Lars O. Baumbusch

  • Senior scientist and project leader; MSc, PhD (Dr.)
  • +47 23 07 33 72

Education

01.2020 - 06.2020     Oslo Metropolitan University, Oslo, Norway
                                    Evaluated for professor competence
01.1997 - 11.2001     Div. of Molecular Biology, Dep. of Biology, University of Oslo, Norway
                                    Dr. scient. (equivalent PhD)
10.1993 - 06.1996     Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
                                    Diploma in Biology (equivalent MSc or cand. scient.)
10.1992 - 09.1993     Dep. of Botany, Trinity College Dublin, Ireland
                                    Studies abroad and student project
10.1989 - 09.1992     Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
                                    Intermediate diploma in biology (equivalent BSc or cand. mag.)
04.1989 - 09.1989     Philosophical faculty, Albert-Ludwig University of Freiburg, Germany
                                    Philosophical studies
08.1987 - 03.1989     St. Fidelius Parish, Offenburg, Germany
                                    Civilian service
08.1978 - 05.1987     Max-Planck Gymnasium Lahr, Germany
                                    Abitur (equivalent university-entrance diploma or examen artium)
08.1974 - 07.1978     Grund- und Hauptschule Sulz, Lahr, Germany
                                    Primary school

Professional experience

04.2021 - present     Dep. of Pediatric Research (PFI), Division of Pediatric and Adolescent Medicine,
                                    Oslo University Hospital (OUS) Rikshospitalet, Oslo, Norway
                                    Senior scientist

01.2021 - 05.2021     Dep. of Mechanical, Electronics and Chemical Engineering,
                                     Oslo Metropolitan University, Oslo, Norway
                                     Professor

01.2020 - 05.2020     Dep. of Mechanical, Electronics and Chemical Engineering,
01.2019 - 05.2019     Oslo Metropolitan University, Oslo, Norway
01.2018 - 05.2018     Associate professor (equivalent førsteamanuensis)

11.2012 - 03.2021     Dep. of Pediatric Research, Division of Pediatric and Adolescent Medicine,
                                    Oslo University Hospital Rikshospitalet, Oslo, Norway
                                    Scientist and project manager

05.2007 - 10.2012     Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
                                    Oslo University Hospital Radiumhospitalet, Oslo, Norway
                                     Scientist and project group leader

09.2006 - 06.2010     Biomedical Research group, Dep. of Informatics, University of Oslo, Norway
                                    Adjunct associate professor (equivalent førsteamanuensis-II)

12.2001 - 04.2007     Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
                                    Oslo University Hospital Radiumhospitalet, Oslo, Norway
                                    Post-doc


Research projects:

visit to the Baumbusch project group home page - Molecular biology of oxidative stress and cancer

 

 

Publications 2021

Hermansen JU, Wojcik DM, Robinson N, Pahnke J, Haugland HK, Jamtøy AH, Flaegstad T, Halvorsen H, Lund B, Baumbusch LO, Munthe-Kaas MC (2021)
The Norwegian childhood cancer biobank
Cancer Rep (Hoboken), e1555
DOI 10.1002/cnr2.1555, PubMed 34541832

Publications 2020

Zasada M, Madetko-Talowska A, Revhaug C, Rognlien AGW, Baumbusch LO, Książek T, Szewczyk K, Grabowska A, Bik-Multanowski M, Józef Pietrzyk J, Kwinta P, Didrik Saugstad O (2020)
Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity
Pediatr Res, 88 (3), 391-397
DOI 10.1038/s41390-020-0793-x, PubMed 32053824

Publications 2019

Rajar P, Åsegg-Atneosen M, Saugstad OD, Solberg R, Baumbusch LO (2019)
Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia
PLoS One, 14 (12), e0227066
DOI 10.1371/journal.pone.0227066, PubMed 31891615

Revhaug C, Bik-Multanowski M, Zasada M, Rognlien AGW, Günther CC, Ksiązek T, Madetko-Talowska A, Szewczyk K, Grabowska A, Kwinta P, Pietrzyk JJ, Baumbusch LO, Saugstad OD (2019)
Immune System Regulation Affected by a Murine Experimental Model of Bronchopulmonary Dysplasia: Genomic and Epigenetic Findings
Neonatology, 116 (3), 269-277
DOI 10.1159/000501461, PubMed 31454811

Revhaug C, Zasada M, Rognlien AGW, Günther CC, Grabowska A, Książek T, Madetko-Talowska A, Szewczyk K, Bik-Multanowski M, Kwinta P, Pietrzyk JJ, Baumbusch LO, Saugstad OD (2019)
Pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia
J Matern Fetal Neonatal Med, 33 (12), 2122-2130
DOI 10.1080/14767058.2018.1541081, PubMed 30428746

Zasada M, Madetko-Talowska A, Revhaug C, Rognlien AGW, Baumbusch LO, Książek T, Szewczyk K, Grabowska A, Bik-Multanowski M, Józef Pietrzyk J, Kwinta P, Saugstad OD (2019)
Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy
Pediatr Res, 87 (3), 485-493
DOI 10.1038/s41390-019-0598-y, PubMed 31578039

Zasada M, Suski M, Bokiniec R, Szwarc-Duma M, Borszewska-Kornacka MK, Madej J, Bujak-Giżycka B, Madetko-Talowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2019)
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
Ital J Pediatr, 45 (1), 112
DOI 10.1186/s13052-019-0676-0, PubMed 31445514

Publications 2018

Benterud T, Manueldas S, Rivera S, Henckel E, Løberg EM, Norgren S, Baumbusch LO, Solberg R, Saugstad OD (2018)
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide
Dis Markers, 2018, 5046372
DOI 10.1155/2018/5046372, PubMed 29651324

Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK (2018)
Correction to: A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 18 (1), 80
DOI 10.1186/s12885-017-3766-7, PubMed 29338700

Manueldas S, Benterud T, Rueegg CS, Garberg HT, Huun MU, Pankratov L, Åsegg-Atneosen M, Solberg R, Escobar J, Saugstad OD, Baumbusch LO (2018)
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia
PLoS One, 13 (11), e0206601
DOI 10.1371/journal.pone.0206601, PubMed 30475817

Suski M, Bokiniec R, Szwarc-Duma M, Madej J, Bujak-Giżycka B, Borszewska-Kornacka MK, Książek T, Grabowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2018)
Plasma proteome changes in cord blood samples from preterm infants
J Perinatol, 38 (9), 1182-1189
DOI 10.1038/s41372-018-0150-7, PubMed 29910464

Suski M, Bokiniec R, Szwarc-Duma M, Madej J, Bujak-Giżycka B, Kwinta P, Borszewska-Kornacka MK, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ (2018)
Prospective plasma proteome changes in preterm infants with different gestational ages
Pediatr Res, 84 (1), 104-111
DOI 10.1038/s41390-018-0003-2, PubMed 29795197

Zasada M, Suski M, Bokiniec R, Szwarc-Duma M, Borszewska-Kornacka MK, Madej J, Bujak-Gizycka B, Madetko-Talowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2018)
An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity
Invest Ophthalmol Vis Sci, 59 (13), 5312-5319
DOI 10.1167/iovs.18-24914, PubMed 30398622

Publications 2017

Kwinta P, Bokiniec R, Bik-Multanowski M, Gunther CC, Grabowska A, Książek T, Madetko-Talowska A, Szewczyk K, Szwarc-Duma M, Borszewska-Kornacka MK, Baumbusch LO, Revhaug C, Saugstad OD, Pietrzyk JJ (2017)
Comparison of whole genome expression profile between preterm and full-term newborns
Ginekol Pol, 88 (8), 434-441
DOI 10.5603/GP.a2017.0080, PubMed 28930370

Publications 2016

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholmen G, Ahmed MS, Sandvik L, Norgren S, Bjørås M, Baumbusch LO, Solberg R, Saugstad OD (2016)
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255, PubMed 27497671

Demeulemeester J, Kumar P, Møller EK, Nord S, Wedge DC, Peterson A, Mathiesen RR, Fjelldal R, Zamani Esteki M, Theunis K, Fernandez Gallardo E, Grundstad AJ, Borgen E, Baumbusch LO, Børresen-Dale AL, White KP, Kristensen VN, Van Loo P, Voet T, Naume B (2016)
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Genome Biol, 17 (1), 250
DOI 10.1186/s13059-016-1109-7, PubMed 27931250

Garberg HT, Huun MU, Baumbusch LO, Åsegg-Atneosen M, Solberg R, Saugstad OD (2016)
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets
Neonatology, 111 (2), 133-139
DOI 10.1159/000449032, PubMed 27750254

Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK (2016)
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16 (1), 913
DOI 10.1186/s12885-016-2899-4, PubMed 27876019

Publications 2015

Benterud T, Pankratov L, Solberg R, Bolstad N, Skinningsrud A, Baumbusch L, Sandvik L, Saugstad OD (2015)
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs
PLoS One, 10 (10), e0140966
DOI 10.1371/journal.pone.0140966, PubMed 26501201

Gul KA, Øverland T, Osnes L, Baumbusch LO, Pettersen RD, Lima K, Abrahamsen TG (2015)
Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features
J Clin Immunol, 35 (4), 408-15
DOI 10.1007/s10875-015-0153-5, PubMed 25814142

Publications 2014

Reiche K, Kasack K, Schreiber S, Lüders T, Due EU, Naume B, Riis M, Kristensen VN, Horn F, Børresen-Dale AL, Hackermüller J, Baumbusch LO (2014)
Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes
PLoS One, 9 (9), e106076
DOI 10.1371/journal.pone.0106076, PubMed 25264628

Publications 2013

Aure MR, Steinfeld I, Baumbusch LO, Liestøl K, Lipson D, Nyberg S, Naume B, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Lingjærde OC, Yakhini Z (2013)
Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data
PLoS One, 8 (1), e53014
DOI 10.1371/journal.pone.0053014, PubMed 23382830

Baumbusch LO, Helland Å, Wang Y, Liestøl K, Schaner ME, Holm R, Etemadmoghadam D, Alsop K, Brown P, Australian Ovarian Cancer Study Group, Mitchell G, Fereday S, DeFazio A, Bowtell DD, Kristensen GB, Lingjærde OC, Børresen-Dale AL (2013)
High levels of genomic aberrations in serous ovarian cancers are associated with better survival
PLoS One, 8 (1), e54356
DOI 10.1371/journal.pone.0054356, PubMed 23372714

Liu Y, Zhou R, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Aarøe J, Wärnberg F, Børresen-Dale AL, Mills GB, Thompson PA, Bondy ML (2013)
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
Breast Cancer Res Treat, 143 (1), 189-201
DOI 10.1007/s10549-013-2796-3, PubMed 24305980

Møller EK, Kumar P, Voet T, Peterson A, Van Loo P, Mathiesen RR, Fjelldal R, Grundstad J, Borgen E, Baumbusch LO, Naume B, Børresen-Dale AL, White KP, Nord S, Kristensen VN (2013)
Next-generation sequencing of disseminated tumor cells
Front Oncol, 3, 320
DOI 10.3389/fonc.2013.00320, PubMed 24427740

Publications 2012

Nilsen G, Liestøl K, Van Loo P, Moen Vollan HK, Eide MB, Rueda OM, Chin SF, Russell R, Baumbusch LO, Caldas C, Børresen-Dale AL, Lingjaerde OC (2012)
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591, PubMed 23442169

Otto B, Gruner K, Heinlein C, Wegwitz F, Nollau P, Ylstra B, Pantel K, Schumacher U, Baumbusch LO, Martin-Subero JI, Siebert R, Wagener C, Streichert T, Deppert W, Tolstonog GV (2012)
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
Int J Cancer, 132 (6), 1300-10
DOI 10.1002/ijc.27783, PubMed 22907219

Publications 2011

Mathiesen RR, Fjelldal R, Liestøl K, Due EU, Geigl JB, Riethdorf S, Borgen E, Rye IH, Schneider IJ, Obenauf AC, Mauermann O, Nilsen G, Christian Lingjaerde O, Børresen-Dale AL, Pantel K, Speicher MR, Naume B, Baumbusch LO (2011)
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Int J Cancer, 131 (4), E405-15
DOI 10.1002/ijc.26444, PubMed 21935921

Molloy TJ, Bosma AJ, Baumbusch LO, Synnestvedt M, Borgen E, Russnes HG, Schlichting E, van't Veer LJ, Naume B (2011)
The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Breast Cancer Res, 13 (3), R61
DOI 10.1186/bcr2898, PubMed 21672237

Publications 2010

Russnes HG, Vollan HKM, Lingjærde OC, Krasnitz A, Lundin P, Naume B, Sørlie T, Borgen E, Rye IH, Langerød A, Chin SF, Teschendorff AE, Stephens PJ, Månér S, Schlichting E, Baumbusch LO, Kåresen R, Stratton MP, Wigler M, Caldas C, Zetterberg A, Hicks J, Børresen-Dale AL (2010)
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Sci Transl Med, 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611, PubMed 20592421

Publications 2009

Geigl JB, Obenauf AC, Waldispuehl-Geigl J, Hoffmann EM, Auer M, Hörmann M, Fischer M, Trajanoski Z, Schenk MA, Baumbusch LO, Speicher MR (2009)
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays
Nucleic Acids Res, 37 (15), e105
DOI 10.1093/nar/gkp526, PubMed 19541849

Publications 2008

Baumbusch LO, Aarøe J, Johansen FE, Hicks J, Sun H, Bruhn L, Gunderson K, Naume B, Kristensen VN, Liestøl K, Børresen-Dale AL, Lingjaerde OC (2008)
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
BMC Genomics, 9, 379
DOI 10.1186/1471-2164-9-379, PubMed 18691401

Publications 2006

Baumbusch LO, Myhre S, Langerød A, Bergamaschi A, Geisler SB, Lønning PE, Deppert W, Dornreiter I, Børresen-Dale AL (2006)
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters
Mol Cancer, 5, 47
DOI 10.1186/1476-4598-5-47, PubMed 17054774

Publications 2004

Baumbusch LO, Hughes DW, Galau GA, Jakobsen KS (2004)
LEC1, FUS3, ABI3 and Em expression reveals no correlation with dormancy in Arabidopsis
J Exp Bot, 55 (394), 77-87
DOI 10.1093/jxb/erh014, PubMed 14676287

Lingjaerde OC, Baumbusch LO, Liestøl K, Glad IK, Børresen-Dale AL (2004)
CGH-Explorer: a program for analysis of array-CGH data
Bioinformatics, 21 (6), 821-2
DOI 10.1093/bioinformatics/bti113, PubMed 15531610

Publications 2001

Baumbusch LO (2001)
Identification and analysis of genes controlling embryogenesis and embryo dormancy in plants
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 181, 1 b. (flere pag.)
BIBSYS 012230200

Baumbusch LO, Sundal IK, Hughes DW, Galau GA, Jakobsen KS (2001)
Efficient protocols for CAPS-based mapping in Arabidopsis
Plant Mol. Biol. Rep., 19 (2), 137-149
DOI 10.1007/BF02772156

Baumbusch LO, Thorstensen T, Krauss V, Fischer A, Naumann K, Assalkhou R, Schulz I, Reuter G, Aalen RB (2001)
The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes
Nucleic Acids Res, 29 (21), 4319-33
DOI 10.1093/nar/29.21.4319, PubMed 11691919

Publications 1999

Polle A, Baumbusch LO, Oschinski C, Eiblmeier M, Kuhlenkamp V, Vollrath B, Scholz F, Rennenberg H (1999)
Growth and protection against oxidative stress in young clones and mature spruce trees (Picea abies L.) at high altitudes
Oecologia, 121 (2), 149-156
DOI 10.1007/s004420050916, PubMed 28308554

Publications 1998

Baumbusch LO, Eiblmeier M, Schnitzler JP, Heller W, Sandermann H, Polle A (1998)
Interactive effects of ozone and low UV-B radiation on antioxidants in spruce (Picea abies) and pine (Pinus sylvestris) needles
Physiol Plant, 104 (2), 248-254
DOI 10.1034/j.1399-3054.1998.1040213.x, PubMed 28244603

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