Publications by Øyvind Sverre Bruland
215 publications found
Publications 2024
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Discontinuation of imatinib in patients with oligometastatic gastrointestinal stromal tumour who are in complete radiological remission: a prospective multicentre phase II study
Acta Oncol, 63, 288-293
DOI 10.2340/1651-226X.2024.39851, PubMed 38712513 -
Denosumab induction and Zoledronic acid maintenance therapy for recurrent unresectable giant cell tumour of the distal tibia: A case report with sustained tumour control after drug withdrawal
J Bone Oncol, 45, 100596
DOI 10.1016/j.jbo.2024.100596, PubMed 38545297
Publications 2023
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Editorial: Targeted alpha particle therapy in oncology
Front Med (Lausanne), 10, 1165747
DOI 10.3389/fmed.2023.1165747, PubMed 36960341 -
Exploring the Patient Perspective of Bone Sarcoma Survivors Who Have Undergone Particle Radiotherapy Abroad
Anticancer Res, 43 (5), 2031-2039
DOI 10.21873/anticanres.16364, PubMed 37097689 -
Radiation safety considerations for the use of radium-224-calciumcarbonate-microparticles in patients with peritoneal metastasis
Front Med (Lausanne), 10, 1058914
DOI 10.3389/fmed.2023.1058914, PubMed 36844217 -
Dual targeting with 224Ra/212Pb-conjugates for targeted alpha therapy of disseminated cancers: A conceptual approach
Front Med (Lausanne), 9, 1051825
DOI 10.3389/fmed.2022.1051825, PubMed 36733936 -
First experience with 224Radium-labeled microparticles (Radspherin®) after CRS-HIPEC for peritoneal metastasis in colorectal cancer (a phase 1 study)
Front Med (Lausanne), 10, 1070362
DOI 10.3389/fmed.2023.1070362, PubMed 36936230 -
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
Nat Commun, 14 (1), 3375
DOI 10.1038/s41467-023-39097-x, PubMed 37291203 -
Outcome of rare primary malignant bone sarcoma treated with multimodal therapy: Results from the EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.)
Cancer, 129 (22), 3564-3573
DOI 10.1002/cncr.34964, PubMed 37530385 -
Effect of Intraperitoneal 224Radium-Labelled Microparticles on Compartmentalized Inflammation After Cytoreductive Surgery and Hypertherm Intraperitoneal Chemotherapy
Technol Cancer Res Treat, 22, 15330338231192902
DOI 10.1177/15330338231192902, PubMed 37574949 -
Psychological and social challenges of patients with locally advanced and metastatic gastrointestinal stromal tumours (GIST) on long-term treatment with tyrosine kinase inhibitors: a qualitative study with patients and medical oncologists
Support Care Cancer, 31 (6), 352
DOI 10.1007/s00520-023-07810-7, PubMed 37233829
Publications 2022
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Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)
BMC Cancer, 22 (1), 629
DOI 10.1186/s12885-022-09697-9, PubMed 35672690 -
Real-world evidence on perioperative chemotherapy in localized soft tissue sarcoma of the extremities and trunk wall; a population-based study
Acta Oncol, 61 (7), 793-800
DOI 10.1080/0284186X.2022.2082259, PubMed 35698755 -
Hope as a Lifeline: Imatinib Discontinuation in Patients With Oligometastatic Gastrointestinal Stromal Tumours
Anticancer Res, 42 (2), 955-963
DOI 10.21873/anticanres.15555, PubMed 35093895 -
Particle Therapy in Adult Patients with Pelvic Ewing Sarcoma-Tumor and Treatment Characteristics and Early Clinical Outcomes
Cancers (Basel), 14 (24)
DOI 10.3390/cancers14246045, PubMed 36551530 -
Factors Influencing the Therapeutic Efficacy of the PSMA Targeting Radioligand 212Pb-NG001
Cancers (Basel), 14 (11)
DOI 10.3390/cancers14112784, PubMed 35681766 -
Targeted alpha therapy with the 224Ra/212Pb-TCMC-TP-3 dual alpha solution in a multicellular tumor spheroid model of osteosarcoma
Front Med (Lausanne), 9, 1058863
DOI 10.3389/fmed.2022.1058863, PubMed 36507500
Publications 2021
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Does the Lightning Process Training Programme Reduce Chronic Fatigue in Adolescent and Young Adult Cancer Survivors? A Mixed-Methods Pilot Study
Cancers (Basel), 13 (16)
DOI 10.3390/cancers13164076, PubMed 34439229 -
Preclinical and Clinical Status of PSMA-Targeted Alpha Therapy for Metastatic Castration-Resistant Prostate Cancer
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040779, PubMed 33668474 -
Early immunohistochemical detection of pulmonary micrometastases in dogs with osteosarcoma
Acta Vet Scand, 63 (1), 41
DOI 10.1186/s13028-021-00608-9, PubMed 34732227 -
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial
JAMA Oncol, 7 (1), e205865
DOI 10.1001/jamaoncol.2020.5865, PubMed 33180100 -
Calcium Carbonate Microparticles as Carriers of 224Ra: Impact of Specific Activity in Mice with Intraperitoneal Ovarian Cancer
Curr Radiopharm, 14 (2), 145-153
DOI 10.2174/1874471013666201201102056, PubMed 33261548 -
Radon-220 diffusion from 224Ra-labeled calcium carbonate microparticles: Some implications for radiotherapeutic use
PLoS One, 16 (3), e0248133
DOI 10.1371/journal.pone.0248133, PubMed 33662039 -
Multimodal functional imaging for early response assessment in patients with gastrointestinal stromal tumor treated with tyrosine kinase inhibitors
Acta Radiol, 63 (8), 995-1004
DOI 10.1177/02841851211027389, PubMed 34171968 -
[Cancer therapy with isolated limb perfusion]
Tidsskr Nor Laegeforen, 141 (2021-12)
DOI 10.4045/tidsskr.21.0194, PubMed 34505491 -
Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094815, PubMed 34062920 -
Health-Related Quality of Life Issues Experienced by Thoracic and Breast Sarcoma Patients: A Rare and Understudied Group
J Clin Med, 10 (22)
DOI 10.3390/jcm10225334, PubMed 34830615
Publications 2020
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Preoperative accelerated radiotherapy combined with chemotherapy in a defined cohort of patients with high risk soft tissue sarcoma: a Scandinavian Sarcoma Group study
Clin Sarcoma Res, 10 (1), 22
DOI 10.1186/s13569-020-00145-5, PubMed 33292545 -
Use of a simple form to facilitate communication on long-term consequences of treatment in sarcoma survivors
Clin Sarcoma Res, 10, 2
DOI 10.1186/s13569-019-0124-3, PubMed 31969978 -
The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review
Front Oncol, 10, 1402
DOI 10.3389/fonc.2020.01402, PubMed 32850452 -
Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples
Appl Radiat Isot, 166, 109362
DOI 10.1016/j.apradiso.2020.109362, PubMed 32979756 -
In situ Generated 212Pb-PSMA Ligand in a 224Ra-Solution for Dual Targeting of Prostate Cancer Sclerotic Stroma and PSMA-positive Cells
Curr Radiopharm, 13 (2), 130-141
DOI 10.2174/1874471013666200511000532, PubMed 32389119 -
Preparation of the alpha-emitting prostate-specific membrane antigen targeted radioligand [212 Pb]Pb-NG001 for prostate cancer
J Labelled Comp Radiopharm, 63 (3), 129-143
DOI 10.1002/jlcr.3825, PubMed 31919866
Publications 2019
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Prognostic Impact of Proximal Versus Distal Localization in Extremity Long Bone Osteosarcomas
Anticancer Res, 39 (5), 2459-2466
DOI 10.21873/anticanres.13365, PubMed 31092440 -
Perspectives on treatment side effects in patients with metastatic gastrointestinal stromal tumour: a qualitative study
Clin Sarcoma Res, 9, 6
DOI 10.1186/s13569-019-0116-3, PubMed 31061697 -
Ewing Sarcoma in Nepal Treated With Combined Chemotherapy and Definitive Radiotherapy
J Glob Oncol, 5, 1-10
DOI 10.1200/JGO.19.00015, PubMed 30917070 -
Treating osteosarcoma with CAR T cells
Scand J Immunol, 89 (3), e12741
DOI 10.1111/sji.12741, PubMed 30549299 -
Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort
Acta Oncol, 58 (3), 273-282
DOI 10.1080/0284186X.2018.1554260, PubMed 30632866
Publications 2018
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Clinical epidemiology and treatment outcomes of spindle cell non-osteogenic bone sarcomas - A nationwide population-based study
J Bone Oncol, 14, 002-2
DOI 10.1016/j.jbo.2018.11.002, PubMed 30568874 -
Validity and completeness of the Scandinavian Sarcoma Group Central Register by comparison with a nationwide cohort of patients with osteosarcoma in Norway
J Surg Oncol, 118 (1), 246-247
DOI 10.1002/jso.25137, PubMed 30208205 -
Genotype and risk of tumour rupture in gastrointestinal stromal tumour
Br J Surg, 105 (2), e169-e175
DOI 10.1002/bjs.10743, PubMed 29341147 -
Alkaline phosphatase in metastatic castration-resistant prostate cancer: reassessment of an older biomarker
Future Oncol, 14 (24), 2543-2556
DOI 10.2217/fon-2018-0087, PubMed 29925281 -
Osteonecrosis of the Jaw in a Patient With Bone Metastatic Prostate Cancer After Long-term Bisphosphonate Treatment With Severe Deterioration Following Radium-223
Clin Genitourin Cancer, 16 (5), 328-331
DOI 10.1016/j.clgc.2018.05.003, PubMed 29861164 -
Ewing sarcoma of the mobile spine; predictive factors for survival, neurological function and local control. A Scandinavian sarcoma group study with a mean follow-up of 12 years
J Bone Oncol, 14, 100216
DOI 10.1016/j.jbo.2018.100216, PubMed 30666289 -
[Not Available]
Tidsskr Nor Laegeforen, 138 (15)
DOI 10.4045/tidsskr.18.0200, PubMed 30277049 -
Recurrence-Free Survival After Resection of Gastric Gastrointestinal Stromal Tumors Classified According to a Strict Definition of Tumor Rupture: A Population-Based Study
Ann Surg Oncol, 25 (5), 1133-1139
DOI 10.1245/s10434-018-6353-5, PubMed 29435684 -
Adjuvant chemotherapy and postoperative radiotherapy in high-risk soft tissue sarcoma patients defined by biological risk factors-A Scandinavian Sarcoma Group study (SSG XX)
Eur J Cancer, 99, 78-85
DOI 10.1016/j.ejca.2018.05.011, PubMed 29929092 -
Therapeutic Effect of α-Emitting 224Ra-Labeled Calcium Carbonate Microparticles in Mice with Intraperitoneal Ovarian Cancer
Transl Oncol, 11 (2), 259-267
DOI 10.1016/j.tranon.2017.12.011, PubMed 29413758 -
Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice
J Labelled Comp Radiopharm, 61 (6), 472-486
DOI 10.1002/jlcr.3610, PubMed 29380410
Publications 2017
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Prediction of long-term survival in patients with metastatic gastrointestinal stromal tumor: analysis of a large, single-institution cohort
Acta Oncol, 56 (10), 1317-1323
DOI 10.1080/0284186X.2017.1330555, PubMed 28557540 -
Three-year Safety of Radium-223 Dichloride in Patients with Castration-resistant Prostate Cancer and Symptomatic Bone Metastases from Phase 3 Randomized Alpharadin in Symptomatic Prostate Cancer Trial
Eur Urol, 73 (3), 427-435
DOI 10.1016/j.eururo.2017.06.021, PubMed 28705540 -
An exploratory analysis of alkaline phosphatase, lactate dehydrogenase, and prostate-specific antigen dynamics in the phase 3 ALSYMPCA trial with radium-223
Ann Oncol, 28 (5), 1090-1097
DOI 10.1093/annonc/mdx044, PubMed 28453701
Publications 2016
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Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
PLoS One, 11 (9), e0163859
DOI 10.1371/journal.pone.0163859, PubMed 27685995 -
Clinical implications of repeated drug monitoring of imatinib in patients with metastatic gastrointestinal stromal tumour
Clin Sarcoma Res, 6, 21
DOI 10.1186/s13569-016-0062-2, PubMed 27999655 -
Definition and clinical significance of tumour rupture in gastrointestinal stromal tumours of the small intestine
Br J Surg, 103 (6), 684-691
DOI 10.1002/bjs.10104, PubMed 26988241 -
Multimodal treatment of craniofacial osteosarcoma with high-grade histology. A single-center experience over 35 years
Neurosurg Rev, 40 (3), 449-460
DOI 10.1007/s10143-016-0802-z, PubMed 27858303 -
Efficacy and Safety of Radium-223 Dichloride in Symptomatic Castration-resistant Prostate Cancer Patients With or Without Baseline Opioid Use From the Phase 3 ALSYMPCA Trial
Eur Urol, 70 (5), 875-883
DOI 10.1016/j.eururo.2016.06.002, PubMed 27344296 -
Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature
Clin Sarcoma Res, 6, 2
DOI 10.1186/s13569-016-0042-6, PubMed 26913180 -
Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma
PLoS One, 11 (10), e0165382
DOI 10.1371/journal.pone.0165382, PubMed 27776176
Publications 2015
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Corrigendum to "Primary bone cancer in Leonbergers may be associated with a higher bodyweight during adolescence" [Prev. Vet. Med. 119 (2015) 48-53]
Prev Vet Med, 120 (2), 252
DOI 10.1016/j.prevetmed.2015.03.015, PubMed 31159133 -
Primary bone cancer in Leonbergers may be associated with a higher bodyweight during adolescence
Prev Vet Med, 119 (1-2), 48-53
DOI 10.1016/j.prevetmed.2015.02.003, PubMed 25732913 -
Extraskeletal osteosarcoma in Norway, between 1975 and 2009, and a brief review of the literature
Anticancer Res, 35 (4), 2129-40
PubMed 25862869 -
Prognostic factors and treatment results of high-grade osteosarcoma in norway: a scope beyond the "classical" patient
Sarcoma, 2015, 516843
DOI 10.1155/2015/516843, PubMed 25784831 -
Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009
Sarcoma, 2015, 917679
DOI 10.1155/2015/917679, PubMed 26412976 -
Negative and Positive Consequences of Cancer Treatment Experienced by Long-term Osteosarcoma Survivors: A Qualitative Study
Anticancer Res, 35 (11), 6081-90
PubMed 26504033 -
Cured of primary bone cancer, but at what cost: a qualitative study of functional impairment and lost opportunities
Sarcoma, 2015, 484196
DOI 10.1155/2015/484196, PubMed 25949211 -
Can Imatinib Be Safely Withdrawn in Patients with Surgically Resected Metastatic GIST?
Anticancer Res, 35 (11), 5759-65
PubMed 26503996 -
Radium-223 in the treatment of osteoblastic metastases: a critical clinical review
Int J Radiat Oncol Biol Phys, 91 (5), 898-906
DOI 10.1016/j.ijrobp.2014.12.061, PubMed 25832684 -
Influence of multiple UV exposures on serum cobalamin and vitamin D levels in healthy females
Scand J Public Health, 43 (3), 324-30
DOI 10.1177/1403494815572206, PubMed 25740614 -
Vitamin D levels and dietary intake among patients with benign soft tissue tumors and sarcomas
Anticancer Res, 35 (2), 1171-80
PubMed 25667508
Publications 2014
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Time-trends on incidence and survival in a nationwide and unselected cohort of patients with skeletal osteosarcoma
Acta Oncol, 54 (1), 25-33
DOI 10.3109/0284186X.2014.923934, PubMed 24957555 -
Response to preoperative chemotherapy in patients undergoing resection of pulmonary metastasis from soft tissue sarcoma - a predictor of outcome?
Acta Oncol, 53 (9), 1180-7
DOI 10.3109/0284186X.2014.899433, PubMed 24697744 -
Advantage of lutetium-177 versus radioiodine immunoconjugate in targeted radionuclide therapy of b-cell tumors
Anticancer Res, 34 (7), 3263-9
PubMed 24982330 -
177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice
PLoS One, 9 (7), e103070
DOI 10.1371/journal.pone.0103070, PubMed 25068508 -
Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial
Lancet Oncol, 15 (7), 738-46
DOI 10.1016/S1470-2045(14)70183-4, PubMed 24836273 -
Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI
J Bone Oncol, 3 (1), 5-9
DOI 10.1016/j.jbo.2014.02.003, PubMed 26909292
Publications 2013
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Comparing high LET 227Th- and low LET 177Lu-trastuzumab in mice with HER-2 positive SKBR-3 xenografts
Curr Radiopharm, 6 (2), 78-86
DOI 10.2174/18744710113069990017, PubMed 23551110 -
Incidence and mortality of second sarcomas - a population-based study
Eur J Cancer, 49 (15), 3292-302
DOI 10.1016/j.ejca.2013.05.017, PubMed 23787025 -
Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma
Anticancer Res, 33 (1), 85-95
PubMed 23267131 -
Malignant phyllodes tumor and acute megakaryoblastic leukemia sharing a common clonal origin
Case Rep Hematol, 2013, 934781
DOI 10.1155/2013/934781, PubMed 24455338 -
Targeted alpha therapy with 227Th-trastuzumab of intraperitoneal ovarian cancer in nude mice
Curr Radiopharm, 6 (2), 106-16
DOI 10.2174/18744710113069990018, PubMed 23551111 -
Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall
Int J Radiat Oncol Biol Phys, 86 (5), 949-55
DOI 10.1016/j.ijrobp.2013.04.015, PubMed 23725998 -
Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial
Br J Dermatol, 169 (2), 434-40
DOI 10.1111/bjd.12349, PubMed 23551243 -
Two cases with fatal outcome following total lung irradiation for metastatic bone sarcoma
J Bone Oncol, 2 (4), 174-9
DOI 10.1016/j.jbo.2013.09.002, PubMed 26909289 -
The clinical impact of mean vessel size and solidity in breast carcinoma patients
PLoS One, 8 (10), e75954
DOI 10.1371/journal.pone.0075954, PubMed 24146798 -
Alpha emitter radium-223 and survival in metastatic prostate cancer
N Engl J Med, 369 (3), 213-23
DOI 10.1056/NEJMoa1213755, PubMed 23863050 -
Multimodal functional imaging for early response assessment in GIST patients treated with imatinib
Acta Oncol, 53 (1), 143-8
DOI 10.3109/0284186X.2013.798428, PubMed 23710697 -
Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H
Acta Oncol, 52 (4), 776-82
DOI 10.3109/0284186X.2013.770920, PubMed 23480638 -
Biologic targets identified from dynamic 18FDG-PET and implications for image-guided therapy
Acta Oncol, 52 (7), 1378-83
DOI 10.3109/0284186X.2013.813071, PubMed 23981046
Publications 2012
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Preclinical evaluation of 227Th-labeled and 177Lu-labeled trastuzumab in mice with HER-2-positive ovarian cancer xenografts
Nucl Med Commun, 33 (8), 838-47
DOI 10.1097/MNM.0b013e328354df7c, PubMed 22643311 -
Superficial-spreading and nodular melanomas in Norway: a comparison by body site distribution and latitude gradients
Melanoma Res, 22 (6), 460-5
DOI 10.1097/CMR.0b013e3283599cc3, PubMed 23010822 -
Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
Sarcoma, 2012, 639038
DOI 10.1155/2012/639038, PubMed 22518090 -
Two-year survival follow-up of the randomized, double-blind, placebo-controlled phase II study of radium-223 chloride in patients with castration-resistant prostate cancer and bone metastases
Clin Genitourin Cancer, 11 (1), 20-6
DOI 10.1016/j.clgc.2012.07.002, PubMed 23021204 -
A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
Eur J Cancer, 48 (5), 678-86
DOI 10.1016/j.ejca.2011.12.023, PubMed 22341993 -
Quantitative dynamic ¹⁸FDG-PET and tracer kinetic analysis of soft tissue sarcomas
Acta Oncol, 52 (6), 1160-7
DOI 10.3109/0284186X.2012.728713, PubMed 23198721 -
Targeted radio-nuclide therapy of skeletal metastases
Cancer Treat Rev, 39 (1), 18-26
DOI 10.1016/j.ctrv.2012.03.006, PubMed 22534284
Publications 2011
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Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab
EJNMMI Res, 1 (1), 18
DOI 10.1186/2191-219X-1-18, PubMed 22214432 -
Age-period-cohort analysis of primary bone cancer incidence rates in the United States (1976-2005)
Cancer Epidemiol Biomarkers Prev, 20 (8), 1770-7
DOI 10.1158/1055-9965.EPI-11-0136, PubMed 21724855 -
Breed-specific incidence rates of canine primary bone tumors--a population based survey of dogs in Norway
Can J Vet Res, 75 (3), 209-15
PubMed 22210997 -
Toxicity and relative biological effectiveness of alpha emitting radioimmunoconjugates
Curr Radiopharm, 4 (4), 321-8
DOI 10.2174/1874471011104040321, PubMed 22202154 -
Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections
Anticancer Res, 31 (12), 4053-60
PubMed 22199261 -
Monitoring the effect of targeted therapies in a gastrointestinal stromal tumor xenograft using a clinical PET/CT
Mol Imaging Biol, 13 (6), 1234-40
DOI 10.1007/s11307-010-0464-0, PubMed 21161686 -
Stromal targeted therapies in prostate and renal cancer: new concepts and knowledge
Clin Genitourin Cancer, 9 (1), 1-2
DOI 10.1016/j.clgc.2011.08.001, PubMed 21925102 -
Stromal targeted therapy in bone metastatic prostate cancer: promise delivered
Asian J Androl, 13 (6), 783-4
DOI 10.1038/aja.2011.120, PubMed 21857688 -
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years
Acta Orthop, 82 (2), 211-6
DOI 10.3109/17453674.2011.566141, PubMed 21434784 -
Radiotherapy or surgery for spine metastases?
Acta Orthop, 82 (3), 365-71
DOI 10.3109/17453674.2011.566142, PubMed 21434789
Publications 2010
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Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007
J Photochem Photobiol B, 101 (2), 174-8
DOI 10.1016/j.jphotobiol.2010.04.002, PubMed 20430639 -
CT density in lung cancer patients after radiotherapy sensitized by metoclopramide. A subgroup analysis of a randomized trial
Strahlenther Onkol, 186 (3), 163-8
DOI 10.1007/s00066-010-2040-6, PubMed 20165821 -
Five-year results from a Scandinavian sarcoma group study (SSG XIII) of adjuvant chemotherapy combined with accelerated radiotherapy in high-risk soft tissue sarcoma of extremities and trunk wall
Int J Radiat Oncol Biol Phys, 81 (5), 1359-66
DOI 10.1016/j.ijrobp.2010.07.037, PubMed 20933339 -
Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association?
Mol Nutr Food Res, 54 (8), 1127-33
DOI 10.1002/mnfr.200900512, PubMed 20512788 -
Seasonal variations of cancer incidence and prognosis
Dermatoendocrinol, 2 (2), 55-7
DOI 10.4161/derm.2.2.12664, PubMed 21547098 -
DW MRI for evaluation of treatment response to imatinib in a rectal gastrointestinal stromal tumour
Acta Oncol, 50 (1), 148-50
DOI 10.3109/0284186X.2010.516273, PubMed 21110775
Publications 2009
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Definitive radiotherapy with adjuvant long-term antiandrogen treatment for locally advanced prostate cancer: health-related quality of life and hormonal changes
Prostate Cancer Prostatic Dis, 12 (3), 269-76
DOI 10.1038/pcan.2009.8, PubMed 19290019 -
Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience
Acta Oncol, 48 (8), 1165-72
DOI 10.3109/02841860903032809, PubMed 19863225 -
Treatment of osteosarcoma. The Scandinavian Sarcoma Group experience
Cancer Treat Res, 152, 309-18
DOI 10.1007/978-1-4419-0284-9_16, PubMed 20213398 -
Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients
Cancer Treat Res, 152, 509-15
DOI 10.1007/978-1-4419-0284-9_30, PubMed 20213412 -
Treatment of soft tissue sarcoma of the extremity and trunk wall The Scandinavian Sarcoma Group perspective
Acta Orthop., 80 334, 52-59 -
Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma model
Int J Radiat Oncol Biol Phys, 75 (3), 878-85
DOI 10.1016/j.ijrobp.2009.04.039, PubMed 19665318 -
Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice
Anticancer Res, 29 (11), 4331-6
PubMed 20032375 -
Long-term follow-up of cancer patients receiving radiotherapy for bone metastases: results from a randomised multicentre trial
Radiother Oncol, 91 (2), 261-6
DOI 10.1016/j.radonc.2009.02.014, PubMed 19307034 -
The role of radiotherapy in oseosarcoma
Cancer Treat Res, 152, 147-64
DOI 10.1007/978-1-4419-0284-9_7, PubMed 20213389 -
Scandinavian experience in classical osteosarcoma Results of the SSG XIV protocol
Acta Orthop., 80 334, 60-66 -
DCEMRI of spontaneous canine tumors during fractionated radiotherapy: a pharmacokinetic analysis
Radiother Oncol, 93 (3), 618-24
DOI 10.1016/j.radonc.2009.08.012, PubMed 19747746
Publications 2008
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Disseminated tumor cells in bone marrow following definitive radiotherapy for intermediate or high-risk prostate cancer
Prostate, 68 (15), 1607-14
DOI 10.1002/pros.20826, PubMed 18655095 -
Radium-223: From Radiochemical Development to Clinical Applications in Targeted Cancer Therapy
Curr. Radiopharm., 1 (3), 203-208
DOI 10.2174/1874471010801030203 -
Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation
Int J Radiat Oncol Biol Phys, 72 (1), 186-92
DOI 10.1016/j.ijrobp.2008.05.029, PubMed 18722269 -
The impact of enzymatic degradation on the uptake of differently sized therapeutic molecules
Anticancer Res, 28 (6A), 3557-66
PubMed 19189635 -
Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study
Int J Radiat Oncol Biol Phys, 71 (4), 1196-203
DOI 10.1016/j.ijrobp.2007.11.023, PubMed 18207661 -
Sun beds and cod liver oil as vitamin D sources
J Photochem Photobiol B, 91 (2-3), 125-31
DOI 10.1016/j.jphotobiol.2008.02.007, PubMed 18417354 -
DCEMRI monitoring of canine tumors during fractionated radiotherapy
Acta Oncol, 47 (7), 1249-56
DOI 10.1080/02841860802244166, PubMed 18618342 -
Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation
Acta Oncol, 47 (2), 248-54
DOI 10.1080/02841860701630267, PubMed 18210300
Publications 2007
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Some musculo-skeletal sequelae in cancer survivors
Acta Oncol, 46 (4), 490-6
DOI 10.1080/02841860701218642, PubMed 17497316 -
Impact of disseminated tumor cells in bone marrow at diagnosis in patients with nonmetastatic prostate cancer treated by definitive radiotherapy
Int J Cancer, 120 (8), 1603-9
DOI 10.1002/ijc.22488, PubMed 17230512 -
10-year survival and quality of life in patients with high-risk pN0 prostate cancer following definitive radiotherapy
Int J Radiat Oncol Biol Phys, 69 (4), 1074-83
DOI 10.1016/j.ijrobp.2007.04.031, PubMed 17703896 -
Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate
Blood, 110 (6), 2049-56
DOI 10.1182/blood-2007-01-066803, PubMed 17536011 -
Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability
Cancer Biother Radiopharm, 22 (3), 431-7
DOI 10.1089/cbr.2006.321, PubMed 17651051 -
Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study
Lancet Oncol, 8 (7), 587-94
DOI 10.1016/S1470-2045(07)70147-X, PubMed 17544845 -
Proton therapy - a systematic review of clinical effectiveness
Radiother Oncol, 83 (2), 123-32
DOI 10.1016/j.radonc.2007.03.001, PubMed 17499374 -
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?
Lung Cancer, 55 (3), 263-70
DOI 10.1016/j.lungcan.2006.11.013, PubMed 17207891 -
Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
Int J Radiat Oncol Biol Phys, 68 (5), 1496-504
DOI 10.1016/j.ijrobp.2007.04.027, PubMed 17674980
Publications 2006
-
Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience
Acta Oncol, 45 (1), 38-46
DOI 10.1080/02841860500466624, PubMed 16464794 -
[Jumping after the Swedes]
Tidsskr Nor Laegeforen, 126 (5), 637
PubMed 16505887 -
High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?
Clin Cancer Res, 12 (20 Pt 2), 6250s-6257s
DOI 10.1158/1078-0432.CCR-06-0841, PubMed 17062709 -
Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
Nucl Med Biol, 33 (2), 271-9
DOI 10.1016/j.nucmedbio.2005.12.004, PubMed 16546683 -
First in vivo evaluation of liposome-encapsulated 223Ra as a potential alpha-particle-emitting cancer therapeutic agent
Anticancer Res, 26 (4B), 2841-8
PubMed 16886603 -
Prospective randomised multicenter trial on single fraction radiotherapy (8 Gy x 1) versus multiple fractions (3 Gy x 10) in the treatment of painful bone metastases
Radiother Oncol, 79 (3), 278-84
DOI 10.1016/j.radonc.2006.05.006, PubMed 16793154 -
Radiotoxicity of the alpha-emitting bone-seeker 223Ra injected intravenously into mice: histology, clinical chemistry and hematology
In Vivo, 20 (3), 325-31
PubMed 16724665 -
Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
Clin Cancer Res, 12 (20 Pt 2), 6209s-6212s
DOI 10.1158/1078-0432.CCR-06-1213, PubMed 17062702 -
Adapting radiotherapy to hypoxic tumours
Phys Med Biol, 51 (19), 4903-21
DOI 10.1088/0031-9155/51/19/012, PubMed 16985278 -
Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study
Phys Med Biol, 52 (2), 499-513
DOI 10.1088/0031-9155/52/2/013, PubMed 17202629
Publications 2005
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Hematogenous micrometastases in osteosarcoma patients
Clin Cancer Res, 11 (13), 4666-73
DOI 10.1158/1078-0432.CCR-05-0165, PubMed 16000559 -
Primary osteosarcoma of the breast
Acta Oncol, 44 (7), 767-70
DOI 10.1080/02841860500254897, PubMed 16227171 -
Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers
Br J Radiol, 78 (930), 528-32
DOI 10.1259/bjr/82990907, PubMed 15900058 -
Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts
Br J Cancer, 93 (1), 81-8
DOI 10.1038/sj.bjc.6602626, PubMed 15942637 -
Preparation and preclinical assessment of folate-conjugated, radiolabelled antibodies
Anticancer Res, 25 (1A), 9-15
PubMed 15816513 -
First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases
Clin Cancer Res, 11 (12), 4451-9
DOI 10.1158/1078-0432.CCR-04-2244, PubMed 15958630 -
Telemedicine in radiotherapy: a study exploring remote treatment planning, supervision and economics
J Telemed Telecare, 11 (5), 245-50
DOI 10.1258/1357633054471858, PubMed 16035967 -
TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma
Clin Orthop Relat Res (430), 142-8
DOI 10.1097/01.blo.0000137544.30200.b6, PubMed 15662316
Publications 2004
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Human osteosarcoma xenografts and their sensitivity to chemotherapy
Pathol Oncol Res, 10 (3), 133-41
DOI 10.1007/BF03033741, PubMed 15448748 -
Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts
Cancer Res, 64 (14), 4768-73
DOI 10.1158/0008-5472.CAN-03-1472, PubMed 15256445 -
Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents
Anticancer Res, 24 (1), 101-5
PubMed 15015582 -
Sterically stabilized liposomes as a carrier for alpha-emitting radium and actinium radionuclides
Nucl Med Biol, 31 (4), 441-9
DOI 10.1016/j.nucmedbio.2003.11.004, PubMed 15093814 -
Interferon-γ Sensitises Human Osteosarcoma Cells to Trail-mediated Apoptosis
Cancer Genomics Proteomics, 1 (2), 95-104
PubMed 31394674
Publications 2003
-
Comparative analyses of the dynamic properties of the rectum studied by cryo-sections of human cadavers and pelvic CT scans of patients
Br J Radiol, 76 (902), 104-8
DOI 10.1259/bjr/75640835, PubMed 12642278 -
Targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice
J Nucl Med, 44 (2), 252-9
PubMed 12571218 -
Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning
Anticancer Res, 23 (3B), 2201-16
PubMed 12894494
Publications 2002
-
High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases
J Clin Oncol, 20 (1), 189-96
DOI 10.1200/JCO.2002.20.1.189, PubMed 11773169 -
Radiation doses to non-Hodgkin's lymphoma cells and normal bone marrow exposed in vitro. Comparison of an alpha-emitting radioimmunoconjugate and external gamma-irradiation
Int J Radiat Biol, 78 (2), 133-42
DOI 10.1080/09553000110094788, PubMed 11779363 -
Significant antitumor effect from bone-seeking, alpha-particle-emitting (223)Ra demonstrated in an experimental skeletal metastases model
Cancer Res, 62 (11), 3120-5
PubMed 12036923 -
A method for measurement of the uptake patterns of two beta-emitting radionuclides in the same tissue section with a digital silicon detector: application to a study of 89SrCl2 and 153Sm-EDTMP in a dog with spontaneous osteosarcoma
Eur J Nucl Med Mol Imaging, 29 (2), 191-7
DOI 10.1007/s00259-001-0693-1, PubMed 11926381 -
Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases
Anticancer Res, 22 (4), 1949-57
PubMed 12174869 -
[Bone and soft tissue sarcomas treated at the Norwegian Radium Hospital 1980-99]
Tidsskr Nor Laegeforen, 122 (21), 2089-94
PubMed 12555642
Publications 2001
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Synthesis, purification and biodistribution of (205)Bi-DOTMP, visualizing bone deposition patterns with autoradiography
Nucl Med Biol, 28 (4), 425-33
DOI 10.1016/s0969-8051(01)00202-5, PubMed 11395316 -
Radionuclide therapy with bone-seeking compounds: Monte Carlo calculations of dose-volume histograms for bone marrow in trabecular bone
Phys Med Biol, 46 (4), 1149-61
DOI 10.1088/0031-9155/46/4/317, PubMed 11324957 -
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A
J Immunother, 24 (2), 144-50
DOI 10.1097/00002371-200103000-00009, PubMed 11265772
Publications 2000
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Exposure of human osteosarcoma and bone marrow cells to tumour-targeted alpha-particles and gamma-irradiation: analysis of cell survival and microdosimetry
Int J Radiat Biol, 76 (8), 1129-41
DOI 10.1080/09553000050111604, PubMed 10947126 -
Demonstration of highly specific toxicity of the alpha-emitting radioimmunoconjugate(211)At-rituximab against non-Hodgkin's lymphoma cells
Br J Cancer, 83 (10), 1375-9
DOI 10.1054/bjoc.2000.1453, PubMed 11044364 -
[Radiotherapy of skeletal metastases]
Tidsskr Nor Laegeforen, 120 (16), 1870-4
PubMed 10925615 -
Interstitial fluid pressure in human osteosarcoma xenografts: significance of implantation site and the response to intratumoral injection of hyaluronidase
Anticancer Res, 20 (5B), 3503-12
PubMed 11131654 -
Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts
Anticancer Res, 20 (5B), 3513-9
PubMed 11131655 -
Oral presentations in science and medicine. An art in decline?
Anticancer Res, 20 (5A), 2795-9
PubMed 11062686
Publications 1999
-
Two human osteoblast-like osteosarcoma cell lines show distinct expression and differential regulation of parathyroid hormone-related protein
J Bone Miner Res, 14 (6), 904-14
DOI 10.1359/jbmr.1999.14.6.904, PubMed 10352098 -
211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation
J Nucl Med, 40 (7), 1197-203
PubMed 10405142 -
Influence of pretreatment with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APB) on organ uptake of 211At and 125I-labeled amidobisphosphonates in mice
Nucl Med Biol, 26 (7), 791-4
DOI 10.1016/s0969-8051(99)00047-5, PubMed 10628558 -
Complement-mediated lysis of cultured osteosarcoma cell lines using chimeric mouse/human TP-1 IgG1 and IgG3 antibodies
Cancer Immunol Immunother, 48 (7), 411-8
DOI 10.1007/s002620050594, PubMed 10501855 -
Expression of a novel factor in human breast cancer cells with metastatic potential
Cancer Res, 59 (18), 4675-80
PubMed 10493524 -
[Patient treatment in radiation accidents]
Tidsskr Nor Laegeforen, 119 (10), 1446-50
PubMed 10354753 -
Internal radionuclide therapy of primary osteosarcoma in dogs, using 153Sm-ethylene-diamino-tetramethylene-phosphonate (EDTMP)
Clin Cancer Res, 5 (10 Suppl), 3148s-3152s
PubMed 10541356
Publications 1998
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Predicting detectability in radioguided surgery: a study based on physical characterization of the probe and on tissue uptake ratios of 125I-, 153Sm- and 165Er-labelled radiopharmaceuticals
Nucl Med Commun, 19 (3), 207-17
DOI 10.1097/00006231-199803000-00004, PubMed 9625495 -
Intratumour injection of immunoglobulins labelled with the alpha-particle emitter 211At: analyses of tumour retention, microdistribution and growth delay
Br J Cancer, 77 (7), 1115-22
DOI 10.1038/bjc.1998.185, PubMed 9569048 -
Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers
Anal Cell Pathol, 16 (1), 45-62
DOI 10.1155/1998/545906, PubMed 9584899 -
IgM secretory tailpiece drives multimerisation of bivalent scFv fragments in eukaryotic cells
Immunotechnology, 4 (2), 141-53
DOI 10.1016/s1380-2933(98)00014-1, PubMed 9853955 -
Radiotherapy in Scandinavia
Acta Oncol, 37 (6), 553-60
DOI 10.1080/028418698430250, PubMed 9860313
Publications 1997
-
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy
Eur J Cancer, 33 (11), 1725-31
DOI 10.1016/s0959-8049(97)00252-9, PubMed 9470825 -
Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis
Life Sci, 61 (19), PL275-80
DOI 10.1016/s0024-3205(97)00839-4, PubMed 9364204 -
212Bi-DOTMP: an alpha particle emitting bone-seeking agent for targeted radiotherapy
Nucl Med Biol, 24 (3), 231-7
DOI 10.1016/s0969-8051(97)00059-0, PubMed 9228657 -
Synovial sarcoma: immunohistochemical expression of P-glycoprotein and glutathione S transferase-pi and clinical drug resistance
Pathol Res Pract, 193 (1), 21-36
DOI 10.1016/s0344-0338(97)80090-8, PubMed 9112270
Publications 1996
-
Targeted radiotherapy of osteosarcoma using 153 Sm-EDTMP. A new promising approach
Acta Oncol, 35 (3), 381-4
DOI 10.3109/02841869609101655, PubMed 8679270 -
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation
J Cell Biochem, 60 (1), 95-106
DOI 10.1002/(SICI)1097-4644(19960101)60:1%3C95::AID-JCB12%3E3.0.CO;2-J, PubMed 8825419 -
Maxillectomy and targeted radionuclide therapy with 153Sm-EDTMP in a recurrent canine osteosarcoma
J Small Anim Pract, 37 (5), 241-6
DOI 10.1111/j.1748-5827.1996.tb01782.x, PubMed 8736231 -
Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling
Acta Oncol, 35 (3), 297-301
DOI 10.3109/02841869609101644, PubMed 8679259 -
Extremity and non-extremity high-grade osteosarcoma -- the Norwegian Radium Hospital experience during the modern chemotherapy era
Acta Oncol, 35 Suppl 8, 129-34
DOI 10.3109/02841869609098531, PubMed 9073059
Publications 1995
-
Cancer therapy with radiolabeled antibodies. An overview
Acta Oncol, 34 (8), 1085-94
DOI 10.3109/02841869509127235, PubMed 8608033 -
Alpha-particle radiotherapy with 211At-labeled monodisperse polymer particles, 211At-labeled IgG proteins, and free 211At in a murine intraperitoneal tumor model
Gynecol Oncol, 57 (1), 9-15
DOI 10.1006/gyno.1995.1093, PubMed 7705707 -
Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling
Nucl Med Biol, 22 (6), 765-71
DOI 10.1016/0969-8051(95)00014-o, PubMed 8535337
Publications 1994
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Immunoscintigraphy of bone sarcomas--results in 5 patients
Eur J Cancer, 30A (10), 1484-9
DOI 10.1016/0959-8049(94)00304-n, PubMed 7833107 -
Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays
Radiat Res, 139 (2), 178-84
DOI 10.2307/3578662, PubMed 8052693 -
Analysis of the therapeutic gain in the treatment of human osteosarcoma microcolonies in vitro with 211At-labelled monoclonal antibody
Br J Cancer, 69 (6), 1000-5
DOI 10.1038/bjc.1994.196, PubMed 8198960 -
PET imaging of osteosarcoma in dogs using a fluorine-18-labeled monoclonal antibody Fab fragment
J Nucl Med, 35 (9), 1506-13
PubMed 8071702
Publications 1993
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p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179
Publications 1992
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Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624 -
Immunoscintigraphic detection of primary and metastatic spontaneous canine osteosarcoma with F(ab')2 fragments of osteosarcoma-associated monoclonal antibody TP-1
Anticancer Res, 12 (6B), 2151-7
PubMed 1295462
Publications 1990
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Radioimmunotargeting of human tumour cells in immunocompetent animals
Br J Cancer, 62 (4), 573-8
DOI 10.1038/bjc.1990.332, PubMed 2223574
Publications 1989
-
Immunohistochemical detection of osteosarcoma-associated antigen in canine osteosarcoma
Anticancer Res, 9 (4), 903-7
PubMed 2684000
Publications 1988
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Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen
Cancer Res, 48 (18), 5302-9
PubMed 2457439