Emma Lång

  • Researcher, Project leader (PI); PhD
  • +47 230 13 916

Research Project:
Navigating the Tunnel - Keratinocyte Dynamics & Therapeutic Targeting of IL-17 in Hidradenitis Suppurativa

Chronic inflammatory skin disease Hidradenitis Suppurativa
The focus of our research activities is to uncover the underlying cellular mechanisms of the chronic inflammatory skin disease, Hidradenitis Suppurativa (HS).
We will perform functional characterization of dysregulated skin cells associated with HS to enhance the clinical understanding of disease initiation, with the aim of preventing progression to severe disease and reducing the need for surgery.
By combining spatial phenotyping of intact tissue, mechanistic studies on primary skin cells, and clinical observations, we aim to uncover how keratinocyte phenotypes drive tunnel formation and how current treatments influence these dynamic processes.

Research aims:

  • Develop and implement multiplex tissue analysis and spatial mapping workflows for HS to identify and localize tunnelassociated cell populations in intact skin.
  • Establish robust protocols to isolate tunnelassociated keratinocytes and characterize their behavior in primary cell assays, including functional phenotyping.
  • Define the role of IL17 signaling in shaping tunnelassociated keratinocyte phenotypes and link keratinocyte dynamics to clinical outcomes.

Contact information:

Emma Lång, PhD, Department of Microbiology, Oslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, NO-0424 Oslo, Norway
Visiting address: Forskningsveien 1, 0373 Oslo, Norway
e-mail address: emma.lang@medisin.uio.no

Key Collaborator:

Olav Sundnes (Associate Professor, MD)

Dermatology Research Group
 

Publications 2025

Angheluta L, Lång A, Lång E, Bøe SO (2025)
Full-Integer Topological Defects in Polar Active Matter: From Collective Migration to Tissue Patterning
Annual Review of Condensed Matter Physics, 17, 305-325
DOI 10.1146/annurev-conmatphys-031620-105420, PublikaID 558

Publications 2024

Lång E, Lång A, Blicher P, Rognes T, Dommersnes PG, Bøe SO (2024)
Topology-guided polar ordering of collective cell migration
Sci Adv, 10 (16), eadk4825
DOI 10.1126/sciadv.adk4825, PubMed 38630812

Publications 2022

Lång E, Pedersen C, Lång A, Blicher P, Klungland A, Carlson A, Bøe SO (2022)
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
Proc Natl Acad Sci U S A, 119 (32), e2201328119
DOI 10.1073/pnas.2201328119, PubMed 35914175

Publications 2019

Lång A, Lång E, Bøe SO (2019)
PML Bodies in Mitosis
Cells, 8 (8)
DOI 10.3390/cells8080893, PubMed 31416160

Publications 2018

Lång A, Øye A, Eriksson J, Rowe AD, Lång E, Bøe SO (2018)
Influence of acute promyelocytic leukemia therapeutic drugs on nuclear pore complex density and integrity
Biochem Biophys Res Commun, 499 (3), 570-576
DOI 10.1016/j.bbrc.2018.03.191, PubMed 29596829

Lång E, Połeć A, Lång A, Valk M, Blicher P, Rowe AD, Tønseth KA, Jackson CJ, Utheim TP, Janssen LMC, Eriksson J, Bøe SO (2018)
Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding
Nat Commun, 9 (1), 3665
DOI 10.1038/s41467-018-05578-7, PubMed 30202009

Publications 2017

Lång A, Eriksson J, Schink KO, Lång E, Blicher P, Połeć A, Brech A, Dalhus B, Bøe SO (2017)
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Nucleus, 8 (4), 404-420
DOI 10.1080/19491034.2017.1306161, PubMed 28402725

Publications 2015

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
DOI 10.1371/journal.pone.0134954, PubMed 26248334

Publications 2014

Palibrk V, Lång E, Lång A, Schink KO, Rowe AD, Bøe SO (2014)
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887

Publications 2012

Lång E, Grudic A, Pankiv S, Bruserud O, Simonsen A, Bjerkvig R, Bjørås M, Bøe SO (2012)
The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling
Blood, 120 (4), 847-57
DOI 10.1182/blood-2011-10-388496, PubMed 22692509

Publications 2011

Benam AV, Lång E, Alfsnes K, Fleckenstein B, Rowe AD, Hovland E, Ambur OH, Frye SA, Tønjum T (2011)
Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation
Microbiology (Reading), 157 (Pt 5), 1329-1342
DOI 10.1099/mic.0.046896-0, PubMed 21330432

Publications 2009

Lång E (2009)
Meningococcal inner membrane proteins and their role in transformation
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 827, 1 b. (flere pag.)
BIBSYS 093812485, ISBN 978-82-8072-333-8

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T (2009)
Identification of neisserial DNA binding components
Microbiology (Reading), 155 (Pt 3), 852-862
DOI 10.1099/mic.0.022640-0, PubMed 19246756

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