Publications 2024

Gopalakrishnan RP, Østrøm MS, Skjeldal FM, Bakke O, Bogen B, Huszthy PC (2024)
B Cells With Complementary B Cell Receptors Can Kill Each Other
Eur J Immunol, e202350890 (in press)
DOI 10.1002/eji.202350890, PubMed 39520365

Haghmorad D, Oksenych V, Huszthy PC (2024)
Editorial: Exploring the role of T helper cells in autoimmune disease
Front Immunol, 15, 1434684
DOI 10.3389/fimmu.2024.1434684, PubMed 38903522

Publications 2022

Tesfaye DY, Bobic S, Lysén A, Huszthy PC, Gudjonsson A, Braathen R, Bogen B, Fossum E (2022)
Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection
Front Immunol, 13, 752714
DOI 10.3389/fimmu.2022.752714, PubMed 35296089

Publications 2021

Szodoray P, Andersen TK, Heinzelbecker J, Imbery JF, Huszthy PC, Stanford SM, Bogen B, Landsverk OB, Bottini N, Tveita A, Munthe LA, Nakken B (2021)
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity
Cell Rep, 36 (6), 109525
DOI 10.1016/j.celrep.2021.109525, PubMed 34380042

Publications 2019

Andersen TK, Huszthy PC, Gopalakrishnan RP, Jacobsen JT, Fauskanger M, Tveita AA, Grødeland G, Bogen B (2019)
Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules
NPJ Vaccines, 4, 9
DOI 10.1038/s41541-019-0101-0, PubMed 30775000

Exner ND, Valenzuela JAC, Abou-El-Ardat K, Miletic H, Huszthy PC, Radehaus PM, Schröck E, Bjerkvig R, Kaderali L, Klink B, Nigro JM (2019)
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes
Oncotarget, 10 (38), 3641-3653
DOI 10.18632/oncotarget.26950, PubMed 31217899

Huszthy PC, Gopalakrishnan RP, Jacobsen JT, Haabeth OAW, Løset GÅ, Braathen R, Schenck K, Tveita AA, Munthe LA, Bogen B (2019)
B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells
Proc Natl Acad Sci U S A, 116 (51), 25850-25859
DOI 10.1073/pnas.1902836116, PubMed 31796587

Publications 2018

Brizić I, Šušak B, Arapović M, Huszthy PC, Hiršl L, Kveštak D, Juranić Lisnić V, Golemac M, Pernjak Pugel E, Tomac J, Oxenius A, Britt WJ, Arapović J, Krmpotić A, Jonjić S (2018)
Brain-resident memory CD8⁺ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation
Eur J Immunol, 48 (6), 950-964
DOI 10.1002/eji.201847526, PubMed 29500823

Publications 2017

Primon M, Huszthy PC, Motaln H, Talasila KM, Miletic H, Atai NA, Bjerkvig R, Lah Turnšek T (2017)
Cathepsin L silencing increases As₂O₃ toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7
Exp Cell Res, 356 (1), 64-73
DOI 10.1016/j.yexcr.2017.04.013, PubMed 28412241

Publications 2015

Huszthy PC, Sakariassen PØ, Espedal H, Brokstad KA, Bjerkvig R, Miletic H (2015)
Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression
PLoS One, 10 (8), e0136089
DOI 10.1371/journal.pone.0136089, PubMed 26291724

Huszthy PC, Sakariassen PØ, Espedal H, Brokstad KA, Bjerkvig R, Miletic H (2015)
Correction: Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression
PLoS One, 10 (10), e0140303
DOI 10.1371/journal.pone.0140303, PubMed 26431334

Nagy G, Huszthy PC, Fossum E, Konttinen Y, Nakken B, Szodoray P (2015)
Selected Aspects in the Pathogenesis of Autoimmune Diseases
Mediators Inflamm, 2015, 351732
DOI 10.1155/2015/351732, PubMed 26300591

Nakken B, Nagy G, Huszthy PC, Fossum E, Konttinen Y, Szodoray P (2015)
Inflammatory Mediators in Autoimmunity and Systemic Autoimmune Diseases
Mediators Inflamm, 2015, 878712
DOI 10.1155/2015/878712, PubMed 26346773

Publications 2014

Slavuljica I, Kveštak D, Huszthy PC, Kosmac K, Britt WJ, Jonjić S (2014)
Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
Cell Mol Immunol, 12 (2), 180-91
DOI 10.1038/cmi.2014.51, PubMed 25042632

Publications 2013

Daphu I, Sundstrøm T, Horn S, Huszthy PC, Niclou SP, Sakariassen PØ, Immervoll H, Miletic H, Bjerkvig R, Thorsen F (2013)
In vivo animal models for studying brain metastasis: value and limitations
Clin Exp Metastasis, 30 (5), 695-710
DOI 10.1007/s10585-013-9566-9, PubMed 23322381

Jarzabek MA, Huszthy PC, Skaftnesmo KO, McCormack E, Dicker P, Prehn JH, Bjerkvig R, Byrne AT (2013)
In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme
Mol Imaging, 12 (3), 161-72
PubMed 23490442

Jarzabek MA, Huszthy PC, Skaftnesmo KO, McCormack E, Dicker P, Prehn JHM, Bjerkvig R, Byrne AT (2013)
In Vivo Bioluminescence Imaging Validation of a Human Biopsy-Derived Orthotopic Mouse Model of Glioblastoma Multiforme
Mol. Imaging, 12 (3)
DOI 10.2310/7290.2012.00029

Klink B, Miletic H, Stieber D, Huszthy PC, Campos Valenzuela JA, Balss J, Wang J, Schubert M, Sakariassen PØ, Sundstrøm T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou SP, Schröck E, Bjerkvig R, Nigro JM (2013)
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1
PLoS One, 8 (3), e59773
DOI 10.1371/journal.pone.0059773, PubMed 23527265

Primon M, Huszthy PC, Motaln H, Talasila KM, Torkar A, Bjerkvig R, Lah Turnšek T (2013)
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids
Exp Cell Res, 319 (17), 2637-48
DOI 10.1016/j.yexcr.2013.08.011, PubMed 23968587

Talasila KM, Soentgerath A, Euskirchen P, Rosland GV, Wang J, Huszthy PC, Prestegarden L, Skaftnesmo KO, Sakariassen PØ, Eskilsson E, Stieber D, Keunen O, Brekka N, Moen I, Nigro JM, Vintermyr OK, Lund-Johansen M, Niclou S, Mørk SJ, Enger PO, Bjerkvig R, Miletic H (2013)
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis
Acta Neuropathol, 125 (5), 683-98
DOI 10.1007/s00401-013-1101-1, PubMed 23429996

Publications 2012

Gole B, Huszthy PC, Popović M, Jeruc J, Ardebili YS, Bjerkvig R, Lah TT (2012)
The regulation of cysteine cathepsins and cystatins in human gliomas
Int J Cancer, 131 (8), 1779-89
DOI 10.1002/ijc.27453, PubMed 22287159

Huszthy PC, Daphu I, Niclou SP, Stieber D, Nigro JM, Sakariassen PØ, Miletic H, Thorsen F, Bjerkvig R (2012)
In vivo models of primary brain tumors: pitfalls and perspectives
Neuro Oncol, 14 (8), 979-93
DOI 10.1093/neuonc/nos135, PubMed 22679124

Najbauer J, Huszthy PC, Barish ME, Garcia E, Metz MZ, Myers SM, Gutova M, Frank RT, Miletic H, Kendall SE, Glackin CA, Bjerkvig R, Aboody KS (2012)
Cellular host responses to gliomas
PLoS One, 7 (4), e35150
DOI 10.1371/journal.pone.0035150, PubMed 22539956

Publications 2011

Euskirchen P, Skaftnesmo KO, Huszthy PC, Brekkå N, Bjerkvig R, Jacobs AH, Miletic H (2011)
NUMB does not impair growth and differentiation status of experimental gliomas
Exp Cell Res, 317 (20), 2864-73
DOI 10.1016/j.yexcr.2011.09.002, PubMed 21939656

Publications 2009

Huszthy PC, Giroglou T, Tsinkalovsky O, Euskirchen P, Skaftnesmo KO, Bjerkvig R, von Laer D, Miletic H (2009)
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy
PLoS One, 4 (7), e6314
DOI 10.1371/journal.pone.0006314, PubMed 19617915

Huszthy PC, Immervoll H, Wang J, Goplen D, Miletic H, Eide GE, Bjerkvig R (2009)
Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment
Gene Ther, 17 (2), 202-16
DOI 10.1038/gt.2009.130, PubMed 19829315

Wang J, Miletic H, Sakariassen PØ, Huszthy PC, Jacobsen H, Brekkå N, Li X, Zhao P, Mørk S, Chekenya M, Bjerkvig R, Enger PØ (2009)
A reproducible brain tumour model established from human glioblastoma biopsies
BMC Cancer, 9, 465
DOI 10.1186/1471-2407-9-465, PubMed 20040089

Publications 2008

Huszthy PC, Goplen D, Thorsen F, Immervoll H, Wang J, Gutermann A, Miletic H, Bjerkvig R (2008)
Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma
Clin Cancer Res, 14 (5), 1571-80
DOI 10.1158/1078-0432.CCR-07-2000, PubMed 18316582

Publications 2006

Huszthy PC, Brekken C, Pedersen TB, Thorsen F, Sakariassen PO, Skaftnesmo KO, Haraldseth O, Lønning PE, Bjerkvig R, Enger PO (2006)
Antitumor efficacy improved by local delivery of species-specific endostatin
J Neurosurg, 104 (1), 118-28
DOI 10.3171/jns.2006.104.1.118, PubMed 16509155

Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, Lønning PE, Hoover F (2006)
Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma
J Gene Med, 8 (9), 1131-40
DOI 10.1002/jgm.939, PubMed 16810631

Publications 2005

Huszthy PC, Svendsen A, Wilson JM, Kotin RM, Lønning PE, Bjerkvig R, Hoover F (2005)
Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts
Hum Gene Ther, 16 (3), 381-92
DOI 10.1089/hum.2005.16.381, PubMed 15812233

Publications 2003

Thorsen F, Ersland L, Nordli H, Enger PO, Huszthy PC, Lundervold A, Standnes T, Bjerkvig R, Lund-Johansen M (2003)
Imaging of experimental rat gliomas using a clinical MR scanner
J Neurooncol, 63 (3), 225-31
DOI 10.1023/a:1024241905888, PubMed 12892228

Publications 2001

Read TA, Farhadi M, Bjerkvig R, Olsen BR, Rokstad AM, Huszthy PC, Vajkoczy P (2001)
Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells
Cancer Res, 61 (18), 6830-7
PubMed 11559558