Research projects

Clinical studies:

• TAME (multicenter international RCT on permissive hypercapnia vs normocapnia during post-resuscitation care in out-of-hospital cardiac arrest (OHCA) patients
• ORANGE (multicenter international RCT investigating Pupillometry for prognostication in comatose patients after severe intracranial bleeding)
• REBOARREST trial (multicenter national RCT investigating effects of ballon-occlusion of the thoracic part of aorta to improve vital organ perfusion and survival during OHCA) 
• Substudies from TAME: different haemodynamic and myocardial effects related to hypercapnia in cardiac arrest patients during post-resuscitation care using Swan-Ganz catheters and echocardiography
• Substudies from NORCAST (clinical observation study on prognostication and long term outcome among comatose, primary resuscitated OHCA patients)
  - quality of life in survivors five years after OHCA
  - changes in quality of life between six months and five years in survivors after OHCA
  - long-term (five years) cognitive function after OHCA
  - outcome and prognostic predictors in comatose OHCA patients with initial shockable vs non-shockable rhythms
  - transcranial doppler for prognostication in comatose patients after OHCA
  - blood pressure and associations with outcome during post-resuscitation care after OHCA
  - imaging (CT/MRI) for prognostication in comatose patients after OHCA
  - biobank-studies (complement factors, biomarkers) in comatose resuscitated OHCA patients
• Comparison of outcome after changing temperature management for comatose admitted resuscitated OHCA patients from therapeutic hypothermia to normothermia
• Different studies on the effects of early rehabilitation after severe traumatic brain injury 

Experimental pig studies:

• Cerebral perfusion and metabolism with mean arterial pressure of 60 vs 90 mmHg with and without therapeutic hypothermia in an experimental pig model
• Haemodynamic effects of different ventilation strategies during resuscitation in an experimental pig model
• Cerebral perfusion and metabolism with targeted hypercapnia vs normocapnia with and without therapeutic hypothermia in an experimental pig model