Ricciardiello L, Rutter M, Helsingen LM, Bleijenberg A, Senore C, van Hooft JE, Dinis-Ribeiro M, Quintero E (2020)
Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020
Endoscopy, 52 (8), 687-700
DOI 10.1055/a-1185-3109, PubMed 32572858

Helsingen LM, Refsum E, Gjøstein DK, Løberg M, Bretthauer M, Kalager M, Emilsson L, Clinical Effectiveness Research group (2020)
The COVID-19 pandemic in Norway and Sweden - threats, trust, and impact on daily life: a comparative survey
BMC Public Health, 20 (1), 1597
DOI 10.1186/s12889-020-09615-3, PubMed 33097011

Holme Ø, Kalager M, Bretthauer M, Adami HO, Helsingen L, Løberg M (2020)
Ongoing Trials Will Not Determine the Comparative Effectiveness of Colorectal Cancer Screening Tests
Gastroenterology, 164 (6), 856-860
DOI 10.1053/j.gastro.2020.02.071, PubMed 32585308

Kalager M, Bretthauer M (2020)
Improving cancer screening programs
Science, 367 (6474), 143-144
DOI 10.1126/science.aay3156, PubMed 31919207

Lousdal ML, Lash TL, Flanders WD, Brookhart MA, Kristiansen IS, Kalager M, Støvring H (2020)
Negative controls to detect uncontrolled confounding in observational studies of mammographic screening comparing participants and non-participants
Int J Epidemiol, 49 (3), 1032-1042
DOI 10.1093/ije/dyaa029, PubMed 32211885

Pedersen IB, Bretthauer M, Kalager M, Løberg M, Hoff G, Matapour S, Hugin S, Frigstad SO, Seip B, Kleist BA, Løvdal L, Botteri E, Holme Ø (2020)
Incomplete endoscopic resection of colorectal polyps: a prospective quality assurance study
Endoscopy, 53 (4), 383-391
DOI 10.1055/a-1243-0379, PubMed 32961579

Wieszczy P, Waldmann E, Løberg M, Regula J, Rupinski M, Bugajski M, Gray K, Kalager M, Ferlitsch M, Kaminski MF, Bretthauer M (2020)
Colonoscopist Performance and Colorectal Cancer Risk After Adenoma Removal to Stratify Surveillance: Two Nationwide Observational Studies
Gastroenterology, 160 (4), 1067-1074.e6
DOI 10.1053/j.gastro.2020.10.009, PubMed 33065063

Publications 2019

Adami HO, Kalager M, Valdimarsdottir U, Bretthauer M, Ioannidis JPA (2019)
Time to abandon early detection cancer screening
Eur J Clin Invest, 49 (3), e13062
DOI 10.1111/eci.13062, PubMed 30565674

Adami HO, Kalager M, Valdimarsdottir U, Bretthauer M, Ioannidis JPA (2019)
Author Reply to: The name of the game: Is preventive screening "cancer screening?"
Eur J Clin Invest, 49 (6), e13097
DOI 10.1111/eci.13097, PubMed 30829396

Bleijenberg A, Klotz D, Løberg M, Dekker E, Adami HO, Kuipers EJ, Holme Ø, Kalager M, Emilsson L, Kleist B, Løvdal L, Regula J, Løberg EM, IJspeert J, Bretthauer M (2019)
Implications of different guidelines for surveillance after serrated polyp resection in United States of America and Europe
Endoscopy, 51 (8), 750-758
DOI 10.1055/a-0916-8598, PubMed 31195423

Bretthauer M, Kalager M, Weinberg DS (2019)
From Colorectal Cancer Screening Guidelines to Headlines: Beware!
Ann Intern Med, 170 (10), 734
DOI 10.7326/L19-0086, PubMed 31108525

Helsingen LM, Vandvik PO, Jodal HC, Agoritsas T, Lytvyn L, Anderson JC, Auer R, Murphy SB, Almadi MA, Corley DA, Quinlan C, Fuchs JM, McKinnon A, Qaseem A, Heen AF, Siemieniuk RAC, Kalager M, Usher-Smith JA, Lansdorp-Vogelaar I, Bretthauer M, Guyatt G (2019)
Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a clinical practice guideline
BMJ, 367, l5515
DOI 10.1136/bmj.l5515, PubMed 31578196

Helsingen LM, Vandvik PO, Jodal HC, Murphy SB, Heen AF, Kalager M, Bretthauer M (2019)
[Colorectal cancer screening, yes or no?]
Tidsskr Nor Laegeforen, 139 (15)
DOI 10.4045/tidsskr.19.0323, PubMed 31642636

Helsingen LM, Vandvik PO, Jodal HC, Murphy SB, Heen AF, Kalager M, Bretthauer M (2019)
Colorectal cancer screening, right?
Tidsskr. Nor. Laegeforen., 139 (15), 1450-1451

Holme Ø, Bretthauer M, Løberg M, Kalager M, Adami HO (2019)
Revisiting surveillance schemes for cancer survivors
Ann Oncol, 30 (6), 881-883
DOI 10.1093/annonc/mdz107, PubMed 30895293

Holme Ø, Bretthauer M, Løberg M, Kalager M, Adami HO (2019)
Reply to the letter to the editor 'Cancer survivors: surveillance or not surveillance?' by Santeufemia and Miolo
Ann Oncol, 30 (9), 1531-1532
DOI 10.1093/annonc/mdz190, PubMed 31198953

Kalager M (2019)
[StatMed – the new oil?]
Tidsskr Nor Laegeforen, 139 (9)
DOI 10.4045/tidsskr.19.0349, PubMed 31140239

Kalager M (2019)
[M. Kalager responds]
Tidsskr Nor Laegeforen, 139 (11)
DOI 10.4045/tidsskr.19.0440, PubMed 31429242

Kalager M (2019)
StatMed- the new oil?
Tidsskr. Nor. Laegeforen., 139 (9), 783

Kalager M (2019)
StatMed - well intended but unknowable Reply
Tidsskr. Nor. Laegeforen., 139 (11), 1017

Refsum E, Helsingen LM, Jodal HC, Loberg M, Hostmaelingen N, Kalager M (2019)
Privacy - an obstacle course
Tidsskr. Nor. Laegeforen., 139 (4), 314-315

Refsum E, Helsingen LM, Jodal HC, Løberg M, Høstmælingen N, Kalager M (2019)
[Data protection – an obstacle course]
Tidsskr Nor Laegeforen, 139 (4)
DOI 10.4045/tidsskr.19.0077, PubMed 30808102

Seppälä TT, Ahadova A, Dominguez-Valentin M, Macrae F, Evans DG, Therkildsen C, Sampson J, Scott R, Burn J, Möslein G, Bernstein I, Holinski-Feder E, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Lautrup CK, Lindblom A, Plazzer JP, Winship I, Tjandra D, Katz LH, Aretz S, Hüneburg R, Holzapfel S, Heinimann K et al. (2019)
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
Hered Cancer Clin Pract, 17, 8
DOI 10.1186/s13053-019-0106-8, PubMed 30858900

Wieszczy P, Kaminski MF, Franczyk R, Loberg M, Kobiela J, Rupinska M, Kocot B, Rupinski M, Holme O, Wojciechowska U, Didkowska J, Ransohoff D, Bretthauer M, Kalager M, Regula J (2019)
Colorectal Cancer Incidence and Mortality After Removal of Adenomas During Screening Colonoscopies
Gastroenterology, 158 (4), 875-883.e5
DOI 10.1053/j.gastro.2019.09.011, PubMed 31563625

Zahl PH, Kalager M (2019)
Reply to: Loss of QALY in mammography screening reported by Zahl et al
Int J Cancer, 146 (4), 1177
DOI 10.1002/ijc.32755, PubMed 31652342

Zahl PH, Kalager M, Suhrke P, Nord E (2019)
Quality-of-life effects of screening mammography in Norway
Int J Cancer, 146 (8), 2104-2112
DOI 10.1002/ijc.32539, PubMed 31254388

Publications 2018

Bretthauer M, Goderstad JM, Løberg M, Emilsson L, Ye W, Adami HO, Kalager M (2018)
Uterine morcellation and survival in uterine sarcomas
Eur J Cancer, 101, 62-68
DOI 10.1016/j.ejca.2018.06.007, PubMed 30025231

Bretthauer M, Kalager M (2018)
When no guideline recommendation is the best recommendation
Lancet, 392 (10151), 898-899
DOI 10.1016/S0140-6736(18)31671-4, PubMed 30238877

Bretthauer M, Kalager M, Weinberg DS (2018)
From Colorectal Cancer Screening Guidelines to Headlines: Beware!
Ann Intern Med, 169 (6), 405-406
DOI 10.7326/M18-1720, PubMed 29987330

Emilsson L, García-Albéniz X, Logan RW, Caniglia EC, Kalager M, Hernán MA (2018)
Examining Bias in Studies of Statin Treatment and Survival in Patients With Cancer
JAMA Oncol, 4 (1), 63-70
DOI 10.1001/jamaoncol.2017.2752, PubMed 28822996

Halvorsen JA, Løberg M, Gjersvik P, Roscher I, Veierød MB, Robsahm TE, Nilsen LTN, Kalager M, Bretthauer M (2018)
Why a randomized melanoma screening trial is not a good idea
Br J Dermatol, 179 (2), 532-533
DOI 10.1111/bjd.16784, PubMed 29893490

Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, Eide TJ, Skovlund E, Lekven J, Schneede J, Tveit KM, Vatn M, Ursin G, Hoff G, NORCCAP Study Group† (2018)
Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial
Ann Intern Med, 168 (11), 775-782
DOI 10.7326/M17-1441, PubMed 29710125

Holme Ø, Løberg M, Kalager M, Bretthauer M, Hoff G (2018)
Long-Term Effectiveness of Sigmoidoscopy Screening in Women and Men
Ann Intern Med, 169 (9), 663-664
DOI 10.7326/L18-0512, PubMed 30398636

Jodal HC, Løberg M, Holme Ø, Adami HO, Bretthauer M, Emilsson L, Ransohoff DF, Hoff G, Kalager M (2018)
Mortality From Postscreening (Interval) Colorectal Cancers Is Comparable to That From Cancer in Unscreened Patients-A Randomized Sigmoidoscopy Trial
Gastroenterology, 155 (6), 1787-1794.e3
DOI 10.1053/j.gastro.2018.08.035, PubMed 30165051

Juul FE, Garborg K, Bretthauer M, Skudal H, Øines MN, Wiig H, Rose Ø, Seip B, Lamont JT, Midtvedt T, Valeur J, Kalager M, Holme Ø, Helsingen L, Løberg M, Adami HO (2018)
Fecal Microbiota Transplantation for Primary Clostridium difficile Infection
N Engl J Med, 378 (26), 2535-2536
DOI 10.1056/NEJMc1803103, PubMed 29860912

Kalager M (2018)
[Health without knowledge?]
Tidsskr Nor Laegeforen, 138 (5)
DOI 10.4045/tidsskr.17.1058, PubMed 29513441

Kalager M (2018)
Health without knowledge?
Tidsskr. Nor. Laegeforen., 138 (5), 432-433

Kalager M, Wieszczy P, Lansdorp-Vogelaar I, Corley DA, Bretthauer M, Kaminski MF (2018)
Overdiagnosis in Colorectal Cancer Screening: Time to Acknowledge a Blind Spot
Gastroenterology, 155 (3), 592-595
DOI 10.1053/j.gastro.2018.07.037, PubMed 30076834

Lousdal ML, Møller MH, Kristiansen IS, Kalager M, Wisløff T, Støvring H (2018)
The Screening Illustrator: separating the effects of lead-time and overdiagnosis in mammography screening
Eur J Public Health, 28 (6), 1138-1142
DOI 10.1093/eurpub/cky085, PubMed 29796623

Løberg M, Kalager M, Hoff G (2018)
Tailoring the message with selective reporting
Eur J Epidemiol, 33 (8), 773
DOI 10.1007/s10654-018-0416-6, PubMed 29846866

Pedersen IB, Løberg M, Hoff G, Kalager M, Bretthauer M, Holme Ø (2018)
Polypectomy techniques among gastroenterologists in Norway - a nationwide survey
Endosc Int Open, 6 (7), E812-E820
DOI 10.1055/a-0607-0727, PubMed 29977999

Pinsky PF, Loberg M, Senore C, Wooldrage K, Atkin W, Bretthauer M, Cross AJ, Hoff G, Holme O, Kalager M, Segnan N, Schoen RE (2018)
Number of Adenomas Removed and Colorectal Cancers Prevented in Randomized Trials of Flexible Sigmoidoscopy Screening
Gastroenterology, 155 (4), 1059-1068.e2
DOI 10.1053/j.gastro.2018.06.040, PubMed 29935150

Publications 2017

Emilsson L, Løberg M, Bretthauer M, Holme Ø, Fall K, Jodal HC, Adami HO, Kalager M (2017)
Colorectal cancer death after adenoma removal in Scandinavia
Scand J Gastroenterol, 52 (12), 1377-1384
DOI 10.1080/00365521.2017.1377763, PubMed 28906163

Holme Ø, Løberg M, Bretthauer M, Kalager M (2017)
Authors' reply to Doherty and Hawkins
BMJ, 356, j1267
DOI 10.1136/bmj.j1267, PubMed 28283482

Holme Ø, Schoen RE, Senore C, Segnan N, Hoff G, Løberg M, Bretthauer M, Adami HO, Kalager M (2017)
Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials
BMJ, 356, i6673
DOI 10.1136/bmj.i6673, PubMed 28087510

Jørgensen KJ, Gøtzsche PC, Kalager M, Zahl PH (2017)
Breast Cancer Screening in Denmark: A Cohort Study of Tumor Size and Overdiagnosis
Ann Intern Med, 166 (5), 313-323
DOI 10.7326/M16-0270, PubMed 28114661

Jørgensen KJ, Gøtzsche PC, Kalager M, Zahl PH (2017)
Breast Cancer Screening in Denmark
Ann Intern Med, 167 (7), 524
DOI 10.7326/L17-0270, PubMed 28973200

Kalager M (2017)
[Share data]
Tidsskr Nor Laegeforen, 137 (10), 679
DOI 10.4045/tidsskr.17.0446, PubMed 28551946

Kalager M (2017)
Breast cancer screening
BMJ, 359, j5625
DOI 10.1136/bmj.j5625, PubMed 29212770

Kalager M, Stoltenberg C (2017)
[Screening for the individual and knowledge for all]
Tidsskr Nor Laegeforen, 137 (12-13), 858
DOI 10.4045/tidsskr.17.0445, PubMed 28655269

Løberg M, Holme Ø, Bretthauer M, Kalager M (2017)
Colorectal adenomas, surveillance, and cancer
Lancet Oncol, 18 (8), e427
DOI 10.1016/S1470-2045(17)30473-4, PubMed 28759374

Olsen SE, Bretthauer M, Kalager M (2017)
[More harm than benefit - how much should the patients know?]
Tidsskr Nor Laegeforen, 137 (3), 175-176
DOI 10.4045/tidsskr.16.0954, PubMed 28181749

Olsen SE, Bretthauer M, Kalager M (2017)
[Not Available]
Tidsskr Nor Laegeforen, 137 (9), 599
DOI 10.4045/tidsskr.17.0296, PubMed 28468459

Olsen SE, Bretthauer M, Kalager M (2017)
More harm than benefit - how much should the patients know? Reply
Tidsskr. Nor. Laegeforen., 137 (9), 599

Publications 2016

Adami HO, Bretthauer M, Emilsson L, Hernán MA, Kalager M, Ludvigsson JF, Ekbom A (2016)
The continuing uncertainty about cancer risk in inflammatory bowel disease
Gut, 65 (6), 889-93
DOI 10.1136/gutjnl-2015-311003, PubMed 27008845

Adami HO, Csermely P, Veres DV, Emilsson L, Løberg M, Bretthauer M, Kalager M (2016)
Are rapidly growing cancers more lethal?
Eur J Cancer, 72, 210-214
DOI 10.1016/j.ejca.2016.11.011, PubMed 28042992

Berstad P, Botteri E, Larsen IK, Løberg M, Kalager M, Holme Ø, Bretthauer M, Hoff G (2016)
Lifestyle changes at middle age and mortality: a population-based prospective cohort study
J Epidemiol Community Health, 71 (1), 59-66
DOI 10.1136/jech-2015-206760, PubMed 27312250

Bretthauer M, Kalager M, Adami HO, Hoff G (2016)
Who Is for CO2? Slow Adoption of Carbon Dioxide Insufflation in Colonoscopy
Ann Intern Med, 165 (2), 145-6
DOI 10.7326/M16-0209, PubMed 27159139

Bretthauer M, Kaminski MF, Hassan C, Kalager M, Holme Ø, Hoff G, Løberg M, Regula J, Castells A, Adami HO (2016)
America, We Are Confused: The Updated U.S. Preventive Services Task Force Recommendation on Colorectal Cancer Screening
Ann Intern Med, 166 (2), 139-140
DOI 10.7326/M16-1805, PubMed 27820949

Bretthauer M, Kaminski MF, Løberg M, Zauber AG, Regula J, Kuipers EJ, Hernán MA, McFadden E, Sunde A, Kalager M, Dekker E, Lansdorp-Vogelaar I, Garborg K, Rupinski M, Spaander MC, Bugajski M, Høie O, Stefansson T, Hoff G, Adami HO, Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group (2016)
Population-Based Colonoscopy Screening for Colorectal Cancer: A Randomized Clinical Trial
JAMA Intern Med, 176 (7), 894-902
DOI 10.1001/jamainternmed.2016.0960, PubMed 27214731

Emilsson L, Holme Ø, Bretthauer M, Cook NR, Buring JE, Løberg M, Adami HO, Sesso HD, Gaziano MJ, Kalager M (2016)
Systematic review with meta-analysis: the comparative effectiveness of aspirin vs. screening for colorectal cancer prevention
Aliment Pharmacol Ther, 45 (2), 193-204
DOI 10.1111/apt.13857, PubMed 27859394

Garborg K, Wiig H, Hasund A, Matre J, Holme Ø, Noraberg G, Løberg M, Kalager M, Adami HO, Bretthauer M (2016)
Gradual stiffness versus magnetic imaging-guided variable stiffness colonoscopes: A randomized noninferiority trial
United European Gastroenterol J, 5 (1), 128-133
DOI 10.1177/2050640616639162, PubMed 28405331

Gjøstein DK, Huitfeldt A, Løberg M, Adami HO, Garborg K, Kalager M, Bretthauer M (2016)
Incentives and participation in a medical survey
Tidsskr Nor Laegeforen, 136 (12-13), 1082-7
DOI 10.4045/tidsskr.15.1096, PubMed 27381786

Holme Ø, de Lange T, Stallemo A, Wiig H, Hasund A, Dvergsnes K, Garborg K, Ystrøm CM, Løberg M, Hoff G, Bretthauer M, Kalager M (2016)
Routine vs. on-demand analgesia in colonoscopy: a randomized clinical trial
Endoscopy, 48 (9), 823-8
DOI 10.1055/s-0042-108433, PubMed 27305424

Huitfeldt A, Hernan MA, Kalager M, Robins JM (2016)
Comparative Effectiveness Research Using Observational Data: Active Comparators to Emulate Target Trials with Inactive Comparators
EGEMS (Wash DC), 4 (1), 1234
DOI 10.13063/2327-9214.1234, PubMed 27891526

Jover R, Bretthauer M, Dekker E, Holme Ø, Kaminski MF, Løberg M, Zauber AG, Hernán MA, Lansdorp-Vogelaar I, Sunde A, McFadden E, Castells A, Regula J, Quintero E, Pellisé M, Senore C, Kalager M, Dinis-Ribeiro M, Emilsson L, Ransohoff DF, Hoff G, Adami HO (2016)
Rationale and design of the European Polyp Surveillance (EPoS) trials
Endoscopy, 48 (6), 571-8
DOI 10.1055/s-0042-104116, PubMed 27042931

Jørgensen KJ, Kalager M, Barratt A, Baines C, Zahl PH, Brodersen J, Harris RP (2016)
Overview of guidelines on breast screening: Why recommendations differ and what to do about it
Breast, 31, 261-269
DOI 10.1016/j.breast.2016.08.002, PubMed 27717717

Kalager M, Adami HO, Bretthauer M (2016)
Recognizing Data Generation
N Engl J Med, 374 (19), 1898
DOI 10.1056/NEJMc1603789, PubMed 27096437

Løberg M, Holme Ø, Kalager M (2016)
Aspirin, Colorectal Cancer, and Cause of Death: A Complex Landscape
J Clin Oncol, 35 (5), 568-569
DOI 10.1200/JCO.2016.70.3751, PubMed 29236619

Løberg M, Kalager M, Bretthauer M (2016)
Commentary: "Randomize, Then Consent" or "Consent, Then Randomize"?: Revitalizing the Issue of Preconsent Randomization
Epidemiology, 27 (3), 393-4
DOI 10.1097/EDE.0000000000000469, PubMed 26849639

Publications 2015

Bretthauer M, Kalager M, Adami HO (2015)
Do's and don'ts in evaluation of endoscopic screening for gastrointestinal cancers
Endoscopy, 48 (1), 75-80
DOI 10.1055/s-0034-1393094, PubMed 26382306

Huitfeldt A, Kalager M, Robins JM, Hoff G, Hernán MA (2015)
Methods to Estimate the Comparative Effectiveness of Clinical Strategies that Administer the Same Intervention at Different Times
Curr Epidemiol Rep, 2 (3), 149-161
DOI 10.1007/s40471-015-0045-5, PubMed 26587368

Løberg M, Lousdal ML, Bretthauer M, Kalager M (2015)
Benefits and harms of mammography screening
Breast Cancer Res, 17 (1), 63
DOI 10.1186/s13058-015-0525-z, PubMed 25928287

Swanson SA, Holme Ø, Løberg M, Kalager M, Bretthauer M, Hoff G, Aas E, Hernán MA (2015)
Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening
Trials, 16, 541
DOI 10.1186/s13063-015-1056-8, PubMed 26620120

Publications 2014

Berstad P, Løberg M, Larsen IK, Kalager M, Holme Ø, Botteri E, Bretthauer M, Hoff G (2014)
Long-term lifestyle changes after colorectal cancer screening: randomised controlled trial
Gut, 64 (8), 1268-76
DOI 10.1136/gutjnl-2014-307376, PubMed 25183203

Bretthauer M, Loberg M, Kalager M (2014)
Long-Term Colorectal-Cancer Mortality after Adenoma Removal REPLY
N. Engl. J. Med., 371 (21), 2035-2036

Bretthauer M, Løberg M, Kalager M (2014)
Long-term colorectal-cancer mortality after adenoma removal
N Engl J Med, 371 (21), 2036-7
DOI 10.1056/NEJMc1411954, PubMed 25409378

Garborg K, Kaminski MF, Lindenburger W, Wiig H, Hasund A, Wronska E, Bie RB, Kleist B, Løvdal L, Holme Ø, Kalager M, Hoff G, Bretthauer M (2014)
Water exchange versus carbon dioxide insufflation in unsedated colonoscopy: a multicenter randomized controlled trial
Endoscopy, 47 (3), 192-9
DOI 10.1055/s-0034-1390795, PubMed 25412093

Hassan C, Gimeno-García A, Kalager M, Spada C, Zullo A, Costamagna G, Senore C, Rex DK, Quintero E (2014)
Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas
Aliment Pharmacol Ther, 39 (9), 905-12
DOI 10.1111/apt.12682, PubMed 24593121

Holme Ø, Bretthauer M, Eide TJ, Løberg EM, Grzyb K, Løberg M, Kalager M, Adami HO, Kjellevold Ø, Hoff G (2014)
Long-term risk of colorectal cancer in individuals with serrated polyps
Gut, 64 (6), 929-36
DOI 10.1136/gutjnl-2014-307793, PubMed 25399542

Holme Ø, Loberg M, Kalager M (2014)
Colorectal cancer and the effect of flexible sigmoidoscopy screening--reply
JAMA, 312 (22), 2411-2
DOI 10.1001/jama.2014.14695, PubMed 25490338

Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, Eide TJ, Skovlund E, Schneede J, Tveit KM, Hoff G (2014)
Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial
JAMA, 312 (6), 606-15
DOI 10.1001/jama.2014.8266, PubMed 25117129

Kalager M, Adami HO, Bretthauer M (2014)
Too much mammography
BMJ, 348, g1403
DOI 10.1136/bmj.g1403, PubMed 24519765

Kalager M, Løberg M, Bretthauer M, Adami HO (2014)
Comparative analysis of breast cancer mortality following mammography screening in Denmark and Norway
Ann Oncol, 25 (6), 1137-43
DOI 10.1093/annonc/mdu122, PubMed 24669012

Løberg M, Kalager M, Holme Ø, Hoff G, Adami HO, Bretthauer M (2014)
Long-term colorectal-cancer mortality after adenoma removal
N Engl J Med, 371 (9), 799-807
DOI 10.1056/NEJMoa1315870, PubMed 25162886

Publications 2013

Bretthauer M, Kalager M (2013)
Principles, effectiveness and caveats in screening for cancer
Br J Surg, 100 (1), 55-65
DOI 10.1002/bjs.8995, PubMed 23212620

Garborg K, Holme Ø, Løberg M, Kalager M, Adami HO, Bretthauer M (2013)
Current status of screening for colorectal cancer
Ann Oncol, 24 (8), 1963-72
DOI 10.1093/annonc/mdt157, PubMed 23619033

Hassan C, Quintero E, Dumonceau JM, Regula J, Brandão C, Chaussade S, Dekker E, Dinis-Ribeiro M, Ferlitsch M, Gimeno-García A, Hazewinkel Y, Jover R, Kalager M, Loberg M, Pox C, Rembacken B, Lieberman D, European Society of Gastrointestinal Endoscopy (2013)
Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Endoscopy, 45 (10), 842-51
DOI 10.1055/s-0033-1344548, PubMed 24030244

Kalager M (2013)
Overdiagnosis in breast cancer screening: women have minimal prior awareness of the issue, and their screening intentions are influenced by the size of the risk
Evid Based Nurs, 17 (1), 7-8
DOI 10.1136/eb-2013-101281, PubMed 24001593

Kalager M, Løberg M, Fønnebø VM, Bretthauer M (2013)
Failure to account for selection-bias
Int J Cancer, 133 (11), 2751-3
DOI 10.1002/ijc.28244, PubMed 23649899

Thiis-Evensen E, Kalager M, Bretthauer M, Hoff G (2013)
Long-term effectiveness of endoscopic screening on incidence and mortality of colorectal cancer: A randomized trial
United European Gastroenterol J, 1 (3), 162-8
DOI 10.1177/2050640613483290, PubMed 24917955

Publications 2012

Berstad P, Løberg M, Kalager M, Jørgensen A, Garborg K, Ruud HK, Bretthauer M, Hoff G (2012)
Risk stratification for advanced colorectal neoplasia--letter
Cancer Prev Res (Phila), 5 (12), 1405; author reply 1406
DOI 10.1158/1940-6207.CAPR-12-0383, PubMed 23151804

Bretthauer M, Kalager M (2012)
Colonoscopy as a triage screening test
N Engl J Med, 366 (8), 759-60
DOI 10.1056/NEJMe1114639, PubMed 22356330

Bretthauer M, Kalager M (2012)
Colorectal-Cancer Screening Reply
N. Engl. J. Med., 366 (22), 2131

Garborg KK, Løberg M, Matre J, Holme O, Kalager M, Hoff G, Bretthauer M (2012)
Reduced pain during screening colonoscopy with an ultrathin colonoscope: a randomized controlled trial
Endoscopy, 44 (8), 740-6
DOI 10.1055/s-0032-1309755, PubMed 22622786

Jørgensen KJ, Kalager M, Zahl PH, Fønnebø VM (2012)
Comparing attendees with non-attendees in breast screening does not provide useful information about an effect on prognostic features or mortality
Breast Cancer Res Treat, 136 (2), 617-8, author reply 619-20
DOI 10.1007/s10549-012-2250-y, PubMed 23011508

Kalager M (2012)
[First, do no harm]
Tidsskr Nor Laegeforen, 132 (4), 383
DOI 10.4045/tidsskr.12.0079, PubMed 22353816

Kalager M (2012)
Letter to the Editor: Hofvind S, Skaane P. Stage distribution of breast cancer diagnosed before and after implementation of population-based mammographic screening. Fortschr Röntgenstr 2012; 184: 437-442
Rofo, 184 (8), 746; author reply 746-7
DOI 10.1055/s-0032-1313010, PubMed 22851265

Kalager M, Adami HO, Bretthauer M, Tamimi RM (2012)
Overdiagnosis of invasive breast cancer due to mammography screening: results from the Norwegian screening program
Ann Intern Med, 156 (7), 491-9
DOI 10.7326/0003-4819-156-7-201204030-00005, PubMed 22473436

Kalager M, Adami HO, Bretthauer M, Tamimi RM (2012)
Overdiagnosis of Invasive Breast Cancer due to Mammography Screening RESPONSE
Ann. Intern. Med., 157 (3), 221-222
DOI 10.7326/0003-4819-157-3-201208070-00025

Kalager M, Løberg M, Bretthauer M (2012)
Limited use of nonprogram screening in Norway
Int J Cancer, 132 (7), 1723-4
DOI 10.1002/ijc.27807, PubMed 22933134

Kalager M, Tamimi RM, Bretthauer M, Adami HO (2012)
Prognosis in women with interval breast cancer: population based observational cohort study
BMJ, 345, e7536
DOI 10.1136/bmj.e7536, PubMed 23160783

Smith RA, Kerlikowske K, Miglioretti DL, Kalager M (2012)
Clinical decisions. Mammography screening for breast cancer
N Engl J Med, 367 (21), e31
DOI 10.1056/NEJMclde1212888, PubMed 23171121

Publications 2011

Kalager M (2011)
Regression of screening-detected breast cancer
Lancet Oncol, 12 (12), 1083-4
DOI 10.1016/S1470-2045(11)70262-5, PubMed 21996167

Publications 2010

Kalager M, Zelen M, Langmark F, Adami HO (2010)
Effect of screening mammography on breast-cancer mortality in Norway
N Engl J Med, 363 (13), 1203-10
DOI 10.1056/NEJMoa1000727, PubMed 20860502

Publications 2009

Kalager M, Bretthauer M (2009)
Spontaneous regression of invasive breast cancer: does this study answer the question?
Arch Intern Med, 169 (10), 997
DOI 10.1001/archinternmed.2009.91, PubMed 19468097

Kalager M, Haldorsen T, Bretthauer M, Hoff G, Thoresen SO, Adami HO (2009)
Improved breast cancer survival following introduction of an organized mammography screening program among both screened and unscreened women: a population-based cohort study
Breast Cancer Res, 11 (4), R44
DOI 10.1186/bcr2331, PubMed 19575807

Kalager M, Kåresen R, Wist E (2009)
[Survival after breast cancer--differences between Norwegian counties]
Tidsskr Nor Laegeforen, 129 (24), 2595-600
DOI 10.4045/tidsskr.09.0024, PubMed 20029554

Publications 2008

Kalager M (2008)
[Unclear about overdiagnosis of breast cancer]
Ugeskr Laeger, 170 (33), 2473; author reply 2473
PubMed 18763381

Publications 2000

Bretthauer M, Kalager M (2000)
[Practice from Germany not sanctioned as specialist education in Norway]
Tidsskr Nor Laegeforen, 120 (21), 2580-1
PubMed 11071005

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